Preparation, characterization, and pharmacokinetics study of capsaicin via hydroxypropyl-beta-cyclodextrin encapsulation

Pharmaceutical Biology

Volumn 54, Issue 1, 2016, Pages 130-138

  Zhao, Yingying ^a   Sun, Chaonan ^a   Shi, Feng ^a   Firempong, Caleb Kesse ^a   Yu, Jiangnan ^a   Xu, Ximing ^a   Zhang, Weiming ^b  

^a JIANGSU UNIVERSITY   (China)

^b Nanjing Institute for Comprehensive Utilization of Wild Plant   (China)

Author keywords

HP CD; in vitro release; irritation; oral bioavailability

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CAPSAICIN; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; ANALGESIC AGENT; ANTINEOPLASTIC AGENT; BETA CYCLODEXTRIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; ENCAPSULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT; STOMACH IRRITATION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOAVAILABILITY; BIOLOGICAL MODEL; BLOOD; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFECTS; GASTRIC MUCOSA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROPHOTOMETRY; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PATHOLOGY; SOLUBILITY; SPRAGUE DAWLEY RAT; ULTRAVIOLET SPECTROPHOTOMETRY;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; ANTINEOPLASTIC AGENTS; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CAPSAICIN; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMPOUNDING; GASTRIC MUCOSA; MALE; MODELS, BIOLOGICAL; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84949757057     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2015.1021816     Document Type: Article

References (40)

1. Bencsik P, Kupai K, Giricz Z, et al. (2008). Cardiac capsaicin-sensitive sensory nerves regulate myocardial relaxation via S -nitrosylation of SERCA: Role of peroxynitrite. Br J Pharmacol 153: 488-96
2. Bernard J, Seidl M, Mayer E, Loerting T. (2012). Formation and stability of bulk carbonic acid (H2CO3) by protonation of tropospheric calcite. Chemphyschem 13: 3087-91
3. Branchu S, Forbes RT, York P, et al. (1999). Hydroxypropyl-beta-cyclodextrin inhibits spray-drying-induced inactivation of beta-galactosidase. J Pharm Sci 88: 905-11
4. Caterina MJ, Schumacher MA, Tominaga M, et al. (1997). The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389: 816-24
5. Chen S, Zhu J, Ma F, et al. (2007). Preparation and characterization of solid dispersions of dipyridamole with a carrier "copolyvidonum Plasdone S-630". Drug Dev Ind Pharm 33: 888-99
6. Chen XY, Sun X, Ren K, et al. (2010). Enhanced aqueous solubility and bioavailability of capsaicin by the preparation of an inclusion complex. Arzneimittel-Forsch 60: 571-4
7. Cheneke BR, Indic M, van den Berg B, Movileanu L. (2012). An outer membrane protein undergoes enthalpy-and entropy-driven transitions. Biochemistry 51: 5348-58
8. de Araujo DR, Tsuneda SS, Cereda CM, et al. (2008). Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-beta-cyclodextrin inclusion complex. Eur J Pharm Sci 33: 60-71
9. de Paula WX, Denadai AML, Santoro MM, et al. (2011). Supramolecular interactions between losartan and hydroxypropyl-beta-CD: ESI mass-spectrometry, NMR techniques, phase solubility, isothermal titration calorimetry and anti-hypertensive studies. Int J Pharm 404: 116-23
10. Del Valle EMM. (2004). Cyclodextrins and their uses: A review. Process Biochem 39: 1033-46
11. Fraceto LF, Grillo R, Sobarzo-Sanchez E. (2014). Cyclodextrin inclusion complexes loaded in particles as drug carrier systems. Curr TopMed Chem 14: 518-25
12. Gassensmith JJ, Arunkumar E, Barr L, et al. (2007). Self-assembly of fluorescent inclusion complexes in competitive media including the interior of living cells. J Am Chem Soc 129: 15054-9
13. Ghosh A, Biswas S, Ghosh T. (2011). Preparation and evaluation of silymarin beta-cyclodextrin molecular inclusion complexes. J Young Pharmacists 3: 205-10
14. Higuchi T, Connors KA. (1965). Phase-solubility techniques. Adv Chem Instrum 4: 117-212
15. Joo JI, Kim DH, Choi JW, Yun JW. (2010). Proteomic analysis for antiobesity potential of capsaicin on white adipose tissue in rats fed with a high fat diet. J Proteome Res 9: 2977-87
16. Li J, Xiao H, Li J, Zhong Y. (2004). Drug carrier systems based on water-soluble cationic beta-cyclodextrin polymers. Int J Pharm 278: 329-42
17. Liu QY, Zhang ZH, Jin X, et al. (2013). Enhanced dissolution and oral bioavailability of tanshinone IIA base by solid dispersion system with low-molecular-weight chitosan. J Pharm Pharmacol 65: 839-46
18. Lu HF, Chen YL, Yang JS, et al. (2010). Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo. J Agric Food Chem 58: 12999-3005
19. Menendez L, Lastra A, Hidalgo A, Baamonde A. (2004). The analgesic effect induced by capsaicin is enhanced in inflammatory states. Life Sci 74: 3235-44
20. Miyake K, Arima H, Hirayama F, et al. (2000). Improvement of solubility and oral bioavailability of rutin by complexation with 2-hydroxypropyl-beta-cyclodextrin. Pharm Dev Tech 5: 399-407
21. Okubo T, Kitano H. (1989). Inclusion process of ionic detergents with cyclodextrins as studied by the conductance stopped-flow method. J Phys Chem 93: 3721-3
22. Peroche S, Degobert G, Putaux JL, et al. (2005). Synthesis and characterisation of novel nanospheres made from amphiphilic perfluoroalkylthio-beta-cyclodextrins. Eur J Pharm Biopharm 60: 123-31
23. Pollard TD. (2010). A guide to simple and informative binding assays. Mol Biol Cell 21: 4061-7
24. Sapkal NP, Kilor VA, Bhusari KP, Daud AS. (2007). Evaluation of some methods for preparing gliclazide beta-cyclodextrin inclusion complexes. Trop J Pharm Res 6: 833-40
25. Sharma MC, Sharma S. (2010). Studies on the preparation, characterization, solubility and stability of cefadroxil-beta-cyclodextrin inclusion complexes. J Optoelectron Adv M 12: 411-15
26. Shulman M, Cohen M, Soto-Gutierrez A, et al. (2011). Enhancement of naringenin bioavailability by complexation with hydroxypropoyl-beta-cyclodextrin. PloS One 6: e18033
27. Strickley RG. (2004). Solubilizing excipients in oral and injectable formulations. Pharm Res 21: 201-30
28. Szallasi A, Blumberg PM. (1999). Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 51: 159-212
29. Szejtli J. (1994). Medicinal applications of cyclodextrins. Med Res Rev 14: 353-586
30. Taupitz T, Dressman JB, Buchanan CM, Klein S. (2013). Cyclodextrin-water soluble polymer ternary complexes enhance the solubility and dissolution behaviour of poorly soluble drugs. Case example: Itraconazole. Eur J Pharm Biopharm 83: 378-87
31. Vega E, Egea MA, Calpena AC, et al. (2012). Role of hydroxypropyl-beta-cyclodextrin on freeze-dried and gamma-irradiated PLGA and PLGA-PEG diblock copolymer nanospheres for ophthalmic flurbiprofen delivery. Int J Nanomed 7: 1357-71
32. Velasco J, Andersen ML, Skibsted LH. (2004). Evaluation of oxidative stability of vegetable oils by monitoring the tendency to radical formation: A comparison of electron spin resonance spectroscopy with the Rancimat method and differential scanning calorimetry. Food Chem 85: 623-32
33. Wang YQ, Han BH. (2013). Cyclodextrin-based porous nanocapsules. Chin J Chem 31: 569-76
34. Wu QB, Li HT, Leng YJ, et al. (2014). Determination of muscone in rats plasma following oral administration of artificial musk: Using of combined headspace gas chromatography-mass spectrometry. J Spectrosc 2014: 906-28
35. Yuvaraja K, Khanam J. (2014). Enhancement of carvedilol solubility by solid dispersion technique using cyclodextrins, water soluble polymers and hydroxyl acid. J Pharm Biomed 96: 10-20
36. Zhang JX, Ma PX. (2013). Cyclodextrin-based supramolecular systems for drug delivery: Recent progress and future perspective. Adv Drug Deliv Rev 65: 1215-33
37. Zhang PL, Pan CY, Tang KW, Li HJ. (2011). Inclusion behavior of oxybutynin with hydroxypropyl-beta-cyclodextrin. J Cent South Univ T 18: 1897-901
38. Zhou CJ, Li LF, Liu Y, et al. (2012). Study on the inclusion complex of rutin/sulfobutylether-beta-cyclodextrin. Future Mater Res Ind Appl Parts 1 and 2, 455-6, 1177-81
39. Zhou YY, Sun JY, Yu HP, et al. (2009). Inclusion complex of riboflavin with cucurbit[7]uril: Study in solution and solid state. Supramol Chem 21: 495-501
40. Zhu Y, Peng W, Zhang JJ, et al. (2014). Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation. J Funct Foods 8: 358-66