Hypocholesterolemic Efficacy of Quercetin Rich Onion Juice in Healthy Mild Hypercholesterolemic Adults: A Pilot Study

Plant Foods for Human Nutrition

Volumn 70, Issue 4, 2015, Pages 395-400

  Lu, Tsong Ming ^a   Chiu, Hui Fang ^b   Shen, You Cheng ^c   Chung, Chia Chun ^c   Venkatakrishnan, Kamesh ^c   Wang, Chin Kun ^c  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b Department of Chinese Medicine   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antioxidation; Cardiovascular disease; Hypercholesterolemia; Lipoproteins; Total cholesterol

Indexed keywords

ANTIOXIDANT; CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; PLANT EXTRACT; QUERCETIN;

ADULT; BLOOD; CHEMISTRY; DRUG EFFECTS; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; ONION; OXIDATION REDUCTION REACTION; PHYTOTHERAPY; PILOT STUDY; TAIWAN; WAIST CIRCUMFERENCE;

ADULT; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; CHOLESTEROL; CHOLESTEROL, LDL; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; LIPIDS; MALE; MIDDLE AGED; ONIONS; OXIDATION-REDUCTION; PHYTOTHERAPY; PILOT PROJECTS; PLACEBOS; PLANT EXTRACTS; QUERCETIN; TAIWAN; WAIST CIRCUMFERENCE;

EID: 84948587371     PISSN: 09219668     EISSN: 15739104     Source Type: Journal    
DOI: 10.1007/s11130-015-0507-4     Document Type: Article

References (29)

1. Stapleton PA, Goodwill AG, James ME, Brock RW, Frisbee JC (2010) Hypercholesterolemia and microvascular dysfunction, interventional strategies. J Inflam 7:54–64
2. Hein TW, Kuo L (1998) LDLs impair vasomotor function of the coronary microcirculation role of superoxide anions. Circulation Res 83:404–14
3. Arts ICW, Hollman PCH (2005) Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 81(1):317S–325S
4. Griffiths G, Trueman L, Crowther T, Thomas B, Smith B (2002) Onions - a global benefit to health. Phytother Res 16:603–615
5. Joshi SC, Jain PK (2014) A review on hypolipidaemic and antioxidant potential of some medicinal plants. World J Pharm Sci 3(11):357–380
6. Srinivasan K (2013) Dietary spices as beneficial modulators of lipid profile in conditions of metabolic disorders and diseases. Food Funct 4:503–21
7. Julkunen-Titto R (1985) Phenolic constituents in the leaves of northern willows: methods for the analysis of certain phenolics. J Agric Food Chem 33:213–217
8. Hertog MGL, Hollman PCH, Venema DP (1992) Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruits. J Agric Food Chem 40:1591–1598
9. Crozier A, Michael E, McDonald MS, Black C (1997) Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. J Agri Food Chem 45:590–595
10. Bordia A, Bansal H, Arora S, Singh S (1975) Effect of the essential oils of garlic and onion on alimentary hyperlipemia. Atherosclerosis 21:15–19
11. Serafini M, Maiani G, Ferro-Luzzi A (1998) Alcohol-free red wine enhances plasma antioxidant capacity in humans. J Nutr 128:1003–1007
12. Arnao MB, Casas JL, Del Rio JA, Acosta M, Garcia-Canovas F (1990) An enzymatic colorimetric method for measuring naringin using 2,20-azino-bis-(3- ethylbenzthiazoline-6-sulfonic acid) (ABTS) in the presence of peroxidase. Anal Biochem 185:335–338
13. Miller NJ, Rice-Evans C, Davies MJ, Gopinathan V, Milner A (1993) A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci (Lond) 84:407–412
14. Draper HH, Hadley M (1990) Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186:421–431
15. Halliwell B, Gutteridge JM (1990) The antioxidants of human extracellular fluids. Arch Biochem Biophys 280:1–8
16. Esterbauer H, Striegl G, Puhl H, Rotheneder M (1989) Continuous monitoring of in vitro oxidation of low density lipoprotein. Free Radic Res Commun 6:67–75
17. Kaneko T, Baba N (1999) Protective effect of flavonoids on endothelial cells against linoleic acid hydroperoxide-induced toxicity. Biosci Biotechnol Biochem 63:323–328
18. Benítez V, Mollá E, Martín-Cabrejas MA, Aguilera Y, López-Andréu FJ, Cools K, Esteban RM (2011) Characterization of industrial onion wastes (Allium cepa L.): dietary fibre and bioactive compounds. Plant Foods Hum Nutr 66(1):48–57
19. Rohn S, Buchner N, Driemel G, Rauser M, Kroh LW (2007) Thermal degradation of onion quercetin glucosides under roasting conditions. J Agric Food Chem 55:1568–1573
20. Hollman PC, Katan MB (1999) Health effects and bioavailability of dietary flavonols. Free Radic Res 31(1):S75–S80
21. Febrianti EZ, Asviandri FL, Lestari R, Cahyohadi S, Rini EA (2013) Correlation between lipid profiles and body mass index of adolescents obesity in Padang. Int J Ped Endocrinol 1:P87
22. Glasser G, Graefe EU, Struck F, Veit M, Gebhardt R (2002) Comparison of antioxidative capacities and inhibitory effects on cholesterol biosynthesis of quercetin and potential metabolites. Phytomed 9:33–40
23. Chávez-Santoscoy RA, Gutiérrez-Uribe JA, Serna-Saldívar SO (2013) Effect of flavonoids and saponins extracted from black bean (Phaseolus vulgaris L.) seed coats as cholesterol micelle disruptors. Plant Foods Hum Nutr 68(4):416–423
24. Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N (2000) Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 130:2243–2250
25. Lee KH, Park E, Lee HJ, Kim MO, Cha YJ, Kim JM, Lee H, Shi MJ (2011) Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers. Nutr Res Pract 5(1):28–33
26. Rice-Evans CA, Miller NJ, Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad Biol Med 20:933–956
27. Shon MY, Choi SD, Kahng GG, Nam SH, Sung NJ (2004) Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions. Food Chem Toxicol 42:659–666
28. Hausenloy D, Yellon D (2008) Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels. Postgrad Med J 84:590–598
29. Osorio-Esquivel O, Ortiz-Moreno A, Garduño-Siciliano L, Álvarez VB, Hernández-Navarro MD (2012) Antihyperlipidemic effect of methanolic extract from Opuntia joconostle seeds in mice fed a hypercholesterolemic diet. Plant Plant Foods Hum Nutr 67(4):365–370