Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase

Antiviral Research

Volumn 125, Issue , 2016, Pages 34-42

  Yuan, Shuofeng ^a   Chu, Hin ^a   Zhao, Hanjun ^a   Zhang, Ke ^a   Singh, Kailash ^b   Chow, Billy K C ^b   Kao, Richard Y T ^a   Zhou, Jie ^a   Zheng, Bo Jian ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Anti influenza; Cross protection; Polymerase assembly

Indexed keywords

3 ( 2 CHLOROPHENYL) 6 ETHYL 7 METHYL[ 1,2,4 ]TRIAZOLO[ 4,3 A]PYRIMIDIN 6 OL; ANTIVIRUS AGENT; PA PROTEIN; PB1 PROTEIN; PB2 PROTEIN; PYRIMIDINE DERIVATIVE; RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; ZANAMIVIR; MOLECULAR LIBRARY; PROTEIN BINDING; RNA DIRECTED RNA POLYMERASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DYNAMICS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A; INFLUENZA A (H1N1); INFLUENZA A VIRUS; INFLUENZA A VIRUS (H1N1); INFLUENZA A VIRUS (H3N2); INFLUENZA A VIRUS (H5N1); INFLUENZA A VIRUS (H7N7); INFLUENZA A VIRUS (H7N9); INFLUENZA A VIRUS (H9N2); INFLUENZA VIRUS; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIROGENESIS; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CLASSIFICATION; DOG; DRUG EFFECTS; ENZYMOLOGY; GENETICS; MDCK CELL LINE; METABOLISM; MOLECULAR DOCKING; MOLECULAR LIBRARY; ORTHOMYXOVIRIDAE; PHARMACOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE;

ALLOSTERIC SITE; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MADIN DARBY CANINE KIDNEY CELLS; MICE; MICE, INBRED BALB C; MOLECULAR DOCKING SIMULATION; ORTHOMYXOVIRIDAE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RNA REPLICASE; SMALL MOLECULE LIBRARIES; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84948397146     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.11.005     Document Type: Article

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