TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization

Cellular and Molecular Life Sciences

Volumn 73, Issue 9, 2016, Pages 1895-1915

  Jouannet, Stéphanie ^a,b   Saint Pol, Julien ^a,b   Fernandez, Laurent ^c   Nguyen, Viet ^b   Charrin, Stéphanie ^a,b   Boucheix, Claude ^a,b   Brou, Christel ^d   Milhiet, Pierre Emmanuel ^c   Rubinstein, Eric ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^d INSTITUT PASTEUR   (France)

Author keywords

ADAM10; Ectodomain shedding; Membrane compartmentalization; Microdomain; Notch; Tetraspanin

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID PRECURSOR PROTEIN; HERMES ANTIGEN; NERVE CELL ADHESION MOLECULE; NOTCH RECEPTOR; PROTEIN TSPAN14; PROTEIN TSPAN15; PROTEIN TSPAN33; PROTEIN TSPAN5; TETRASPANIN; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; CADHERIN; MEMBRANE PROTEIN; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR; SECRETASE; SMALL INTERFERING RNA; TSPAN14 PROTEIN, HUMAN; TSPAN15 PROTEIN, HUMAN; TSPAN33 PROTEIN, HUMAN; TSPAN5 PROTEIN, HUMAN;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FRACTIONATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SUCROSE GRADIENT; ANTAGONISTS AND INHIBITORS; CONFOCAL MICROSCOPY; ENZYME SPECIFICITY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; RNA INTERFERENCE; TANDEM MASS SPECTROMETRY; TUMOR CELL LINE;

ADAM PROTEINS; ADAM10 PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTIGENS, CD44; CADHERINS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; RECEPTOR, NOTCH1; RNA INTERFERENCE; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY; TETRASPANINS;

EID: 84950246980     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-2111-z     Document Type: Article

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