Role of magnesium in parathyroid physiology

Hypoparathyroidism

Volumn , Issue , 2015, Pages 61-67

  Steen, Oren ^a   Khan, Aliya ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Absorption; Intestinal; Magnesium; Magnesium physiology; Parathyroid diseases; Parathyroid glands; Parathyroid hormone

Indexed keywords

EID: 84948734710     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-88-470-5376-2_7     Document Type: Chapter

References (69)

1. Navarro-González JF, Mora-Fernández C, García- Pérez J (2009) Clinical implications of disordered magnesium homeostasis in chronic renal failure and dialysis. Semin Dial 22(1):37-44
2. Vetter T, Lohse M (2002) Magnesium and the parathyroid. Curr Opin Nephrol Hypertens 11:403-410
3. Wacker WE, Parisi AF (1968) Magnesium metabolism. N Engl J Med 278:772-776
4. Pironi L, Malucetti E, Guidetti M et al (2009) The complex relationship between magnesium and serum parathyroid hormone: a study in patients with chronic intestinal failure. Magnes Res 22(1):37-43
5. Hoorn EJ, Zietse R (2013) Disorders of calcium and magnesium balance: a physiology-based approach. Pediatr Nephrol 28:1195-1206
6. Speich M, Bousquet B, Nicolas G (1981) Reference values for ionized, complexed, and protein-bound plasma magnesium in men and women. Clin Chem 27:246-248
7. Elin RJ (1988) Magnesium metabolism in health and disease. Dis Mon 34:165-218
8. Ferrè S, Hoenderop JG, Bindels RJ (2012) Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis. Kidney Int 82:1157-1166
9. Glaudemans B, Knoers NV, Hoenderop JG, Bindels RJ (2010) New molecular players facilitating Mg(2+) reabsorption in the distal convoluted tubule. Kidney Int 77(1):17-22
10. Graham LA, Caesar JJ, Burgen AS (1960) Gastrointestinal absorption and excretion of Mg2+ in man. Metabolism 9:646-659
11. Brannan PG, Bergne-Marini P, Pak CY et al (1976) Magnesium absorption in the human small intestine. J Clin Invest 57:1412-1418
12. Quamme GA (2008) Recent developments in intestinal magnesium absorption. Curr Opin Gastroenterol 24:230-235
13. Ferrè S, Hoenderop JJ, Bindels RJ (2011) Role of the distal convoluted tubule in renal Mg2+ handling: molecular lessons from inherited hypomagnesemia. Magnes Res 24(3):S101-S108
14. Bindels RJ (2010) 2009 Homer W. Smith Award: minerals in motion: from new ion transporters to new concepts. J Am Soc Nephrol 21:1263-1269
15. Gunzel D, Yu AS (2009) Function and regulation of claudins in the thick ascending limb of Henle. Pflugers Arch 458:77-88
16. Hou J, Renigunta A, Gomes AS et al (2009) Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. Proc Natl Acad Sci U S A 106:15350-15355
17. Hou J, Goodenough DA (2010) Claudin-16 and claudin- 19 function in the thick ascending limb. Curr Opin Nephrol Hypertens 19(5):483-488
18. Reilly RF, Ellison DH (2000) Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy. Physiol Rev 80:277-313
19. Schlingmann KP, Weber S, Peters M et al (2002) Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 31(2):166-170
20. Walder RY, Landau D, Meyer P et al (2002) Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet 31:171-174
21. Voets T, Nilius B, Hoefs S et al (2004) TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem 279:19-25
22. Takahashi S, Okada K, Yanai M (1994) Magnesium and parathyroid hormone changes to magnesium-free dialysate in continuous ambulatory peritoneal dialysis patients. Perit Dial Int 14:75-78
23. Pletka P, Bernstein DS, Hampers CL et al (1974) Relationship between magnesium and secondary hyperparathyroidism during long-term hemodialysis. Metabolism 23:619-630
24. Parsons V, Papapoulos SE, Weston MJ et al (1980) The long-term effect of lowering dialysate magnesium on circulating parathyroid hormone in patients on regular haemodialysis therapy. Acta Endocrinol 93:455-460
25. Gonella M, Bonaguidi F, Buzzigoli G, Bartolini V, Mariani G (1981) On the effect of magnesium on the PTH secretion in uremic patients on maintenance hemodialysis. Nephron 27:40-42
26. Massry SG, Coburn JW, Kleeman CR (1970) Evidence for suppression of parathyroid gland activity by hypermagnesemia. J Clin Invest 49:1619-1629
27. Alfrey AC, Miller NL, Butkus D (1974) Evaluation of body magnesium stores. J Lab Clin Med 84:153-162
28. Rob PM, Dick K, Bley N et al (1999) Can one really measure magnesium deficiency using the short-term magnesium loading test? J Intern Med 246(4):373-378
29. Dynker T, Wester PO (1978) The relation between extra- and intracellular electrolytes in patients with hypokalemia and/or diuretic treatment. Acta Med Scand 204:269-282
30. Rob PM, Bley N, Dick K et al (1995) Magnesium deficiency after renal transplantion and cyclosporine treatment despite normal serum magnesium concentration detected by a modified magnesium-loadingtest. Transplant Proc 27:3442-3443
31. Hess MW, Hoenderop JG, Bindels RJ, Drenth JP (2012) Systematic review: hypomagnesaemia induced by proton pump inhibition. Aliment Pharmacol Ther 36:405-413
32. Hoorn EJ, van der Hoek J, de Man RA et al (2010) A case series of proton pump inhibitor-induced hypomagnesemia. Am J Kidney Dis 56:112-116
33. Cundy T, Dissanayake A (2008) Severe hypomagnesaemia in long-term users of proton-pump inhibitors. Clin Endocrinol (Oxf) 69:338-341
34. Groenestege WT, Thébault S, van der Wijst J et al (2007) Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. J Clin Invest 117:2260-2267
35. Hoorn EJ, Walsh SB, McCormick JA et al (2011) The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension. Nat Med 17:1304-1309
36. Nijenhuis T, Hoenderop JG, Bindels RJ (2004) Downregulation of Ca(2+) and Mg(2+) transport proteins in the kidney explains tacrolimus (FK506)- induced hypercalciuria and hypomagnesemia. J Am Soc Nephrol 15:549-557
37. Nijenhuis T, Vallon V, van der Kemp AW et al (2005) Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest 115:1651-1658
38. Topf JM, Murray PT (2003) Hypomagnesemia and hypermagnesemia. Rev Endocr Metab Disord 4:195-206
39. Sutton RA, Domrongkitchaiporn S (1993) Abnormal renal magnesium handling. Miner Electrolyte Metab 19:232-240
40. Weber C, Santiago R (1989) Hypermagnesemia: a potential complication during treatment of theophylline intoxication with oral activated charcoal and magnesium-containing cathartics. Chest 95:56-59
41. Gren J, Woolf A (1989) Hypermagnesemia associated with catharsis in a salicylate-intoxicated patient with anorexia nervosa. Ann Emerg Med 18(2):200-203
42. Ashton MR, Sutton D, Nielsen M (1990) Severe magnesium toxicity after magnesium sulphate enema in a chronically constipated child. BMJ 300:541
43. Collinson PO, Burroughs AK (1986) Severe hypermagnesaemia due to magnesium sulphate enemas in patients with hepatic coma. Br Med J (Clin Res Ed) 293:1013-1014
44. Outerbridge EW, Papageorgiou A, Stern L (1973) Severe hypermagnesaemia due to magnesium sulphate enemas in patients with hepatic coma. JAMA 224:1392-1393
45. Porath A, Mosseri M, Harmon I et al (1989) Dead sea water poisoning. Ann Emerg Med 18(2):187-191
46. Grubbs RD, Maguire ME (1987) Magnesium as a regulatory cation: criteria and evaluation. Magnesium 6:113-127
47. Butters RR Jr, Chattopadhyay N, Nielsen P et al (1997) Cloning and characterization of a calcium- sensing receptor from the hypercalcemic New Zealand white rabbit reveals unaltered responsiveness to extracellular calcuim. J Bone Miner Res 12(4):568-579
48. Ruat M, Snowman AM, Hester LD, Snyder SH (1996) Cloned and expressed rat Ca2+-sensing receptor. J Biol Chem 271(11):5972-5975
49. Chang W, Pratt S, Chen TH et al (1998) Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide sera. J Bone Miner Res 13(4):570-580
50. Wittner M, Mandon B, Roinel N et al (1993) Hormonal stimulation of Ca2+ and Mg2+ transport in the cortical thick ascending limb of Henle’s loop of the mouse: evidence for a change in the paracellular pathway permeability. Pflugers Arch 423:387-396
51. Pollak MR, Brown EM, Estep HL et al (1994) Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation. Nat Genet 8:303-307
52. Pollak MR, Brown EM, Chou YH et al (1993) Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 75(7): 1297-1303
53. Duran MJ, Borst GC 3rd, Osburne RC, Eil C (1984) Concurrent renal hypomagnesemia and hypoparathyroidism with normal parathormone responsiveness. Am J Med 76(1):151-154
54. Anast CS, Mohs JM, Kaplan SL, Burns TW (1973) Magnesium, vitamin D, and parathyroid hormone. Lancet 1(7816):1389-1390
55. Mennes P, Rosenbaum R, Martin K, Slatopolsky E (1978) Hypomagnesemia and impaired parathyroid hormone secretion in chronic renal disease. Ann Intern Med 88(2):206-209
56. Quitterer U, Hoffmann M, Freichel M, Lohse MJ (2001) Paradoxical block of parathormone secretion is mediated by increased activity of G alpha subunits. J Biol Chem 276(9):6763-6769
57. Fatemi S, Ryzen E, Flores J et al (1991) Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25- dihydroxyvitamin D metabolism. J Clin Endocrinol Metab 73:1067-1072
58. Stromme JH, Nesbakken R, Normann T et al (1969) Familial hypomagnesemia: biochemical, histological and hereditary aspects studied in two brothers. Acta Paediatr Scand 58(5):433-444
59. Rude RK, Oldham SB, Sharp CF Jr, Singer FR (1978) Parathyroid hormone secretion in magnesium deficiency. J Clin Endocrinol Metab 47(4):800-806
60. Anast CS, Mohs JM, Kaplan SL, Burns TW (1972) Evidence for parathyroid failure in magnesium deficiency. Science 177(4049):606-608
61. Suh SM, Tashijah AH Jr, Matsuo N et al (1973) Pathogenesis of hypocalcemia in primary hypomagnesemia: normal end-organ responsiveness to parathyroid hormone, impaired parathyroid gland function. J Clin Invest 52(1):153-160
62. Mune T, Yasuda K, Ishii M et al (1993) Tetany due to hypomagnesemia induced by cisplatin and doxorubicin treatment for synovial sarcoma. Intern Med 32:434-437
63. Mori S, Harada S, Okazaki R et al (1992) Hypomagnesemia with increased metabolism of parathyroid hormone and reduced responsiveness to calcitropic hormones. Intern Med 31:820-824
64. Mihara M, Kamikubo K, Hiramatsu K et al (1995) Renal refractoriness to phosphaturic action of parathyroid hormone in a patient with hypomagnesemia. Intern Med 34:666-669
65. Leicht E, Biro G (1992) Mechanisms of hypocalcaemia in the clinical form of severe magnesium deficit in the human. Magnes Res 5:37-44
66. Risco F, Traba ML, de la Piedra C (1995) Possible alterations of the in vivo 1,25(OH)2D3 synthesis and its tissue distribution in magnesium-deficient rats. Magnes Res 8:27-35
67. Clark B, Brown R (1992) Unsuspected morbid hypermagnesemia in elderly patients. Am J Nephrol 12:336-343
68. Cruikshank DP, Pitkin RM, Reynolds WA et al (1979) Effects of magnesium sulfate treatment on perinatal calcium metabolism. I. Maternal and fetal responses. Am J Obstet Gynecol 134:243-249
69. Cholst IN, Steinberg SF, Tropper PJ et al (1984) The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. N Engl J Med 310:1221-1225