Acinetobacter baumannii repeatedly evolves a hypermutator phenotype in response to tigecycline that effectively surveys evolutionary trajectories to resistance

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Hammerstrom, Troy G ^a   Beabout, Kathryn ^a   Clements, Thomas P ^a   Saxer, Gerda ^a,b   Shamoo, Yousif ^a  

^a RICE UNIVERSITY   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TIGECYCLINE; ANTIINFECTIVE AGENT; BACTERIAL DNA; MINOCYCLINE; PROTEIN MUTS;

ACINETOBACTER BAUMANNII; ADES GENE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE DELETION; GENE FREQUENCY; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; GNA GENE; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MSBA GENE; MUTS GENE; NONHUMAN; RPSJ GENE; RRF GENE; SINGLE NUCLEOTIDE POLYMORPHISM; ADAPTATION; ANALOGS AND DERIVATIVES; BACTERIAL GENOME; DNA SEQUENCE; DRUG EFFECTS; GENETICS; INTERSPERSED REPEAT; MICROBIAL SENSITIVITY TEST; MOLECULAR EVOLUTION; MUTATION RATE; NUCLEOTIDE SEQUENCE;

ACINETOBACTER BAUMANNII; ADAPTATION, PHYSIOLOGICAL; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; EVOLUTION, MOLECULAR; GENOME, BACTERIAL; INTERSPERSED REPETITIVE SEQUENCES; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; MUTATION RATE; MUTS DNA MISMATCH-BINDING PROTEIN; SEQUENCE ANALYSIS, DNA;

EID: 84949511311     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0140489     Document Type: Article

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