Clinical applications of intravenous lipid emulsion therapy

Journal of Anesthesia

Volumn 29, Issue 6, 2015, Pages 920-926

  Muller, Sam H ^a   Diaz, James H ^a,b   Kaye, Alan David ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Intralipid; Intravenous lipid emulsion therapy; Lipid emulsion; Local anesthetic systemic toxicity

Indexed keywords

INTRALIPID; EMULSION; LIPID EMULSION; LOCAL ANESTHETIC AGENT; PHOSPHOLIPID; SOYBEAN OIL; SOYBEAN OIL, PHOSPHOLIPID EMULSION;

CARDIOPULMONARY ARREST; CLINICAL ARTICLE; DRUG OVERDOSE; HUMAN; INTERNET; REVIEW; SEARCH ENGINE; TREATMENT FAILURE; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; EMULSION; LOCAL ANESTHESIA;

ANESTHESIA, LOCAL; ANESTHETICS, LOCAL; DRUG OVERDOSE; EMULSIONS; FAT EMULSIONS, INTRAVENOUS; HUMANS; PHOSPHOLIPIDS; SOYBEAN OIL;

EID: 84949314655     PISSN: 09138668     EISSN: 14388359     Source Type: Journal    
DOI: 10.1007/s00540-015-2036-6     Document Type: Review

References (38)

1. Ozcan MS, Weinberg G. Intravenous lipid emulsion for the treatment of drug toxicity. J Intensiv Care Med. 2012;29(2):59–70.
2. Presley JD, Chyka PA. Intravenous lipid emulsion to reverse acute drug toxicity in pediatric patients. Ann Pharmacother. 2013;47(5):735–43.
3. Weinberg GL. Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose. Anesthesiology. 2012;117:180–7.
4. French D, Armenian P, Ruan W, Wong A, Drasner K, Olson KR, Wu AH. Serum verapamil concentrations before and after intralipid therapy during treatment of an overdose. Clin Toxicol (Phila). 2011;49(4):340–4.
5. Moon HJ, Lee JW. Availability of intravenous lipid emulsion therapy on endosulfan-induced cardiovascular collapse. Am J Emerg Med. 2013;31(5):886.
6. Moon JM, Chun BJ. Acute endosulfan poisoning: a retrospective study. Human Exp Toxicol. 2009;28(5):309–16.
7. Cevik SE, Tasyurek T, Guneysel O. Intralipid emulsion as an antidote in lipophilic drug intoxications. Am J Emerg Med. 2014;32(9):1103–8.
8. Oda Y. Lipid resuscitation: development in basic research and application to clinical practice. J Anesth. 2013;27:811–4.
9. Levine M, Brooks DE, Franken A, Graham R. Delayed-onset seizure and cardiac arrest after amitriptyline overdose, treated with intravenous lipid emulsion therapy. Pediatrics. 2012;130(2):e432–8.
10. Sirianni AJ, Osterhoudt KC, Calello DP, Muller AA, Waterhouse MR, Goodkin MB, Weinberg GL, Henretig FM. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med. 2008;51:412–5.
11. Blaber MS, Khan JN, Brebner JA. “Lipid rescue” for tricyclic antidepressant cardiotoxicity. J Emerg Med. 2012;43(4):465–7.
12. Espinet AJ, Emmerton MT. The successful use of intralipid for treatment of local anesthetic-induced central nervous system toxicity: some considerations for administration of intralipid in an emergency. Clin J Pain. 2009;25(9):808–9.
13. Rothschild L, Bern S, Oswald S, Weinberg G. Intravenous lipid emulsion in clinical toxicology. Scand J Trauma Resusc Emerg Med. 2010;18:51.
14. Arora NP, Berk WA, Aaron CK, Williams KA. Usefulness of intravenous lipid emulsion for cardiac toxicity from cocaine overdose. Am J Cardiol. 2013;111(3):445–7.
15. Bologa C, Lionte C, Coman A, Sorodoc L. Lipid emulsion therapy in cardiodepressive syndrome after diltiazem overdose—case report. Am J Emerg Med. 2013;31(7):1154e3–4.
16. Buck D, Kreeger R, Spaeth J. Case discussion and root cause analysis; bupivacaine overdose in an infant leading to ventricular tachycardia. Anesth Analg. 2014;119(1):137–40.
17. Cordell CL, Schubkegel T, Light TR, Ahmad F. Lipid infusion rescue for bupivicaine-induced cardiac arrest after axillary block. J Hand Surg Am. 2010;35:144–6.
18. Finn SD, Uncles DR, Willers J, Sable N. Early treatment of a quetiapine and sertraline overdose with Intralipid. Anaesthesia. 2009;64(2):191–4.
19. Foxall G, McCahon R, Lamb J, Hardman JG, Bedforth NM. Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia. 2007;62(5):516–8.
20. Hendron D, Menagh G, Sandlilands EA, Scullion D. Tricyclic antidepressant overdose in a toddler treated with intravenous lipid emulsion. Pediatrics. 2011;128(6):e1628–32.
21. Hillyard SG, Barrera-Groba C, Tighe R. Intralipid reverses coma associated with zopiclone and venlafaxine overdose. Eur J Anaesthesiol. 2010;27(6):582–3.
22. Jovic-Stosic J, Gligic B, Putic V. Severe propranolol and ethanol overdose with wide complex tachycardia treated with intravenous lipid emulsion: a case report. Clin Toxicol (Phila). 2011;49(5):426–30.
23. Kiberd MB, Minor SF. Lipid therapy for the treatment of a refractory amitriptyline overdose. CJEM. 2012;14(3):193–7.
24. Lange DB, Schwartz D, DaRoza G. Use of intravenous lipid emulsion to reverse central nervous system toxicity of an iatrogenic local anesthetic overdose in a patient on peritoneal dialysis. Ann Pharmacother. 2012;46(12):e37.
25. Lin EP, Aronson LA. Successful resuscitation of bupivacaine-induced cardiotoxicity in a neonate. Paediatr Anaesth. 2010;20(10):955–7.
26. Litz RJ, Popp M, Stehr SN, Koch T. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia. 2006;61(8):800–1.
27. Ludot H, Tharin JY, Belouadah M, Mazoit JX, Malinovsky JM. Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg. 2008;106:1572–4.
28. Markowitz S, Neal JM. Immediate lipid emulsion therapy in the successful treatment of bupivacaine systemic toxicity. Reg Anesth Pain Med. 2009;34:276.
29. McAllister RK, Tutt CD. Lipid 20 % emulsion ameliorates the symptoms of olanzapine toxicity in a 4-year-old. Am J Emerg Med. 2012;30:1012e1–2.
30. McCutchen T, Gerancher JC. Early intralipid therapy may have prevented bupivacaine-associated cardiac arrest. Reg Anesth Pain Med. 2008;33(2):178–80.
31. Mizutani K, Oda Y, Sato H. Successful treatment of ropivacaine-induced central nervous system toxicity by use of lipid emulsion: effect on total and unbound plasma fractions. J Anesth. 2011;25:442–5.
32. Montiel V, Gougnard T, Hantson P. Diltiazem poisoning treated with hyperinsulinemic euglycemia therapy and intravenous lipid emulsion. Eur J Emerg Med. 2011;18(2):121–3.
33. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB. Successful use of a 20 % lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology. 2006;105:217–8.
34. Shah S, Gopalakrishnan S, Apuya J, Shah S, Martin T. Use of Intralipid in an infant with impending cardiovascular collapse due to local anesthetic toxicity. J Anesth. 2009;23(3):439–41.
35. Spence AG. Lipid reversal of central nervous system symptoms of bupivacaine toxicity. Anesthesiology. 2007;107:516–7.
36. Whiteman DM, Kushins SI. Successful resuscitation with Intralipid after Marcaine overdose. Anesthet Surg J. 2014;34(5):738–40.
37. Wong GK, Joo DT, McDonnell C. Lipid resuscitation in a carnitine deficient child following intravascular migration of an epidural catheter. Anaesthesia. 2010;65:192–5.
38. Young AC, Velez LI, Kleinschmidt KC. Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose. Resuscitation. 2009;80(5):591–3.