Early Intralipid Therapy May Have Prevented Bupivacaine-Associated Cardiac Arrest

Regional Anesthesia and Pain Medicine

Volumn 33, Issue 2, 2008, Pages 178-180

  McCutchen, Thomas ^a   Gerancher, J C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Bupivacaine toxicity; Cardiotoxicity; Lipid rescue; Lipid therapy; Local anesthetic toxicity

Indexed keywords

ADRENALIN; AMIODARONE; BUPIVACAINE; FENTANYL; INTRALIPID; MIDAZOLAM; OXYGEN; ROPIVACAINE;

AGED; ANAMNESIS; ANESTHESIA INDUCTION; ARTERY CATHETERIZATION; ARTICLE; CARDIOTOXICITY; CASE REPORT; ELECTROCARDIOGRAM; FEMALE; FEMORAL ARTERY; HEART ARREST; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; HYPOTHYROIDISM; LOCAL ANESTHESIA; NERVE BLOCK; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RESUSCITATION; TONIC CLONIC SEIZURE; TOTAL KNEE REPLACEMENT; TREATMENT OUTCOME;

AGED, 80 AND OVER; ANESTHETICS, LOCAL; BUPIVACAINE; FAT EMULSIONS, INTRAVENOUS; FEMALE; HEART ARREST; HUMANS; RESUSCITATION; TACHYCARDIA, VENTRICULAR; TIME FACTORS;

EID: 39449135622     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rapm.2007.09.006     Document Type: Article

References (10)

1. Weinberg G.L., VadeBoncouer T., Ramaraju G.A., Garcia-Amaro M.F., and Cwik M.J. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 88 (1998) 1071-1075
2. Weinberg G., Ripper R., Feinstein D.L., and Hoffman W. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 28 (2003) 198-202
3. Dalgleish D., and Katawaroo S. Lipid emulsion to treat bupivacaine toxicity. Anaesthesia 60 (2005) 817-830
4. Rosenblatt M.A., Abel M., Fischer G.W., Itzkovich C.J., and Eisenkraft J.B. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 105 (2006) 217-218
5. Litz R.J., Popp M., Stehr S.N., and Koch T. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia 61 (2006) 800-801
6. Soltesz E.G., van Pelt F., and Byrne J.G. Emergent cardiopulmonary bypass for bupivacaine toxicity. J Cardiothorac Vasc Anesth 17 (2003) 357-358
7. Long W.B., Rosenblum S., and Grady I.P. Successful resuscitation of bupivacaine-induced cardiac arrest using cardiopulmonary bypass. Anesth Analg 69 (1989) 403-406
8. Weinberg G.L., Laurito C.E., Geldner P., Pygon B.H., and Burton B.K. Malignant ventricular dysrhythmias in a patient with isovaleric acidemia receiving general and local anesthesia for suction lipectomy. J Clin Anesth 9 (1997) 668-670
9. Weinberg G.L., Palmer J.W., VadeBoncouer T.R., Zuechner M.B., Edelman G., and Hoppel C.L. Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria. Anesthesiology 92 (2000) 523-528
10. Moore D.C. Lipid rescue from bupivacaine cardiac arrest: a result of failure to ventilate and maintain cardiac perfusion?. Anesthesiology 106 (2007) 636-637