Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery

Journal of Biomedical Materials Research - Part A

Volumn 104, Issue 1, 2016, Pages 17-25

  Heffernan, John M ^a,b   Overstreet, Derek J ^a   Srinivasan, Sanjay ^a,b   Le, Long D ^b   Vernon, Brent L ^b   Sirianni, Rachael W ^a,b  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

^b Arizona State University   (United States)

Author keywords

cell recollection; glioblastoma; NIPAAm; RGD; thermoreversible scaffold

Indexed keywords

ACRYLIC MONOMERS; AMIDES; CELL ADHESION; CELL CULTURE; CELLS; CYTOLOGY; GELS; MOLECULAR BIOLOGY; RECOVERY; SCAFFOLDS (BIOLOGY); SOLUTIONS;

CELL ADHESION PEPTIDES; GLIOBLASTOMAS; HYDROXYETHYLMETHACRYLATE; NIPAAM; RGD; TEMPERATURE-RESPONSIVE HYDROGELS; THERMOREVERSIBLE; THREEDIMENSIONAL (3-D);

HYDROGELS;

ARGINYLGLYCYLASPARTIC ACID; MONOMER; POLY(N ISOPROPYLACRYLAMIDE); ACRYLAMIDE DERIVATIVE; HYDROGEL; N-ISOPROPYLACRYLAMIDE;

AMINO ACID SEQUENCE; AQUEOUS SOLUTION; ARTICLE; CANCER CELL CULTURE; CELL STRUCTURE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISSOLUTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HYDROGEL; HYDROPHILICITY; IMAGE PROCESSING; PHASE TRANSITION; POLYMERIZATION; SYNTHESIS; TEMPERATURE; CELL CULTURE TECHNIQUE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ELASTICITY; FLOW KINETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOLOGY; PROCEDURES; SIZE EXCLUSION CHROMATOGRAPHY; TISSUE SCAFFOLD; TUMOR CELL CULTURE; VISCOSITY;

ACRYLAMIDES; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CHROMATOGRAPHY, GEL; ELASTICITY; HUMANS; HYDROGELS; MAGNETIC RESONANCE SPECTROSCOPY; RHEOLOGY; TEMPERATURE; TISSUE SCAFFOLDS; TUMOR CELLS, CULTURED; VISCOSITY;

EID: 84949845746     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35534     Document Type: Article

References (35)

1. Baker BM, Chen CS., Deconstructing the third dimension-How 3D culture microenvironments alter cellular cues. J Cell Sci 2012; 125: 3015-3024.
2. Griffith LG, Swartz MA., Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 2006; 7: 211-224.
3. Tibbitt MW, Anseth KS., Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol Bioeng 2009; 103: 655-663.
4. Bissell MJ, Radisky D., Putting tumours in context. Nat Rev Cancer 2001; 1: 46-54.
5. Charles NA, Holland EC, Gilbertson R, Glass R, Kettenmann H., The brain tumor microenvironment. Glia 2011; 59: 1169-1180.
6. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM., Tensional homeostasis and the malignant phenotype. Cancer Cell 2005; 8: 241-254.
7. Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW., The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol 2007; 1: 84-96.
8. Ananthanarayanan B, Kim Y, Kumar S., Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform. Biomaterials 2011; 32: 7913-7923.
9. Wang C, Tong X, Yang F., Bioengineered 3D brain tumor model to elucidate the effects of matrix stiffness on glioblastoma cell behavior using PEG-based hydrogels. Mol Pharm 2014; 11: 2115-2125.
10. Schild HG., Poly (N-isopropylacrylamide): Experiment, theory and application. Prog Polym Sci 1992; 17: 163-249.
11. Overstreet DJ, McLemore RY, Doan BD, Farag A, Vernon BL., Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery. Soft Mater 2013; 11: 294-304.
12. Overstreet DJ, Huynh R, Jarbo K, McLemore RY, Vernon BL., In situ forming, resorbable graft copolymer hydrogels providing controlled drug release. J Biomed Mater Res A 2013; 101: 1437-1446.
13. Park K-H, Yun K., Immobilization of Arg-Gly-Asp (RGD) sequence in a thermosensitive hydrogel for cell delivery using pheochromocytoma cells (PC12). J Biosci Bioeng 2004; 97: 374-377.
14. Park K-H, Na K, Kim SW, Jung SY, Park KH, Chung H-M., Phenotype of hepatocyte spheroids behavior within thermo-sensitive poly(NiPAAm-co-PEG-g-GRGDS) hydrogel as a cell delivery vehicle. Biotechnol Lett 2005; 27: 1081-1086.
15. Park K-H, Na K, Chung H-M., Enhancement of the adhesion of fibroblasts by peptide containing an Arg-Gly-Asp sequence with poly (ethylene glycol) into a thermo-reversible hydrogel as a synthetic extracellular matrix. Biotechnol Lett 2005; 27: 227-231.
16. Stile RA, Healy KE., Thermo-responsive peptide-modified hydrogels for tissue regeneration. Biomacromolecules 2001; 2: 185-194.
17. Park K-H, Na K, Jung SY, Kim SW, Park KH, Cha KY, Chung H-M., Insulinoma cell line (MIN6) adhesion and spreading mediated by Arg-Gly-Asp (RGD) sequence conjugated in thermo-reversible gel. J Biosci Bioeng 2005; 99: 598-602.
18. Na K, Park K-H., Conjugation of Arg-Gly-Asp sequence into thermo-reversible gel as an extracellular matrix for 3T3-L1 fibroblast cell culture. Biotechnol Lett 2000; 22: 1553-1556.
19. Okano T, Yamada N, Sakai H, Sakurai Y., A novel recovery system for cultured cells using plasma-treated polystyrene dishes grafted with poly(N-isopropylacrylamide). J Biomed Mater Res 1993; 27: 1243-1251.
20. Kim MR, Jeong JH, Park TG., Swelling induced detachment of chondrocytes using RGD-modified poly(N-isopropylacrylamide) hydrogel beads. Biotechnol Prog 2002; 18: 495-500.
21. Nishida K, Yamato M, Hayashida Y, Watanabe K, Maeda N, Watanabe H, Yamamoto K, Nagai S, Kikuchi A, Tano Y, Okano T., Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface. Transplantation 2004; 77: 379-385.
22. Nitschke M, Gramm S, Götze T, Valtink M, Drichel J, Voit B, Engelmann K, Werner C., Thermo-responsive poly(NiPAAm-co-DEGMA) substrates for gentle harvest of human corneal endothelial cell sheets. J Biomed Mater Res A. 2007; 80: 1003-1010.
23. Haraguchi K, Takehisa T, Ebato M., Control of cell cultivation and cell sheet detachment on the surface of polymer/clay nanocomposite hydrogels. Biomacromolecules 2006; 7: 3267-3275.
24. Stupp R, Mason WP, Van Den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U., Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-996.
25. Lee BH, West B, McLemore R, Pauken C, Vernon BL., In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization. Biomacromolecules 2006; 7: 2059-2064.
26. Shu XZ, Ghosh K, Liu Y, Palumbo FS, Luo Y, Clark RA, Prestwich GD., Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogel. J Biomed Mater Res A 2004; 68: 365-375.
27. Siegwart DJ, Oh JK, Gao H, Bencherif SA, Perineau F, Bohaty AK, Hollinger JO, Matyjaszewski K., Biotin-, Pyrene-, and GRGDS-functionalized polymers and nanogels via ATRP and end group modification. Macromol Chem Phys 2008; 209: 2179-2193.
28. Del Duca D, Werbowetski T, Del Maestro RF., Spheroid preparation from hanging drops: Characterization of a model of brain tumor invasion. J Neurooncol 2004; 67: 295-303.
29. Heffernan J, Overstreet D, Le L, Vernon B, Sirianni R., Bioengineered scaffolds for 3D analysis of glioblastoma proliferation and invasion. Ann Biomed Eng 2014; 1-13.
30. Guzman A, Ziperstein MJ, Kaufman LJ., The effect of fibrillar matrix architecture on tumor cell invasion of physically challenging environments. Biomaterials 2014; 35: 6954-6963.
31. Weiss-Malik RA, Solis FJ, Vernon BL., Independent control of lower critical solution temperature and swelling behavior with pH for poly(N-isopropylacrylamide-co-maleic acid). J Appl Polym Sci 2004; 94: 2110-2116.
32. Chen G, Hoffman AS., Graft co-polymers that exhibit temperature induced phase transitions over a wide range of pH. Nature 1995; 373.
33. Pollock JF, Healy KE., Mechanical and swelling characterization of poly(N-isopropyl acrylamide -co- methoxy poly(ethylene glycol) methacrylate) sol-gels. Acta Biomater 2010; 6: 1307-1318.
34. Vernon B, Kim SW, Bae YH., Thermoreversible copolymer gels for extracellular matrix. J Biomed Mater Res 2000; 51: 69-79.
35. Ponten J, Macintyre E., Long term culture of normal and neoplastic human glia. Acta Pathol Microbiol Scand 1968; 74: 465-486.