Intravenous lipid emulsion to reverse acute drug toxicity in pediatric patients;Emulsión lipídica intravenosa para revertir la toxicidad farmacológica aguda en pacientes pediátricos

Annals of Pharmacotherapy

Volumn 47, Issue 5, 2013, Pages 735-743

  Presley, Joseph D ^a   Chyka, Peter A ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; AMITRIPTYLINE; ANTIDOTE; ATROPINE; BICARBONATE; DIAZEPAM; DILTIAZEM; DOSULEPIN; INTRALIPID; LAMOTRIGINE; LIPID EMULSION; LIPOSYN; MAGNESIUM; MEDIALIPIDE; MIDAZOLAM; OLANZAPINE; QUETIAPINE; VERAPAMIL;

ACUTE DRUG TOXICITY; ADOLESCENT; ARTICLE; CARDIOTOXICITY; CHILD HEALTH CARE; CLINICAL ARTICLE; CONTINUOUS INFUSION; DRUG DOSE REGIMEN; DRUG INTOXICATION; DRUG OVERDOSE; DRUG SAFETY; EMBASE; FEMALE; HEALTH HAZARD; HUMAN; HYPERTRIGLYCERIDEMIA; MALE; MEDICAL LITERATURE; MEDLINE; OUTCOME ASSESSMENT; PANCREATITIS; PRIORITY JOURNAL; PUBLICATION; RESUSCITATION; RETROSPECTIVE STUDY; SOMNOLENCE; TACHYCARDIA; TONIC CLONIC SEIZURE;

EID: 84877093115     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1R666     Document Type: Article

References (46)

1. Jamaty C, Bailey B, Larocque A, Notebaert E, Sanogo K, Chauny J. Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies. Clin Toxicol 2010;48:1-27. doi: 10.3109/15563650903544124
2. Cave G, Harvey M. Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review. Acad Emerg Med 2009;16:815-24. doi: 10.1111/j.1553-2712.2009.00499.x
3. Cave G, Harvey M, Graudins A. Review article: intravenous lipid emulsion as antidote: a summary of published human experience. Emerg Med Australas 2011;23:123-41. doi: 10.1111/j.1742-6723.2011.01398.x
4. Russell R, Westfall B. Alleviation of barbiturate depression by fat emulsion. Anesth Analg 1962;41:582-5. doi: 10.1213/00000539-196209000-00015
5. Krieglestein J, Meffert A, Neimeyer DH. Influence of emulsified fat on chlorpromazine availability in rabbit blood. Experientia 1974;30:924-6. doi: 10.1007/BF01938365
6. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998;88:1071-5. doi: 10.1097/00000542-199804000-00028
7. Weinberg GL. Lipid emulsion infusion resuscitation for local anesthetic and other drug overdose. Anesthesiology 2012;117:180-7.
8. Lin EP, Aronson LA. Successful resuscitation of bupivacaine-induced cardiotoxicity in a neonate. Paediatr Anaesth 2010;20:955-7. doi: 10.1111/j.1460-9592.2010.03406.x
9. Shah S, Gopalakrishnan S, Apuya J, Shah S, Martin T. Use of Intralipid in an infant with impending cardiovascular collapse due to local anesthetic toxicity. J Anesth 2009;23:439-41. doi: 10.1007/s00540-009-0754-3
10. Wong GK, Joo DT, McDonnell C. Lipid resuscitation in a carnitine deficient child following intravascular migration of an epidural catheter. Anaesthesia 2010;65:192-5. doi: 10.1111/j.1365-2044.2009.06131.x
11. Ludot H, Tharin JY, Belouadah M, Mazoit JX, Malinovsky JM. Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg 2008;106:1572-4. doi: 10.1213/01.ane.0000286176.55971.f0
12. Markowitz S, Neal JM. Immediate lipid emulsion therapy in the successful treatment of bupivacaine systemic toxicity. Reg Anesth Pain Med 2009;34:276. doi: 10.1097/AAP.0b013e31819a1323
13. Cordell CL, Schubkegel T, Light TR, Ahmad F. Lipid infusion rescue for bupivicaine-induced cardiac arrest after axillary block. J Hand Surg Am 2010;35:144-6. doi: 10.1016/j.jhsa.2009.10.018
14. Spence AG. Lipid reversal of central nervous system symptoms of bupivacaine toxicity. Anesthesiology 2007;107:516-7. doi: 10.1097/01.anes.0000278864.75082.72
15. Hendron D, Menagh G, Sandilands EA, Scullion D. Tricyclic antidepressant overdose in a toddler treated with intravenous lipid emulsion. Pediatrics 2011;128:e1628-32. doi: 10.1542/peds.2011-0867
16. McAllister RK, Tutt CD. Lipid 20% emulsion ameliorates the symptoms of olanzapine toxicity in a 4-year-old. Am J Emerg Med 2012;30:1012e1-2. doi: 10.1016/j.ajem.2011.03.025
17. Levine M, Brooks DE, Franken A, Graham R. Delayed-onset seizure and cardiac arrest after amitriptyline overdose, treated with intravenous lipid emulsion therapy. Pediatrics 2012;130:e432-8. doi: 10.1542/peds.2011-2511
18. Aaronson PM, Wassil SK, Kunisaki TA. Hyperinsulinemic euglycemia, continuous veno-venous hemofiltration, and extracorporeal life support for severe verapamil poisoning: case report (abstract 198). Clin Toxicol 2009;47:742.
19. Lu JJ, Hast HA, Erickson TB. Dramatic QTc narrowing after Intralipid administration in quetiapine overdose (abstract number 188). Clin Toxicol 2009;47:740.
20. Sirianni AJ, Osterhoudt KC, Calello DP, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2008;51:412-5. doi: 10.1016/j.annemergmed.2007.06.004
21. Montiel V, Gougnard T, Hantson P. Diltiazem poisoning treated with hyperinsulinemic euglycemia therapy and intravenous lipid emulsion. Eur J Emerg Med 2011;18:121-3. doi: 10.1097/MEJ.0b013e32834130ab
22. Mirtallo JM, Dasta JF, Kleinschmidt KC, Varon J. State of the art review: intravenous fat emulsions: current applications, safety profile, and clinical implications. Ann Pharmacother 2010;44:688-700. doi: 10.1345/aph.1M626
23. Package insert. Intralipid (IV fat emulsion). Uppsala, Sweden: Fresenius Kabi AB, April 2007. http://dailymed.nlm.nih.gov/dailymed/lookup. cfm?setid=b007eb60-e18e-4dbc-bf8d-1a3cf434a722 (accessed 2012 Oct 5).
24. Klein S, Miles JM. Metabolic effects of long-chain and medium-chain triglyceride emulsions in humans. JPEN J Parenter Enteral Nutr 1994;18:396-7. doi: 10.1177/0148607194018005396
25. Hansen LM, Hardie WR, Hidalgo J. Fat emulsion for intravenous administration: clinical experience with Intralipid 10%. Ann Surg 1976;184:80-8. doi: 10.1097/00000658-197607000-00014
26. Levene MI, Wigglesworth JS, Desai R. Pulmonary fat accumulation after Intralipid infusion in the preterm infant. Lancet 1980;2:815-8. doi: 10.1016/S0140-6736(80)90170-1
27. Geig A, Liebelt E, Manini AF. Clinical experience with intravenous lipid emulsion for drug-induced cardiovascular collapse. J Med Toxicol 2012;8:10-4.
28. Levine M, Skolnik A, Levitan R, Pizon AF. Assessing the prevalence of pancreatitis following resuscitative use of intravenous lipid emulsion (abstract 238). Clin Toxicol 2012;50:681.
29. Grunbaum A, Gosselin S, Gilfix BM, Blank D. Analytical interferences resulting from intravenous lipid emulsion. Clin Toxicol 2012;50:812-7.
30. Kleinman ME, Chameides L, Schexnayder SM, et al. Part 14: pediatric advanced life support: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010;122(suppl 3):S876-S908. doi: 10.1161/CIRCULATIONAHA.110.971101
31. Association of Anaesthetists of Great Britain & Ireland. AAGBI safety guideline: management of severe local anaesthetic toxicity, 2010. www.aagbi.org/sites/default/files/la_toxicity_2010_0.pdf (accessed 2012 Sep 23).
32. American Society of Regional Anesthesia and Pain Medicine. Checklist for treatment of local anesthetic systemic toxicity, 2012. www.asra.com/ checklist-for-local-anesthetic-toxicity-treatment-1-18-12.pdf (accessed 2012 Sep 23).
33. American College of Medical Toxicology. Interim guidance for the use lipid resuscitation therapy, 2010. www.acmt.net/cgi/page.cgi/zine_service. html?aid=3384&zine=show (accessed 2012 Dec 5).
34. Vanden Hoek TL, Morrison LJ, Shuster M, et al. Part 12: cardiac arrest in special situations: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010;122(suppl 3):S829-61. doi: 10.1161/CIRCULATIONAHA.110.971069
35. Weinberg GL. Treatment of local anesthetic systemic toxicity (LAST). Reg Anesth Pain Med 2010;35:188-93. doi: 10.1097/AAP.0b013e3181d246c3
36. Mazoit J, Le Guen R, Beloeil H, Benhamou D. Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology 2009;110:380-6. doi: 10.1097/ALN.0b013e318194b252
37. Fairchild KD, Patterson A, Gumpper KF. Overdose of intravenous fat emulsion in a preterm infant: case report. Nutr Clin Pract 1999;14:116-19. doi: 10.1177/088453369901400304
38. Low E, Ryan CA. Overdose of intravenous Intralipid in a premature neonate. Jt Comm J Qual Patient Saf 2007;33:588-9.
39. Bora KM, Hedge MW. Neonatal triglyceride levels after massive lipid bolus-implications for lipid rescue (abstract 287). Clin Toxicol 2009;47: 760.
40. Rosenblatt M, Able M, Fischer G, et al. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Crit Care Med 2011;39:872-4. doi: 10.1097/00000542-200607000-00033
41. Cave G, Harvey M. Intravenous lipid emulsion as antidote: how should we chew the fat in 2011? (editorial). Crit Care Med 2011;39:919-20. doi: 10.1097/CCM.0b013e31820e4496
42. Lönnqvist P. Toxicity of local anesthetic drugs: a pediatric perspective. Pediatr Anesthesia 2012;22:39-43. doi: 10.1111/j.1460-9592.2011.03631.x
43. Farzad G. Comment on "Lipid 20% emulsion ameliorates the symptoms of olanzapine toxicity in a 4-year-old" (letter). Am J Emerg Med 2012; 30:1003-4. doi: 10.1016/j.ajem.2012.03.015
44. American Academy of Pediatrics. Council on Child and Adolescent Health. Age limits in Pediatrics. Pediatrics 1988;81:736.
45. Dobson JV, Bryce L, Glaeser PW, Losek JD. Age limits and transition of health care in pediatric emergency medicine. Pediatr Emerg Care 2007; 23:294-7.
46. Holubkov R, Dean JM, Berger J, et al. Is "rescue" therapy ethical in randomized controlled trials? Pediatr Crit Care Med 2009;10:431-8. doi: 10.1097/PCC.0b013e318198bd13