Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors

British Journal of Pharmacology

Volumn 172, Issue 3, 2015, Pages 829-840

  Mangas Sanjuan, V ^a   Olah J ^b   Gonzalez Alvarez, I ^a   Lehotzky, A ^b   Tokesi N ^b   Bermejo, M ^a   Ovádi, Judit ^b  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

AKG 2; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; MICROTUBULE ASSOCIATED PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; TRICHOSTATIN A; TUBULIN; TUBULIN POLYMERIZATION PROMOTING PROTEIN; UNCLASSIFIED DRUG; HISTONE DEACETYLASE; NERVE PROTEIN; P25 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TRANSPORT; HELA CELL LINE; HUMAN; IN VITRO STUDY; INTESTINE ABSORPTION; MALE; MICROTUBULE; NONHUMAN; PROTEIN ACETYLATION; PROTEIN EXPRESSION; RAT; STRUCTURE ACTIVITY RELATION; ABSORPTION; ACETYLATION; ANIMAL; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; KINETICS; METABOLISM; WISTAR RAT;

ABSORPTION, PHYSIOLOGICAL; ACETYLATION; ANIMALS; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; KINETICS; MALE; NERVE TISSUE PROTEINS; RATS; RATS, WISTAR; TUBULIN;

EID: 84920843368     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12946     Document Type: Article

References (41)

1. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M et al (2013). The Concise Guide to PHARMACOLOGY 2013/14: Enzymes. Br J Pharmacol 170: 1797-1867.
2. Amidon GL, Lennernäs H, Shah VP, Crison JR (1995). A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12: 413-420.
3. Bauer NG, Richter-Landsberg C, Ffrench-Constant C (2009). Role of the oligodendroglial cytoskeleton in differentiation and myelination. Glia 57: 1691-1705.
4. Beal SL, Sheiner LB, Boeckmann AJ, Bauer RJ (1989-2011). NONMEM Users Guides. Icon Development Solutions: Ellicott City, MD.
5. Chuang DM, Leng Y, Marinova Z, Kim HJ, Chiu CT (2009). Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci 32: 591-601.
6. Conde C, Cáceres A (2009). Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci 10: 319-332.
7. Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O et al. (2009). Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell 136: 551-564.
8. De Forges H, Bouissou A, Perez F (2012). Interplay between microtubule dynamics and intracellular organization. Int J Biochem Cell Biol 44: 266-274.
9. Doluisio JT, Billups NF, Dittert LW, Sugita ET, Swintosky JV (1969). Drug absorption. I. An in situ rat gut technique yielding realistic absorption rates. J Pharm Sci 58: 1196-1200.
10. Furumai R, Komatsu Y, Nishino N, Khochbin S, Yoshida M, Horinouchi S (2001). Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc Natl Acad Sci U S A 98: 87-92.
11. Hlavanda E, Kovács J, Oláh J, Orosz F, Medzihradszky KF, Ovádi J (2002). Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations. Biochemistry 41: 8657-8664.
12. Höftberger R, Fink S, Aboul-Enein F, Botond G, Oláh J, Berki T et al. (2010). Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis. Glia 58: 1847-1857.
13. Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A et al. (2002). HDAC6 is a microtubule-associated deacetylase. Nature 417: 455-458.
14. Janke C, Bulinski JC (2011). Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat Rev Mol Cell Biol 12: 773-786.
15. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG (2010). Animal research: Reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160: 1577-1579.
16. Konno A, Setou M, Ikegami K (2012). Ciliary and flagellar structure and function - their regulations by posttranslational modifications of axonemal tubulin. Int Rev Cell Mol Biol 294: 133-170.
17. Kopito RR (2000). Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10: 524-530.
18. Kovács GG, László L, Kovács J, Jensen PH, Lindersson E, Botond G et al. (2004). Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Neurobiol Dis 17: 155-162.
19. Lehotzky A, Tirián L, To{combining double acute accent}kési N, Lénárt P, Szabó B, Kovács J et al. (2004). Dynamic targeting of microtubules by TPPP/p25 affects cell survival. J Cell Sci 117 (Pt 25): 6249-6259.
20. Lehotzky A, Lau P, To{combining double acute accent}kési N, Muja N, Hudson LD, Ovádi J (2010). Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Glia 58: 157-168.
21. Li W, Zhang B, Tang J, Cao Q, Wu Y, Wu C et al. (2007). Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin. J Neurosci 27: 2606-2616.
22. Lindbom L, Pihlgren P, Jonsson EN (2005). PsN-Toolkit - a collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM. Comput Methods Programs Biomed 79: 241-257.
23. Louis JC, Magal E, Muir D, Manthorpe M, Varon S (1992). CG-4, a new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligodendrocytes or type-2 astrocytes. J Neurosci Res 31: 193-204.
24. McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
25. Nahhas F, Dryden SC, Abrams J, Tainsky MA (2007). Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin. Mol Cell Biochem 303: 221-230.
26. North BJ, Marshall BL, Borra MT, Denu JM, Verdin E (2003). The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell 11: 437-444.
27. Ohkawa N, Sugisaki S, Tokunaga E, Fujitani K, Hayasaka T, Setou M et al. (2008). N-acetyltransferase ARD1-NAT1 regulates neuronal dendritic development. Genes Cells 13: 1171-1183.
28. Oláh J, Vincze O, Virók D, Simon D, Bozsó Z, To{combining double acute accent}kési N et al. (2011). Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. J Biol Chem 286: 34088-34100.
29. Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM et al. (2007). Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317: 516-519.
30. Parmigiani RB, Xu WS, Venta-Perez G, Erdjument-Bromage H, Yaneva M, Tempst P et al. (2008). HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A 105: 9633-9638.
31. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP et al.; NC-IUPHAR (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledge base of drug targets and their ligands. Nucl. Acids Res. 42 (Database Issue): D1098-1106.
32. Preusser M, Lehotzky A, Budka H, Ovádi J, Kovács GG (2007). TPPP/p25 in brain tumours: expression in non-neoplastic oligodendrocytes but not in oligodendroglioma cells. Acta Neuropathol 113: 213-215.
33. Reed NA, Cai D, Blasius TL, Jih GT, Meyhofer E, Gaertig J et al. (2006). Microtubule acetylation promotes kinesin-1 binding and transport. Curr Biol 16: 2166-2172.
34. Rodriguez-Berna G, Diaz MJ, Mangas-Sanjuan V, Gonzalez-Alvarez M, Gonzalez-Alvarez I, Abasolo I et al. (2013). Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9 substituted camptothecin derivatives. ACS Med Chem Lett 4: 651-655.
35. Samiei N, Mangas-Sanjuan V, Gonzalez-Alvarez I, Foroutan M, Shafaati A, Zarghi A et al. (2013). Ion-pair strategy for enabling amifostine oral absorption: rat in situ and in vivo experiments. Eur J Pharm Sci 49: 499-504.
36. Takahashi M, Tomizawa K, Fujita SC, Sato K, Uchida T, Imahori K (1993). A brain-specific protein p25 is localized and associated with oligodendrocytes, neuropil, and fiber-like structures of the CA3 hippocampal region in the rat brain. J Neurochem 60: 228-235.
37. Tang BL, Chua CE (2008). SIRT2, tubulin deacetylation, and oligodendroglia differentiation. Cell Motil Cytoskeleton 65: 179-182.
38. To{combining double acute accent}kési N, Lehotzky A, Horváth I, Szabó B, Oláh J, Lau P et al. (2010). TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6. J Biol Chem 285: 17896-17906.
39. Tran AD, Marmo TP, Salam AA, Che S, Finkelstein E, Kabarriti R et al. (2007). HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci 120 (Pt 8): 1469-1479.
40. Wang SZ, Dulin J, Wu H, Hurlock E, Lee SE, Jansson K et al. (2006). An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Development 133: 3389-3398.
41. Yang WM, Yao YL, Sun JM, Davie JR, Seto E (1997). Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem 272: 28001-28007.