An updated review on the neuropsychological profile of subjects with bipolar disorder

Revista de Psiquiatria Clinica

Volumn 42, Issue 5, 2015, Pages 139-146

  Szmulewicz, Alejandro G ^a,b   Samamé, Cecilia ^a,c,d   Martino, Diego J ^a,c   Strejilevich, Sergio A ^a,e  

^a FAVALORO UNIVERSITY   (Argentina)

^b Hospital Alvear   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^e INSTITUTE OF COGNITIVE NEUROLOGY INECO   (Argentina)

Author keywords

Bipolar disorder; Evolution; Heterogeneity; Neuropsychological functioning

Indexed keywords

BIBLIOGRAPHIC DATABASE; BIPOLAR DISORDER; CHILD PSYCHIATRY; CLINICAL ASSESSMENT; COGNITION; COGNITIVE DEFECT; DEMENTIA; DEPRESSION; DISEASE DURATION; HUMAN; LONGITUDINAL STUDY; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGY; REVIEW; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; VERBAL MEMORY;

EID: 84948774279     PISSN: 01016083     EISSN: 1806938X     Source Type: Journal    
DOI: 10.1590/0101-60830000000064     Document Type: Review

References (109)

1. Tohen M, Strakowski SM, Zarate C Jr, Hennen J, Stoll AL, Suppes T, et al. The McLean-Harvard first-episode project: 6-month symptomatic and functional outcome in affective and nonaffective psychosis. Biol Psychiatry. 2000;48(6):467-76
2. Wingo AP, Baldessarini RJ, Holtzheimer PE, Harvey PD. Factors associated with functional recovery in bipolar disorder patients. Bipolar Disord. 2010;12(3):319-26
3. Martino DJ, Marengo E, Igoa A, Scápola M, Ais ED, Perinot L, et al. Neurocognitive and symptomatic predictors of functional outcome in bipolar disorders: a prospective 1 year follow-up study. J Affect Disord. 2009;116(1-2):37-42
4. Burdick KE, Goldberg JF, Harrow M. Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up. Acta Psychiatr Scand. 2010;122(6):499-506
5. Depp CA, Mausbach BT, Harmell AL, Savla GN, Bowie CR, Harvey PD, et al. Meta-analysis of the association between cognitive abilities and everyday functioning in bipolar disorder. Bipolar Disord. 2012;14(3):217-26
6. Strejilevich SA, Samamé C, Martino DJ. The trajectory of neuropsychological dysfunctions in bipolar disorders: a critical examination of a hypothesis. J Affect Disord. 2015;175:396-402
7. Martino DJ, Samamé C, Ibañez A, Strejilevich SA. Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: a systematic review. Psychiatry Res. 2015;226(1):23-30
8. Tiihonen J, Haukka J, Henriksson M, Cannon M, Kieseppä T, Laaksonen I, et al. Premorbid intellectual functioning in bipolar disorder and schizophrenia: results from a cohort study of male conscripts. Am J Psychiatry. 2005;162(10):1904-10
9. Reichenberg A, Weiser M, Rabinowitz J, Caspi A, Schmeidler J, Mark M, et al. A population-based cohort study of premorbid intellectual, language, and behavioral functioning in patients with schizophrenia, schizoaffective disorder, and nonpsychotic bipolar disorder. Am J Psychiatry. 2002;159(12):2027-35
10. Zammit S, Allebeck P, David AS, Dalman C, Hemmingsson T, Lundberg I, et al. A longitudinal study of premorbid IQ Score and risk of developing schizophrenia, bipolar disorder, severe depression, and other nonaffective psychoses. Arch Gen Psychiatry. 2004;61(4):354-60
11. Sørensen HJ, Sæbye D, Urfer-Parnas A, Mortensen EL, Parnas J. Premorbid intelligence and educational level in bipolar and unipolar disorders: a Danish draft board study. J Affect Disord. 2012;136(3):1188-91
12. Trotta A, Murray RM, MacCabe JH. Do premorbid and post-onset cognitive functioning differ between schizophrenia and bipolar disorder? A systematic review and meta-analysis. Psychol Med. 2015;45(2):381-94
13. Meyer SE, Carlson GA, Wiggs EA, Martinez PE, Ronsaville DS, Klimes- Dougan B, et al. A prospective study of the association among impaired executive functioning, childhood attentional problems, and the development of bipolar disorder. Dev Psychopathol. 2004;16(2):461-76
14. Ratheesh A, Lin A, Nelson B, Wood SJ, Brewer W, Betts J, et al. Neurocognitive functioning in the prodrome of mania – an exploratory study. J Affect Disord. 2013;147(1-3):441-5
15. Klimes-Dougan B, Ronsaville D, Wiggs EA, Martinez PE. Neuropsychological functioning in adolescent children of mothers with a history of bipolar or major depressive disorders. Biol Psychiatry. 2006;60(9):957-65
16. Frías Á, Palma C, Farriols N. Neurocognitive impairments among youth with pediatric bipolar disorder: a systematic review of neuropsychological research. J Affect Disord. 2014;166:297-306
17. Joseph MF, Frazier TW, Youngstrom EA, Soares JC. A quantitative and qualitative review of neurocognitive performance in pediatric bipolar disorder. J Child Adolesc Psychopharmacol. 2008;18(6):595-605
18. Nieto RG, Castellanos FX. A meta-analysis of neuropsychological functioning in patients with early onset schizophrenia and pediatric bipolar disorder. J Clin Child Adolesc Psychol. 2011;40(2):266-80
19. Pavuluri MN, Schenkel LS, Aryal S, Harral EM, Hill SK, Herbener ES, et al. Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients. Am J Psychiatry. 2006;163(2):286-93
20. Robinson LJ, Thompson JM, Gallagher P, Goswami U, Young AH, Ferrier IN, et al. A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord. 2006;93(1-3):105-15
21. Torres IJ, Boudreau VG, Yatham LN. Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis. Acta Psychiatr Scand Suppl. 2007;(434):17-26
22. Arts B, Jabben N, Krabbendam L, van Os J. Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med. 2008;38(6):771-85
23. Bora E, Yucel M, Pantelis C. Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord. 2009;113(1-2):1-20
24. Bora E, Yücel M, Pantelis C, Berk M. Meta-analytic review of neurocognition in bipolar II disorder. Acta Psychiatr Scand. 2011;123(3):165-74
25. Kurtz MM, Gerraty RT. A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state. Neuropsychology. 2009;23(5):551-62
26. Mann-Wrobel MC, Carreno JT, Dickinson D. Meta-analysis of neuropsychological functioning in euthymic bipolar disorder: an update and investigation of moderator variables. Bipolar Disord. 2011;13(4):334-42
27. Bourne C, Aydemir Ö, Balanzá-Martínez V, Bora E, Brissos S, Cavanagh JT, et al. Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatr Scand. 2013;128(3):149-62
28. Samamé C. Social cognition throughout the three phases of bipolar disorder: a state-of-the-art overview. Psychiatry Res. 2013;210(3):1275-86
29. Samamé C, Martino DJ, Strejilevich SA. An individual task meta-analysis of social cognition in euthymic bipolar disorders J Affect Disord. 2015;173:146-53
30. Samamé C, Martino DJ, Strejilevich SA. Social cognition in euthymic bipolar disorder: systematic review and meta-analytic approach. Acta Psychiatr Scand. 2012;125(4):266-80
31. Murphy FC, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES, et al. Decision-making cognition in mania and depression. Psychol Med. 2001;31(4):679-93
32. Adida M, Jollant F, Clark L, Besnier N, Guillaume S, Kaladjian A, et al. Trait-related decision-making impairment in the three phases of bipolar disorder. Biol Psychiatry. 2011;70(4):357-65
33. Samamé C, Martino DJ, Strejilevich SA. A quantitative review of neurocognition in euthymic late-life bipolar disorder. Bipolar Disord. 2013;15(6):633-44
34. Schürhoff F, Bellivier F, Jouvent R, Mouren-Siméoni MC, Bouvard M, Allilaire JF, et al. Early and late onset bipolar disorders: two different forms of manic-depressive illness? J Affect Disord. 2000;58(3):215-21
35. Moorhead SR, Young AH. Evidence for a late onset bipolar-I disorder sub-group from 50 years. J Affect Disord. 2003;73(3):271-7
36. Depp CA, Jeste DV. Bipolar disorder in older adults: a critical review. Bipolar Disord. 2004;6(5):343-67
37. Martino DJ, Strejilevich SA, Manes F. Neurocognitive functioning in early-onset and late-onset older patients with euthymic bipolar disorder. Int J Geriatr Psychiatry. 2013;28(2):142-8
38. Aprahamian I, Ladeira RB, Diniz BS, Forlenza OV, Nunes PV. Cognitive impairment in euthymic older adults with bipolar disorder: a controlled study using cognitive screening tests. Am J Geriatr Psychiatry. 2014;22(4):389-97
39. Martino DJ, Strejilevich SA, Marengo E, Ibañez A, Scápola M, Igoa A. Toward the identification of neurocognitive subtypes in euthymic patients with bipolar disorder. J Affect Disord. 2014;167:118-24
40. Martino DJ, Strejilevich SA, Scápola M, Igoa A, Marengo E, Ais ED, et al. Heterogeneity in cognitive functioning among patients with bipolar disorder. J Affect Disord. 2008;109(1-2):149-56
41. Gualtieri CT, Morgan DW. The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: an unaccounted source of variance in clinical trials. J Clin Psychiatry. 2008;69(7):1122-30
42. Reichenberg A, Harvey PD, Bowie CR, Mojtabai R, Rabinowitz J, Heaton RK, et al. Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophr Bull. 2009;35:1022-9
43. Iverson GL, Brooks BL, Langenecker SA, Young AH. Identifying a cognitive impairment subgroup in adults with mood disorders. J Affect Disord. 2011;132(3):360-7
44. Burdick KE, Braga RJ, Gopin CB, Malhotra AK. Dopaminergic influences on emotional decision making in euthymic bipolar patients. Neuropsychopharmacology. 2014;39(2):274-82
45. Nehra R, Chakrabarti S, Pradhan BK, Khehra N. Comparison of cognitive functions between first- and multi-episode bipolar affective disorders. J Affect Disord. 2006;93(1-3):185-92
46. Torres IJ, DeFreitas VG, DeFreitas CM, Kauer-Sant’Anna M, Bond DJ, Honer WG, et al. Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode. J Clin Psychiatry. 2010;71(9):1234-42
47. López-Jaramillo C, Lopera-Vásquez J, Gallo A, Ospina-Duque J, Bell V, Torrent C, et al. Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence. Bipolar Disord. 2010;12(5):557-67
48. Lee RS, Hermens DF, Scott J, Redoblado-Hodge MA, Naismith SL, Lagopoulos J, et al. A meta-analysis of neuropsychological functioning in first-episode bipolar disorders. J Psychiatr Res. 2014;57:1-11
49. Bora E, Pantelis C. Meta-analysis of cognitive impairment in first-episode bipolar disorder: comparison with first-episode schizophrenia and healthy controls. Schizophr Bull. 2015. [Epub ahead of print]
50. Daglas R, Yücel M, Cotton S, Allott K, Hetrick S, Berk M. Cognitive impairment in first-episode mania: a systematic review of the evidence in the acute and remission phases of the illness. Int J Bipolar Disord. 2015;3:9
51. Samamé C, Martino DJ, Strejilevich SA. Longitudinal course of cognitive deficits in bipolar disorder: a meta-analytic study. J Affect Disord. 2014;164:130-8
52. Torres IJ, Kozicky J, Popuri S, Bond DJ, Honer WG, Lam RW, et al. 12-month longitudinal cognitive functioning in patients recently diagnosed with bipolar disorder. Bipolar Disord. 2014;16(2):159-71
53. Santos JL, Aparicio A, Bagney A, Sánchez-Morla EM, Rodríguez-Jiménez R, Mateo J, et al. A five-year follow-up study of neurocognitive functioning in bipolar disorder. Bipolar Disord. 2014;16(7):722-31
54. Lee RS, Hermens DF, Naismith SL, Lagopoulos J, Jones A, Scott J, et al. Neuropsychological and functional outcomes in recent-onset major depression, bipolar disorder and schizophrenia-spectrum disorders: a longitudinal cohort study. Transl Psychiatry. 2015;5:e555
55. Strejilevich SA, Martino DJ. Cognitive function in adulthood and elderly euthymic bipolar patients: a comparison to test models of cognitive evolution. J Affect Disord. 2013;150(3):1188-91
56. Dhingra U, Rabins PV. Mania in the elderly: a 5-7 year follow-up. J Am Geriatr Soc. 1991;39(6):581-3
57. Gildengers AG, Butters MA, Seligman K, McShea M, Miller MD, Mulsant BH, et al. Cognitive functioning in late-life bipolar disorder. Am J Psychiatry. 2004;161(4):736-8
58. Kessing LV, Olsen EW, Mortensen PB, Andersen PK. Dementia in affective disorder: a case-register study. Acta Psychiatr Scand. 1999;100(3):176-85
59. Wu KY, Chang CM, Liang HY, Wu CS, Chia-Hsuan Wu E, Chen CH, et al. Increased risk of developing dementia in patients with bipolar disorder: a nested matched case-control study. Bipolar Disord. 2013;15(7):787-94
60. Goldberg JF, Harrow M. Consistency of remission and outcome in bipolar and unipolar mood disorders: a 10-year prospective follow-up. J Affect Disord. 2004;81(2):123-31
61. Martino DJ, Igoa A, Marengo E, Scápola M, Ais ED, Strejilevich SA. Cognitive and motor features in elderly people with bipolar disorder. J Affect Disord. 2008;105(1-3):291-5
62. Zhao L, Lin Y, Lao G, Wang Y, Guan L, Wei J, et al. Association study of dopamine receptor genes polymorphism with cognitive functions in bipolar I disorder patients. J Affect Disord. 2015;170:85-90
63. Savitz JB, van der Merwe L, Stein DJ, Solms M, Ramesar RS. Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma. Bipolar Disord. 2008;10(4):479-94
64. Dickerson F, Stallings C, Sullens A, Origoni A, Leister F, Krivogorsky B, et al. Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorder. Brain Behav Immun. 2008;22(7):1103-7
65. Gerber SI, Krienke UJ, Biedermann NC, Grunze H, Yolken RH, Dittmann S, et al. Impaired functioning in euthymic patients with bipolar disorder--HSV-1 as a predictor. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36(1):110-6
66. Wu HI, Chang YH, Lai CC, Wu JY, Chen SL, Chu CH, et al. The effect of comorbid anxiety disorder on neuropsychological function in bipolar II disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(8):1841-5
67. van Gorp WG, Altshuler L, Theberge DC, Wilkins J, Dixon W. Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study. Arch Gen Psychiatry. 1998;55(1):41-6
68. Levy B, Monzani BA, Stephansky MR, Weiss RD. Neurocognitive impairment in patients with co-occurring bipolar disorder and alcohol dependence upon discharge from inpatient care. Psychiatry Res. 2008;161(1):28-35
69. Sanchez-Moreno J, Martinez-Aran A, Colom F, Scott J, Tabares-Seisdedos R, Sugranyes G, et al. Neurocognitive dysfunctions in euthymic bipolar patients with and without prior history of alcohol use. J Clin Psychiatry. 2009;70(8):1120-7
70. Schouws SNTM, Comijs HC, Stek ML, Dekker J, Oostervink F, Naarding P, et al. Cognitive impairment in early and late bipolar disorder. Am J Geriatr Psychiatry. 2009;17(6):508-15
71. Martino DJ, Strejilevich SA. Subclinical hypothyroidism and neurocognitive functioning in bipolar disorder. J Psychiatr Res. 2015;61:166-7
72. Frangou S, Donaldson S, Hadjulis M, Landau S, Goldstein LH. The Maudsley Bipolar Disorder Project: executive dysfunction in bipolar disorder I and its clinical correlates. Biol Psychiatry. 2005;58(11):859-64
73. Torrent C, Martinez-Arán A, Daban C, Amann B, Balanzá-Martínez V, del Mar Bonnín C, et al. Effects of atypical antipsychotics on neurocognition in euthymic bipolar patients. Compr Psychiatry. 2011;52(6):613-22
74. Robinson LJ, Ferrier IN. Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence. Bipolar Disord. 2006;8(2):103-16
75. Post RM, Fleming J, Kapczinski F. Neurobiological correlates of illness progression in the recurrent affective disorders. J Psychiatr Res. 2012;46(5):561-73
76. Martino DJ, Strejilevich SA, Marengo E, Igoa A, Fassi G, Teitelbaum J, et al. Relationship between neurocognitive functioning and episode recurrences in bipolar disorder. J Affect Disord. 2013;147(1-3):345-51
77. Martinez-Aran A, Scott J, Colom F, Torrent C, Tabares-Seisdedos R, Daban C, et al. Treatment nonadherence and neurocognitive impairment in bipolar disorder. J Clin Psychiatry. 2009;70(7):1017-23
78. Elshahawi HH, Essawi H, Rabie MA, Mansour M, Beshry ZA, Mansour AN. Cognitive functions among euthymic bipolar I patients after a single manic episode versus recurrent episodes. J Affect Disord. 2011;130(1- 2):180-91
79. Berk M, Berk L, Dodd S, Cotton S, Macneil C, Daglas R, et al. Stage managing bipolar disorder. Bipolar Disord. 2014;16(5):471-7
80. Kapczinski F, Magalhães PV, Balanzá-Martinez V, Dias VV, Frangou S, Gama CS, et al. Staging systems in bipolar disorder: an International Society for Bipolar Disorders Task Force Report. Acta Psychiatr Scand. 2014;130(5):354-63
81. Martino DJ, Samamé C, Marengo E, Igoa A, Strejilevich S. Is bipolar disorder a neuroprogressive condition? A critical review of the clinical evidence. 2015. Submitted.
82. Rosa AR, Magalhães PV, Czepielewski L, Sulzbach MV, Goi PD, Vieta E, et al. Clinical staging in bipolar disorder: focus on cognition and functioning. J Clin Psychiatry. 2014;75(5):e450-6
83. Czepielewski LS, Massuda R, Goi P, Sulzbach-Vianna M, Reckziegel R, Costanzi M, et al. Verbal episodic memory along the course of schizophrenia and bipolar disorder: a new perspective. Eur Neuropsychopharmacol. 2015;25(2):169-75
84. Martínez-Arán A, Vieta E, Colom F, Torrent C, Sánchez-Moreno J, Reinares M, et al. Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome. Bipolar Disord. 2004;6(3):224-32
85. Torres IJ, DeFreitas CM, DeFreitas VG, Bond DJ, Kunz M, Honer WG, et al. Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorder. Psychol Med. 2011;41(5):971-82
86. Pattanayak RD, Sagar R, Mehta M. Neuropsychological performance in euthymic Indian patients with bipolar disorder type I: correlation between quality of life and global functioning. Psychiatry Clin Neurosci. 2012;66(7):553-63
87. MacCabe JH, Lambe MP, Cnattingius S, Sham PC, David AS, Reichenberg A, et al. Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study. Br J Psychiatry. 2010;196(2):109-15
88. Lee J, Altshuler L, Glahn DC, Miklowitz DJ, Ochsner K, Green MF. Social and nonsocial cognition in bipolar disorder and schizophrenia: relative levels of impairment. Am J Psychiatry. 2013;170(3):334-41
89. Nocjar C, Hammonds MD, Shim SS. Chronic lithium treatment magnifies learning in rats. Neuroscience. 2007;150(4):774-88
90. Tsaltas E, Kyriazi T, Poulopoulou C, Kontis D, Maillis A. Enhancing effects of lithium on memory are not by-products of learning or attentional deficits. Behav Brain Res. 2007;180(2):241-5
91. Tsaltas E, Kontis D, Boulougouris V, Papakosta VM, Giannou H, Poulopoulou C, et al. Enhancing effects of chronic lithium on memory in the rat. Behav Brain Res. 2007;177(1):51-60
92. Li Q, Li H, Roughton K, Wang X, Kroemer G, Blomgren K, et al. Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia. Cell Death Dis. 2010 Jul 15;1:e56
93. Nunes PV, Forlenza OV, Gattaz WF. Lithium and risk for Alzheimer’s disease in elderly patients with bipolar disorder. Br J Psychiatry. 2007;190:359-60
94. Gerhard T, Devanand DP, Huang C, Crystal S, Olfson M. Lithium treatment and risk for dementia in adults with bipolar disorder: populationbased cohort study. Br J Psychiatry. 2015;207(1):46-51
95. Gildengers AG, Butters MA, Aizenstein HJ, Marron MM, Emanuel J, Anderson SJ, et al. Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder. Bipolar Disord. 2015;17(3):248-56
96. Adida M, Jollant F, Clark L, Guillaume S, Goodwin GM, Azorin JM, et al. Lithium might be associated with better decision-making performance in euthymic bipolar patients. Eur Neuropsychopharmacol. 2015;25(6):788-97
97. Muralidharan K, Kozicky JM, Bücker J, Silveira LE, Torres IJ, Yatham LN. Are cognitive deficits similar in remitted early bipolar I disorder patients treated with lithium or valproate? Data from the STOP-EM study. Eur Neuropsychopharmacol. 2015;25(2):223-30
98. Aprahamian I, Teixeira de Sousa R, Valiengo LCL, Machado-Vieira R, Forlenza OV. Lithium safety and tolerability in mood disorders: a critical review. Arch Clin Psychiatry. 2014;41(1):9-14
99. Wingo AP, Wingo TS, Harvey PD, Baldessarini RJ. Effects of lithium on cognitive performance: a meta-analysis. J Clin Psychiatry. 2009;70(11):1588-97
100. Ferrara SD, Giorgetti R, Zancaner S, Orlando R, Tagliabracci A, Cavarzeran F, et al. Effects of single dose of gamma-hydroxybutyric acid and lorazepam on psychomotor performance and subjective feelings in healthy volunteers. Eur J Clin Pharmacol. 1999;54(11):821-7
101. Goldberg JF, Burdick KE. Cognitive side effects of anticonvulsants. J Clin Psychiatry. 2001;62 Suppl 14:27-33
102. Donaldson S, Goldstein LH, Landau S, Raymont V, Frangou S. The Maudsley Bipolar Disorder Project: the effect of medication, family history, and duration of illness on IQ and memory in bipolar I disorder. J Clin Psychiatry. 2003;64(1):86-93
103. Jamrozinski K, Gruber O, Kemmer C, Falkai P, Scherk H. Neurocognitive functions in euthymic bipolar patients. Acta Psychiatr Scand. 2009;119(5):365-74
104. Pålsson E, Figueras C, Johansson AG, Ekman CJ, Hultman B, Östlind J, et al. Neurocognitive function in bipolar disorder: a comparison between bipolar I and II disorder and matched controls. BMC Psychiatry. 2013 J;13:165
105. Yim CY, Soczynska JK, Kennedy SH, Woldeyohannes HO, Brietzke E, McIntyre RS. The effect of overweight/obesity on cognitive function in euthymic individuals with bipolar disorder. Eur Psychiatry. 2012;27(3):223-8
106. Depp CA, Strassnig M, Mausbach BT, Bowie CR, Wolyniec P, Thornquist MH, et al. Association of obesity and treated hypertension and diabetes with cognitive ability in bipolar disorder and schizophrenia. Bipolar Disord. 2014;16(4):422-31
107. Joffe RT, MacDonald C, Kutcher SP. Lack of differential cognitive effects of lithium and carbamazepine in bipolar affective disorder. J Clin Psychopharmacol. 1988;8(6):425-8
108. López-Jaramillo C, Lopera-Vásquez J, Ospina-Duque J, García J, Gallo A, Cortez V, et al. Lithium treatment effects on the neuropsychological functioning of patients with bipolar I disorder. J Clin Psychiatry. 2010;71(8):1055-60
109. Mintzer MZ, Griffiths RR. Lorazepam and scopolamine: A single-dose comparison of effects on human memory and attentional processes. Exp Clin Psychopharmacol. 2003;11(1):56-72.