The effect of melatonin on spinal cord after ischemia in rats

Spinal Cord

Volumn 54, Issue 5, 2016, Pages 360-363

  Aydemir, S ^a   Dogan, D ^a   Kocak, A ^a   Dilsiz, N ^b  

^a INONU UNIVERSITY   (Turkey)

^b HARRAN UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GLUTATHIONE; MALONALDEHYDE; MELATONIN; ANTIOXIDANT;

ADULT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SPINAL CORD; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; NONPARAMETRIC TEST; PATHOLOGY; REPERFUSION;

ANIMALS; ANTIOXIDANTS; CASPASE 3; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GLUTATHIONE; MALONDIALDEHYDE; MELATONIN; RATS; REPERFUSION; SPINAL CORD; SPINAL CORD ISCHEMIA; STATISTICS, NONPARAMETRIC;

EID: 84949032468     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2015.204     Document Type: Article

References (21)

1. Samantaray S, Sribnick EA, Das A, Knaryan VH, Matzelle DD, Yallapragada AV, et al. Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats. J Pneal Res 2008; 44: 348-357.
2. Ayala A, Munoz MF, Arguelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014; 2014: 360438.
3. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990; 186: 421-431.
4. Allegra M, Reiter RJ, Tan DX, Gentile C, Tesoriere L, Livrea MA. The chemistry of melatonin's interaction with reactive species. J Pineal Res 2003; 34: 1-10.
5. Erten SF, Kocak A, Ozdemir I, Aydemir S, Colak A, Reeder BS. Protective effect of melatonin on experimental spinal cord ischemia. Spinal Cord 2003; 41: 533-538.
6. Rodriguez C, Mayo JC, Sainz RM, Antolin I, Herrera F, Martin V, et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004; 36: 1-9.
7. Jain A, Bhatnagar M. Melatonin-A 'magic biomolecule'. Ann Neurosci 2007; 14: 1-13.
8. Li M, Ona VO, Chen M, Kaul M, Tenneti L, Zhang X, et al. Functional role and therapeutic implications of neuronal caspase-1 and-3 in a mouse model of traumatic spinal cord injury. Neuroscience 2000; 99: 333-342.
9. Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM, et al. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem 2001; 276: 33869-33874.
10. Friedlander RM. Mechanisms of disease: Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 2003; 348: 1365-1375.
11. Keane RW, Kraydieh S, Lotocki G, Bethea JR, Krajewski S, Reed JC, et al. Apoptotic and anti-Apoptotic mechanisms following spinal cord injury. J Neuropathol Exp Neurol 2001; 60: 422-429.
12. Ventimiglia R, Lau LF, Kinloch RA, Hopkins A, Karran EH, Petalidis LP, et al. Role of caspases in neuronal apoptosis. Drug Dev Res 2001; 52: 515-533.
13. Zivin JA, Degirolami U. Spinal-Cord Infarction-Highly Reproducible Stroke Model. Stroke 1980; 11: 200-202.
14. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-278.
15. Lee AY, Chung SS. Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J 1999; 13: 23-30.
16. Bonnefont-Rousselot D, Collin F, Jore D, Gardes-Albert M. Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro. J Pineal Res 2011; 50: 328-335.
17. Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 2004; 58: 39-46.
18. Sinha K, Degaonkar MN, Jagannathan NR, Gupta YK. Effect of melatonin on ischemia reperfusion injury induced by middle cerebral artery occlusion in rats. Eur J Pharmacol 2001; 428: 185-192.
19. Kilic U, Kilic E, Reiter RJ, Bassetti CL, Hermann DM. Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice. J Pineal Res 2005; 38: 67-71.
20. Ersahin M, Ozdemir Z, Ozsavci D, Akakin D, Yegen BC, Reiter RJ, et al. Melatonin treatment protects against spinal cord injury induced functional and biochemical changes in rat urinary bladder. J Pineal Res 2012; 52: 340-348.
21. Fujimoto T, Nakamura T, Ikeda T, Takagi K. Potent protective effects of melatonin on experimental spinal cord injury. Spine 2000; 25: 769-775.