Periconceptional multiple-micronutrient supplementation and placental function in rural Gambian women: A double-blind, randomized, placebo-controlled trial

American Journal of Clinical Nutrition

Volumn 102, Issue 6, 2015, Pages 1450-1459

  Owens, Stephen ^a,b,c   Gulati, Ruchi ^b,c   Fulford, Anthony J ^b,c   Sosseh, Fatou ^b,c   Denison, Fiona C ^d   Brabin, Bernard J ^e   Prentice, Andrew M ^b,c  

^a NORTHUMBRIA HEALTHCARE NHS FOUNDATION TRUST   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Africa; Birth weight; Fetal growth; Micronutrients; Periconceptional; Placenta; Pregnancy

Indexed keywords

MATERNAL MEASLES ANTIBODY; MEASLES ANTIBODY; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATOR INHIBITOR 2; TRACE ELEMENT; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ACTIVE TRANSPORT; ADOLESCENT; ADULT; ARTERY RESISTANCE; ARTICLE; CONCEPTION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; MENSTRUATION; MULTIPLE MICRONUTRIENT SUPPLEMENTATION; OUTCOME ASSESSMENT; PLACENTA FUNCTION; PREGNANCY; PRENATAL CARE; RANDOMIZED CONTROLLED TRIAL; UTERINE ARTERY; ADVERSE EFFECTS; BLOOD; COHORT ANALYSIS; DEFICIENCY DISEASES; DIETARY SUPPLEMENT; FOLLOW UP; GAMBIA; HEALTH; MATERNAL NUTRITION; PATHOPHYSIOLOGY; PLACENTA CIRCULATION; PREGNANCY COMPLICATIONS; PREPREGNANCY CARE; REPRODUCTION; UNITED NATIONS; VASCULAR RESISTANCE; YOUNG ADULT;

ADOLESCENT; ADULT; BIOMARKERS; COHORT STUDIES; DEFICIENCY DISEASES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; GAMBIA; HUMANS; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MICRONUTRIENTS; PLACENTAL CIRCULATION; PLACENTATION; PRECONCEPTION CARE; PREGNANCY; PREGNANCY COMPLICATIONS; RURAL HEALTH; UNITED NATIONS; VASCULAR RESISTANCE; YOUNG ADULT;

EID: 84948734889     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.113.072413     Document Type: Article

References (40)

1. Ramakrishnan U. Prevalence of micronutrient malnutrition worldwide. Nutr Rev 2002;60:S46-52
2. Torheim LE, Ferguson EL, Penrose K, Arimond M. Women in resource-poor settings are at risk of inadequate intakes of multiple micronutrients. J Nutr 2010;140:2051S-8S
3. Ramakrishnan U, Manjrekar R, Rivera J, Gonzáles-Cossío T, Martorell R. Micronutrients and pregnancy outcome: a review of the literature. Nutr Res 1999;19:103-59
4. Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev 2012;4; CD004905
5. Ramakrishnan U, Grant F, Goldenberg T, Zongrone A, Martorell R. Effect of women's nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr Perinat Epidemiol 2012;26(Suppl 1):285-301
6. Cha J, Sun X, Dey SK. Mechanisms of implantation: strategies for successful pregnancy. Nat Med 2012;18:1754-67
7. Chaddha V, Viero S, Huppertz B, Kingdom J. Developmental biology of the placenta and the origins of placental insufficiency. Semin Fetal Neonatal Med 2004;9:357-69
8. Redmer DA, Wallace JM, Reynolds LP. Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development. Domest Anim Endocrinol 2004;27:199-217
9. Khong TY. Placental vascular development and neonatal outcome. Semin Neonatol 2004;9:255-63
10. Cetin I, Berti C, Calabrese S. Role of micronutrients in the periconceptional period. Hum Reprod Update 2010;16:80-95
11. Wu G, Imhoff-Kunsch B, Girard AW. Biological mechanisms for nutritional regulation of maternal health and fetal development. Paediatr Perinat Epidemiol 2012;26(Suppl 1):4-26
12. Yajnik CS, Deshmukh US. Fetal programming: maternal nutrition and role of one-carbon metabolism. Rev Endocr Metab Disord 2012;13:121-7
13. Stewart FM, Freeman DJ, Ramsay JE, Greer IA, Caslake M, Ferrell WR. Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. J Clin Endocrinol Metab 2007;92:969-75
14. Estellés A, Gilabert J, Aznar J, Loskutoff DJ, Schleef RR. Changes in the plasma levels of type 1 and type 2 plasminogen activator inhibitors in normal pregnancy and in patients with severe preeclampsia. Blood 1989;74:1332-8
15. Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW, Wapner RJ, Thorp JMJ, Mercer BM, Grobman WA, et al. The utility of uterine artery Doppler velocimetry in prediction of preeclampsia in a low-risk population. Obstet Gynecol 2012;120:815-22
16. UNICEF. Composition of a multi-micronutrient supplement to be used in pilot programmes among pregnant women in developing countries: report of a United Nations Children's Fund (UNICEF), World Health Organization (WHO) and United Nations University workshop. New York: UNICEF; 1999
17. Bates CJ, Prentice AM, Paul AA. Seasonal variations in vitamins A, C, riboflavin and folate intakes and status of pregnant and lactating women in a rural Gambian community: some possible implications. Eur J Clin Nutr 1994;48:660-8
18. Rayco-Solon P, Fulford AJ, Prentice AM. Differential effects of seasonality on preterm birth and intrauterine growth restriction in rural Africans. Am J Clin Nutr 2005;81:134-9
19. Rayco-Solon P, Moore SE, Fulford AJ, Prentice AM. Fifty-year mortality trends in three rural African villages. Trop Med Int Health 2004; 9:1151-60
20. Schim Loeff MF, Sarge-Njie R, Ceesay S, Awasana AA, Jaye P, Sam O, Jaiteh KO, Cubitt D, Milligan P, Whittle HC. Regional differences in HIV trends in The Gambia: results from sentinel surveillance among pregnant women. AIDS 2003;17:1841-6
21. Cole-Ceesay R, Cherian M, Sonko A, Shivute N, Cham M, Davis M, Fatty F, Wieteska S, Baro M, Watson D. Strengthening the emergency healthcare system for mothers and children in The Gambia. Reprod Health 2010;7:21
22. Breathnach FM, Malone FD. Fetal growth disorders in twin gestations. Semin Perinatol 2012;36:175-81
23. Gulati R, Bailey R, Prentice AM, Brabin BJ, Owens S. Haematological effects of multimicronutrient supplementation in non-pregnant Gambian women. Eur J Clin Nutr 2009;63:970-7
24. Taylor RA, Denison FC, Beyai S, Owens S. The external Ballard examination does not accurately assess the gestational age of infants born at home in a rural community of The Gambia. Ann Trop Paediatr 2010; 30:197-204
25. Thurnham DI, Smith E, Flora PS. Concurrent liquid-chromatographic assay of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, lycopene, and beta-cryptoxanthin in plasma, with tocopherol acetate as internal standard. Clin Chem 1988;34:377-81
26. Chudleigh P, Thilaganathan B. Obstetric ultrasound: how, why, and when. London: Churchill Livingstone; 2004
27. Chappell LC, Seed PT, Briley AL, Kelly FJ, Lee R, Hunt BJ, Parmar K, Bewley SJ, Shennan AH, Steer PJ. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6
28. Owens S, Harper G, Amuasi J, Offei-Larbi G, Ordi J, Brabin BJ. Placental malaria and immunity to infant measles. Arch Dis Child 2006;91:507-8
29. Medical Research Council. MRC guidelines for good clinical practice in clinical trials. London: MRC; 1998
30. Sciscione AC, Hayes EJ; Society for Maternal-Fetal Medicine. Uterine artery Doppler flow studies in obstetric practice. Am J Obstet Gynecol 2009;201:121-6
31. Timmermans S, Jaddoe VW, Silva LM, Hofman A, Raat H, Steegers-Theunissen RP, Steegers EA. Folic acid is positively associated with uteroplacental vascular resistance: the Generation R study. Nutr Metab Cardiovasc Dis 2011;21:54-61
32. Nafee TM, Farrell WE, Carroll WD, Fryer AA, Ismail KM. Epigenetic control of fetal gene expression. BJOG 2008;115:158-68
33. Cooper WN, Khulan B, Owens S, Elks CE, Seidel V, Prentice AM, Belteki G, Ong KK, Affara NA, Constancia M, et al. DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial. FASEB J 2012;26:1782-90
34. Khulan B, Cooper WN, Skinner BM, Bauer J, Owens S, Prentice AM, Belteki G, Constancia M, Dunger D, Affara NA. Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in The Gambia. Hum Mol Genet 2012;21:2086-101
35. Cross JC, Mickelson L. Nutritional influences on implantation and placental development. Nutr Rev 2006;64:S12-8
36. Catov JM, Bodnar LM, Olsen J, Olsen S, Nohr EA. Periconceptional multivitamin use and risk of preterm or small-for-gestational-age births in the Danish National Birth Cohort. Am J Clin Nutr 2011;94: 906-12
37. Shaw GM, Liberman RF, Todoroff K, Wasserman CR. Low birth weight, preterm delivery, and periconceptional vitamin use. J Pediatr 1997;130:1013-4
38. Wheeler T, Sollero C, Alderman S, Landen J, Anthony F, Osmond C. Relation between maternal haemoglobin and placental hormone concentrations in early pregnancy. Lancet 1994;343:511-3
39. Stokes E, Dumbaya I, Owens S, Brabin L. The right to remain silent: a qualitative study of the medical and social ramifications of pregnancy disclosure for Gambian women. BJOG 2008;115:1641-7; discussion: 1647
40. Christian P. Micronutrients, birth weight and survival. Annu Rev Nutr 2010;30:83-104