Absorption of ipratropium and l-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters

International Journal of Pharmaceutics

Volumn 496, Issue 2, 2015, Pages 834-841

  Al Jayyoussi, Ghaith ^a   Price, Daniel F ^a   Kreitmeyr, Katharina ^a   Keogh, John P ^b   Smith, Mathew W ^a   Gumbleton, Mark ^a   Morris, Christopher J ^c  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b JPK Consulting   (United Kingdom)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Isolated perfused rat lung (IPRL); Lung; Organic cation transporters, OCT1, OCT2, OCT3, OCTN; Pulmonary absorption; SLC22; Transporters

Indexed keywords

CARNITINE; CARNITINE TRANSPORTER 1; CARNITINE TRANSPORTER 2; CARRIER PROTEINS AND BINDING PROTEINS; IPRATROPIUM BROMIDE; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; CARRIER PROTEIN; MEMBRANE PROTEIN; OCTN1 PROTEIN, RAT; ORGANIC CATION TRANSPORTER; SLC22A5 PROTEIN, RAT;

ACTIVE TRANSPORT; AIRWAY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD; CELL VIABILITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG TRANSPORT; DRUG UPTAKE; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTACT PERFUSED RAT LUNG; ISOTOPE LABELING; LUNG; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM CELL; LUNG CIRCULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; EPITHELIUM CELL; METABOLISM; PHYSIOLOGY;

ANIMALS; CARNITINE; CARRIER PROTEINS; CELLS, CULTURED; EPITHELIAL CELLS; HUMANS; IPRATROPIUM; LUNG; MEMBRANE PROTEINS; ORGANIC CATION TRANSPORT PROTEINS; PULMONARY CIRCULATION; RATS;

EID: 84949575740     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.10.036     Document Type: Article

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