Synthesis and evaluation of imidazole-4,5-and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus

European Journal of Medicinal Chemistry

Volumn 87, Issue , 2014, Pages 529-539

  Saudi, Milind ^a   Zmurko, Joanna ^a   Kaptein, Suzanne ^a   Rozenski, Jef ^a   Neyts, Johan ^a   Van Aerschot, Arthur ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Dengue virus; Flavivirus inhibitors; Imidazole dicarboxylic acid; Pyrazine dicarboxylic acid; Yellow fever virus

Indexed keywords

AMIDE; ANTIVIRUS AGENT; IMIDAZOLE DERIVATIVE; N 2 (4 FLUOROPHENYL) N 3 [2 (PYRIDIN 3 YL)PHENYL]PYRAZINE 2,3 DICARBOXAMIDE; N 2 (4 FLUOROPHENYL) N 3 [2 (PYRIDIN 4 YL)BENZYL]PYRAZINE 2,3 DICARBOXAMIDE; N 2 (4 FLUOROPHENYL) N 3 [2 (PYRIDIN 4 YL)PHENYL]PYRAZINE 2,3 DICARBOXAMIDE; N 2 (4 FLUOROPHENYL) N 3 [4 (PYRIDIN 3 YL)BENZYL]PYRAZINE 2,3 DICARBOXAMIDE; N 2 (4 FLUOROPHENYL) N 3 [4 (PYRIDIN 4 YL)BENZYL] PYRAZINE 2,3 DICARBOXAMIDE; N 2 (4 FLUOROPHENYL) N 3 [4 METHYL 2 (PYRIDIN 3 YL)PHENYL]PYRAZINE 2,3 DICARBOXAMIDE; N 2 (4 FLUOROPHENYL) N 3 [4 METHYL 2 (PYRIDIN 4 YL)PHENYL]PYRAZINE 2,3 DICARBOXAMIDE; N 2 [2 (PYRIDIN 4 YL)PHENYL] N 3 (P TOLYL)PYRAZINE 2,3 DICARBOXAMIDE; N 2 [4 (PYRIDIN 3 YL)BENZYL] N 3 (P TOLYL)PYRAZINE 2,3 DICARBOXAMIDE; N 2 [4 (PYRIDIN 4 YL)BENZYL] N 3 (P TOLYL)PYRAZINE 2,3 DICARBOXAMIDE; N 2 [4 METHYL 2 (PYRIDIN 3 YL)PHENYL] N 3 (P TOLYL)PYRAZINE 2,3 DICARBOXAMIDE; N 4 [2 (FURAN 2 YL) 4 METHYLPHENYL] N 5 (P TOLYL) 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 4 [4 METHYL 2 (THIOPHEN 3 YL)PHENYL] N 5 (P TOLYL) 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 4 [4 METHYL 2 (THIOPHEN 3 YL)PHENYL] N 5 PHENYL 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 (4 FLUOROPHENETHYL) N 4 [2 (FURAN 2 YL) 4 METHYLPHENYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 (4 FLUOROPHENYL) N 4 [2 (3 METHYL 1H PYRAZOL 5 YL)PHENYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 (4 FLUOROPHENYL) N 4 [2 (FURAN 2 YL) 4 METHYLPHENYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 (4 FLUOROPHENYL) N 4 [2 (PYRIDIN 3 YL)BENZYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 (4 FLUOROPHENYL) N 4 [2 (PYRIDIN 4 YL)BENZYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 (4 FLUOROPHENYL) N 4 [2 (THIOPHEN 3 YL)BENZYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 (4 FLUOROPHENYL) N 4 [4 (PYRIDIN 3 YL)BENZYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 (4 FLUOROPHENYL) N 4 [4 (THIOPHEN 3 YL)BENZYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 (4 FLUOROPHENYL) N 4 [4 METHYL 2 (THIOPHEN 3 YL)PHENYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 BENZYL N 4 [2 (FURAN 2 YL) 4 METHYLPHENYL] 1H IMIDAZOLE 4,5 DICARBOXAMIDE; N 5 [5 METHYL 3 (5 METHYLTHIOPHEN 2 YL)PYRIDIN 2 YL) N 4 PHENYL 1H IMIDAZOLE 4,5 DICARBOXAMIDE; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DENGUE VIRUS 2; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; EC50; HIGH THROUGHPUT SCREENING; NONHUMAN; PHARMACOPHORE; REPLICON; SUBSTITUTION REACTION; SUZUKI REACTION; VIRUS REPLICATION; YELLOW FEVER FLAVIVIRUS; CHEMISTRY; DENGUE VIRUS; DRUG EFFECTS; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TEST; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; YELLOW FEVER VIRUS;

AMIDES; DENGUE VIRUS; DRUG EVALUATION, PRECLINICAL; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; PYRAZINES; YELLOW FEVER VIRUS;

EID: 84949117804     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.09.062     Document Type: Article

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