Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells

Life Sciences

Volumn 144, Issue , 2016, Pages 30-36

  Silva, Sara M ^a   Martinho, Ana ^a   Moreno, Ivo ^a   Silvestre, Samuel ^a,b   Granadeiro, Luiza Breitenfeld ^a   Alves, Gilberto ^a,b   Duarte, Ana Paula ^a   Domingues, Fernanda ^a   Gallardo, Eugenia ^a  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

CYP1A2; CYP2D6; Hepatic cells; Herb drug interactions; Hyperforin; Hypericin; Hypericum perforatum

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; HYPERFORIN; HYPERICIN; HYPERICUM PERFORATUM EXTRACT; CYP1A2 PROTEIN, HUMAN; CYTOCHROME P450 INHIBITOR; PERYLENE; PHLOROGLUCINOL; PLANT EXTRACT; RNA; TERPENE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HEPG2 CELL LINE; HERB DRUG INTERACTION; HYPERICUM PERFORATUM; LIVER CELL; LIVER TOXICITY; LONG TERM EXPOSURE; METABOLITE; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG INTERACTION; ENZYME INDUCTION; ENZYMOLOGY; GENETICS; HUMAN; HYPERICUM; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME INHIBITORS; DRUG INTERACTIONS; ENZYME INDUCTION; HEPATOCYTES; HUMANS; HYPERICUM; PERYLENE; PHLOROGLUCINOL; PLANT EXTRACTS; RNA, NEOPLASM; TERPENES; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84948692116     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.11.004     Document Type: Article

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