Klotho protects dopaminergic neuron oxidant-induced degeneration by modulating ASK1 and p38 MAPK signaling pathways

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Brobey, Reynolds K ^a   German, Dwight ^b   Sonsalla, Patricia K ^c   Gurnani, Prem ^d   Pastor, Johanne ^b   Hsieh, C C ^e   Papaconstantinou, John ^e   Foster, Philip P ^a,f   Kuro O, Makoto ^g,h   Rosenblatt, Kevin P ^a,d  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c ROBERT WOOD JOHNSON UNIVERSITY HOSPITAL   (United States)

^d Companion Dx Reference Lab LLC ^*  (United States)

^e University of Texas Medical Branch School of Medicine   (United States)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^g UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^h JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; KLOTHO PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN 14 3 3; REACTIVE OXYGEN METABOLITE; SERINE; THIOREDOXIN; BETA GLUCURONIDASE; MAP3K5 PROTEIN, MOUSE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MOUSE; NERVE CELL DEGENERATION; NEUROMODULATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUBSTANTIA NIGRA PARS COMPACTA; UPREGULATION; ANIMAL; BRAIN; GENETICS; KNOCKOUT MOUSE; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; DOPAMINERGIC NEURONS; ENZYME ACTIVATION; GLUCURONIDASE; MAP KINASE KINASE KINASE 5; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; OXIDATION-REDUCTION; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 84949035890     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0139914     Document Type: Article

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