Antiobesity, hypolipidemic, antioxidant and hepatoprotective effects of Achyranthes aspera seed saponins in high cholesterol fed albino rats

Archives of Medical Science

Volumn 11, Issue 6, 2015, Pages 1261-1271

  Khan, Naveed ^a   Akhtar, Muhammad Shoaib ^a   Khan, Barkat Ali ^a,b,c   De Andrade Braga, Valdir ^d   Reich, Adam ^e  

^a UNIVERSITY OF SARGODHA   (Pakistan)

^b THE ISLAMIA UNIVERSITY OF BAHAWALPUR   (Pakistan)

^c GOMAL UNIVERSITY   (Pakistan)

^d University of Paraiba   (Brazil)

^e WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

ABTS; Achyranthes aspera; Antioxidant; Hepatoprotection; High cholesterol diet; Hyperlipidemia

Indexed keywords

2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); CHOLESTEROL; FERRIC ION; HIGH DENSITY LIPOPROTEIN; LIPID; LIVER ENZYME; LOW DENSITY LIPOPROTEIN; SAPONIN; SCAVENGER; SUPEROXIDE DISMUTASE;

ACHYRANTHES ASPERA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FOOD INTAKE; HYPOLIPEMIA; LIPID BLOOD LEVEL; LIVER FUNCTION; LIVER PROTECTION; MALE; NONHUMAN; OBESITY; RAT;

EID: 84949762511     PISSN: 17341922     EISSN: 18969151     Source Type: Journal    
DOI: 10.5114/aoms.2015.56353     Document Type: Article

References (36)

1. Braunwald E. Shattuck lecture-cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med 1997; 337: 1360-9.
2. Mahley RW, Weisgraber KH, Farese RV Jr. Disorders of lipid metabolism. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS (eds.). Williams textbook of endocrinology. 10th ed. Saunders, Philadelphia (PA), 2003; 1642-1705.
3. Burchardt P, Zurawski J, Zuchowski B, et al. Low-density lipoprotein, its susceptibility to oxidation and the role of lipoprotein-associated phospholipase A2 and carboxyl ester lipase lipases in atherosclerotic plaque formation. Arch Med Sci 2013; 9: 151-8.
4. Bhatnagar D, Soran H, Durrington PN. Hypercholesterolaemia and its management. Br Med J 2008; 337: a993.
5. McCord JM. Therapeutic control of free radicals. Drug Discov Today 2004; 9: 781-2.
6. Amira S, Dade M, Schinella G, Rios J. Anti-inflammatory, anti-oxidant, and apoptotic activities of four plant species used in folk medicine in the Mediterranean basin. Pak J Pharm Sci 2012; 25: 65-72.
7. Barlow SM. Toxicological aspects of antioxidants used as food additives. In: Food antoxidants. Hudson BJF (eds.). Elsevier, London 1990; 253-307.
8. Branen AL. Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene. J Am Oil Chem Soc 1975; 52: 59-63.
9. Krishnakumari S, Priya K. Hypolipidemic efficacy of Achyranthes aspera on lipid profile in sesame oil fed rats. Anc Sci Life 2006; 25: 49-56.
10. Rani N, Sharma SK, Vasudeva N. Assessment of antiobesity potential of Achyranthes aspera Linn. seed. Evid Based Complement Alternat Med 2012; 2012: 715912.
11. Gokhale AB, Damre AS, Kulkami KR, Saraf MN. Preliminary evaluation of anti-inflammatory and anti-arthritic activity of S. lappa, A. speciosa and A. aspera. Phytomedicine 2002; 9: 433-7.
12. Gülçin I, Küfrevioglu OI, Oktay M, Büyükokuroglu ME. Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). J Ethnopharmacol 2004; 90: 205-15.
13. Huang D, Ou B, Prior RL. The chemistry behind antioxidant capacity assays. J Agric Food Chem 2005; 53: 1841-56.
14. Pellegrini N, Del Rio D, Colombi B, Bianchi M, Brighenti F. Application of the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation assay to a flow injection system for the evaluation of antioxidant activity of some pure compounds and beverages. J Agric Food Chem 2003; 51: 260-4.
15. Arif M, Saify ZS, Rashid S, Ahmad M. Effect of newly synthesized compound on various serum lipid parameters. J Isl Acad Sci 1990; 3: 118-23.
16. El-Hazmi MA, Warsy AS. Prevalence of plasma lipid abnormalities in Saudi children. Ann Saudi Med 2001; 21: 21-5.
17. Parab RS, Mengi SA. Hypolipidemic activity of Acorus calamus L. in rats. Fitoterapia 2002; 73: 451-5.
18. Aziz K, Aziz S, Faruqui AMA, et al. Evaluation and comparison of coronary heart disease risk factor profiles of children in a country with developing economy. J Pak Med Assoc 2004; 54: 364-71.
19. Bhosale UA, Yegnanarayan R, Pophale PD, Zambare MR, Somani RS. Study of central nervous system depressant and behavioral activity of an ethanol extract of Achyranthes aspera (Agadha) in different animal models. Int J App Basic Med Res 2011; 1: 104-8.
20. Padwal RS, Majumdar SR. Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet 2007; 369: 71-7.
21. Astrup A, Buemann B, Western P, Toubro S, Raben A, Christensen NJ. Obesity as an adaptation to a high-fat diet: evidence from a cross-sectional study. Am J Clin Nutr 1994; 59: 350-5.
22. Portillo MP, Simón E, García-Calonge MA, Del Barrio AS. Effect of high-fat diet on lypolisis in isolated adipocytes from visceral and subcutaneous WAT. Eur J Nutr 1999; 38: 177-82.
23. Rebuffé-Scrive M, Surwit R, Feinglos M, Kuhn C, Rodin J. Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus. Metabolism 1993; 42: 1405-9.
24. Dandona P, Aljada A, Bandyopadhyay A. Inflammation: The link between insulin resistance, obesity and diabetes. Trends Immunol 2004; 1: 4-7.
25. Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr 2010; 30: 173-99.
26. German AJ, Ryan VH, German AC, Wood IS, Trayhurn P. Obesity, its associated disorders and the role of inflammatory adipokines in companion animals. Vet J 2010; 1: 4-9.
27. Tan DX, Manchester LC, Fuentes-Broto L, Paredes SD, Reiter RJ. Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity. Obes Rev 2010; 12: 167-88.
28. Parthasarathy S, Quinn MT, Schwenke DC, Carew TE, Steinberg D. Oxidative modification of beta-very low density lipoprotein. Potential role in monocyte recruitment and foam cell formation. Arteriosclerosis 1989; 9: 398-404.
29. Frishman WH. Biologic markers as predictors of cardiovascular disease. Am J Med 1998; 104: 18S-27S.
30. Agil A, Navarro-Alarcón M, Ruiz R, Abuhamadah S, El-Mir MY, Vázquez GF. Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats. J Pineal Res 2011; 50: 207-12.
31. Aikawa M, Libby P. The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach. Cardiovasc Pathol 2004; 13: 125-38.
32. Aviram M, Rosenblat M, Bisgaier CL, Newton RS. Atorvastatin and gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation. Atherosclerosis 1998; 138: 271-80.
33. Chakraborty A, Brantner A, Mukainaka T, et al. Cancer chemopreventive activity of Achyranthes aspera leaves on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Cancer Letters 2002; 177: 1-5.
34. Tahiliani P, Kar A. Achyranthes aspera elevates thyroid hormone levels and decreases hepatic lipid peroxidation in male rats. J Ethnopharmacol 2000; 71: 527-32.
35. Lyons TJ, Bailie KE, Dyer DG, Dunn JA, Baynes JW. Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus. J Clin Invest 1991; 87: 1910-5.
36. Trocha M, Merwid-Ląd A, Chlebda E, et al. Influence of ezetimibe on selected parameters of oxidative stress in rat liver subjected to ischemia/reperfusion. Arch Med Sci 2014; 10: 817-24.