The influence of genetic polymorphisms in TLR4 and TIRAP, and their expression levels in peripheral blood, on susceptibility to sepsis

Experimental and Therapeutic Medicine

Volumn 11, Issue 1, 2016, Pages 131-139

  Zhang, Jianping ^a   Yang, Jingping ^b   Xu, Xiyuan ^b   Liang, Liangshen ^a   Sun, Haixia ^a   Liu, Guohua ^a   Zhang, Lihong ^a   Su, Yun ^a  

^a Ordos Central Hospital   (China)

^b Third Affiliated Hospital of Inner Mongolian Medical University   (China)

Author keywords

Genetic polymorphisms; Sepsis; Toll like receptor 4; Toll interleukin 1 receptor associated protein

Indexed keywords

INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; TOLL LIKE RECEPTOR 4;

ADULT; AGED; ALLELE; APACHE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEPSIS;

EID: 84949466731     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2015.2884     Document Type: Article

References (37)

1. Fry DE: Sepsis, systemic inflammatory response and multiple organ dysfunction: The mystery continues. Am Surg 78: 1-8, 2012.
2. Maloney PJ: Sepsis and septic shock. Emerg Med Clin North Am 31: 583-600, 2013.
3. Lopez-Bushnell K, Demaray WS and Jaco C: Reducing sepsis mortality. Med Surg Nurs 23: 9-14, 2014.
4. Mayr FB, Yende S and Angus DC: Epidemiology of severe sepsis. Virulence 5: 4-11, 2014.
5. Martin GS: Sepsis, severe sepsis and septic shock: Changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther 10: 701-706, 2012.
6. Wiersinga WJ, Leopold SJ, Cranendonk DR and van der Poll T: Host innate immune responses to sepsis. Virulence 5: 36-44, 2014.
7. Esposito S, Molteni CG, Zampiero A, Baggi E, Lavizzari A, Semino M, Daleno C, Groppo M, Scala A, Terranova L, et al: Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children. Malar J 11: 196, 2012.
8. Plantinga TS, Ioana M, Alonso S, Izagirre N, Hervella M, Joosten LA, van der Meer JW, de la Rúa C and Netea MG: The evolutionary history of TLR4 polymorphisms in Europe. J Innate Immun 4: 168-175, 2012.
9. Namath A and Patterson AJ: Genetic polymorphisms in sepsis. Crit Care Clin 25: 835-856, 2009.
10. Yang H, Wei C, Li Q, Shou T, Yang Y, Xiao C, Yu M, Li M, Yang Z, Zhang J and Zheng B: Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population. Rheumatol Int 33: 1283-1288, 2013.
11. Sekulic AD, Trpkovic SV, PavlovicAP, Marinkovic OM and Ilic AN: Scoring systems in assessing survival of critically ill ICU patients. Med Sci Monit 21:2621-2629, 2015.
12. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL and Ramsay G; SCCM/ESICM/ACCP/ATS/SIS: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31: 1250-1256, 2003.
13. Sunna A, Gibbs MD, Chin CW, Nelson PJ and Bergquist PL: A gene encoding a novel multidomain beta-1,4-mannanase from Caldibacillus cellulovorans and action of the recombinant enzyme on kraft pulp. Appl Environ Microbiol 66: 664-670, 2000.
14. Jin SB, Zhang XF, Lu JG, Fu HT, Jia ZY and Sun XW: Genetic analysis of QTL for eye cross and eye diameter in common carp (Cyprinus carpio L.) using microsatellites and SNPs. Genet Mol Res 14: 3557-3569, 2015.
15. Chen HY, Huang W, Leung VH, Fung SL, Ma SL, Jiang H and Tang NL: Functional interaction between SNPs and microsatellite in the transcriptional regulation of insulin-like growth factor 1. Hum Mutat 34: 1289-1297, 2013.
16. Papathanassoqlou ED, Giannakopoulou MD and Bozas E: Genomic variations and susceptibility to sepsis. AACN Adv Crit Care 17: 394-422, 2006.
17. Salomao R, Brunialti MK, Gomes NE, Mendes ME, Diaz RS, Komninakis S, Machado FR, da Silva ID and Rigato O: Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock. Crit Care Med 37:132-139, 2009.
18. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J and Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome and associated costs of care. Crit Care Med 29: 1303-1310, 2001.
19. Akira S, Takeda K and Kaisho T: Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol 2: 675-680, 2001.
20. Janeway CA Jr and Medzhitov R: Innate immune recognition. Annu Rev Immunol 20: 197-216, 2002.
21. Hagberg L, Hull R, Hull S, McGhee JR, Michalek SM and Svanborg Edén C: Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice. Infect Immun 46: 839-844, 1984.
22. Song Z, Yin J, Yao C, Sun Z, Shao M, Zhang Y, Tao Z, Huang P and Tong C: Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population. Crit Care 15: R12, 2011.
23. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL and Schwartz DA: TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25: 187-191, 2000.
24. Schröder NW and Schumann RR: Single nucleotide polymorphisms of Tol-llike receptors and susceptibility to infectious disease. Lancet Infect Dis 5: 156-164, 2005.
25. Ferwerda B, McCall MB, Alonso S, Giamarellos-Bourboulis EJ, Mouktaroudi M, Izagirre N, Syafruddin D, Kibiki G, Cristea T, Hijmans A, et al: TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci USA 104: 16645-16650, 2007.
26. Okayama N, Fujimura K, Suehiro Y, Hamanaka Y, Fujiwara M, Matsubara T, Maekawa T, Hazama S, Oka M, Nohara H, et al: Simple genotype analysis of the Asp299Gly polymorphism of the toll-like receptor-4 gene that is associated with lipopolysaccharide hyporesponsiveness. J Clin Lab Anal 16: 56-58, 2002.
27. Lin YC, Chang YM, Yu JM, Yen JH, Chan JG and Hu CJ: Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan. Atherosclerosis 180: 305-309, 2005.
28. Hall C, Flores MV, Chien A, Davidson A, Crosier K and Crosier P: Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages. J Leukoc Biol 85: 751-765, 2009.
29. Couture LA, Piao W, Ru LW, Vogel SN and Toshchakov VY: Targeting Toll-like receptor (TLR) signaling by Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal)-derived decoy peptides. J Biol Chem 287: 24641-24648, 2012.
30. Kumpf O, Giamarellos-Bourboulis EJ, Koch A, Hamann L, Mouktaroudi M, Oh DY, Latz E, Lorenz E, Schwartz DA, Ferwerda B, et al: Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: An observational study in three cohorts. Crit Care 14: R103, 2010.
31. Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, et al: Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci USA 106: 10272-10277, 2009.
32. Hamann L, Kumpf O, Schuring RP, Alpsoy E, Bedu-Addo G, Bienzle U, Oskam L, Mockenhaupt FP and Schumann RR: Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. BMC Med Genet 10: 65, 2009.
33. Yew KH, Carpenter C, Duncan RS and Harrison CJ: Human cytomegalovirus induces TLR4 signaling components in monocytes altering TIRAP, TRAM and downstream interferon-beta and TNF-alpha expression. PLoS One 7: e44500, 2012.
34. Tsujimoto H, Ono S, Efron PA, Scumpia PO, Moldawer LL and Mochizki H: Role of toll-like receptors in the development of sepsis. Shock 29: 315-321, 2008.
35. Du L, Zhou J, Zhang J, Yan M, Gong L, Liu X, Chen M, Tao K, Luo N and Liu J: Actin filament reorganization is a key step in lung inflammation induced by systemic inflammatory response syndrome. Am J Respir Cell Mol Biol 47: 597-603, 2012.
36. Bhatia M, Zemans RL and JeyaseelanS: Role of chemokines in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol 46: 566-572, 2012.
37. Song Z, Tong C, Sun Z, Shen Y, Yao C, Jiang J, Yin J, Gao L, Song Y and Bai C: Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury. BMC Med Genet 11: 168, 2010.