In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer

Oncotarget

Volumn 6, Issue 36, 2015, Pages 38789-38803

  Hirano, Toshiyuki ^a   Yasuda, Hiroyuki ^a   Tani, Tetsuo ^a   Hamamoto, Junko ^a   Oashi, Ayano ^a   Ishioka, Kota ^a   Arai, Daisuke ^a   Nukaga, Shigenari ^a   Miyawaki, Masayoshi ^a   Kawada, Ichiro ^a   Naoki, Katsuhiko ^a   Costa, Daniel B ^b   Kobayashi, Susumu S ^b   Betsuyaku, Tomoko ^a   Soejima, Kenzo ^a  

^a KEIO UNIVERSITY   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

EGFR exon 20 insertion mutations; EGFR mutation; EGFR tyrosine kinase inhibitors; In vitro modeling; Lung cancer

Indexed keywords

AFATINIB; ERLOTINIB; MITOGEN ACTIVATED PROTEIN KINASE; OSIMERTINIB; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; ROCILETINIB; VASCULOTROPIN RECEPTOR; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN KINASE INHIBITOR;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BA F3 CELL LINE; BID007 CELL LINE; CANCER INHIBITION; CANCER RESISTANCE; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SPECIFICITY; EGFR GENE; EXON; GENE DELETION; GENE INSERTION; GENE MUTATION; H1975 CELL LINE; H3255 CELL LINE; HUMAN; HUMAN CELL; IC50; IMMORTALIZED CELL LINE; IN VITRO STUDY; LUNG CANCER CELL LINE; NON SMALL CELL LUNG CANCER; PC 9 CELL LINE; PC 9ER CELL LINE; PROTEIN PHOSPHORYLATION; WILD TYPE; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG SCREENING; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; LUNG NEOPLASMS; MUTATION; PHOSPHORYLATION; TUMOR CELL LINE;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; EXONS; HUMANS; LUNG NEOPLASMS; MUTATION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SUBSTRATE SPECIFICITY;

EID: 84948758689     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5887     Document Type: Article

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