메뉴 건너뛰기




Volumn 23, Issue 6, 2016, Pages 1038-1048

Cdk12 is essential for embryonic development and the maintenance of genomic stability

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 12; UNCLASSIFIED DRUG; ATM PROTEIN; ATR PROTEIN, MOUSE; BRCA1 PROTEIN; CDK12 PROTEIN, MOUSE; FANCI PROTEIN, MOUSE; FANCONI ANEMIA GROUP D2 PROTEIN; FANCONI ANEMIA PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; POU5F1 PROTEIN, MOUSE; TRP53BP1 PROTEIN, MOUSE; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1;

EID: 84949604125     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2015.157     Document Type: Article
Times cited : (77)

References (36)
  • 1
    • 0020004246 scopus 로고
    • Lineage analysis of inner cell mass and trophectoderm using microsurgically reconstituted mouse blastocysts
    • Papaioannou VE. Lineage analysis of inner cell mass and trophectoderm using microsurgically reconstituted mouse blastocysts. J Embryol Exp Morphol 1982; 68: 199-209
    • (1982) J Embryol Exp Morphol , vol.68 , pp. 199-209
    • Papaioannou, V.E.1
  • 3
    • 0033566905 scopus 로고    scopus 로고
    • The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage
    • Van Sloun PP, Jansen JG,Weeda G, Mullenders LH, Van Zeeland AA, Lohman PH., et al. The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage. Nucleic Acids Res 1999; 27: 3276-3282
    • (1999) Nucleic Acids Res , vol.27 , pp. 3276-3282
    • Van Sloun, P.P.1    Jansen Jgweeda, G.2    Mullenders, L.H.3    Van Zeeland, A.A.4    Lohman, P.H.5
  • 4
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001; 27: 247-254
    • (2001) Nat Genet , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 5
    • 38049173021 scopus 로고    scopus 로고
    • Homologous recombination in DNA repair and DNA damage tolerance
    • Li X, Heyer WD. Homologous recombination in DNA repair and DNA damage tolerance. Cell Res 2008; 18: 99-113
    • (2008) Cell Res , vol.18 , pp. 99-113
    • Li, X.1    Heyer, W.D.2
  • 6
    • 34247626923 scopus 로고    scopus 로고
    • Multipotent hematopoietic cells susceptible to alternative doublestrand break repair pathways that promote genome rearrangements
    • Francis R, Richardson C. Multipotent hematopoietic cells susceptible to alternative doublestrand break repair pathways that promote genome rearrangements. Genes Dev 2007; 21: 1064-1074
    • (2007) Genes Dev , vol.21 , pp. 1064-1074
    • Francis, R.1    Richardson, C.2
  • 7
    • 2342524565 scopus 로고    scopus 로고
    • Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks
    • Yang YG, Cortes U, Patnaik S, Jasin M, Wang ZQ. Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene 2004; 23: 3872-3882
    • (2004) Oncogene , vol.23 , pp. 3872-3882
    • Yang, Y.G.1    Cortes, U.2    Patnaik, S.3    Jasin, M.4    Wang, Z.Q.5
  • 9
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
    • Luo G, Yao MS, Bender CF, Mills M, Bladl AR, Bradley A., et al. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci USA 1999; 96: 7376-7381
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7376-7381
    • Luo, G.1    Yao, M.S.2    Bender, C.F.3    Mills, M.4    Bladl, A.R.5    Bradley, A.6
  • 10
    • 0029784528 scopus 로고    scopus 로고
    • Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
    • Liu CY, Flesken-Nikitin A, Li S, Zeng Y, Lee WH. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev 1996; 10: 1835-1843
    • (1996) Genes Dev , vol.10 , pp. 1835-1843
    • Liu, C.Y.1    Flesken-Nikitin, A.2    Li, S.3    Zeng, Y.4    Lee, W.H.5
  • 11
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000; 14: 397-402
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 12
    • 33645214031 scopus 로고    scopus 로고
    • Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation
    • Chen HH, Wang YC, Fann MJ. Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation. Mol Cell Biol 2006; 26: 2736-2745
    • (2006) Mol Cell Biol , vol.26 , pp. 2736-2745
    • Chen, H.H.1    Wang, Y.C.2    Fann, M.J.3
  • 13
    • 84868681176 scopus 로고    scopus 로고
    • Interaction of cyclindependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.
    • Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF., et al. Interaction of cyclindependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II. Mol Cell Biol 2012; 32: 4691-4704
    • (2012) Mol Cell Biol , vol.32 , pp. 4691-4704
    • Cheng, S.W.1    Ma, K.2    Moradian, A.3    Ichu, T.A.4    Chang, V.C.5    Tien, J.F.6
  • 14
    • 80054756087 scopus 로고    scopus 로고
    • The cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
    • Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z., et al. The cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev 2011; 25: 2158-2172
    • (2011) Genes Dev , vol.25 , pp. 2158-2172
    • Blazek, D.1    Kohoutek, J.2    Bartholomeeusen, K.3    Johansen, E.4    Hulinkova, P.5    Luo, Z.6
  • 15
    • 84864103862 scopus 로고    scopus 로고
    • Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells
    • Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B., et al. Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells. J Biol Chem 2012; 287: 25344-25352
    • (2012) J Biol Chem , vol.287 , pp. 25344-25352
    • Dai, Q.1    Lei, T.2    Zhao, C.3    Zhong, J.4    Tang, Y.Z.5    Chen, B.6
  • 16
    • 13944273471 scopus 로고    scopus 로고
    • P53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
    • Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E., et al. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 2005; 7: 165-171
    • (2005) Nat Cell Biol , vol.7 , pp. 165-171
    • Lin, T.1    Chao, C.2    Saito, S.3    Mazur, S.J.4    Murphy, M.E.5    Appella, E.6
  • 18
    • 78651403369 scopus 로고    scopus 로고
    • Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing
    • Zang ZJ, Ong CK, Cutcutache I, Yu W, Zhang SL, Huang D., et al. Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. Cancer Res 2011; 71: 29-39
    • (2011) Cancer Res , vol.71 , pp. 29-39
    • Zang, Z.J.1    Ong, C.K.2    Cutcutache, I.3    Yu, W.4    Zhang, S.L.5    Huang, D.6
  • 19
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 2011; 474: 609-615
    • (2011) Nature , vol.474 , pp. 609-615
  • 21
    • 84897457200 scopus 로고    scopus 로고
    • Ovarian cancer-Associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors
    • Joshi PM, Sutor SL, Huntoon CJ, Karnitz LM. Ovarian cancer-Associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors. J Biol Chem 2014; 289: 9247-9253
    • (2014) J Biol Chem , vol.289 , pp. 9247-9253
    • Joshi, P.M.1    Sutor, S.L.2    Huntoon, C.J.3    Karnitz, L.M.4
  • 22
    • 84937622540 scopus 로고    scopus 로고
    • Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex
    • Ekumi KM, Paculova H, Lenasi T, Pospichalova V, Bosken CA, Rybarikova J., et al. Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex. Nucleic Acids Res 2015; 43: 2575-2589
    • (2015) Nucleic Acids Res , vol.43 , pp. 2575-2589
    • Ekumi, K.M.1    Paculova, H.2    Lenasi, T.3    Pospichalova, V.4    Bosken, C.A.5    Rybarikova, J.6
  • 23
    • 84905218763 scopus 로고    scopus 로고
    • Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression
    • Chen HR, Lin GT, Huang CK, Fann MJ. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. Exp Neurol 2014; 261: 10-21
    • (2014) Exp Neurol , vol.261 , pp. 10-21
    • Chen, H.R.1    Lin, G.T.2    Huang, C.K.3    Fann, M.J.4
  • 24
    • 0031443874 scopus 로고    scopus 로고
    • Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells
    • O'Gorman S, Dagenais NA, Qian M, Marchuk Y. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci USA 1997; 94: 14602-14607
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14602-14607
    • O'Gorman, S.1    Dagenais, N.A.2    Qian, M.3    Marchuk, Y.4
  • 25
    • 0031080163 scopus 로고    scopus 로고
    • Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line
    • Lewandoski M, Wassarman KM, Martin GR. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr Biol 1997; 7: 148-151
    • (1997) Curr Biol , vol.7 , pp. 148-151
    • Lewandoski, M.1    Wassarman, K.M.2    Martin, G.R.3
  • 26
    • 38049095768 scopus 로고    scopus 로고
    • Stochastic patterning in the mouse pre-implantation embryo
    • Dietrich JE, Hiiragi T. Stochastic patterning in the mouse pre-implantation embryo. Development 2007; 134: 4219-4231
    • (2007) Development , vol.134 , pp. 4219-4231
    • Dietrich, J.E.1    Hiiragi, T.2
  • 28
    • 0034739853 scopus 로고    scopus 로고
    • P53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • Schultz LB, Chehab NH, Malikzay A, Halazonetis TD. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol 2000; 151: 1381-1390
    • (2000) J Cell Biol , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 29
    • 0031947965 scopus 로고    scopus 로고
    • Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells
    • MacAuley A, Cross JC, Werb Z. Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells. Mol Biol Cell 1998; 9: 795-807
    • (1998) Mol Biol Cell , vol.9 , pp. 795-807
    • MacAuley, A.1    Cross, J.C.2    Werb, Z.3
  • 30
    • 55749085302 scopus 로고    scopus 로고
    • Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity
    • Ullah Z, Kohn MJ, Yagi R, Vassilev LT, DePamphilis ML. Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity. Genes Dev 2008; 22: 3024-3036
    • (2008) Genes Dev , vol.22 , pp. 3024-3036
    • Ullah, Z.1    Kohn, M.J.2    Yagi, R.3    Vassilev, L.T.4    DePamphilis, M.L.5
  • 31
    • 0035313218 scopus 로고    scopus 로고
    • Endogenous DNA damage and mutation
    • Marnett LJ, Plastaras JP. Endogenous DNA damage and mutation. Trends Genet 2001; 17: 214-221
    • (2001) Trends Genet , vol.17 , pp. 214-221
    • Marnett, L.J.1    Plastaras, J.P.2
  • 32
    • 5644273037 scopus 로고    scopus 로고
    • Impact of mismatch repair deficiency on genomic stability in the maternal germline and during early embryonic development
    • Larson JS, Stringer SL, Stringer JR. Impact of mismatch repair deficiency on genomic stability in the maternal germline and during early embryonic development. Mutat Res 2004; 556: 45-53
    • (2004) Mutat Res , vol.556 , pp. 45-53
    • Larson, J.S.1    Stringer, S.L.2    Stringer, J.R.3
  • 33
    • 84947465824 scopus 로고    scopus 로고
    • Maternal BCAS2 protects genomic integrity in mouse early embryonic development
    • Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z., et al. Maternal BCAS2 protects genomic integrity in mouse early embryonic development. Development 2015; 142: 3943-3953
    • (2015) Development , vol.142 , pp. 3943-3953
    • Xu, Q.1    Wang, F.2    Xiang, Y.3    Zhang, X.4    Zhao, Z.5    Gao, Z.6
  • 34
    • 33846634676 scopus 로고    scopus 로고
    • CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing
    • Chen HH, Wong YH, Geneviere AM, Fann MJ. CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. Biochem Biophys Res Commun 2007; 354: 735-740
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 735-740
    • Chen, H.H.1    Wong, Y.H.2    Geneviere, A.M.3    Fann, M.J.4
  • 35
    • 84895929400 scopus 로고    scopus 로고
    • Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast
    • Natrajan R, Wilkerson PM, Marchio C, Piscuoglio S, Ng CK, Wai P., et al. Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. J Pathol 2014; 232: 553-565
    • (2014) J Pathol , vol.232 , pp. 553-565
    • Natrajan, R.1    Wilkerson, P.M.2    Marchio, C.3    Piscuoglio, S.4    Ng, C.K.5    Wai, P.6
  • 36
    • 84892712017 scopus 로고    scopus 로고
    • Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity
    • Bajrami I, Frankum JR, Konde A, Miller RE, Rehman FL, Brough R., et al. Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. Cancer Res 2014; 74: 287-297
    • (2014) Cancer Res , vol.74 , pp. 287-297
    • Bajrami, I.1    Frankum, J.R.2    Konde, A.3    Miller, R.E.4    Rehman, F.L.5    Brough, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.