Evaluation of class i HDAC isoform selectivity of largazole analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3728-3731

  Kim, Bumki ^a   Park, Heekwang ^a   Salvador, Lilibeth A ^b,c   Serrano, Patrick E ^a   Kwan, Jason C ^b   Zeller, Sabrina L ^a   Chen, Qi Yin ^b,d   Ryu, Soyoung ^a   Liu, Yanxia ^b,d   Byeon, Seongrim ^a   Luesch, Hendrik ^b,d   Hong, Jiyong ^a,e  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

^c University of the Philippines Diliman   (Philippines)

^d UNIVERSITY OF FLORIDA   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Class I histone deacetylase; HDAC inhibitor; Isoform selectivity; Largazole; Structure activity relationship

Indexed keywords

ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; LARGAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VALINE; DEPSIPEPTIDE; HDAC1 PROTEIN, HUMAN; ISOENZYME; LARGAZOLE; THIAZOLE DERIVATIVE;

AMINO ACID SUBSTITUTION; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HCT116 CELL LINE; HYDROGEN BOND; NUCLEOTIDE SEQUENCE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; SYNTHESIS;

DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITORS; HUMANS; ISOENZYMES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84905911217     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.006     Document Type: Article

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