메뉴 건너뛰기




Volumn 29, Issue 2, 2015, Pages 560-567

Ulinastatin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of AMPK/NF-κB pathway

Author keywords

Acute lung injury (ALI); AMPK NF B pathway; Mice; Ulinastatin

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN; ANTIINFLAMMATORY AGENT; CYTOKINE; GLYCOPROTEIN; LIPOPOLYSACCHARIDE; TRYPSIN INHIBITOR;

EID: 84948457052     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.09.028     Document Type: Article
Times cited : (57)

References (45)
  • 1
    • 34547410905 scopus 로고    scopus 로고
    • Acute lung injury and acute respiratory distress syndrome
    • author reply 4-5
    • N. Singh Acute lung injury and acute respiratory distress syndrome Lancet 370 2007 383 384 author reply 4-5
    • (2007) Lancet , vol.370 , pp. 383-384
    • Singh, N.1
  • 2
    • 34247588117 scopus 로고    scopus 로고
    • Acute lung injury and the acute respiratory distress syndrome: A clinical review
    • A.P. Wheeler, and G.R. Bernard Acute lung injury and the acute respiratory distress syndrome: a clinical review Lancet 369 2007 1553 1564
    • (2007) Lancet , vol.369 , pp. 1553-1564
    • Wheeler, A.P.1    Bernard, G.R.2
  • 3
    • 84859903016 scopus 로고    scopus 로고
    • Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis
    • K. Xie, Y. Yu, Y. Huang, L. Zheng, J. Li, H. Chen, and et al. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis Shock 37 2012 548 555
    • (2012) Shock , vol.37 , pp. 548-555
    • Xie, K.1    Yu, Y.2    Huang, Y.3    Zheng, L.4    Li, J.5    Chen, H.6
  • 4
  • 5
    • 33645769722 scopus 로고    scopus 로고
    • Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury
    • M.B. Everhart, W. Han, T.P. Sherrill, M. Arutiunov, V.V. Polosukhin, J.R. Burke, and et al. Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury J. Immunol. 176 2006 4995 5005
    • (2006) J. Immunol. , vol.176 , pp. 4995-5005
    • Everhart, M.B.1    Han, W.2    Sherrill, T.P.3    Arutiunov, M.4    Polosukhin, V.V.5    Burke, J.R.6
  • 6
    • 41149147968 scopus 로고    scopus 로고
    • P38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway
    • S. Liu, G. Feng, G.L. Wang, and G.J. Liu p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway Eur. J. Pharmacol. 584 2008 159 165
    • (2008) Eur. J. Pharmacol. , vol.584 , pp. 159-165
    • Liu, S.1    Feng, G.2    Wang, G.L.3    Liu, G.J.4
  • 7
    • 33645116785 scopus 로고    scopus 로고
    • NF-kappa B activation as a pathological mechanism of septic shock and inflammation
    • S.F. Liu, and A.B. Malik NF-kappa B activation as a pathological mechanism of septic shock and inflammation Am. J. Physiol. Lung Cell. Mol. Physiol. 290 2006 L622 L645
    • (2006) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.290 , pp. L622-L645
    • Liu, S.F.1    Malik, A.B.2
  • 8
    • 0034132919 scopus 로고    scopus 로고
    • NF-kappaB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome
    • P. Moine, R. McIntyre, M.D. Schwartz, D. Kaneko, R. Shenkar, Y. Le Tulzo, and et al. NF-kappaB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome Shock 13 2000 85 91
    • (2000) Shock , vol.13 , pp. 85-91
    • Moine, P.1    McIntyre, R.2    Schwartz, M.D.3    Kaneko, D.4    Shenkar, R.5    Le Tulzo, Y.6
  • 9
    • 77956063983 scopus 로고    scopus 로고
    • Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice
    • Z. Chen, X. Zhang, X. Chu, X. Zhang, K. Song, Y. Jiang, and et al. Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice Inflammation 33 2010 306 314
    • (2010) Inflammation , vol.33 , pp. 306-314
    • Chen, Z.1    Zhang, X.2    Chu, X.3    Zhang, X.4    Song, K.5    Jiang, Y.6
  • 10
    • 84855563615 scopus 로고    scopus 로고
    • Suppression of NF-kappaB pathway by crocetin contributes to attenuation of lipopolysaccharide-induced acute lung injury in mice
    • R. Yang, L. Yang, X. Shen, W. Cheng, B. Zhao, K.H. Ali, and et al. Suppression of NF-kappaB pathway by crocetin contributes to attenuation of lipopolysaccharide-induced acute lung injury in mice Eur. J. Pharmacol. 674 2012 391 396
    • (2012) Eur. J. Pharmacol. , vol.674 , pp. 391-396
    • Yang, R.1    Yang, L.2    Shen, X.3    Cheng, W.4    Zhao, B.5    Ali, K.H.6
  • 11
    • 34250694982 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling
    • R.Y. Su, Y. Chao, T.Y. Chen, D.Y. Huang, and W.W. Lin 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling Mol. Cancer Ther. 6 2007 1562 1571
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1562-1571
    • Su, R.Y.1    Chao, Y.2    Chen, T.Y.3    Huang, D.Y.4    Lin, W.W.5
  • 12
    • 77957913650 scopus 로고    scopus 로고
    • AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis
    • A. Bai, A.G. Ma, M. Yong, C.R. Weiss, Y. Ma, Q. Guan, and et al. AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis Biochem. Pharmacol. 80 2010 1708 1717
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1708-1717
    • Bai, A.1    Ma, A.G.2    Yong, M.3    Weiss, C.R.4    Ma, Y.5    Guan, Q.6
  • 13
    • 1642499162 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: A possible role of AMP-activated protein kinase
    • S. Giri, N. Nath, B. Smith, B. Viollet, A.K. Singh, and I. Singh 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase J. Neurosci. 24 2004 479 487
    • (2004) J. Neurosci. , vol.24 , pp. 479-487
    • Giri, S.1    Nath, N.2    Smith, B.3    Viollet, B.4    Singh, A.K.5    Singh, I.6
  • 14
    • 52649141738 scopus 로고    scopus 로고
    • Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
    • X. Zhao, J.W. Zmijewski, E. Lorne, G. Liu, Y.J. Park, Y. Tsuruta, and et al. Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury Am. J. Physiol. Lung Cell. Mol. Physiol. 295 2008 L497 L504
    • (2008) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.295 , pp. L497-L504
    • Zhao, X.1    Zmijewski, J.W.2    Lorne, E.3    Liu, G.4    Park, Y.J.5    Tsuruta, Y.6
  • 15
    • 14244260288 scopus 로고    scopus 로고
    • Pathophysiology and diagnostic value of urinary trypsin inhibitors
    • M.J. Pugia, and J.A. Lott Pathophysiology and diagnostic value of urinary trypsin inhibitors Clin. Chem. Lab. Med. 43 2005 1 16
    • (2005) Clin. Chem. Lab. Med. , vol.43 , pp. 1-16
    • Pugia, M.J.1    Lott, J.A.2
  • 16
    • 14944350369 scopus 로고    scopus 로고
    • Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide
    • K. Inoue, H. Takano, A. Shimada, R. Yanagisawa, M. Sakurai, S. Yoshino, and et al. Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide Mol. Pharmacol. 67 2005 673 680
    • (2005) Mol. Pharmacol. , vol.67 , pp. 673-680
    • Inoue, K.1    Takano, H.2    Shimada, A.3    Yanagisawa, R.4    Sakurai, M.5    Yoshino, S.6
  • 17
    • 77952492404 scopus 로고    scopus 로고
    • Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders
    • K. Inoue, and H. Takano Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders Expert Opin. Investig. Drugs 19 2010 513 520
    • (2010) Expert Opin. Investig. Drugs , vol.19 , pp. 513-520
    • Inoue, K.1    Takano, H.2
  • 18
    • 84859651122 scopus 로고    scopus 로고
    • Ulinastatin protects pulmonary tissues from lipopolysaccharide-induced injury as an immunomodulator
    • C. Gao, R. Li, and S. Wang Ulinastatin protects pulmonary tissues from lipopolysaccharide-induced injury as an immunomodulator J. Trauma Acute Care Surg. 72 2012 169 176
    • (2012) J. Trauma Acute Care Surg. , vol.72 , pp. 169-176
    • Gao, C.1    Li, R.2    Wang, S.3
  • 19
    • 33750567782 scopus 로고    scopus 로고
    • Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha
    • Y. Kumazawa, K. Kawaguchi, and H. Takimoto Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha Curr. Pharm. Des. 12 2006 4271 4279
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 4271-4279
    • Kumazawa, Y.1    Kawaguchi, K.2    Takimoto, H.3
  • 21
    • 84879086917 scopus 로고    scopus 로고
    • Effect of tyrosine kinase inhibitors, imatinib and nilotinib, in murine lipopolysaccharide-induced acute lung injury during neutropenia recovery
    • I.K. Kim, C.K. Rhee, C.D. Yeo, H.H. Kang, D.G. Lee, S.H. Lee, and et al. Effect of tyrosine kinase inhibitors, imatinib and nilotinib, in murine lipopolysaccharide-induced acute lung injury during neutropenia recovery Crit. Care 17 2013 R114
    • (2013) Crit. Care , vol.17 , pp. R114
    • Kim, I.K.1    Rhee, C.K.2    Yeo, C.D.3    Kang, H.H.4    Lee, D.G.5    Lee, S.H.6
  • 22
    • 84858769367 scopus 로고    scopus 로고
    • Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury
    • M.H. Chien, M.Y. Bien, C.C. Ku, Y.C. Chang, H.Y. Pao, Y.L. Yang, and et al. Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury Crit. Care Med. 40 2012 1245 1253
    • (2012) Crit. Care Med. , vol.40 , pp. 1245-1253
    • Chien, M.H.1    Bien, M.Y.2    Ku, C.C.3    Chang, Y.C.4    Pao, H.Y.5    Yang, Y.L.6
  • 23
    • 33646518813 scopus 로고    scopus 로고
    • Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome
    • M. Cepkova, and M.A. Matthay Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome J. Intensive Care Med. 21 2006 119 143
    • (2006) J. Intensive Care Med. , vol.21 , pp. 119-143
    • Cepkova, M.1    Matthay, M.A.2
  • 24
    • 84903354918 scopus 로고    scopus 로고
    • Critical role of toll-like receptor 4 in hypoxia-inducible factor 1alpha activation during trauma/hemorrhagic shocky induced acute lung injury after lymph infusion in mice
    • H. Jiang, R. Hu, L. Sun, D. Chai, Z. Cao, and Q. Li Critical role of toll-like receptor 4 in hypoxia-inducible factor 1alpha activation during trauma/hemorrhagic shocky induced acute lung injury after lymph infusion in mice Shock 42 2014 271 278
    • (2014) Shock , vol.42 , pp. 271-278
    • Jiang, H.1    Hu, R.2    Sun, L.3    Chai, D.4    Cao, Z.5    Li, Q.6
  • 25
    • 84892618602 scopus 로고    scopus 로고
    • Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury
    • D. Shah, F. Romero, W. Stafstrom, M. Duong, and R. Summer Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury Am. J. Physiol. Lung Cell. Mol. Physiol. 306 2014 L152 L161
    • (2014) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.306 , pp. L152-L161
    • Shah, D.1    Romero, F.2    Stafstrom, W.3    Duong, M.4    Summer, R.5
  • 26
    • 1142299409 scopus 로고    scopus 로고
    • Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
    • M. Bhatia, and S. Moochhala Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome J. Pathol. 202 2004 145 156
    • (2004) J. Pathol. , vol.202 , pp. 145-156
    • Bhatia, M.1    Moochhala, S.2
  • 27
    • 0035100129 scopus 로고    scopus 로고
    • Effects of a dual inhibitor of tumor necrosis factor-α and interleukin-1 on lipopolysaccharide-induced lung injury in rats: Involvement of the p38 mitogen-activated protein kinase pathway
    • D. Yoshinari, I. Takeyoshi, Y. Koibuchi, K. Matsumoto, Y. Kawashima, T. Koyama, and et al. Effects of a dual inhibitor of tumor necrosis factor-α and interleukin-1 on lipopolysaccharide-induced lung injury in rats: involvement of the p38 mitogen-activated protein kinase pathway Crit. Care Med. 29 2001 628 634
    • (2001) Crit. Care Med. , vol.29 , pp. 628-634
    • Yoshinari, D.1    Takeyoshi, I.2    Koibuchi, Y.3    Matsumoto, K.4    Kawashima, Y.5    Koyama, T.6
  • 28
    • 41149147968 scopus 로고    scopus 로고
    • P38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-κB pathway
    • S. Liu, G. Feng, G.-L. Wang, and G.-J. Liu p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-κB pathway Eur. J. Pharmacol. 584 2008 159 165
    • (2008) Eur. J. Pharmacol. , vol.584 , pp. 159-165
    • Liu, S.1    Feng, G.2    Wang, G.-L.3    Liu, G.-J.4
  • 29
    • 0442329090 scopus 로고    scopus 로고
    • Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase
    • L.-F. Li, L. Yu, and D.A. Quinn Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase Am. J. Respir. Crit. Care Med. 169 2004 518 524
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , pp. 518-524
    • Li, L.-F.1    Yu, L.2    Quinn, D.A.3
  • 30
    • 67349251922 scopus 로고    scopus 로고
    • Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury
    • K. Schuh, and A. Pahl Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury Biochem. Pharmacol. 77 2009 1827 1834
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 1827-1834
    • Schuh, K.1    Pahl, A.2
  • 31
    • 77954532054 scopus 로고    scopus 로고
    • Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils
    • J.-p. Lee, L. Y-c, C. H-y, R.-h. Lin, H. S-s, C. H-l, and et al. Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils Acta Pharmacol. Sin. 31 2010 831 838
    • (2010) Acta Pharmacol. Sin. , vol.31 , pp. 831-838
    • Lee, J.-P.1    Lin, R.-H.2
  • 32
    • 75149129007 scopus 로고    scopus 로고
    • PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway
    • C. Li, H. Liu, Y. Sun, H. Wang, F. Guo, S. Rao, and et al. PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway J. Mol. Cell Biol. 1 2009 37 45
    • (2009) J. Mol. Cell Biol. , vol.1 , pp. 37-45
    • Li, C.1    Liu, H.2    Sun, Y.3    Wang, H.4    Guo, F.5    Rao, S.6
  • 33
    • 0035575706 scopus 로고    scopus 로고
    • Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury
    • H.-K. Yum, J. Arcaroli, J. Kupfner, R. Shenkar, J.M. Penninger, T. Sasaki, and et al. Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury J. Immunol. 167 2001 6601 6608
    • (2001) J. Immunol. , vol.167 , pp. 6601-6608
    • Yum, H.-K.1    Arcaroli, J.2    Kupfner, J.3    Shenkar, R.4    Penninger, J.M.5    Sasaki, T.6
  • 35
    • 77957913650 scopus 로고    scopus 로고
    • AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis
    • A. Bai, A.G. Ma, M. Yong, C.R. Weiss, Y. Ma, Q. Guan, and et al. AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis Biochem. Pharmacol. 80 2010 1708 1717
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1708-1717
    • Bai, A.1    Ma, A.G.2    Yong, M.3    Weiss, C.R.4    Ma, Y.5    Guan, Q.6
  • 36
    • 1642499162 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: A possible role of AMP-activated protein kinase
    • S. Giri, N. Nath, B. Smith, B. Viollet, A.K. Singh, and I. Singh 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase J. Neurosci. 24 2004 479 487
    • (2004) J. Neurosci. , vol.24 , pp. 479-487
    • Giri, S.1    Nath, N.2    Smith, B.3    Viollet, B.4    Singh, A.K.5    Singh, I.6
  • 37
    • 52649141738 scopus 로고    scopus 로고
    • Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
    • X. Zhao, J.W. Zmijewski, E. Lorne, G. Liu, Y.-J. Park, Y. Tsuruta, and et al. Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury Am. J. Physiol. Lung Cell. Mol. Physiol. 295 2008 L497 L504
    • (2008) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.295 , pp. L497-L504
    • Zhao, X.1    Zmijewski, J.W.2    Lorne, E.3    Liu, G.4    Park, Y.-J.5    Tsuruta, Y.6
  • 38
    • 36549014136 scopus 로고    scopus 로고
    • Compound C inhibits hypoxic activation of HIF-1 independent of AMPK
    • B.M. Emerling, B. Viollet, K.V. Tormos, and N.S. Chandel Compound C inhibits hypoxic activation of HIF-1 independent of AMPK FEBS Lett. 581 2007 5727 5731
    • (2007) FEBS Lett. , vol.581 , pp. 5727-5731
    • Emerling, B.M.1    Viollet, B.2    Tormos, K.V.3    Chandel, N.S.4
  • 39
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, and et al. Role of AMP-activated protein kinase in mechanism of metformin action J. Clin. Invest. 108 2001 1167 1174
    • (2001) J. Clin. Invest. , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3    Chen, Y.4    Shen, X.5    Fenyk-Melody, J.6
  • 41
    • 79951689086 scopus 로고    scopus 로고
    • Identification of aneuploidy-selective antiproliferation compounds
    • Y.C. Tang, B.R. Williams, J.J. Siegel, and A. Amon Identification of aneuploidy-selective antiproliferation compounds Cell 144 2011 499 512
    • (2011) Cell , vol.144 , pp. 499-512
    • Tang, Y.C.1    Williams, B.R.2    Siegel, J.J.3    Amon, A.4
  • 44
    • 4544228457 scopus 로고    scopus 로고
    • Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology
    • S. Beinke, and S.C. Ley Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology Biochem. J. 382 2004 393 409
    • (2004) Biochem. J. , vol.382 , pp. 393-409
    • Beinke, S.1    Ley, S.C.2
  • 45
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • D. Sag, D. Carling, R.D. Stout, and J. Suttles Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype J. Immunol. 181 2008 8633 8641
    • (2008) J. Immunol. , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.