Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 1, 2016, Pages 154-159

  Zwick, Vincent ^a   Nurisso, Alessandra ^a   Simões Pires, Claudia ^a   Bouchet, Samuel ^g,h   Martinet, Nadine ^b   Lehotzky, Attila ^c   Ovadi, Judit ^c   Cuendet, Muriel ^a   Blanquart, Christophe ^d,e,f,h   Bertrand, Philippe ^g,h  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITÉ DE NICE SOPHIA ANTIPOLIS   (France)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d INSERM   (France)

^e CNRS   (France)

^f UNIVERSITÉ DE NANTES   (France)

^g Institut de Chimie des Milieux et Matériaux de Poitiers UMR CNRS 7285   (France)

^h Réseau Epigénétique du Cancéropôle Grand Ouest ^*  (France)

Author keywords

Cancer; Histone deacetylases; Metathesis; Tubulin

Indexed keywords

ALKENE; BENZAMIDE; BENZAMIDE DERIVATIVE; CARBONYL DERIVATIVE; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; HYDROXAMIC ACID DERIVATIVE; PHENYLENEDIAMINE; TACEDINALINE; TERT BUTYLOXYCARBONYL; TRICHOSTATIN A; TUBULIN; UNCLASSIFIED DRUG; VORINOSTAT; FORMIC ACID DERIVATIVE; HISTONE DEACETYLASE; T-BUTYLOXYCARBONYL GROUP;

ACETYLATION; ARTICLE; CATALYST; CELL MEMBRANE PERMEABILITY; CHEMICAL REACTION; CONTROLLED STUDY; CROSS METATHESIS; DEACETYLATION; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTRINSIC ACTIVITY; PROTON NUCLEAR MAGNETIC RESONANCE; RING CLOSING METATHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; STRUCTURE ACTIVITY RELATION;

ALKENES; BENZAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMIC ACID ESTERS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84949623954     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.11.011     Document Type: Article

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