메뉴 건너뛰기




Volumn 496, Issue 2, 2015, Pages 976-983

Effect of sterilization on the physical stability of brimonidine-loaded solid lipid nanoparticles and nanostructured lipid carriers

Author keywords

Autoclaving; Brimonidine; Glaucoma; Nanostructured lipid carriers; Ocular; Solid lipid nanoparticles

Indexed keywords

BRIMONIDINE; GLYCEROL STEARATE; NANOCARRIER; NANOMATERIAL; SOLID LIPID NANOPARTICLE; DRUG CARRIER; LIPID; NANOPARTICLE;

EID: 84949556196     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.10.043     Document Type: Article
Times cited : (61)

References (46)
  • 1
    • 34250890158 scopus 로고    scopus 로고
    • Solid lipid nanodispersions containing mixed lipid core and a polar heterolipid: Characterization
    • A.A. Attama, B.C. Schicke, T. Paepenmüller, and C.C. Müller-Goymann Solid lipid nanodispersions containing mixed lipid core and a polar heterolipid: characterization Eur. J. Pharm Biopharm. 67 1 2007 48 57
    • (2007) Eur. J. Pharm Biopharm. , vol.67 , Issue.1 , pp. 48-57
    • Attama, A.A.1    Schicke, B.C.2    Paepenmüller, T.3    Müller-Goymann, C.C.4
  • 2
    • 0028954379 scopus 로고
    • Solid lipid nanoparticles (SLN): An alternative colloidal carrier system for controlled drug delivery
    • R.H. Müller, W. Mehnert, J.S. Lucks, C. Schwarz, A. Zur Mühlen, H. Meyhers, and et al. Solid lipid nanoparticles (SLN): an alternative colloidal carrier system for controlled drug delivery Eur. J. Pharm. Biopharm. 41 1 1995 62 69
    • (1995) Eur. J. Pharm. Biopharm. , vol.41 , Issue.1 , pp. 62-69
    • Müller, R.H.1    Mehnert, W.2    Lucks, J.S.3    Schwarz, C.4    Zur Mühlen, A.5    Meyhers, H.6
  • 3
    • 0037093721 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin
    • R. Cavalli, M.R. Gasco, P. Chetoni, S. Burgalassi, and M.F. Saettone Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin Int. J. Pharm. 238 1 2002 241 245
    • (2002) Int. J. Pharm. , vol.238 , Issue.1 , pp. 241-245
    • Cavalli, R.1    Gasco, M.R.2    Chetoni, P.3    Burgalassi, S.4    Saettone, M.F.5
  • 4
    • 41349106751 scopus 로고    scopus 로고
    • Diclofenac sodium delivery to the eye: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
    • A.A. Attama, S. Reichl, and C.C. Müller-Goymann Diclofenac sodium delivery to the eye: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct Int. J. Pharm. 355 1 2008 307 313
    • (2008) Int. J. Pharm. , vol.355 , Issue.1 , pp. 307-313
    • Attama, A.A.1    Reichl, S.2    Müller-Goymann, C.C.3
  • 7
    • 2242472082 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
    • R.H. Müller, M. Radtke, and S.A. Wissing Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations Adv. Drug Deliv. Rev. 54 2002 S131 S155
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. S131-S155
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 8
    • 79251585943 scopus 로고    scopus 로고
    • Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery
    • E. Gonzalez-Mira, M.A. Egea, E.B. Souto, A.C. Calpena, and M.L. Garcia Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery Nanotechnology 22 4 2011 1 15
    • (2011) Nanotechnology , vol.22 , Issue.4 , pp. 1-15
    • Gonzalez-Mira, E.1    Egea, M.A.2    Souto, E.B.3    Calpena, A.C.4    Garcia, M.L.5
  • 9
    • 0037151496 scopus 로고    scopus 로고
    • Nanostructured lipid matrices for improved microencapsulation of drugs
    • R.H. Müller, M. Radtke, and S.A. Wissing Nanostructured lipid matrices for improved microencapsulation of drugs Int. J. Pharm. 242 1 2002 121 128
    • (2002) Int. J. Pharm. , vol.242 , Issue.1 , pp. 121-128
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 10
    • 84855864937 scopus 로고    scopus 로고
    • Novel surface modified nanostructured lipid carriers with partially deacetylated water soluble chitosan for efficient ocular delivery
    • B. Tian, Q. Luo, S. Song, D. Liu, H. Pan, W. Zhang, and et al. Novel surface modified nanostructured lipid carriers with partially deacetylated water soluble chitosan for efficient ocular delivery J. Pharm. Sci. 101 3 2012 1040 1049
    • (2012) J. Pharm. Sci. , vol.101 , Issue.3 , pp. 1040-1049
    • Tian, B.1    Luo, Q.2    Song, S.3    Liu, D.4    Pan, H.5    Zhang, W.6
  • 11
    • 0036210727 scopus 로고    scopus 로고
    • Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes
    • A.A. Acheampong, M. Shackleton, B. John, J. Burke, L.A. Wheeler, and D. Tang-Liu Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes Drug Metab. Dispos. 30 4 2002 421 429
    • (2002) Drug Metab. Dispos. , vol.30 , Issue.4 , pp. 421-429
    • Acheampong, A.A.1    Shackleton, M.2    John, B.3    Burke, J.4    Wheeler, L.A.5    Tang-Liu, D.6
  • 12
    • 58149335188 scopus 로고    scopus 로고
    • Absorption of brimonidine 0.1% and 0.15% ophthalmic solutions in the aqueous humor of cataract patients
    • L.B. Cantor, D. WuDunn, Y. Catoira-Boyle, and C.W. Yung Absorption of brimonidine 0.1% and 0.15% ophthalmic solutions in the aqueous humor of cataract patients J. Glaucoma 17 7 2008 529 534
    • (2008) J. Glaucoma , vol.17 , Issue.7 , pp. 529-534
    • Cantor, L.B.1    WuDunn, D.2    Catoira-Boyle, Y.3    Yung, C.W.4
  • 13
    • 33745468352 scopus 로고    scopus 로고
    • The management of glaucoma and intraocular hypertension: Current approaches and recent advances
    • R.J. Noecker The management of glaucoma and intraocular hypertension: current approaches and recent advances Ther. Clin. Risk Manag. 2 2 2006 193 205
    • (2006) Ther. Clin. Risk Manag. , vol.2 , Issue.2 , pp. 193-205
    • Noecker, R.J.1
  • 14
    • 84890476145 scopus 로고    scopus 로고
    • Preparation and evaluation of ocular inserts containing Brimonidine tartrate
    • P. Dipti, M.M. Patel, N.M. Patel, and P. Manish Preparation and evaluation of ocular inserts containing Brimonidine tartrate IJPCR 1 2009 19 22
    • (2009) IJPCR , vol.1 , pp. 19-22
    • Dipti, P.1    Patel, M.M.2    Patel, N.M.3    Manish, P.4
  • 15
    • 0035690626 scopus 로고    scopus 로고
    • A comparison of the efficacy and tolerability of brimonidine and latanoprost in adults with open-angle glaucoma or ocular hypertension: A three-month, multicenter, randomized, double-masked, parallel-group trial
    • H.B.D. Biner, M. Mroz, A.M. Shapiro, and M.S. Dirks A comparison of the efficacy and tolerability of brimonidine and latanoprost in adults with open-angle glaucoma or ocular hypertension: a three-month, multicenter, randomized, double-masked, parallel-group trial Clin. Ther. 23 12 2001 1969 1983
    • (2001) Clin. Ther. , vol.23 , Issue.12 , pp. 1969-1983
    • Biner, H.B.D.1    Mroz, M.2    Shapiro, A.M.3    Dirks, M.S.4
  • 16
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • W. Mehnert, and K. Mäder Solid lipid nanoparticles: production, characterization and applications Adv. Drug Deliv. Rev. 47 2 2001 165 196
    • (2001) Adv. Drug Deliv. Rev. , vol.47 , Issue.2 , pp. 165-196
    • Mehnert, W.1    Mäder, K.2
  • 17
    • 0022623387 scopus 로고
    • Intravenous infusion of high doses of liposomes containing NSC 251635, a water-insoluble cytostatic agent. A pilot study with pharmacokinetic data
    • J.P. Sculier, A. Coune, C. Brassinne, C. Laduron, G. Atassi, J.M. Ruysschaert, and et al. Intravenous infusion of high doses of liposomes containing NSC 251635, a water-insoluble cytostatic agent. A pilot study with pharmacokinetic data J. Clin. Oncol. 4 5 1986 789 797
    • (1986) J. Clin. Oncol. , vol.4 , Issue.5 , pp. 789-797
    • Sculier, J.P.1    Coune, A.2    Brassinne, C.3    Laduron, C.4    Atassi, G.5    Ruysschaert, J.M.6
  • 18
    • 0000418142 scopus 로고
    • Sterilization of drug-free and tetracaine-loaded solid lipid nanoparticles (SLN)
    • Budapest
    • Sterilization of drug-free and tetracaine-loaded solid lipid nanoparticles (SLN) C. Schwarz, and W. Mehnert Proc First World Meeting APGI/APV Budapest 1995
    • (1995) Proc First World Meeting APGI/APV
    • Schwarz, C.1    Mehnert, W.2
  • 20
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery - A review of the state of the art
    • R.H. Muéller, K. Maéder, and S. Gohla Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art Eur. J. Pharm. Biopharm. 50 1 2000 161 177
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , Issue.1 , pp. 161-177
    • Muéller, R.H.1    Maéder, K.2    Gohla, S.3
  • 21
    • 0031929391 scopus 로고    scopus 로고
    • Drug retention and stability of solid lipid nanoparticles containing azidothymidine palmitate after autoclaving, storage and lyophilization
    • H. Heiati, R. Tawashi, and N.C. Phillips Drug retention and stability of solid lipid nanoparticles containing azidothymidine palmitate after autoclaving, storage and lyophilization J. Microencapsul. 15 2 1998 173 184
    • (1998) J. Microencapsul. , vol.15 , Issue.2 , pp. 173-184
    • Heiati, H.1    Tawashi, R.2    Phillips, N.C.3
  • 23
    • 84870364134 scopus 로고    scopus 로고
    • Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide
    • J. Youshia, A.O. Kamel, A.E. Shamy, and S. Mansour Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide Int. J. Nanomed. 7 2012 2483 2496
    • (2012) Int. J. Nanomed. , vol.7 , pp. 2483-2496
    • Youshia, J.1    Kamel, A.O.2    Shamy, A.E.3    Mansour, S.4
  • 24
    • 84867590653 scopus 로고    scopus 로고
    • Formation of a physical stable delivery system by simply autoclaving nanostructured lipid carriers (NLC)
    • J. Pardeike, S. Weber, N. Matsko, and A. Zimmer Formation of a physical stable delivery system by simply autoclaving nanostructured lipid carriers (NLC) Int. J. Pharm. 439 1 2012 22 27
    • (2012) Int. J. Pharm. , vol.439 , Issue.1 , pp. 22-27
    • Pardeike, J.1    Weber, S.2    Matsko, N.3    Zimmer, A.4
  • 25
    • 53649090334 scopus 로고    scopus 로고
    • A review of analytical methods for the identification and characterization of nano delivery systems in food
    • D.M.A.M. Luykx, R.J.B. Peters, R. Van, S.M. uth, and H. Bouwmeester A review of analytical methods for the identification and characterization of nano delivery systems in food J. Agric. Food Chem. 56 18 2008 8231 8247
    • (2008) J. Agric. Food Chem. , vol.56 , Issue.18 , pp. 8231-8247
    • Luykx, D.M.A.M.1    Peters, R.J.B.2    Van, R.3    Uth, S.M.4    Bouwmeester, H.5
  • 26
    • 84865355409 scopus 로고    scopus 로고
    • Nanostructured lipid carriers as novel ophthalmic delivery system for mangiferin: Improving in vivo ocular bioavailability
    • R. Liu, Z. Liu, C. Zhang, and B. Zhang Nanostructured lipid carriers as novel ophthalmic delivery system for mangiferin: Improving in vivo ocular bioavailability J. Pharm. Sci. 101 10 2012 3833 3844
    • (2012) J. Pharm. Sci. , vol.101 , Issue.10 , pp. 3833-3844
    • Liu, R.1    Liu, Z.2    Zhang, C.3    Zhang, B.4
  • 27
    • 84982209327 scopus 로고    scopus 로고
    • Novel Solid Lipid Nanoparticles for Oral Delivery of Oxyresveratrol: Effect of the Formulation Parameters on the Physicochemical Properties and in vitro Release
    • Y. Sangsen, K. Likhitwitayawuid, B. Sritularak, K. Wiwattanawongsa, and R. Wiwattanapatapee Novel Solid Lipid Nanoparticles for Oral Delivery of Oxyresveratrol: Effect of the Formulation Parameters on the Physicochemical Properties and in vitro Release Int. J. Med. Pharm. Sci. Eng. 7 12 2013 506 513
    • (2013) Int. J. Med. Pharm. Sci. Eng. , vol.7 , Issue.12 , pp. 506-513
    • Sangsen, Y.1    Likhitwitayawuid, K.2    Sritularak, B.3    Wiwattanawongsa, K.4    Wiwattanapatapee, R.5
  • 29
    • 85019278363 scopus 로고    scopus 로고
    • Preparation and evaluation of charged solid lipid nanoparticles of tetrandrine for ocular drug delivery system: Pharmacokinetics, cytotoxicity and cellular uptake studies
    • J. Li, X. Guo, Z. Liu, C.I. Okeke, N. Li, H. Zhao, and et al. Preparation and evaluation of charged solid lipid nanoparticles of tetrandrine for ocular drug delivery system: pharmacokinetics, cytotoxicity and cellular uptake studies Drug Dev. Ind. Pharm. 0 2013 1 8
    • (2013) Drug Dev. Ind. Pharm. , pp. 1-8
    • Li, J.1    Guo, X.2    Liu, Z.3    Okeke, C.I.4    Li, N.5    Zhao, H.6
  • 30
    • 79953234715 scopus 로고    scopus 로고
    • Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo
    • Z. Liu, X. Zhang, H. Wu, J. Li, L. Shu, R. Liu, and et al. Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo Drug Dev. Ind. Pharm. 37 4 2011 475 481
    • (2011) Drug Dev. Ind. Pharm. , vol.37 , Issue.4 , pp. 475-481
    • Liu, Z.1    Zhang, X.2    Wu, H.3    Li, J.4    Shu, L.5    Liu, R.6
  • 31
    • 77949419485 scopus 로고    scopus 로고
    • Preparation, characterization, and evaluation of gatifloxacin loaded solid lipid nanoparticles as colloidal ocular drug delivery system
    • M.A. Kalam, Y. Sultana, A. Ali, M. Aqil, A.K. Mishra, and K. Chuttani Preparation, characterization, and evaluation of gatifloxacin loaded solid lipid nanoparticles as colloidal ocular drug delivery system J. Drug Target 18 3 2010 191 204
    • (2010) J. Drug Target , vol.18 , Issue.3 , pp. 191-204
    • Kalam, M.A.1    Sultana, Y.2    Ali, A.3    Aqil, M.4    Mishra, A.K.5    Chuttani, K.6
  • 32
    • 0000021897 scopus 로고
    • Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes
    • J.H. Draize, G. Woodard, and H.O. Calvery Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes J. Pharmacol. Exp. Ther. 82 3 1944 377 390
    • (1944) J. Pharmacol. Exp. Ther. , vol.82 , Issue.3 , pp. 377-390
    • Draize, J.H.1    Woodard, G.2    Calvery, H.O.3
  • 33
    • 69049107397 scopus 로고    scopus 로고
    • A stability-indicating assay of Brimonidine tartrate ophthalmic solution and stress testing using HILIC
    • M.S. Ali, A.R. Khatri, M.I. Munir, and M. Ghori A stability-indicating assay of Brimonidine tartrate ophthalmic solution and stress testing using HILIC Chromatographia 70 3-4 2009 539 544
    • (2009) Chromatographia , vol.70 , Issue.3-4 , pp. 539-544
    • Ali, M.S.1    Khatri, A.R.2    Munir, M.I.3    Ghori, M.4
  • 34
    • 79955067679 scopus 로고    scopus 로고
    • Potential impurity in brimonidine - Their synthesis and mass spectrometry identification
    • L. Kvapil, M. Grepl, and P. Hradil Potential impurity in brimonidine - their synthesis and mass spectrometry identification Acta Univ. Palacki Olomuc. Fac. Rer. Nat. Chem. 42 2003 19 26
    • (2003) Acta Univ. Palacki Olomuc. Fac. Rer. Nat. Chem. , vol.42 , pp. 19-26
    • Kvapil, L.1    Grepl, M.2    Hradil, P.3
  • 35
    • 0031000858 scopus 로고    scopus 로고
    • Sterilization and freeze-drying of drug-free and drug-loaded solid lipid nanoparticles
    • R. Cavalli, O. Caputo, M.E. Carlotti, M. Trotta, C. Scarnecchia, and M.R. Gasco Sterilization and freeze-drying of drug-free and drug-loaded solid lipid nanoparticles Int. J. Pharm. 148 1 1997 47 54
    • (1997) Int. J. Pharm. , vol.148 , Issue.1 , pp. 47-54
    • Cavalli, R.1    Caputo, O.2    Carlotti, M.E.3    Trotta, M.4    Scarnecchia, C.5    Gasco, M.R.6
  • 37
    • 0032729872 scopus 로고    scopus 로고
    • Influence of an optimized non-ionic emulsifier blend on properties of oil-in-water emulsions
    • R.P. Gullapalli, and B.B. Sheth Influence of an optimized non-ionic emulsifier blend on properties of oil-in-water emulsions Eur. J. Pharm. Biopharm. 48 3 1999 233 238
    • (1999) Eur. J. Pharm. Biopharm. , vol.48 , Issue.3 , pp. 233-238
    • Gullapalli, R.P.1    Sheth, B.B.2
  • 38
    • 35448977211 scopus 로고    scopus 로고
    • Investigations of the effect of the lipid matrix on drug entrapment, in vitro release, and physical stability of olanzapine-loaded solid lipid nanoparticles
    • K. Vivek, H. Reddy, and R.S.R. Murthy Investigations of the effect of the lipid matrix on drug entrapment, in vitro release, and physical stability of olanzapine-loaded solid lipid nanoparticles AAPS PharmSciTech 8 4 2007 16 24
    • (2007) AAPS PharmSciTech , vol.8 , Issue.4 , pp. 16-24
    • Vivek, K.1    Reddy, H.2    Murthy, R.S.R.3
  • 39
    • 80052103054 scopus 로고    scopus 로고
    • Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye
    • J. Araújo, S. Nikolic, M.A. Egea, E.B. Souto, and M.L. Garcia Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye Colloids Surf B Biointerfaces 88 1 2011 150 157
    • (2011) Colloids Surf B Biointerfaces , vol.88 , Issue.1 , pp. 150-157
    • Araújo, J.1    Nikolic, S.2    Egea, M.A.3    Souto, E.B.4    Garcia, M.L.5
  • 40
    • 28444450861 scopus 로고    scopus 로고
    • Transformation of vesicular into cubic nanoparticles by autoclaving of aqueous monoolein/poloxamer dispersions
    • G. Wörle, B. Siekmann, M.H.J. Koch, and H. Bunjes Transformation of vesicular into cubic nanoparticles by autoclaving of aqueous monoolein/poloxamer dispersions Eur. J. Pharm. Sci. 27 1 2006 44 53
    • (2006) Eur. J. Pharm. Sci. , vol.27 , Issue.1 , pp. 44-53
    • Wörle, G.1    Siekmann, B.2    Koch, M.H.J.3    Bunjes, H.4
  • 41
    • 0024821463 scopus 로고
    • Effects of variations in physicochemical properties of glyceryl monostearate on the stability of an oil-in-water cream
    • R. O'laughlin, C. Sachs, H. Brittain, and E. Cohen Effects of variations in physicochemical properties of glyceryl monostearate on the stability of an oil-in-water cream J. Soc. Cosmet Chem. 40 1989 215 229
    • (1989) J. Soc. Cosmet Chem. , vol.40 , pp. 215-229
    • O'Laughlin, R.1    Sachs, C.2    Brittain, H.3    Cohen, E.4
  • 42
    • 26244444984 scopus 로고    scopus 로고
    • Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system
    • F.Q. Hu, S.P.J.Y. Du, Z.H. Yuan, Y.Q. Ye, and S. Zeng Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system Colloids Surf B Biointerfaces 45 3 2005 167 173
    • (2005) Colloids Surf B Biointerfaces , vol.45 , Issue.3 , pp. 167-173
    • Hu, F.Q.1    Du, S.P.J.Y.2    Yuan, Z.H.3    Ye, Y.Q.4    Zeng, S.5
  • 43
    • 73349088434 scopus 로고    scopus 로고
    • Preparation and characterization of silybin-loaded nanostructured lipid carriers
    • L.J. Jia, D.R. Zhang, Z.Y. Li, F.F. Feng, Y.C. Wang, W.T. Dai, and et al. Preparation and characterization of silybin-loaded nanostructured lipid carriers Drug Deliv 17 1 2010 11 18
    • (2010) Drug Deliv , vol.17 , Issue.1 , pp. 11-18
    • Jia, L.J.1    Zhang, D.R.2    Li, Z.Y.3    Feng, F.F.4    Wang, Y.C.5    Dai, W.T.6
  • 44
    • 52949112251 scopus 로고    scopus 로고
    • Lipid nanoparticles as vehicles for topical psoralen delivery: Solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC)
    • J.Y. Fang, C.L. Fang, C.H. Liu, and Y.H. Su Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC) Eur J Pharm Biopharm 70 2 2008 633 640
    • (2008) Eur J Pharm Biopharm , vol.70 , Issue.2 , pp. 633-640
    • Fang, J.Y.1    Fang, C.L.2    Liu, C.H.3    Su, Y.H.4
  • 46
    • 85019282528 scopus 로고    scopus 로고
    • Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 1: Physicochemical characterisation and in vitro release
    • I.D. Rupenthal, C.R. Green, and R.G. Alany Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 1: Physicochemical characterisation and in vitro release Int. J. Pharm. 77 2011 1
    • (2011) Int. J. Pharm. , vol.77 , pp. 1
    • Rupenthal, I.D.1    Green, C.R.2    Alany, R.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.