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Volumn 46, Issue 4, 2015, Pages 277-284

Chronic wound biofilms: Pathogenesis and potential therapies

Author keywords

Bacteria; Biofilms; Chronic wounds; Exopolysaccharide; Polymicrobial; Quorum sensing

Indexed keywords

ANTIBIOTIC SENSITIVITY; BACTERIAL VIRULENCE; BIOFILM; CHRONIC WOUND; NONHUMAN; PATHOGENESIS; QUORUM SENSING; REVIEW; CHRONIC DISEASE; HUMAN; MICROBIOLOGY; PATHOPHYSIOLOGY; WOUND INFECTION;

EID: 84949782349     PISSN: 00075027     EISSN: 19437730     Source Type: Journal    
DOI: 10.1309/LMBNSWKUI4JPN7SO     Document Type: Review
Times cited : (163)

References (64)
  • 1
    • 84946496941 scopus 로고    scopus 로고
    • Prevalence of chronic wounds and structural quality indicators of chronic wound care in Dutch nursing homes
    • e-pub ahead of print
    • Rondas AALM, Schols JMGA, Stobberingh EE, Halfens RJG. Prevalence of chronic wounds and structural quality indicators of chronic wound care in Dutch nursing homes. Int Wound J. 2013; e-pub ahead of print. doi: 10.1111/iwj.12172.
    • (2013) Int Wound J
    • Rondas, A.A.L.M.1    Schols, J.M.G.A.2    Stobberingh, E.E.3    Halfens, R.J.G.4
  • 2
    • 84897554952 scopus 로고    scopus 로고
    • Evaluation of wound care and health-care use costs in patients with diabetic foot ulcers treated with negative pressure wound therapy versus advanced moist wound therapy
    • Driver VR, Blume PA. Evaluation of wound care and health-care use costs in patients with diabetic foot ulcers treated with negative pressure wound therapy versus advanced moist wound therapy. J Am Podiatr Med Assoc. 2014;104(2):147-153.
    • (2014) J Am Podiatr Med Assoc , vol.104 , Issue.2 , pp. 147-153
    • Driver, V.R.1    Blume, P.A.2
  • 5
    • 0037368181 scopus 로고    scopus 로고
    • Wound bed preparation: A systematic approach to wound management
    • Schultz GS, Sibbald RG, Falanga V, et al. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen. 2003;11 Suppl 1:S1-S28.
    • (2003) Wound Repair Regen , vol.11 , pp. S1-S28
    • Schultz, G.S.1    Sibbald, R.G.2    Falanga, V.3
  • 6
    • 77949434458 scopus 로고    scopus 로고
    • The necessity of wound debridement
    • Spear M. The necessity of wound debridement. Plastic Surg Nurs. 2010;30(1):54-56.
    • (2010) Plastic Surg Nurs , vol.30 , Issue.1 , pp. 54-56
    • Spear, M.1
  • 7
    • 84894225530 scopus 로고    scopus 로고
    • Polymicrobial wound infections: Pathophysiology and current therapeutic approaches
    • Bertesteanu S, Triaridis S, Stankovic M, et al. Polymicrobial wound infections: pathophysiology and current therapeutic approaches. Int J Pharm. 2014;463(2):119-126.
    • (2014) Int J Pharm , vol.463 , Issue.2 , pp. 119-126
    • Bertesteanu, S.1    Triaridis, S.2    Stankovic, M.3
  • 8
    • 84877118787 scopus 로고    scopus 로고
    • The role of bacterial biofilms in chronic infections
    • Bjarnsholt T. The role of bacterial biofilms in chronic infections. APMIS Suppl. 2013(136):1-58.
    • (2013) APMIS Suppl , Issue.136 , pp. 1-58
    • Bjarnsholt, T.1
  • 10
    • 0033591467 scopus 로고    scopus 로고
    • Bacterial biofilms: A common cause of persistent infections
    • Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science. 1999;284(5418):1318-1322.
    • (1999) Science , vol.284 , Issue.5418 , pp. 1318-1322
    • Costerton, J.W.1    Stewart, P.S.2    Greenberg, E.P.3
  • 11
    • 77953381240 scopus 로고    scopus 로고
    • Extracellular DNA: A major proinflammatory component of Pseudomonas aeruginosa biofilms
    • Fuxman Bass JI, Russo DM, Gabelloni ML, et al. Extracellular DNA: a major proinflammatory component of Pseudomonas aeruginosa biofilms. J Immunol. 2010;184(11):6386-6395.
    • (2010) J Immunol , vol.184 , Issue.11 , pp. 6386-6395
    • Fuxman Bass, J.I.1    Russo, D.M.2    Gabelloni, M.L.3
  • 12
    • 84890851760 scopus 로고    scopus 로고
    • Insulin treatment modulates the host immune system to enhance Pseudomonas aeruginosa wound biofilms
    • Watters C, Everett JA, Haley C, Clinton A, Rumbaugh KP. Insulin treatment modulates the host immune system to enhance Pseudomonas aeruginosa wound biofilms. Infect Immun. 2014;82(1):92-100.
    • (2014) Infect Immun , vol.82 , Issue.1 , pp. 92-100
    • Watters, C.1    Everett, J.A.2    Haley, C.3    Clinton, A.4    Rumbaugh, K.P.5
  • 15
    • 36549042076 scopus 로고    scopus 로고
    • The EPS matrix: The "house of biofilm cells
    • Flemming H-C, Neu TR, Wozniak DJ. The EPS matrix: the "house of biofilm cells". J Bacteriol. 2007;189(22):7945-7947.
    • (2007) J Bacteriol , vol.189 , Issue.22 , pp. 7945-7947
    • Flemming, H.-C.1    Neu, T.R.2    Wozniak, D.J.3
  • 17
    • 25144447426 scopus 로고    scopus 로고
    • Squeezing the antibiotic balloon: The impact of antimicrobial classes on emerging resistance
    • Peterson LR. Squeezing the antibiotic balloon: the impact of antimicrobial classes on emerging resistance. Clin Microbiol Infect. 2005;11 Suppl 5:4-16.
    • (2005) Clin Microbiol Infect , vol.11 , pp. 4-16
    • Peterson, L.R.1
  • 19
    • 79957586352 scopus 로고    scopus 로고
    • Role of persister cells in chronic infections: Clinical relevance and perspectives on anti-persister therapies
    • Fauvart M, De Groote VN, Michiels J. Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies. J Med Microbiol. 2011;60(Pt 6):699-709.
    • (2011) J Med Microbiol , vol.60 , pp. 699-709
    • Fauvart, M.1    De Groote, V.N.2    Michiels, J.3
  • 20
    • 77956809159 scopus 로고    scopus 로고
    • Healing and healing rates of chronic wounds in the age of molecular pathogen diagnostics
    • 280-281
    • Wolcott RD, Cox SB, Dowd SE. Healing and healing rates of chronic wounds in the age of molecular pathogen diagnostics. J Wound Care. 2010;19(7):272-278, 280-281.
    • (2010) J Wound Care , vol.19 , Issue.7 , pp. 272-278
    • Wolcott, R.D.1    Cox, S.B.2    Dowd, S.E.3
  • 21
    • 58149161243 scopus 로고    scopus 로고
    • Maintenance debridement in the treatment of difficult-to-heal chronic wounds. Recommendations of an expert panel
    • quiz 14-15
    • Falanga V, Brem H, Ennis WJ, Wolcott R, Gould LJ, Ayello EA. Maintenance debridement in the treatment of difficult-to-heal chronic wounds. Recommendations of an expert panel. Ostomy Wound Manage. 2008;Suppl:2-13;quiz 14-15.
    • (2008) Ostomy Wound Manage , pp. 2-13
    • Falanga, V.1    Brem, H.2    Ennis, W.J.3    Wolcott, R.4    Gould, L.J.5    Ayello, E.A.6
  • 22
    • 84907961902 scopus 로고    scopus 로고
    • Synergistic interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro wound model
    • DeLeon S, Clinton A, Fowler H, Everett J, Horswill AR, Rumbaugh KP. Synergistic interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro wound model. Infect Immun. 2014;82:4718-4728.
    • (2014) Infect Immun , vol.82 , pp. 4718-4728
    • DeLeon, S.1    Clinton, A.2    Fowler, H.3    Everett, J.4    Horswill, A.R.5    Rumbaugh, K.P.6
  • 23
    • 33745163926 scopus 로고    scopus 로고
    • Enhanced biofilm formation and increased resistance to antimicrobial agents and bacterial invasion are caused by synergistic interactions in multispecies biofilms
    • Burmølle M, Webb JS, Rao D, Hansen LH, Sørensen SJ, Kjelleberg S. Enhanced biofilm formation and increased resistance to antimicrobial agents and bacterial invasion are caused by synergistic interactions in multispecies biofilms. Appl Environ Microbiol. 2006;72(6):3916-3923.
    • (2006) Appl Environ Microbiol , vol.72 , Issue.6 , pp. 3916-3923
    • Burmølle, M.1    Webb, J.S.2    Rao, D.3    Hansen, L.H.4    Sørensen, S.J.5    Kjelleberg, S.6
  • 24
    • 80455145221 scopus 로고    scopus 로고
    • An in vivo polymicrobial biofilm wound infection model to study interspecies interactions
    • Dalton T, Dowd SE, Wolcott RD, et al. An in vivo polymicrobial biofilm wound infection model to study interspecies interactions. PloS One. 2011;6(11):e27317. doi: 10.1371/journal.pone.0027317.
    • (2011) PloS One , vol.6 , Issue.11
    • Dalton, T.1    Dowd, S.E.2    Wolcott, R.D.3
  • 25
    • 60449106108 scopus 로고    scopus 로고
    • A retrospective analysis of biofilm antibiotic susceptibility testing: A better predictor of clinical response in cystic fibrosis exacerbations
    • Keays T, Ferris W, Vandemheen KL, et al. A retrospective analysis of biofilm antibiotic susceptibility testing: a better predictor of clinical response in cystic fibrosis exacerbations. J Cyst Fibros. 2009;8(2):122-127.
    • (2009) J Cyst Fibros , vol.8 , Issue.2 , pp. 122-127
    • Keays, T.1    Ferris, W.2    Vandemheen, K.L.3
  • 26
    • 84887153497 scopus 로고    scopus 로고
    • In vitro models for the growth and analysis of chronic wound biofilms
    • James GA, Agostinho AM, Pulcini E de L. In vitro models for the growth and analysis of chronic wound biofilms. Adv Wound Care. 2010;1:293-298.
    • (2010) Adv Wound Care , vol.1 , pp. 293-298
    • James, G.A.1    Agostinho, A.M.2    Pulcini De, E.L.3
  • 27
    • 84877692888 scopus 로고    scopus 로고
    • In vitro susceptibility to antibiotics of staphylococci in biofilms isolated from orthopaedic infections
    • Molina-Manso D, del Prado G, Ortiz-Pérez A, et al. In vitro susceptibility to antibiotics of staphylococci in biofilms isolated from orthopaedic infections. Int J Antimicrob Agents. 2013;41(6):521-523.
    • (2013) Int J Antimicrob Agents , vol.41 , Issue.6 , pp. 521-523
    • Molina-Manso, D.1    Del Prado, G.2    Ortiz-Pérez, A.3
  • 28
    • 85030554249 scopus 로고    scopus 로고
    • Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis
    • Waters V, Ratjen F. Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis. Cochrane Database Syst Rev. 2012;11:CD009528. doi: 10.1002/14651858.CD009528.pub2.
    • (2012) Cochrane Database Syst Rev , vol.11
    • Waters, V.1    Ratjen, F.2
  • 29
    • 77954666495 scopus 로고    scopus 로고
    • Use of biofilm model systems to study antimicrobial susceptibility
    • Pratten J, Ready D. Use of biofilm model systems to study antimicrobial susceptibility. Methods Mol Biol. 2010;642:203-215.
    • (2010) Methods Mol Biol , vol.642 , pp. 203-215
    • Pratten, J.1    Ready, D.2
  • 30
    • 84871043917 scopus 로고    scopus 로고
    • A novel approach combining the Calgary Biofilm Device and Phenotype MicroArray for the characterization of the chemical sensitivity of bacterial biofilms
    • Santopolo L, Marchi E, Frediani L, Decorosi F, Viti C, Giovannetti L. A novel approach combining the Calgary Biofilm Device and Phenotype MicroArray for the characterization of the chemical sensitivity of bacterial biofilms. Biofouling. 2012;28(9):1023-1032.
    • (2012) Biofouling , vol.28 , Issue.9 , pp. 1023-1032
    • Santopolo, L.1    Marchi, E.2    Frediani, L.3    Decorosi, F.4    Viti, C.5    Giovannetti, L.6
  • 31
    • 79951522594 scopus 로고    scopus 로고
    • A simple colorimetric method for testing antimicrobial susceptibility of biofilmed bacteria
    • Kim S, Kim MJ, Kang HY, Seol SY, Cho DT, Kim J. A simple colorimetric method for testing antimicrobial susceptibility of biofilmed bacteria. J Microbiol. 2010;48(5):709-711.
    • (2010) J Microbiol , vol.48 , Issue.5 , pp. 709-711
    • Kim, S.1    Kim, M.J.2    Kang, H.Y.3    Seol, S.Y.4    Cho, D.T.5    Kim, J.6
  • 32
    • 0037378570 scopus 로고    scopus 로고
    • Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: A transcriptome analysis
    • Schuster M, Lostroh CP, Ogi T, Greenberg EP. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J Bacteriol. 2003;185(7):2066-2079.
    • (2003) J Bacteriol , vol.185 , Issue.7 , pp. 2066-2079
    • Schuster, M.1    Lostroh, C.P.2    Ogi, T.3    Greenberg, E.P.4
  • 33
    • 0035171969 scopus 로고    scopus 로고
    • The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium
    • Taga ME, Semmelhack JL, Bassler BL. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol Microbiol. 2001;42(3):777-793.
    • (2001) Mol Microbiol , vol.42 , Issue.3 , pp. 777-793
    • Taga, M.E.1    Semmelhack, J.L.2    Bassler, B.L.3
  • 34
    • 34547768760 scopus 로고    scopus 로고
    • Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: Effects on small RNA and biofilm architecture
    • Li J, Attila C, Wang L, Wood TK, Valdes JJ, Bentley WE. Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture. J Bacteriol. 2007;189(16):6011-6020.
    • (2007) J Bacteriol , vol.189 , Issue.16 , pp. 6011-6020
    • Li, J.1    Attila, C.2    Wang, L.3    Wood, T.K.4    Valdes, J.J.5    Bentley, W.E.6
  • 35
    • 30744444010 scopus 로고    scopus 로고
    • Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)
    • González Barrios AF, Zuo R, Hashimoto Y, Yang L, Bentley WE, Wood TK. Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J Bacteriol. 2006;188(1):305-316.
    • (2006) J Bacteriol , vol.188 , Issue.1 , pp. 305-316
    • González Barrios, A.F.1    Zuo, R.2    Hashimoto, Y.3    Yang, L.4    Bentley, W.E.5    Wood, T.K.6
  • 36
    • 37449026650 scopus 로고    scopus 로고
    • Quorum sensing, communication and cross-kingdom signalling in the bacterial world
    • Williams P. Quorum sensing, communication and cross-kingdom signalling in the bacterial world. Microbiology. 2007;153(Pt 12):3923-3938.
    • (2007) Microbiology , vol.153 , pp. 3923-3938
    • Williams, P.1
  • 37
    • 0032692797 scopus 로고    scopus 로고
    • How bacteria talk to each other: Regulation of gene expression by quorum sensing
    • Bassler BL. How bacteria talk to each other: regulation of gene expression by quorum sensing. Curr Opin Microbiol. 1999;2(6):582-587.
    • (1999) Curr Opin Microbiol , vol.2 , Issue.6 , pp. 582-587
    • Bassler, B.L.1
  • 40
    • 0027476965 scopus 로고
    • Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease
    • Kessler E, Safrin M, Olson JC, Ohman DE. Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease. J Biol Chem. 1993;268(10):7503-7508.
    • (1993) J Biol Chem , vol.268 , Issue.10 , pp. 7503-7508
    • Kessler, E.1    Safrin, M.2    Olson, J.C.3    Ohman, D.E.4
  • 42
    • 0033598693 scopus 로고    scopus 로고
    • Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa
    • Whiteley M, Lee KM, Greenberg EP. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 1999;96(24):13904-13909.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.24 , pp. 13904-13909
    • Whiteley, M.1    Lee, K.M.2    Greenberg, E.P.3
  • 43
    • 0030045365 scopus 로고    scopus 로고
    • Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection
    • Tang HB, DiMango E, Bryan R, et al. Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infect Immun. 1996;64(1):37-43.
    • (1996) Infect Immun , vol.64 , Issue.1 , pp. 37-43
    • Tang, H.B.1    DiMango, E.2    Bryan, R.3
  • 44
    • 0032755655 scopus 로고    scopus 로고
    • Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections
    • Rumbaugh KP, Griswold JA, Iglewski BH, Hamood AN. Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections. Infect Immun. 1999;67(11):5854-5862.
    • (1999) Infect Immun , vol.67 , Issue.11 , pp. 5854-5862
    • Rumbaugh, K.P.1    Griswold, J.A.2    Iglewski, B.H.3    Hamood, A.N.4
  • 45
    • 84873033968 scopus 로고    scopus 로고
    • Staphylococcal infections: Mechanisms of biofilm maturation and detachment as critical determinants of pathogenicity
    • Otto M. Staphylococcal infections: mechanisms of biofilm maturation and detachment as critical determinants of pathogenicity. Annu Rev Med. 2013;64:175-188.
    • (2013) Annu Rev Med , vol.64 , pp. 175-188
    • Otto, M.1
  • 46
    • 0141707658 scopus 로고    scopus 로고
    • Quorum sensing controls biofilm formation in Vibrio cholerae
    • Hammer BK, Bassler BL. Quorum sensing controls biofilm formation in Vibrio cholerae. Mol Microbiol. 2003;50(1):101-104.
    • (2003) Mol Microbiol , vol.50 , Issue.1 , pp. 101-104
    • Hammer, B.K.1    Bassler, B.L.2
  • 47
    • 84866360434 scopus 로고    scopus 로고
    • Antibiofilm activity of β-amylase from Bacillus subtilis S8-18 against biofilm forming human bacterial pathogens
    • Kalpana BJ, Aarthy S, Pandian SK. Antibiofilm activity of β-amylase from Bacillus subtilis S8-18 against biofilm forming human bacterial pathogens. Appl Biochem Biotechnol. 2012;167(6):1778-1794.
    • (2012) Appl Biochem Biotechnol , vol.167 , Issue.6 , pp. 1778-1794
    • Kalpana, B.J.1    Aarthy, S.2    Pandian, S.K.3
  • 48
    • 70549098563 scopus 로고    scopus 로고
    • Therapeutic potential of biofilm-dispersing enzymes
    • Kaplan JB. Therapeutic potential of biofilm-dispersing enzymes. Int J Artif Organs. 2009;32(9):545-554.
    • (2009) Int J Artif Organs , vol.32 , Issue.9 , pp. 545-554
    • Kaplan, J.B.1
  • 50
    • 78650798814 scopus 로고    scopus 로고
    • Dispersal of biofilms by secreted, matrix degrading, bacterial DNase
    • Nijland R, Hall MJ, Burgess JG. Dispersal of biofilms by secreted, matrix degrading, bacterial DNase. PloS One. 2010;5(12):e15668. doi:10.1371/journal.pone.0015668.
    • (2010) PloS One , vol.5 , Issue.12
    • Nijland, R.1    Hall, M.J.2    Burgess, J.G.3
  • 51
    • 77951226720 scopus 로고    scopus 로고
    • Synergistic effects between conventional antibiotics and 2-aminoimidazolederived antibiofilm agents
    • Rogers SA, Huigens RW 3rd, Cavanagh J, Melander C. Synergistic effects between conventional antibiotics and 2-aminoimidazolederived antibiofilm agents. Antimicrob Agents Chemother. 2010;54(5):2112-2118.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.5 , pp. 2112-2118
    • Rogers, S.A.1    Huigens, R.W.2    Cavanagh, J.3    Melander, C.4
  • 52
    • 84907083345 scopus 로고    scopus 로고
    • Inhibitory effects of 4-hydroxy- 2, 5-dimethyl-3(2H)-furanone (HDMF) on acyl-homoserine lactonemediated virulence factor production and biofilm formation in Pseudomonas aeruginosa PAO1
    • Choi S-C, Zhang C, Moon S, Oh Y-S. Inhibitory effects of 4-hydroxy- 2, 5-dimethyl-3(2H)-furanone (HDMF) on acyl-homoserine lactonemediated virulence factor production and biofilm formation in Pseudomonas aeruginosa PAO1. J Microbiol. 2014;52:734-742.
    • (2014) J Microbiol , vol.52 , pp. 734-742
    • Choi, S.-C.1    Zhang, C.2    Moon, S.3    Oh, Y.-S.4
  • 53
    • 84861884994 scopus 로고    scopus 로고
    • Use of the quorum sensing inhibitor furanone C-30 to interfere with biofilm formation by Streptococcus mutans and its luxS mutant strain
    • He Z, Wang Q, Hu Y, et al. Use of the quorum sensing inhibitor furanone C-30 to interfere with biofilm formation by Streptococcus mutans and its luxS mutant strain. Int J Antimicrob Agents. 2012;40(1):30-35.
    • (2012) Int J Antimicrob Agents , vol.40 , Issue.1 , pp. 30-35
    • He, Z.1    Wang, Q.2    Hu, Y.3
  • 54
    • 84892557832 scopus 로고    scopus 로고
    • Synthetic brominated furanone F202 prevents biofilm formation by potentially human pathogenic Escherichia coli O103: H2 and Salmonella ser. Agona on abiotic surfaces
    • Vestby LK, Johannesen KCS, Witsø IL, et al. Synthetic brominated furanone F202 prevents biofilm formation by potentially human pathogenic Escherichia coli O103:H2 and Salmonella ser. Agona on abiotic surfaces. J Appl Microbiol. 2014;116:258-268.
    • (2014) J Appl Microbiol , vol.116 , pp. 258-268
    • Vestby, L.K.1    Johannesen, K.C.S.2    Witsø, I.L.3
  • 56
    • 84903487653 scopus 로고    scopus 로고
    • Selective chemical inhibition of agrquorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance
    • Sully EK, Malachowa N, Elmore BO, et al. Selective chemical inhibition of agrquorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog. 2014;10(6):e1004174. doi:10.1371/journal.ppat.1004174.
    • (2014) PLoS Pathog , vol.10 , Issue.6
    • Sully, E.K.1    Malachowa, N.2    Elmore, B.O.3
  • 57
    • 84949788075 scopus 로고    scopus 로고
    • Research and Testing Laboratory., Accessed on: April 12, 2015
    • Research and Testing Laboratory. Microbial Diversity Analysis. 2014. Available at: http://www.researchandtesting.com/microbial-diversityanalysis. html. Accessed on: April 12, 2015.
    • (2014) Microbial Diversity Analysis
  • 58
    • 84858955694 scopus 로고    scopus 로고
    • Comparison of culture and molecular identification of bacteria in chronic wounds
    • Rhoads DD, Wolcott RD, Sun Y, Dowd SE. Comparison of culture and molecular identification of bacteria in chronic wounds. Int J Mol Sci. 2012;13(3):2535-2550.
    • (2012) Int J Mol Sci , vol.13 , Issue.3 , pp. 2535-2550
    • Rhoads, D.D.1    Wolcott, R.D.2    Sun, Y.3    Dowd, S.E.4
  • 59
    • 79956285781 scopus 로고    scopus 로고
    • Molecular diagnostics and personalised medicine in wound care: Assessment of outcomes
    • 234-239
    • Dowd SE, Wolcott RD, Kennedy J, Jones C, Cox SB. Molecular diagnostics and personalised medicine in wound care: assessment of outcomes. J Wound Care. 2011;20(5):232, 234-239.
    • (2011) J Wound Care , vol.20 , Issue.5 , pp. 232
    • Dowd, S.E.1    Wolcott, R.D.2    Kennedy, J.3    Jones, C.4    Cox, S.B.5
  • 60
    • 0022377451 scopus 로고
    • Adherence of coagulase-negative staphylococci to plastic tissue culture plates: A quantitative model for the adherence of staphylococci to medical devices
    • Christensen GD, Simpson WA, Younger JJ, et al. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J Clin Microbiol. 1985;22(6):996-1006.
    • (1985) J Clin Microbiol , vol.22 , Issue.6 , pp. 996-1006
    • Christensen, G.D.1    Simpson, W.A.2    Younger, J.J.3
  • 61
    • 0032908465 scopus 로고    scopus 로고
    • The Calgary Biofilm Device: New technology for rapid determination of antibiotic susceptibilities of bacterial biofilms
    • Ceri H, Olson ME, Stremick C, Read RR, Morck D, Buret A. The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J Clin Microbiol. 1999;37(6):1771-1776.
    • (1999) J Clin Microbiol , vol.37 , Issue.6 , pp. 1771-1776
    • Ceri, H.1    Olson, M.E.2    Stremick, C.3    Read, R.R.4    Morck, D.5    Buret, A.6
  • 62
    • 0031710092 scopus 로고    scopus 로고
    • Spatial physiological heterogeneity in Pseudomonas aeruginosa biofilm is determined by oxygen availability
    • Xu KD, Stewart PS, Xia F, Huang C-T, McFeters GA. Spatial physiological heterogeneity in Pseudomonas aeruginosa biofilm is determined by oxygen availability. Appl Environ Microbiol. 1998;64(10):4035-4039.
    • (1998) Appl Environ Microbiol , vol.64 , Issue.10 , pp. 4035-4039
    • Xu, K.D.1    Stewart, P.S.2    Xia, F.3    Huang, C.-T.4    McFeters, G.A.5
  • 64
    • 77949532607 scopus 로고    scopus 로고
    • Validation of the CDC biofilm reactor as a dynamic model for assessment of encrustation formation on urological device materials
    • Gilmore BF, Hamill TM, Jones DS, Gorman SP. Validation of the CDC biofilm reactor as a dynamic model for assessment of encrustation formation on urological device materials. J Biomed Mater Res B Appl Biomater. 2010;93B(1):128-140.
    • (2010) J Biomed Mater Res B Appl Biomater , vol.93 B , Issue.1 , pp. 128-140
    • Gilmore, B.F.1    Hamill, T.M.2    Jones, D.S.3    Gorman, S.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.