Subset of Kappa and Lambda Germline Sequences Result in Light Chains with a Higher Molecular Mass Phenotype

Journal of Proteome Research

Volumn 14, Issue 12, 2015, Pages 5283-5290

  Barnidge, David R ^a   Lundström, Susanna L ^b   Zhang, Bo ^b   Dasari, Surendra ^a   Murray, David L ^a   Zubarev, Roman A ^b  

^a MAYO CLINIC   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

de novo; germline gene sequence; immunoglobulin; kappa; lambda; light chain; mass spectrometry; monoclonal; phenotype; variable region

Indexed keywords

AMINO ACID; IMMUNOGLOBULIN M; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN VARIABLE REGION;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; CLONE; COMPUTER PROGRAM; ENZYME DEGRADATION; LIGHT CHAIN; MASS SPECTROMETRY; MOLECULAR WEIGHT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; ANTIBODY SPECIFICITY; BLOOD; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR GENETICS; PROCEDURES; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANTIBODY DIVERSITY; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PHENOTYPE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84949008976     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.5b00711     Document Type: Article

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