Occurrence and Profile Characteristics of the Pesticide Imidacloprid, Preservative Parabens, and Their Metabolites in Human Urine from Rural and Urban China

Environmental Science and Technology

Volumn 49, Issue 24, 2015, Pages 14633-14640

  Wang, Lei ^a   Liu, Tianzhen ^a   Liu, Fang ^a   Zhang, Junjie ^a   Wu, Yinghong ^b   Sun, Hongwen ^a  

^a NANKAI UNIVERSITY   (China)

^b Tianjing Centre for Disease Control and Prevention   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; INSECTICIDES; METABOLITES; ORGANIC POLYMERS; PESTICIDES; PROPYLPARABEN; RURAL AREAS;

6-CHLORONICOTINIC ACID; GEOMETRIC MEAN; HUMAN EXPOSURES; HYDROXYBENZOIC ACIDS; IMIDACLOPRIDS; PESTICIDE SPRAYING; RURAL AND URBAN; URINE SAMPLE;

PARABENS;

4 HYDROXYBENZOIC ACID; 4 HYDROXYBENZOIC ACID ESTER; 6 CHLORONICOTINIC ACID; BUTYL PARABEN; ETHYL PARABEN; IMIDACLOPRID; METHYL PARABEN; PROPYL PARABEN; UNCLASSIFIED DRUG; 4-HYDROXYBENZOIC ACID; 6-CHLORONICOTINIC ACID; ETHYL-P-HYDROXYBENZOATE; IMIDAZOLE DERIVATIVE; NICOTINIC ACID DERIVATIVE; NITRO DERIVATIVE; PESTICIDE; PRESERVATIVE;

BIOACCUMULATION; BIOCHEMICAL COMPOSITION; IMIDACLOPRID; METABOLISM; METABOLITE; RURAL POPULATION; URBAN POPULATION; URINE;

ADULT; AGED; ARTICLE; CHINA; CONCENTRATION (PARAMETERS); ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MALE; METABOLISM; METABOLITE; OCCUPATIONAL EXPOSURE; PESTICIDE SPRAYING; RURAL AREA; RURAL POPULATION; SEX DIFFERENCE; TOXICOKINETICS; URBAN AREA; URBAN POPULATION; URBAN RURAL DIFFERENCE; URINALYSIS; URINE LEVEL; ANALYSIS; CHILD; MIDDLE AGED; PRESCHOOL CHILD; URINE; VERY ELDERLY;

CHINA;

ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; CHINA; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; IMIDAZOLES; MALE; MIDDLE AGED; NICOTINIC ACIDS; NITRO COMPOUNDS; PARABENS; PESTICIDES; PRESERVATIVES, PHARMACEUTICAL; RURAL POPULATION; URBAN POPULATION;

EID: 84950106443     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/acs.est.5b04037     Document Type: Article

References (53)

1. Hites, R. A. Polybrominated diphenyl ethers in the environment and in people: A meta-analysis of concentrations Environ. Sci. Technol. 2004, 38, 945-956 10.1021/es035082g
2. Meeker, J. D.; Yang, T.; Ye, X.; Calafat, A. M.; Hauser, R. Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage Environ. Health Perspect. 2010, 119, 252-257 10.1289/ehp.1002238
3. USCDC. Fourth National Report on HumanExposure to EnvironmentalChemicals Updated Tables. http://www.cdc.gov/biomonitoring/pdf/FourthReport UpdatedTables Feb2015.pdf (accessed Aug 8th, 2015).
4. Yamamoto, I. Nicotine to nicotinoids: 1962 to 1997. In Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor. Yamamoto, I.; Casida, J. E., Eds.; Springer-Verlag: Tokyo, pp 3-27.
5. Tomizawa, M.; Casida, J. E. Neonicotinoid insecticides: Highlights of a symposium on strategic molecular designs J. Agric. Food Chem. 2011, 59, 2883-2886 10.1021/jf103856c
6. Elbert, A.; Haas, M.; Springer, B.; Thielert, W.; Nauen, R. Applied aspects of neonicotinoid uses in crop protection Pest Manage. Sci. 2008, 64, 1099-1105 10.1002/ps.1616
7. Kimura-Kuroda, J.; Komuta, Y.; Kuroda, Y.; Hayashi, M.; Kawano, H. Nicotine-like effects of the neonicotinoid insecticides acetamiprid and imidacloprid on cerebellar neurons from neonatal rats PLoS One 2012, 7, e32432 10.1371/journal.pone.0032432
8. Ozsahin, A. D.; Bal, R.; Yilmaz, O. Biochemical alterations in kidneys of infant and adult male rats due to exposure to the neonicotinoid insecticides imidacloprid and clothianidin Toxicol. Res. 2014, 3, 324-330 10.1039/C4TX00006D
9. Pandey, S. P.; Mohanty, B. The neonicotinoid pesticide imidacloprid and the dithiocarbamate fungicide mancozeb disrupt the pituitary-thyroid axis of a wildlife bird Chemosphere 2015, 122, 227-234 10.1016/j.chemosphere.2014.11.061
10. Crosby, E. B.; Bailey, J. M.; Oliveri, A. N.; Levin, E. D. Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish Neurotoxicol. Teratol. 2015, 49, 81-90 10.1016/j.ntt.2015.04.006
11. Malev, O.; Klobučar, R. S.; Fabbretti, E.; Trebše, P. Comparative toxicity of imidacloprid and its transformation product 6-chloronicotinic acid to non-target aquatic organisms: Microalgae Desmodesmus subspicatus and amphipod Gammarus fossarum Pestic. Biochem. Physiol. 2012, 104, 178-186 10.1016/j.pestbp.2012.07.008
12. Kavvalakis, M. P.; Tzatzarakis, M. N.; Theodoropoulou, E. P.; Barbounis, E. G.; Tsakalof, A. K.; Tsatsakis, A. M Development and application of LC-APCI-MS method for biomonitoring of animal and human exposure to imidacloprid Chemosphere 2013, 93, 2612-2620 10.1016/j.chemosphere.2013.09.087
13. Mohamed, F.; Gawarammana, I.; Robertson, T. A.; Roberts, M. S.; Palangasinghe, C.; Zawahir, S.; Jayamanne, S.; Kandasamy, J.; Eddleston, M.; Buckley, N. A.; Dawson, A. H.; Roberts, D. M. Acute Human Self-Poisoning with Imidacloprid Compound: A Neonicotinoid Insecticide PLoS One 2009, 4, e5127 10.1371/journal.pone.0005127
14. Proença, P.; Teixeira, H.; Castanheira, F.; Pinheiro, J.; Monsanto, P. V.; Marques, E. P.; Vieira, D. N. Two fatal intoxication cases with imidacloprid: LC/MS analysis Forensic Sci. Int. 2005, 153, 75-80 10.1016/j.forsciint.2005.04.015
15. Ueyama, J.; Nomura, H.; Kondo, T.; Saito, I.; Ito, Y.; Osaka, A.; Kamijima, M. Biological monitoring method for urinary neonicotinoid insecticides using LC-MS/MS and its application to Japanese adults J. Occup. Health 2014, 56, 461-468 10.1539/joh.14-0077-OA
16. China Crop Protection Industry Association. China PesticidesProducts Reports. http://www.agrochemex.org/wp-content/uploads/2012/02/2012.12.pdf (accessed Aug 10th, 2015).
17. Soni, M. G.; Carabin, I. G.; Burdock, G. A. Safety assessment of esters of p-hydroxybenzoic acid (parabens) Food Chem. Toxicol. 2005, 43, 985-1015 10.1016/j.fct.2005.01.020
18. Routledge, E. J.; Parker, J.; Odum, J.; Ashby, J.; Sumpter, J. P. Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic Toxicol. Appl. Pharmacol. 1998, 153, 12-19 10.1006/taap.1998.8544
19. Isling, L. K.; Boberg, J.; Jacobsen, P. R.; Mandrup, K. R.; Axelstad, M.; Christiansen, S.; Vinggaard, A. M.; Taxvig, C.; Kortenkamp, A.; Hass, U. Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters Reproduction 2014, 147, 465-476 10.1530/REP-13-0448
20. Golden, R.; Gandy, J.; Vollmer, G. A review of the endocrine activity of parabens and implications for potential risks to human health Crit. Rev. Toxicol. 2005, 35, 435-458 10.1080/10408440490920104
21. Darbre, P. D.; Byford, J. R.; Shaw, L. E.; Hall, S.; Coldham, N. G.; Pope, G. S.; Sauer, M. J. Oestrogenic activity of benzyl paraben J. Appl. Toxicol. 2003, 23, 43-51 10.1002/jat.886
22. Oishi, S. Effects of butyl paraben on the male reproductive system in mice Arch. Toxicol. 2002, 76, 423-429 10.1007/s00204-002-0360-8
23. Miller, D.; Wheals, B. B.; Beresford, N.; Sumpter, J. P. Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay Environ. Health Perspect. 2001, 109, 133-138 10.2307/3434765
24. Wang, L.; Asimakopoulos, A. G.; Kannan, K. Accumulation of 19 environmental phenolic and xenobiotic heterocyclic aromatic compounds in human adipose tissue Environ. Int. 2015, 78, 45-50 10.1016/j.envint.2015.02.015
25. Barr, L.; Metaxas, G.; Harbach, C. A.; Savoy, L. A.; Darbre, P. D. Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum J. Appl. Toxicol. 2012, 32, 219-232 10.1002/jat.1786
26. Darbre, P. D.; Aljarrah, A.; Miller, W. R.; Coldham, N. G.; Sauer, M. J.; Pope, G. S. Concentrations of parabens in human breast tumors J. Appl. Toxicol. 2004, 24, 5-13 10.1002/jat.958
27. Savage, J. H.; Matsui, E. C.; Wood, R. A.; Keet, C. A. Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization J. Allergy Clin. Immunol. 2012, 130, 453-460 10.1016/j.jaci.2012.05.006
28. Asimakopoulos, A. G.; Thomaidis, N. S.; Kannan, K. Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoicacid esters (parabens), benzophenone type-UV filters, triclosan, andtriclocarban in human urine from Athens, Greece Sci. Total Environ. 2014, 470-471, 1243-1249 10.1016/j.scitotenv.2013.10.089
29. Larsson, K.; Ljung Björklund, K.; Palm, B.; Wennberg, M.; Kaj, L.; Lindh, C. H.; Jönsson, B. A.; Berglund, M. Exposure determinants of phthalates, parabens, bisphenol A and triclosan in Swedish mothers and their children Environ. Int. 2014, 73, 323-333 10.1016/j.envint.2014.08.014
30. Moos, R. K.; Angerer, J.; Wittsiepe, J.; Wilhelm, M.; Brüning, T.; Koch, H. M. Rapid determination of nine parabens and seven other environmental phenols in urine samples of German children and adults Int. J. Hyg. Environ. Health 2014, 217, 845-53 10.1016/j.ijheh.2014.06.003
31. Ma, W. L.; Wang, L.; Guo, Y.; Liu, L. Y.; Qi, H.; Zhu, N. Z.; Gao, C. J.; Li, Y. F.; Kannan, K. Urinary concentrations of parabens in Chinese young adults: implications for human exposure Arch. Environ. Contam. Toxicol. 2013, 65, 611-618 10.1007/s00244-013-9924-2
32. Shirai, S.; Suzuki, Y.; Yoshinaga, J.; Shiraishi, H.; Mizumoto, Y. Urinary excretion of parabens in pregnant Japanese women Reprod. Toxicol. 2013, 35, 96-101 10.1016/j.reprotox.2012.07.004
33. Wang, L.; Wu, Y.; Zhang, W.; Kannan, K. Characteristic profiles of urinary p-hydroxybenzoic acid and its esters (parabens) in children and adults from the United States and China Environ. Sci. Technol. 2013, 47, 2069-2076 10.1021/es304659r
34. Frederiksen, H.; Jørgensen, N.; Andersson, A. M. Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) J. Exposure Sci. Environ. Epidemiol. 2011, 21, 262-271 10.1038/jes.2010.6
35. Calafat, A. M.; Ye, X.; Wong, L. Y.; Bishop, A. M.; Needham, L. L. Urinary concentrations of four parabens in the U.S. population: 2005-2006 Environ. Health Perspect. 2010, 118, 679-685 10.1289/ehp.0901560
36. Ye, X.; Bishop, A. M.; Reidy, J. A.; Needham, L. L.; Calafat, A. M. Parabens as urinary biomarkers of exposure in humans Environ. Health Perspect. 2006, 114, 1843-1846 10.1289/ehp.9413
37. Fu, J.; Gao, Y.; Wang, T.; Liang, Y.; Zhang, A.; Wang, Y.; Jiang, G. Elevated levels of perfluoroalkyl acids in family members of occupationally exposed workers: the importance of dust transfer Sci. Rep. 2015, 5, 9313 10.1038/srep09313
38. Elvia, L. F.; Sioban, H. D.; Bernardo, H. P.; Costanza, S. C. Organochlorine pesticide exposure in rural and urban areas in Mexico J. Exposure Anal. Environ. Epidemiol. 2000, 10, 394-399 10.1038/sj.jea.7500103
39. Chen, M.; Tao, L.; McLean, J.; Lu, C. Quantitative Analysis of Neonicotinoid Insecticide Residues in Foods: Implication for Dietary Exposures J. Agric. Food Chem. 2014, 62, 6082-6090 10.1021/jf501397m
40. Xu, T.; Xu, Q. G.; Li, H.; Wang, J.; Li, Q. X.; Shelver, W. L.; Li, J. Strip-based immune assay for the simultaneous detection of the neonicotinoid insecticides imidacloprid and thiamethoxam in agricultural products Talanta 2012, 101, 85-90 10.1016/j.talanta.2012.08.047
41. Watanabe, E.; Baba, K.; Eun, H.; Miyake, S. Application of a commercial immunoassay to the direct determination of insecticide imidacloprid in fruit juices Food Chem. 2007, 102, 745-750 10.1016/j.foodchem.2006.06.031
42. 14C]-NTN 33893: Biokinetic part of the "General metabolism study" in the rat. Unpublished report from Bayer AG, Report No. PF2889, dated 9 November 1987, GLP. Submitted to WHO by Bayer AG, Mannheim, Germany.
43. Ford, K. A.; Casida, J. E. Chloropyridinyl neonicotinoid insecticides: diverse molecular substituents contribute to facile metabolism in mice Chem. Res. Toxicol. 2006, 19, 944-951 10.1021/tx0600696
44. Uroz, F. J.; Arrebola, F. J.; Egea-González, F. J.; Martínez-Vidal, J. L. Monitoring of 6-chloronicotinic acid in human urine by gas chromatography-tandem mass spectrometry as indicator of exposure to the pesticide imidacloprid Analyst 2001, 126, 1355-1358 10.1039/b101167g
45. Frederiksen, H.; Nielsen, J. K.; Mørck, T. A.; Hansen, P. W.; Jensen, J. F.; Nielsen, O.; Andersson, A. M.; Knudsen, L. E. Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs Int. J. Hyg. Environ. Health 2013, 216, 772-783 10.1016/j.ijheh.2013.02.006
46. The Statistics Bureau of Shandong Province. 2014 Statistical Bulletin of National Economic and Social Development in Shandong Province (in Chinese). http://www.stats-sd.gov.cn/art/2015/2/27/art 3902158678.html (accessed Aug 8th, 2015).
47. Guo, Y.; Wang, L.; Kannan, K. Phthalates and parabens in personal care products from China: concentrations and human exposure Arch. Environ. Contam. Toxicol. 2014, 66, 113-119 10.1007/s00244-013-9937-x
48. Liao, C.; Chen, L.; Kannan, K. Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure Environ. Int. 2013, 57-58, 68-74 10.1016/j.envint.2013.04.001
49. 14C]-methyl-, propyl- and butylparaben in rats after oral, topical or subcutaneous administration Food Chem. Toxicol. 2012, 50, 445-454 10.1016/j.fct.2011.12.045
50. Harville, H. M.; Voorman, R.; Prusakiewicz, J. J. Comparison of paraben stability in human and rat skin Drug Metab. Lett. 2007, 1, 17-21 10.2174/187231207779814300
51. Jewell, C.; Prusakiewicz, J. J.; Ackermann, C.; Payne, N. A.; Fate, G.; Voorman, R.; Williams, F. M. Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture Toxicol. Appl. Pharmacol. 2007, 225, 221-228 10.1016/j.taap.2007.08.002
52. Tsukamoto, H.; Terada, S. Metabolism of drugs. XLVII. Metabolic fate of rho-hydroxybenzoic acid and its derivatives in rabbit Chem. Pharm. Bull. 1964, 12, 765-769 10.1248/cpb.12.765
53. Hopf, N. B.; Vernez, D.; Berthet, A.; Charriere, N.; Arnoux, C.; Tomicic, C. Effect of age on toxicokinetics among human volunteers exposed to propylene glycol methyl ether (PGME) Toxicol. Lett. 2012, 211, 77-84 10.1016/j.toxlet.2012.02.018