Extravasated platelet aggregation in liver zone 3 is associated with thrombocytopenia and deterioration of graft function after living-donor liver transplant

Experimental and Clinical Transplantation

Volumn 13, Issue 6, 2015, Pages 556-562

  Nakanuma, Shinichi ^a   Miyashita, Tomoharu ^a   Hayashi, Hironori ^a   Tajima, Hidehiro ^a   Takamura, Hiroyuki ^a   Makino, Isamu ^a   Oyama, Katsunobu ^a   Nakagawara, Hisatoshi ^a   Fushida, Sachio ^a   Ohta, Tetsuo ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Allograft tissue; CD42b; Liver biopsy

Indexed keywords

BILIRUBIN; GLYCOPROTEIN IB ALPHA; MYCOPHENOLATE MOFETIL; PREDNISOLONE; TACROLIMUS;

ADULT; ALLOGRAFT; ARTICLE; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEGRANULATION; DETERIORATION; FEMALE; GRAFT FAILURE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; INTERNATIONAL NORMALIZED RATIO; LIVER GRAFT; LIVING DONOR; MALE; PERIOPERATIVE PERIOD; POSTOPERATIVE COMPLICATION; PROTEIN EXPRESSION; PROTHROMBIN TIME; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT OUTCOME; BIOPSY; LIVER; LIVER TRANSPLANTATION; PATHOLOGY;

ALLOGRAFTS; BIOPSY; HUMANS; LIVER; LIVER TRANSPLANTATION; LIVING DONORS; PERIOPERATIVE PERIOD; PLATELET AGGREGATION; POSTOPERATIVE COMPLICATIONS; THROMBOCYTOPENIA; TREATMENT OUTCOME;

EID: 84949681676     PISSN: 13040855     EISSN: None     Source Type: Journal    
DOI: 10.6002/ect.2015.0063     Document Type: Article

References (31)

1. Pereboom IT, Lisman T, Porte RJ. Platelets in liver transplantation: friend or foe? Liver Transpl. 2008;14(7):923-931. doi: 10.1002/lt.21510.
2. Nobuoka Y, Wada H, Mizuno S, et al. Prolonged thrombocytopenia after living-donor liver transplantation is a strong prognostic predictor irrespective of splenectomy: the significance of ADAMTS13 and graft function. Int J Hematol. 2014;99(4):418-428. doi: 10.1007/s12185-014-1543-9. Erratum in: Int J Hematol. 2014; 100(1):105
3. Coppell JA, Brown SA, Perry DJ. Veno-occlusive disease: cytokines, genetics, and haemostasis. Blood Rev. 2003;17(2):63-70
4. Nakanuma S, Miyashita T, Hayashi H, et al. Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living-donor liver transplantation: A case report. Exp Ther Med. 2015;9(4):1119-1124
5. Rappaport AM, Borowy ZJ, Lougheed WM, Lotto WN. Subdivision of hexagonal liver lobules into a structural and functional unit; role in hepatic physiology and pathology. Anat Rec. 1954;119(1):11-33
6. Marubashi S, Dono K, Miyamoto A, et al. Impact of graft size on postoperative thrombocytopenia in living-donor liver transplant. Arch Surg. 2007;142(11):1054-1058
7. Jassem W, Koo DD, Cerundolo L, Rela M, Heaton ND, Fuggle SV. Cadaveric versus living-donor livers: differences in inflammatory markers after transplantation. Transplantation. 2003;76(11):1599-1603
8. Jassem W, Fuggle SV, Cerundolo L, Heaton ND, Rela M. Ischemic preconditioning of cadaver donor livers protects allografts following transplantation. Transplantation. 2006;81(2):169-174
9. Peralta C, Jiménez-Castro MB, Gracia-Sancho J. Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu. J Hepatol. 2013;59(5):1094-1106. doi: 10.1016/j.jhep.2013.06.017
10. Man K, Fan ST, Lo CM, et al. Graft injury in relation to graft size in right lobe live donor liver transplantation: a study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression. Ann Surg. 2003;237(2):256-264
11. Ikezoe T, Yang J, Nishioka C, Honda G, Furihata M, Yokoyama A. Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signalregulated kinase/myeloid leukemia cell-1 signaling. Arterioscler Thromb Vasc Biol. 2012;32(9):2259-2270. doi: 10.1161/ ATVBAHA.112.251157
12. Yamamoto M, Sumiyoshi H, Nakagami K, Tahara E. Distribution of collagen types I, III, and V in fibrotic and neoplastic human liver. Acta Pathol Jpn. 1984;34(1):77-86
13. Jung SM, Takemura Y, Imamura Y, Hayashi T, Adachi E, Moroi M. Collagen-type specificity of glycoprotein VI as a determinant of platelet adhesion. Platelets. 2008;19(1):32-42. doi: 10.1080/09537100701609027
14. Brech A, Kjeken R, Synnes M, Berg T, Roos N, Prydz K. Endocytosed ricin and asialoorosomucoid follow different intracellular pathways in hepatocytes. Biochim Biophys Acta. 1998;1373(1):195-208
15. Sørensen AL, Rumjantseva V, Nayeb-Hashemi S, et al. Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. Blood. 2009 114(8):1645-54. doi: 10.1182/blood-2009-01-199414
16. Ito T, Kiuchi T, Yamamoto H, et al. Changes in portal venous pressure in the early phase after living-donor liver transplantation: pathogenesis and clinical implications. Transplantation. 2003;75(8): 1313-1317
17. Kera Y, Penttilä KE, Lindros KO. Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes. Biochem J. 1988;254(2):411-417
18. DeLeve LD. Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation. Hepatology. 1996;24(4):830-837
19. Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels. Molecules. 2010;15(3):1242-1264. doi: 10.3390/molecules15031242
20. Zhang W, Wang M, Xie HY, et al. Role of reactive oxygen species in mediating hepatic ischemia-reperfusion injury and its therapeutic applications in liver transplantation. Transplant Proc. 2007;39(5): 1332-1337
21. Wang X, Kanel GC, DeLeve LD. Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat. Hepatology. 2000;31(2):428-434
22. Takamura H, Nakanuma S, Hayashi H, et al. Severe veno-occlusive disease/sinusoidal obstruction syndrome after deceased-donor and living-donor liver transplantation. Transplant Proc. 2014;46(10): 3523-3535. doi: 10.1016/j.transproceed.2014.09.110
23. Mars WM, Zarnegar R, Michalopoulos GK. Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Am J Pathol. 1993;143(3):949-958
24. Watanabe K, Togo S, Takahashi T, et al. PAI-1 plays an important role in liver failure after excessive hepatectomy in the rat. J Surg Res. 2007;143(1):13-19
25. Umeda Y, Yagi T, Sadamori H, et al. Effects of prophylactic splenic artery modulation on portal overperfusion and liver regeneration in small-for-size graft. Transplantation. 2008;86(5):673-680. doi: 10.1097/TP.0b013e318181e02d.
26. Wang H, Ikegami T, Harada N, et al. Optimal changes in portal hemodynamics induced by splenectomy during living-donor liver transplantation. Surg Today. 2014 Aug 2
27. Arai M, Thurman RG, Lemasters JJ. Contribution of adenosine A(2) receptors and cyclic adenosine monophosphate to protective ischemic preconditioning of sinusoidal endothelial cells against Storage/Reperfusion injury in rat livers. Hepatology. 2000;32(2): 297-302
28. Iba T, Kidokoro A, Fukunaga M, Takuhiro K, Ouchi M, Ito Y. Comparison of the protective effects of type III phosphodiesterase (PDE3) inhibitor (cilostazol) and acetylsalicylic acid on intestinal microcirculation after ischemia reperfusion injury in mice. Shock. 2006;26(5):522-526
29. Wang S, Yan C, Xu H, Zhao X, Han Y. Suppression of encephalitogenic T-cell responses by cilostazol is associated with upregulation of regulatory T cells. Neuroreport. 2010;21(9):629-635.doi: 10.1097/WNR.0b013e32833a4d4d.
30. Narita M, Hatano E, Ikai I, et al. A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction. Ann Surg. 2009;249(5):806-813. doi: 10.1097/SLA.0b013e3181a38ed5
31. Ikegami T, Nishizaki T, Hiroshige S, Ohta R, Yanaga K, Sugimachi K. Experimental study of a type 3 phosphodiesterase inhibitor on liver graft function. Br J Surg. 2001;88(1):59-64.