Focal Screening to Identify the Subpatent Parasite Reservoir in an Area of Low and Heterogeneous Transmission in the Kenya Highlands

Journal of Infectious Diseases

Volumn 212, Issue 10, 2015, Pages 1768-1777

  Stresman, Gillian H ^a   Baidjoe, Amrish Y ^b   Stevenson, Jennifer ^a,c   Grignard, Lynn ^a   Odongo, Wycliffe ^d   Owaga, Chrispin ^d   Osoti, Victor ^d   Makori, Euniah ^d   Shagari, Shehu ^d   Marube, Elisabeth ^d   Cox, Jonathan ^a   Drakeley, Chris ^a   Bousema, Teun ^a,b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

Elimination; Malaria transmission; Screening; Subpatent infection

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; DISEASE ASSOCIATION; ENDEMIC DISEASE; FEMALE; FEVER; GAMETOCYTE; HUMAN; KENYA; MALARIA; MALARIA RAPID TEST; MALE; MASS SCREENING; NESTED POLYMERASE CHAIN REACTION; NUCLEIC ACID SEQUENCE BASED AMPLIFICATION; PARASITE LOAD; PARASITE TRANSMISSION; PARASITEMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SUBPATENT PARASITE RESERVOIR; AGED; ASYMPTOMATIC INFECTIONS; CHILD; CROSS-SECTIONAL STUDY; FAMILY SIZE; INFANT; MIDDLE AGED; PRESCHOOL CHILD; TRANSMISSION; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASYMPTOMATIC INFECTIONS; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FAMILY CHARACTERISTICS; FEMALE; HUMANS; INFANT; KENYA; MALARIA; MALE; MASS SCREENING; MIDDLE AGED; PARASITEMIA; YOUNG ADULT;

EID: 84948393364     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv302     Document Type: Article

References (44)

1. Cotter C, Sturrock HJW, Hsiang MS, et al. The changing epidemiology of malaria elimination: new strategies for new challenges. Lancet 2013; 382:900-11.
2. Woolhouse MEJ, Dye C, Etard J-F, et al. Heterogeneities in the transmission of infectious agents: Implications for the design of control programs. Proc Natl Acad Sci USA 1997; 94:338-42.
3. Baliraine FN, Afrane YA, Amenya DA, et al. High prevalence of asymptomatic Plasmodium falciparum infections in a highland area of western Kenya: A cohort study. J Infect Dis 2009; 200:66-74.
4. Okell LC, Bousema T, Griffin JT, Ouedraogo AL, Ghani AC, Drakeley CJ. Factors determining the occurrence of submicroscopic malaria infections and their relevance for control. Nat Commun 2012; 3:1237.
5. Diarra A, Nebie I, Tiono A, et al. Seasonal performance of a malaria rapid diagnosis test at community health clinics in a malaria-hyperendemic region of Burkina Faso. Parasit Vectors 2012; 5:103.
6. Harris I, Sharrock WW, Bain LM, et al. A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting. Malar J 2010; 9:254.
7. Cook J, Xu W, Msellem M, et al. Mass screening and treatment using a falciparum-specific rapid diagnostic test did not reduce malaria incidence in Zanzibar. J Infect Dis 2015; 211:1476-83.
8. Nsobya SL, Parikh S, Kironde F, et al. Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis 2004; 189:2220-6.
9. Bousema T, Griffin JT, Sauerwein RW, et al. Hitting hotspots: spatial targeting of malaria for control and elimination. PLOS Med 2012; 9: e1001165.
10. Lindblade KA, Steinhardt L, Samuels A, Kachur SP, Slutsker L. The silent threat: asymptomatic parasitemia and malaria transmission. Expert Rev Anti Infect Ther 2013; 11:623-39.
11. malERA, TDR, WHO. A research agenda for malaria eradication: diagnoses and diagnostics. PLOS Med 2011; 8:e1000396.
12. Tietje K, Hawkins K, Clerk C, et al. The essential role of infection-detection technologies for malaria elimination and eradication. Trends Parasitol 2014; 30:259-66.
13. Drakeley CJ, Corran PH, Coleman PG, et al. Estimating medium-and long-term trends in malaria transmission by using serological markers of malaria exposure. Proc Natl Acad Sci USA 2005; 102:5108-13.
14. Pinkevych M, Petravic J, Berecsky S, Rooth I, Farnert A, Davenport MP. Understanding the relationship between parasite growth rate and multiplicity of infection with the malaria parasite Plasmodium falciparum. J Infect Dis 2015; 211:1121-7.
15. Proietti C, Verra F, Bretscher MT, et al. Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda. Parasite Immunol 2013; 35: 164-73.
16. Nguyen HV, van den Eede P, van Overmeir C, et al. Marked age-dependent prevalence of symptomatic and patent infections and complexity of distribution of human Plasmodium species in central Vietnam. Am J Trop Med Hyg 2012; 87:989-95.
17. Sutcliffe CG, Kobayashi T, Hamapumbu H, et al. Reduced risk of malaria parasitemia following household screening and treatment: A crosssectional and longitudinal cohort study. PLOS One 2012; 7:e31396.
18. von Seidlein L. The failure of screening and treating as a malaria elimination strategy. PLOS Med 2014; 11:e1001595.
19. Hamainza B, Moonga H, Sikaala CH, et al. Monitoring, characterization and control of chronic, symptomatic malaria infections in rural Zambia through monthly household visits by paid community health workers. Malar J 2014; 13:128.
20. Poirot E, Skarbinski J, Sinclair D, Kachur SP, Slutsker L, Hwang J. Mass drug administration for malaria. Cochrane Database Syst Rev 2013; 12: CD008846.
21. von Seidlein L, Greenwood BM. Mass administrations of antimalarial drugs. Trends Parasitol 2003; 19:452-60.
22. Maude RJ, Socheat D, Nguon C, et al. Optimising strategies for Plasmodium falciparum malaria elimination in Cambodia: primaquine, mass drug administration and artemisinin resistance. PLOS One 2012; 7: e37166.
23. Bejon P, Williams TN, Liljander A, et al. Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya. PLOS Med 2010; 7: e1000304.
24. Littrell M, Sow GD, Ngom A, et al. Case investigation and reactive case detection for malaria elimination in northern Senegal. Malar J 2013; 12:331.
25. Stresman GH, Kamanga A, Moono P, et al. A method of active case detection to target reservoirs of asymptomatic malaria and gametocyte carriers in a rural area in Southern Province, Zambia. Malar J 2010; 9:265.
26. Stuckey EM, Stevenson JC, Cooke MK, et al. Simulation of malaria epidemiology and control in the highlands of western Kenya. Malar J 2012; 11:357.
27. Bousema T, Stevenson J, Baidjoe A, et al. The impact of hotspot-targeted interventions on malaria transmission: study protocol for a clusterrandomized controlled trial. Trials 2013; 14:36.
28. Stevenson JC, Stresman GH, Gitonga CW, et al. Reliability of school surveys in estimating geographic variation in malaria transmission in the western Kenyan highlands. PLOS One 2013; 8:e77641.
29. Sanitation MoPHa. National Guidelines for HIV Testing and Counselling in Kenya. In: Programme NAaSC, ed. 2nd ed. Nairobi, Kenya: Ministry of Public Health and Sanitation, 2010.
30. Stresman GH, Stevenson JC, Ngwu N, et al. High levels of asymptomatic and subpatent Plasmodium falciparum parasite carriage at health facilities in an area of heterogeneous malaria transmission intensity in the Kenyan highlands. Am J Trop Med Hyg 2014; 91:1101-8.
31. Baidjoe A, Stone W, Ploemen I, et al. Combined DNA extraction and antibody elution from filter papers for the assessment of malaria transmission intensity in epidemiological studies. Malar J 2013; 12:272.
32. Snounou G, Viriyakosol S, Zhu XP, et al. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 1993; 61:315-20.
33. Mueller I, Schoepflin S, Smith T, et al. Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. Proc Natl Acad Sci USA 2012; 109: 10030-5.
34. Schneider P, Schoone G, Schallig HD, et al. Quantification of Plasmodium falciparum gametocytes in differential stage of development by quantitative nucleic acid sequence-based amplification. Mol Biochem Parasitol 2004; 137:35-41.
35. Schellenberg JRM, Mrisho M, Manzi F, et al. Health and survival of young children in southern Tanzania. BMC Public Health 2008; 8:194.
36. Hsiang MS, Hwang J, Tao AR, et al. Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China. Malar J 2013; 12:383.
37. Bejon P, Williams TN, Nyundo C, et al. A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots. Elife 2014; 3:e02130.
38. Searle KM, Shields T, Hamapumbu H, et al. Efficiency of household reactive case detection for malaria in rural Southern Zambia: simulations based on cross-sectional surveys from two epidemiological settings. PLOS One 2013; 8:e70972.
39. Bousema T, Okell L, Felger I, Drakeley C. Asymptomatic malaria infections: detectability, transmissibility and public health relevance. Nat Rev Microbiol 2014; 12:833-40.
40. Tiono AB, Ouedraogo A, Ogutu B, et al. A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso. Malar J 2013; 12:79.
41. Greenhouse B, Ho B, Hubbard A, et al. Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. J Infect Dis 2011; 204:19-26.
42. Bejon P, Warimwe G, Mackintosh CL, et al. Analysis of immunity to febrile malaria in children that distinguishes immunity from lack of exposure. Infect Immun 2009; 77:1917-23.
43. Beshir KB, Sutherland CJ, Sawa P, et al. Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence. J Infect Dis 2013; 208:2017-24.
44. Bell DR,Wilson DW, Martin LB. False-positive results of a Plasmodium falciparum histidine-rich protein 2-detecting malaria rapid diagnostic test due to high sensitivity in a community with fluctuating low parasite density. Am J Trop Med Hyg 2005; 73:199-203.