Investigation of Tumor Cell Behaviors on a Vascular Microenvironment-Mimicking Microfluidic Chip

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Huang, Rong ^a   Zheng, Wenfu ^b   Liu, Wenwen ^b   Zhang, Wei ^b   Long, Yunze ^a   Jiang, Xingyu ^b  

^a QINGDAO UNIVERSITY   (China)

^b NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84949222781     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17768     Document Type: Article

References (41)

1. Joyce, J. A. & Pollard, J. W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9, 239-252 (2009).
2. Reymond, N., d'Agua, B. B. & Ridley, A. J. Crossing the endothelial barrier during metastasis. Nat. Rev. Cancer 13, 858-870 (2013).
3. Plaks, V., Koopman, C. D. & Werb, Z. Circulating Tumor Cells. Science 341, 1186-1188 (2013).
4. Ortega, F. G. et al. miRNA in situ hybridization in circulating tumor cells - MishCTC. Sci. Rep. 5, 9207 (2015).
5. Chen, Z. et al. Patterning mammalian cells for modeling three types of naturally occurring cell-cell interactions. Angew. Chem. Int. Ed. 48, 8303-8305 (2009).
6. Polacheck, W. J., Charest, J. L. & Kamm, R. D. Interstitial flow influences direction of tumor cell migration through competing mechanisms. Proc. Natl. Acad. Sci. USA. 108, 11115-11120 (2011).
7. Jiang, B., Zheng, W. F., Zhang, W. & Jiang, X. Y. Organs on microfluidic chips: A mini review. Sci. China Chem. 57, 356-364 (2014).
8. Mu, X., Zheng, W. F., Sun, J. S., Zhang, W. & Jiang, X. Y. Microfluidics for Manipulating Cells. Small 9, 9-21 (2013).
9. Deng, Y. L. et al. An Integrated Microfluidic Chip System for Single-Cell Secretion Profiling of Rare Circulating Tumor Cells. Sci. Rep. 4, 7499 (2014).
10. Song, J. W. et al. Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells. PloS ONE 4, e5756 (2009).
11. Zhang, Q., Liu, T. J. & Qin, J. H. A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime. Lab Chip 12, 2837-2842 (2012).
12. Zervantonakis, I. K. et al. Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc. Natl. Acad. Sci. USA. 109, 13515-13520 (2012).
13. Jeon, J. S., Zervantonakis, I. K., Chung, S., Kamm, R. D. & Charest, J. L. In Vitro Model of Tumor Cell Extravasation. PloS ONE 8, e56910 (2013).
14. Fenner, J. et al. Macroscopic Stiffness of Breast Tumors Predicts Metastasis. Sci. Rep. 4, 5512 (2014).
15. Zheng, W. F. et al. A microfluidic flow-stretch chip for investigating blood vessel biomechanics. Lab Chip 12, 3441-3450 (2012).
16. Wirtz, D., Konstantopoulos, K. & Searson, P. C. The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat. Rev. Cancer 11, 512-522 (2011).
17. Gakhar, G. et al. Circulating Tumor Cells from Prostate Cancer Patients Interact with E-Selectin under Physiologic Blood Flow. PloS ONE 8, e85143 (2013).
18. Haessler, U., Teo, J. C. M., Foretay, D., Renaud, P. & Swartz, M. A. Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber. Integr. Biol. 4, 401-409 (2012).
19. Aceto, N. et al. Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis. Cell 158, 1110-1122 (2014).
20. Egberts, J. H. et al. Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis. Cancer Res. 68, 1443-1450 (2008).
21. Fan, L. M. et al. Endothelial Cell-Specific Reactive Oxygen Species Production Increases Susceptibility to Aortic Dissection. Circulation 129, 2661-2672 (2014).
22. Kajita, M. et al. Platinum nanoparticle is a useful scavenger of superoxide anion and hydrogen peroxide. Free Radical Res. 41, 615-626 (2007).
23. Zheng, W. F. et al. Screening reactive oxygen species scavenging properties of platinum nanoparticles on a microfluidic chip. Biofabrication 6, 045004 (2014).
24. Mitchell, M. J. & King, M. R. Fluid shear stress sensitizes cancer cells to receptor-mediated apoptosis via trimeric death receptors. New J. Phys. 15, 015008 (2013).
25. Haier, J. & Nicolson, G. L. Tumor cell adhesion under hydrodynamic conditions of fluid flow. APMIS 109, 241-262 (2001).
26. Rini, B. I. et al. Hypertension as a Biomarker of Efficacy in Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib. J. Natl. Cancer Inst. 103, 763-773 (2011).
27. Cai, J. et al. Correlation of bevacizumab-induced hypertension and outcomes of metastatic colorectal cancer patients treated with bevacizumab: a systematic review and meta-analysis. World J. Surg. Oncol. 11, 306 (2013).
28. Hughes, A. D. & Schachter, M. Hypertension and Blood-Vessels. Br. Med. Bull. 50, 356-370 (1994).
29. Varfolomeev, E. E. & Ashkenazi, A. Tumor necrosis factor: An apoptosis JuNKie? Cell 116, 491-497 (2004).
30. Petros, J. A. et al. mtDNA mutations increase tumorigenicity in prostate cancer. Proc. Natl. Acad. Sci. USA. 102, 719-724 (2005).
31. Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M. & Mazur, M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol Interact 160, 1-40 (2006).
32. Szatrowski, T. P. & Nathan, C. F. Production of Large Amounts of Hydrogen-Peroxide by Human Tumor-Cells. Cancer Res 51, 794-798 (1991).
33. Woo, C. H. et al. Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic phospholipase A(2)-linked cascade. J. Biol. Chem. 275, 32357-32362 (2000).
34. You, W. C. et al. Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors. J. Natl. Cancer Inst. 92, 1607-1612 (2000).
35. White, E., Shannon, J. S. & Patterson, R. E. Relationship between vitamin and calcium supplement use and colon cancer. Cancer Epidem. Biomar. 6, 769-774 (1997).
36. Onizawa, S., Aoshiba, K., Kajita, M., Miyamoto, Y. & Nagai, A. Platinum nanoparticle antioxidants inhibit pulmonary inflammation in mice exposed to cigarette smoke. Pulm. Pharmacol. Ther. 22, 340-349 (2009).
37. Dobrin, P. B. Mechanical-Properties of Arteries. Physiol. Rev. 58, 397-460 (1978).
38. Giannoglou, G. D. et al. Elevated heart rate and atherosclerosis: An overview of the pathogenetic mechanisms. Int. J. Cardiol. 126, 302-312 (2008).
39. Young, E. W. K., Wheeler, A. R. & Simmons, C. A. Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels. Lab Chip 7, 1759-1766 (2007).
40. Watanabe, A. et al. In vitro free radical scavenging activity of platinum nanoparticles. Nanotechnology 20, 455105 (2009).
41. Mannel, D. N., Ruschoff, J. & Orosz, P. The Role of Tnf in Tumor-Growth and Metastasis. Res. Immunol. 144, 364-369 (1993).