메뉴 건너뛰기




Volumn 125, Issue 12, 2015, Pages 4514-4528

Endothelial-to-mesenchymal transition drives atherosclerosis progression

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBRONECTIN; INTERCELLULAR ADHESION MOLECULE 1; NOTCH3 RECEPTOR; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN RECEPTOR 2; VIMENTIN; APOLIPOPROTEIN E; FGFR1 PROTEIN, HUMAN; FGFR1 PROTEIN, MOUSE; FRS2 PROTEIN, HUMAN; FRS2ALPHA PROTEIN, MOUSE; MEMBRANE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 84948808417     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI82719     Document Type: Article
Times cited : (420)

References (38)
  • 1
    • 84888103520 scopus 로고    scopus 로고
    • Flow-dependent cel lular mechanotransduction in atherosclerosis
    • Conway DE, Schwartz MA. Flow-dependent cel lular mechanotransduction in atherosclerosis. J Cell Sci. 2013;126(pt 22):5101-5109.
    • (2013) J Cell Sci. , vol.126 , pp. 5101-5109
    • Conway, D.E.1    Schwartz, M.A.2
  • 2
    • 58049213928 scopus 로고    scopus 로고
    • Mechanotransduction in vascular physiology and atherogenesis
    • Hahn C, Schwartz MA. Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol. 2009;10(1):53-62.
    • (2009) Nat Rev Mol Cell Biol. , vol.10 , Issue.1 , pp. 53-62
    • Hahn, C.1    Schwartz, M.A.2
  • 3
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473(7347):317-325.
    • (2011) Nature. , vol.473 , Issue.7347 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 4
    • 84879569545 scopus 로고    scopus 로고
    • Immune effector mechanisms implicated in atherosclerosis: From mice to humans
    • Libby P, Lichtman AH, Hansson GK. Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Immunity. 2013;38(6):1092-1104.
    • (2013) Immunity. , vol.38 , Issue.6 , pp. 1092-1104
    • Libby, P.1    Lichtman, A.H.2    Hansson, G.K.3
  • 5
    • 84928254049 scopus 로고    scopus 로고
    • Recent insights into the cellular biology of atherosclerosis
    • Tabas I, Garcia-Cardena G, Owens GK. Recent insights into the cellular biology of atherosclerosis. J Cell Biol. 2015;209(1):13-22.
    • (2015) J Cell Biol. , vol.209 , Issue.1 , pp. 13-22
    • Tabas, I.1    Garcia-Cardena, G.2    Owens, G.K.3
  • 6
    • 34547676391 scopus 로고    scopus 로고
    • Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    • Zeisberg EM, et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med. 2007;13(8):952-961.
    • (2007) Nat Med. , vol.13 , Issue.8 , pp. 952-961
    • Zeisberg, E.M.1
  • 7
    • 84879690589 scopus 로고    scopus 로고
    • EndMT contributes to the onset and progression of cerebral cavernous malformations
    • Maddaluno L, et al. EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature. 2013;498(7455):492-496.
    • (2013) Nature. , vol.498 , Issue.7455 , pp. 492-496
    • Maddaluno, L.1
  • 8
    • 68449088473 scopus 로고    scopus 로고
    • Endothelial to mesenchymal transition via transforming growth factor-β1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension
    • Kitao A, et al. Endothelial to mesenchymal transition via transforming growth factor-β1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. Am J Pathol. 2009;175(2):616-626.
    • (2009) Am J Pathol. , vol.175 , Issue.2 , pp. 616-626
    • Kitao, A.1
  • 9
    • 80052851503 scopus 로고    scopus 로고
    • Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders
    • Piera-Velazquez S, Li Z, Jimenez SA. Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders. Am J Pathol. 2011;179(3):1074-1080.
    • (2011) Am J Pathol. , vol.179 , Issue.3 , pp. 1074-1080
    • Piera-Velazquez, S.1    Li, Z.2    Jimenez, S.A.3
  • 10
    • 84871676561 scopus 로고    scopus 로고
    • FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression
    • Chen PY, et al. FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012;2(6):1684-1696.
    • (2012) Cell Rep. , vol.2 , Issue.6 , pp. 1684-1696
    • Chen, P.Y.1
  • 11
    • 84897521932 scopus 로고    scopus 로고
    • TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling
    • Cooley BC, et al. TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med. 2014;6(227):227ra34.
    • (2014) Sci Transl Med. , vol.6 , Issue.227 , pp. 227ra34
    • Cooley, B.C.1
  • 12
    • 78650018824 scopus 로고    scopus 로고
    • Conversion of vascular endothelial cells into multipotent stem-like cells
    • Medici D, Shore EM, Lounev VY, Kaplan FS, Kalluri R, Olsen BR. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med. 2010;16(12):1400-1406.
    • (2010) Nat Med. , vol.16 , Issue.12 , pp. 1400-1406
    • Medici, D.1    Shore, E.M.2    Lounev, V.Y.3    Kaplan, F.S.4    Kalluri, R.5    Olsen, B.R.6
  • 13
    • 84857824476 scopus 로고    scopus 로고
    • Regulation of endothelial cell plasticity by TGF-β
    • van Meeteren LA, ten Dijke P. Regulation of endothelial cell plasticity by TGF-β. Cell Tissue Res. 2012;347(1):177-186.
    • (2012) Cell Tissue Res. , vol.347 , Issue.1 , pp. 177-186
    • Van Meeteren, L.A.1    Ten Dijke, P.2
  • 14
    • 84907512294 scopus 로고    scopus 로고
    • Fibro-blast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium
    • Chen PY, Qin L, Tellides G, Simons M. Fibro-blast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Sci Signal. 2014;7(344):ra90.
    • (2014) Sci Signal. , vol.7 , Issue.344 , pp. ra90
    • Chen, P.Y.1    Qin, L.2    Tellides, G.3    Simons, M.4
  • 15
    • 84857489355 scopus 로고    scopus 로고
    • TGF-β signaling in endothelial-to-mesenchymal transition: The role of shear stress and primary cilia
    • Ten Dijke P, Egorova AD, Goumans MJ, Poel-mann RE, Hierck BP. TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia. Sci Signal. 2012;5(212):pt2.
    • (2012) Sci Signal. , vol.5 , Issue.212 , pp. pt2
    • Ten Dijke, P.1    Egorova, A.D.2    Goumans, M.J.3    Poel-Mann, R.E.4    Hierck, B.P.5
  • 16
    • 77955860340 scopus 로고    scopus 로고
    • Inducible gene targeting in the neonatal vascula-ture and analysis of retinal angiogenesis in mice
    • Pitulescu ME, Schmidt I, Benedito R, Adams RH. Inducible gene targeting in the neonatal vascula-ture and analysis of retinal angiogenesis in mice. Nat Protoc. 2010;5(9):1518-1534.
    • (2010) Nat Protoc. , vol.5 , Issue.9 , pp. 1518-1534
    • Pitulescu, M.E.1    Schmidt, I.2    Benedito, R.3    Adams, R.H.4
  • 17
    • 77953809406 scopus 로고    scopus 로고
    • Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation
    • Feaver RE, Gelfand BD, Wang C, Schwartz MA, Blackman BR. Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation. Circ Res. 2010;106(11):1703-1711.
    • (2010) Circ Res. , vol.106 , Issue.11 , pp. 1703-1711
    • Feaver, R.E.1    Gelfand, B.D.2    Wang, C.3    Schwartz, M.A.4    Blackman, B.R.5
  • 18
    • 84863467640 scopus 로고    scopus 로고
    • Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation
    • Rohwedder I, et al. Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. EMBO Mol Med. 2012;4(7):564-576.
    • (2012) EMBO Mol Med. , vol.4 , Issue.7 , pp. 564-576
    • Rohwedder, I.1
  • 19
    • 85027951331 scopus 로고    scopus 로고
    • Adaptive immunity in atherosclerosis: Mechanisms and future therapeutic targets
    • Lahoute C, Herbin O, Mallat Z, Tedgui A. Adaptive immunity in atherosclerosis: mechanisms and future therapeutic targets. Nat Rev Cardiol. 2011;8(6):348-358.
    • (2011) Nat Rev Cardiol. , vol.8 , Issue.6 , pp. 348-358
    • Lahoute, C.1    Herbin, O.2    Mallat, Z.3    Tedgui, A.4
  • 20
    • 84865485915 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Arterio-scler Thromb Vasc Biol. 2012;32(9):2045-2051.
    • (2012) Arterio-scler Thromb Vasc Biol. , vol.32 , Issue.9 , pp. 2045-2051
    • Libby, P.1
  • 21
    • 84898470805 scopus 로고    scopus 로고
    • The role of the inflam-masome in cardiovascular diseases
    • Li X, Deroide N, Mallat Z. The role of the inflam-masome in cardiovascular diseases. J Mol Med (Berl). 2014;92(4):307-319.
    • (2014) J Mol Med (Berl). , vol.92 , Issue.4 , pp. 307-319
    • Li, X.1    Deroide, N.2    Mallat, Z.3
  • 22
    • 79959771065 scopus 로고    scopus 로고
    • Hemodynamic activation of β-catenin and T-cell-specific transcription factor signaling in vascular endothelium regulates fibronectin expression
    • Gelfand BD, et al. Hemodynamic activation of β-catenin and T-cell-specific transcription factor signaling in vascular endothelium regulates fibronectin expression. Ar terioscler Thromb Vasc Biol. 2011;31(7):1625-1633.
    • (2011) Ar Terioscler Thromb Vasc Biol. , vol.31 , Issue.7 , pp. 1625-1633
    • Gelfand, B.D.1
  • 23
    • 84929483921 scopus 로고    scopus 로고
    • Molecular pathways: Linking tumor microenvironment to epithelial-mesenchymal transition in metastasis
    • Jung HY, Fattet L, Yang J. Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis. Clin Cancer Res. 2015;21(5):962-968.
    • (2015) Clin Cancer Res. , vol.21 , Issue.5 , pp. 962-968
    • Jung, H.Y.1    Fattet, L.2    Yang, J.3
  • 24
    • 84872416422 scopus 로고    scopus 로고
    • Biomarkers of epithelial-mesenchy-mal transition in squamous cell carcinoma
    • Scanlon CS, Van Tubergen EA, Inglehart RC, D'Silva NJ. Biomarkers of epithelial-mesenchy-mal transition in squamous cell carcinoma. J Dent Res. 2013;92(2):114-121.
    • (2013) J Dent Res. , vol.92 , Issue.2 , pp. 114-121
    • Scanlon, C.S.1    Van Tubergen, E.A.2    Inglehart, R.C.3    D'Silva, N.J.4
  • 25
    • 3042708208 scopus 로고    scopus 로고
    • Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis
    • Tan MH, Sun Z, Opitz SL, Schmidt TE, Peters JH, George EL. Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. Blood. 2004;104(1):11-18.
    • (2004) Blood. , vol.104 , Issue.1 , pp. 11-18
    • Tan, M.H.1    Sun, Z.2    Opitz, S.L.3    Schmidt, T.E.4    Peters, J.H.5    George, E.L.6
  • 26
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell P, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010;464(7293):1357-1361.
    • (2010) Nature. , vol.464 , Issue.7293 , pp. 1357-1361
    • Duewell, P.1
  • 27
    • 84869491455 scopus 로고    scopus 로고
    • Distribution of macrophage polarization markers in human atherosclerosis
    • Stoger JL, et al. Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis. 2012;225(2):461-468.
    • (2012) Atherosclerosis. , vol.225 , Issue.2 , pp. 461-468
    • Stoger, J.L.1
  • 29
    • 0034642570 scopus 로고    scopus 로고
    • Interferon-γ elicits arterio-sclerosis in the absence of leukocytes
    • Tellides G, et al. Interferon-γ elicits arterio-sclerosis in the absence of leukocytes. Nature. 2000;403(6766):207-211.
    • (2000) Nature. , vol.403 , Issue.6766 , pp. 207-211
    • Tellides, G.1
  • 31
    • 84880918511 scopus 로고    scopus 로고
    • Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of athero-thrombosis
    • Everett BM, et al. Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of athero-thrombosis. Am Heart J. 2013;166(2):199-207.e15.
    • (2013) Am Heart J. , vol.166 , Issue.2 , pp. 199-199e15
    • Everett, B.M.1
  • 32
    • 0036078307 scopus 로고    scopus 로고
    • Transforming growth factor-p mediates balance between inflammation and fibrosis during plaque progression
    • Lutgens E, et al. Transforming growth factor-p mediates balance between inflammation and fibrosis during plaque progression. Arterioscler Thromb Vasc Biol. 2002;22(6):975-982.
    • (2002) Arterioscler Thromb Vasc Biol. , vol.22 , Issue.6 , pp. 975-982
    • Lutgens, E.1
  • 33
    • 0036773855 scopus 로고    scopus 로고
    • The role of transforming growth factor p in atherosclerosis: Novel insights and future perspectives
    • Mallat Z, Tedgui A. The role of transforming growth factor p in atherosclerosis: novel insights and future perspectives. Curr Opin Lipidol. 2002;13(5):523-529.
    • (2002) Curr Opin Lipidol. , vol.13 , Issue.5 , pp. 523-529
    • Mallat, Z.1    Tedgui, A.2
  • 34
    • 84859440795 scopus 로고    scopus 로고
    • Transforming growth factor-p and atherosclerosis: Interwoven atherogenic and atheroprotective aspects
    • Toma I, McCaffrey TA. Transforming growth factor-p and atherosclerosis: interwoven atherogenic and atheroprotective aspects. Cell Tissue Res. 2012;347(1):155-175.
    • (2012) Cell Tissue Res. , vol.347 , Issue.1 , pp. 155-175
    • Toma, I.1    McCaffrey, T.A.2
  • 35
    • 84914165959 scopus 로고    scopus 로고
    • Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling
    • Baeyens N, et al. Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proc Natl Acad Sci USA. 2014;111(48):17308-17313.
    • (2014) Proc Natl Acad Sci USA. , vol.111 , Issue.48 , pp. 17308-17313
    • Baeyens, N.1
  • 36
    • 35548988423 scopus 로고    scopus 로고
    • Generation of an Frs2a conditional null allele
    • Lin Y, Zhang J, Zhang Y, Wang F. Generation of an Frs2a conditional null allele. Genesis. 2007;45(9):554-559.
    • (2007) Genesis. , vol.45 , Issue.9 , pp. 554-559
    • Lin, Y.1    Zhang, J.2    Zhang, Y.3    Wang, F.4
  • 37
    • 84875372488 scopus 로고    scopus 로고
    • AIP 1 suppresses atherosclerosis by limiting hyperlipidemia-induced inflammation and vascular endothelial dysfunction
    • Huang Q, et al. AIP1 suppresses atherosclerosis by limiting hyperlipidemia-induced inflammation and vascular endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2013;33(4):795-804.
    • (2013) Arterioscler Thromb Vasc Biol. , vol.33 , Issue.4 , pp. 795-804
    • Huang, Q.1
  • 38
    • 0034019601 scopus 로고    scopus 로고
    • Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions
    • Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20(5):1262-1275.
    • (2000) Arterioscler Thromb Vasc Biol. , vol.20 , Issue.5 , pp. 1262-1275
    • Virmani, R.1    Kolodgie, F.D.2    Burke, A.P.3    Farb, A.4    Schwartz, S.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.