Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat

Hepatology

Volumn 31, Issue 2, 2000, Pages 428-434

  Wang, Xiangdong ^a   Kanel, Gary C ^a   DeLeve, Laurie D ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; DRUG EFFECT; DRUG EFFICACY; HISTOPATHOLOGY; LIVER PROTECTION; LIVER VEIN OBSTRUCTION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033951973     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510310224     Document Type: Article

References (10)

1. DeLeve LD, McCuskey RS, Wang X, Hu L, McCuskey MK, Epstein RB, Kanel G. Characterization of a reproducible rat model of hepalic veno-occlusive disease. HEPATOLOGY 1999;29:1779-1791.
2. DeLeve LD. Dacarbazine toxicity in murine liver cells: a novel model of hepatic endothelial injury and glutathione defense. J Pharmacol Exp Ther 1994;268:1261-1270.
3. DeLeve LD, Wang X, Kuhlenkamp JF, Kaplowitz N. Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. HEPATOLOGY 1996:23:589-599.
4. DeLeve LD. Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation. HEPATOLOGY 1996;24:830-837.
5. Wilson DW, Segall HJ, Pan LC, Lame MW, Estep JE, Morin D. Mechanisms and pathology of monocrotaline pulmonary toxicity. Crit Rev Toxicol 1992;22:307-325.
6. Pan LC, Wilson DW, Lamé MW, Jones AD, Segall HJ. Cor pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizidine. Toxicol Appl Pharmacol 1993;118:87-97.
7. Van CC, Huxtable RJ. Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated perfused liver. Toxicol Appl Pharmacol 1995;130:132-139.
8. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidised glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969;27:502-522.
9. Baumgarten H. A simple microplate assay for the determination of cellular protein. J Immunol Methods 1985;82:25-37.
10. Corcoran GB, Wong BK. Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice. J Pharmacol Exp Ther 1986;238:54-61.