Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains

Neuropsychopharmacology

Volumn 41, Issue 2, 2016, Pages 568-577

  Weed, Michael R ^a   Bookbinder, Mark ^a   Polino, Joseph ^a   Keavy, Deborah ^a   Cardinal, Rudolf N ^b,c   Simmermacher Mayer, Jean ^a   Cometa, Fu Ni L ^a   King, Dalton ^a   Thangathirupathy, Srinivasan ^a   Macor, John E ^a   Bristow, Linda J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c CAMBRIDGESHIRE AND PETERBOROUGH NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BMT 108908; KETAMINE; LANICEMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2D; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TRAXOPRODIL; UNCLASSIFIED DRUG; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; AMINO ACID RECEPTOR BLOCKING AGENT; BETA CYCLODEXTRIN DERIVATIVE; BROMINE; DRUG COMBINATION; GLUTAMIC ACID DERIVATIVE; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR2B NMDA RECEPTOR; PHENETHYLAMINE DERIVATIVE; PIPERIDINE DERIVATIVE; PSYCHOVERLAN; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; COGNITIVE DEFECT; LEARNING; MACACA FASCICULARIS; MEMORY; MEMORY DISORDER; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PRIORITY JOURNAL; RAT; TASK PERFORMANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; COGNITION; COHORT ANALYSIS; COMPARATIVE STUDY; DEPTH PERCEPTION; DRUG COMBINATION; DRUG EFFECTS; MACACA; MALE; METABOLISM; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; REACTION TIME; RECOGNITION; SHORT TERM MEMORY;

ANIMALS; BETA-CYCLODEXTRINS; BROMINE; COGNITION; COGNITION DISORDERS; COHORT STUDIES; DRUG COMBINATIONS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMATES; KETAMINE; MACACA; MAGNESIUM; MALE; MEMORY, SHORT-TERM; NEUROPSYCHOLOGICAL TESTS; PHENETHYLAMINES; PIPERIDINES; PSYCHOMOTOR PERFORMANCE; PYRIDINES; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; RECOGNITION (PSYCHOLOGY); SPACE PERCEPTION;

EID: 84949599459     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2015.184     Document Type: Article

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