Protective effect of vanillic acid against hyperinsulinemia, hyperglycemia and hyperlipidemia via alleviating hepatic insulin resistance and inflammation in High-Fat Diet (HFD)-fed rats

Nutrients

Volumn 7, Issue 12, 2015, Pages 9946-9959

  Chang, Wen Chang ^a   Wu, James Swi Bea ^a   Chen, Chen Wen ^a   Kuo, Po Ling ^b   Chien, Hsu Min ^c   Wang, Yuh Tai ^d   Shen, Szu Chuan ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^c TAIPEI CITY HOSPITAL   (Taiwan)

^d HSING WU UNIVERSITY   (Taiwan)

Author keywords

Hyperglycemia; Hyperinsulinemia; Hyperlipidemia; Insulin resistance; Vanillic acid

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CYCLOOXYGENASE 2; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; INSULIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VANILLIC ACID; FAT INTAKE; PHENOL DERIVATIVE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; HOMEOSTASIS; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLIPIDEMIA; INFLAMMATION; INSULIN RESISTANCE; LIPID DIET; LIPID METABOLISM; MALE; MOUSE; MTT ASSAY; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; FAT INTAKE; HYPERINSULINISM; HYPERLIPIDEMIAS; LIVER; LIVER CELL; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CELL LINE; CELL SURVIVAL; DIETARY FATS; HEPATOCYTES; HYPERGLYCEMIA; HYPERINSULINISM; HYPERLIPIDEMIAS; INFLAMMATION; INSULIN RESISTANCE; LIVER; MICE; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA; VANILLIC ACID;

EID: 84949563542     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu7125514     Document Type: Article

References (53)

1. World Health Organization. Preventing Diabetes is Essential for Keeping Health and Well-Being in Tajikistan. 2011. Available online: http://www. euro. who. int/en/health-topics/noncommunicable-diseases/diabetes/news/news/2011/11/preventing-diabetes-is-essential-for-keeping-health-and-well-being-in-tajikistan (accessed on 21 November 2011).
2. Buettner, R.; Parhofer, K. G.; Woenckhaus, M.; Wrede, C. E.; Kunz-Schughart, L. A.; Scholmerich, J.; Bollheimer, L. C. Defining high-fat-diet rat models: Metabolic and molecular effect of different fat types. Mol. Endocrinol. 2006, 36, 485-501. [CrossRef] [PubMed].
3. Okabayashi, Y.; Maddux, B. A.; Mcdonald, A. R.; Logsdon, C. D.; Williams, J. A.; Goldfine, I. D. Mechanisms of insulin-induced insulin-receptor downregulation: Decrease of receptor biosynthesis and mRNA levels. Diabetes 1989, 38, 182-187. [CrossRef] [PubMed].
4. Samuel, V. T. Fructose induced lipogenesis: From sugar to fat to insulin resistance. Trends Endocrinol. Metab. 2011, 22, 60-65. [CrossRef] [PubMed].
5. Xu, H.; Barnes, G. T.; Yang, Q.; Tan, G.; Yang, D.; Chou, C. J.; Sole, J.; Nichols, A.; Ross, J. S.; Tartaglia, L. A.; et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Investig. 2003, 112, 1821-1830. [CrossRef] [PubMed].
6. Arkan, M. C.; Hevener, A. L.; Greten, F. R.; Maeda, S.; Li, Z. W.; Long, J. M.; Wynshaw-Boris, A.; Poli, G.; Olefsky, J.; Karin, M. IKK-β links inflammation to obesity-induced insulin resistance. Nat. Med. 2005, 11, 191-198. [CrossRef] [PubMed].
7. Cai, D.; Yuan, M.; Frantz, D. F.; Melendez, P. A.; Hansen, L.; Lee, J.; Shoelson, S. E. Local and systemic insulin resistance resulting from hepatic activation of IKK+ and NF-βB. Nat. Med. 2005, 11, 183-190. [CrossRef] [PubMed].
8. Qatanani, M.; Lazar, M. A. Mechanisms of obesity-associated insulin resistance: Many choices on the menu. Gene. Dev. 2007, 21, 1443-1455. [CrossRef] [PubMed].
9. Kilmartin, P. A.; Zou, H.; Waterhouse, A. L. A cyclic voltammetry method suitable for characterizing antioxidant properties of wine and wine phenolics. J. Agric. Food Chem. 2001, 49, 1957-1965. [CrossRef].
10. Adisakwattana, S.; Roengsamarn, S.; Hsu, W. H.; Yibchok-Anun, S. Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats. Life Sci. 2005, 78, 406-412. [CrossRef] [PubMed].
11. Ohnishi, M.; Matuo, T.; Tsuno, T.; Hosoda, A.; Normura, E.; Taniguchi, H.; Sasaki, H.; Morishita, H. Antioxidation activity and hypoglycemic effect of ferulic acid in STZ-induced diabetic mice and KK-Ay mice. Biofactors 2004, 21, 315-319. [CrossRef] [PubMed].
12. Jung, U. J.; Lee, M. K.; Park, Y. B.; Jeon, S. M.; Choi, M. S. Antihyperglycemic and antioxidant properties of caffeic acid I db/db mice. J. Pharmacol. Exp. Ther. 2006, 318, 476-483. [CrossRef] [PubMed].
13. Chang, W. C.; Shen, S. C. Effect of water extracts from edible Myrtaceae plants on uptake of 2-(N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) in tumor necrosis factor-β-treated FL83B mouse hepatocytes. Phytother. Res. 2013, 27, 236-243. [CrossRef] [PubMed].
14. Matthews, D. R.; Hosker, J. P.; Rudenski, A. S.; Naylor, B. A.; Treacher, D. F.; Turner, R. C. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diavetologia 1985, 28, 412-419. [CrossRef].
15. Sargent, J. M. The use of the MTT assay to study drug resistance in fresh tumor samples. Recent Results Cancer Res. 2003, 161, 13-25.
16. Bahorun, T.; Luximon-Ramma, A.; Crozier, A.; Aruoma, O. I. Total phenol, flavonoid, proanthocyanidin and vitamin C levels and antioxidant activities of Mauritian vegetables. J. Sci. Food Agric. 2004, 84, 1553-1561. [CrossRef].
17. Inoue, M.; Suzuki, R.; Sakaguchi, N.; Li, Z.; Takeda, T.; Ogihara, Y.; Jiang, B. Y.; Chen, Y. Selective induction of cell death in cancer cells by gallic acid. Biol. Pharm. Bull. 1995, 18, 1526-1530. [CrossRef].
18. Scalbert, A. R.; Johnson, I. T.; Saltmarsh, M. Polyphenols: Antioxidants and beyond. Am. J. Clin. Nutr. 2005, 81, 215S-217S. [PubMed].
19. Feinstein, R.; Kanety, H.; Papa, M. Z.; Lunenfeld, B.; Karasik, A. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J. Biol. Chem. 1993, 268, 26055-26058.
20. Peraldi, P.; Hotamisligil, G. S.; Buurman, W. A.; White, M. F.; Spiegelman, B. M. Tumor necrosis factor (TNF-β) inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J. Biol. Chem. 1996, 271, 13018-13022.
21. Kroder, G.; Bossenmayer, B.; Kellerer, M.; Capp, E.; Stoyanov, B.; Muhlhofer, A.; Berti, L.; Horikoshi, H.; Ullrich, A.; Haring, H. Tumor necrosis factor-alpha and hyperglycemia-induced insulin resistance. J. Clin. Investig. 1996, 97, 1471-1477. [CrossRef] [PubMed].
22. Yoshioka, K.; Oh, K. B.; Saito, M.; Nemoto, Y.; Matsuoka, H. Evaluation of 2-[N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)amino]-2-deoxy-D-glucose, a new fluorescent derivative of glucose, for viability assessment of yeast Candida albicans. Appl. Microbiol. Biotechnol. 1996, 46, 400-404.
23. Louzao, M. C.; Espiña, B.; Vieytes, M. R.; Vega, F. V.; Rubiolo, J. A.; Baba, O.; Terashima, T.; Botana, L. M. "Fluorescent glycogen" formation with sensibility for in vivo and in vitro detection. Glycoconj. J. 2008, 25, 503-510. [CrossRef] [PubMed].
24. Kraegen, E. W.; James, D. E.; Storlien, L. H.; Burleigh, K. M.; Chisholm, D. J. In vivo insulin resistance in individual peripheral tissues of the high fat fed rat: Assessment by euglycaemic clamp plus deoxyglucose administration. Diabetologia 1986, 29, 192-198. [CrossRef].
25. Pedersen, O.; Kahn, C. R.; Flier, J. S.; Kahn, B. B. High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats. Endocrinology 1991, 129, 771-777. [CrossRef] [PubMed].
26. Ahren, B.; Gudbjartsson, T.; Al-Amin, A. N. Islet perturbations in rats fed a high-fat diet. Pancreas 1999, 18, 75-83. [CrossRef] [PubMed].
27. Kaiyala, K. J.; Prigeon, R. L.; Kahn, S. E.; Woods, S. C.; Porte, D.; Schwartz, M. W. Reduced β-cell function contributes to impaired glucose tolerance in dogs made obese by high-fat feeding. Am. J. Physiol. 1999, 277, E659-E667. [PubMed].
28. Ginsberg, H. N. Insulin resistance and cardiovascular disease. J. Clin. Investig. 2000, 106, 453-458. [CrossRef] [PubMed].
29. Jellinger, P. S. Metabolic consequences of hyperglycemia and insulin resistance. Clin. Cornerstone 2007, 8, S30-S42. [CrossRef].
30. Bahadoran, Z.; Mirmiran, P.; Azizi, F. Potential efficacy of broccoli sprouts as a unique supplement for management of type 2 diabetes and its complications. J. Med. Food 2013, 16, 375-382. [CrossRef] [PubMed].
31. Hekmatdoost, A.; Mirmiran, P.; Hosseini-Esfahani, F.; Azizi, F. Dietary fatty acid composition and metabolic syndrome in Tehranian adults. Nutrition 2011, 27, 1002-1007. [CrossRef] [PubMed].
32. Prada, P. O.; Zecchin, H. G.; Gasparetti, A. L.; Torsoni, M. A.; Ueno, M.; Hirata, A. E.; do Amaral, M. E.; Höer, N. F.; Boschero, A. C.; Saad, M. J. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology 2005, 146, 1576-1587. [CrossRef] [PubMed].
33. Huang, B. W.; Chiang, M. T.; Yao, H. T.; Chiang, W. The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats. Diabetes Obes. Metab. 2004, 6, 120-126. [CrossRef].
34. Bonora, E.; Targher, G.; Alberiche, M.; Bonadonna, R. C.; Saggiani, F.; Zenere, M. B.; Monauni, T.; Muggeo, M. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000, 23, 57-63. [CrossRef] [PubMed].
35. Feng, Y.; Carroll, A. R.; Addepalli, R.; Fechner, G. A.; Avery, V. M.; Quinn, R. J. Vanillic acid derivatives from the green algae Cladophora socialis as potent protein tyrosine phosphatase 1B inhibitors. J. Nat. Prod. 2007, 70, 1790-1792. [CrossRef] [PubMed].
36. Fraze, E.; Chiou, M.; Chen, Y.; Reaven, G. M. Age-related changes in postprandial plasma glucose, insulin, and free fatty acid concentrations in nondiabetic individuals. J. Am. Geriatr. Soc. 1987, 35, 224-228. [CrossRef] [PubMed].
37. Jensen, M. D.; Haymond, M. W.; Rizza, R. A.; Cryer, P. E.; Miles, J. M. Influence of body fat distribution on free fatty acid metabolism in obesity. J. Clin. Investig. 1989, 83, 1168-1173. [CrossRef] [PubMed].
38. Wang, Y.; Wang, P. Y.; Qin, L. Q.; Davaasambuu, G.; Kaneko, T.; Xu, J.; Murata, S. I.; Katoh, R.; Sato, A. The development of diabetes mellitus in wistar rats kept on a high-fat low-carbohydrate diet for long periods. Endocrine 2003, 22, 85-92. [CrossRef].
39. Considine, R. V.; Sinha, M. K.; Heiman, M. L.; Kriauciunas, A.; Stephens, T. W.; Nyce, M. R.; Ohannesian, J. P.; Marco, C. C.; Mckee, L. J.; Baur, T. L.; et al. Serum immunoreative-leptin concentrations in normal weight and obese human. N. Engl. J. Med. 1996, 334, 292-295. [CrossRef] [PubMed].
40. Maffei, M.; Halaas, J.; Ravussin, E.; Pratley, R. E.; Lee, G. H.; Zhang, Y.; Fei, H.; Kim, S.; Lallone, R.; Ranganathan, S.; et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1995, 1, 1155-1161. [CrossRef].
41. Pelleymounter, M. A.; Cullen, M. J.; Baker, M. B.; Hecht, R.; Winters, D.; Boone, T.; Collins, F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995, 269, 540-543. [CrossRef] [PubMed].
42. Halaas, J. L.; Gajiwala, K. S.; Maffei, M.; Cohen, S. L.; Chait, B. T.; Rabinowitz, D.; Lallone, R. L.; Burley, S. K.; Friedman, J. M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995, 269, 543-546. [CrossRef].
43. Ghorbani, Z.; Hekmatdoost, A.; Mirmiran, P. Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin. Int. J. Endocrinol. Metab. 2014, 12. [CrossRef] [PubMed].
44. Panzhinskiy, E.; Hua, Y.; Lapchak, P. A.; Topchiy, E.; Lehmann, T. E.; Ren, J.; Nair, S. Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. J. Pharmacol. Exp. Ther. 2014, 349, 248-257. [CrossRef] [PubMed].
45. Martyn, J. A.; Kaneki, M.; Yasuhara, S. Obesity-induced insulin resistance and hyperglycemia: Etiologic factors and molecular mechanisms. Anesthesiology 2008, 109, 137-148. [CrossRef] [PubMed].
46. Bose, T.; Alvarenga, J. C.; Tejero, M. E.; Voruganti, V. S.; Proffitt, J. M.; Freeland-Graves, J. H. Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers. J. Med. Primatol. 2009, 38, 418-424. [CrossRef] [PubMed].
47. Weisberg, S. P.; Hunter, D.; Huber, R.; Lemieux, J.; Slaymaker, S.; Vaddi, K.; Charo, I.; Leibel, R. L.; Ferrante, A. W. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J. Clin. Investig. 2006, 116, 115-124. [CrossRef] [PubMed].
48. Esposito, E.; Iacono, A.; Bianco, G.; Autore, G.; Cuzzocrea, S.; Vajro, P.; Canani, R. B.; Calignano, A.; Raso, G. M.; Meli, R. Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats. J. Nutr. 2009, 139, 905-911. [CrossRef] [PubMed].
49. Capurso, C.; Capurso, A. From excess adiposity to insulin resistance: The role of free fatty acids. Vascul. Pharmacol. 2012, 57, 91-97. [CrossRef] [PubMed].
50. Jiang, C. H.; Yao, N.; Wang, Q. Q.; Zhang, J. H.; Sun, Y.; Xiao, N.; Liu, K.; Huang, F.; Fang, S. Z.; Shang, X. L.; et al. Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice. J. Ethnopharmacol. 2014, 153, 344-351. [CrossRef] [PubMed].
51. Hsieh, P. S.; Jin, J. S.; Chiang, C. F.; Chan, P. C.; Chen, C. H.; Shih, K. C. COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver. Obesity 2009, 17, 1150-1157. [CrossRef] [PubMed].
52. Lloyd, E. E.; Gaubatz, J. W.; Burns, A. R.; Pownall, H. J. Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation. Atherosclerosis 2007, 192, 49-55. [CrossRef] [PubMed].
53. Mas, S.; Martínez-Pinna, R.; Martín-Ventura, J. L.; Pérez, R.; Gomez-Garre, D.; Ortiz, A.; Fernandez-Cruz, A.; Vivanco, F.; Egido, J. Local non-esterified fatty acids correlate with inflammation in atheroma plaques of patients with type 2 diabetes. Diabetes 2010, 59, 1292-301. [CrossRef] [PubMed].