Understanding the relationship between plasmodium falciparum growth rate and multiplicity of infection

Journal of Infectious Diseases

Volumn 211, Issue 7, 2015, Pages 1121-1127

  Pinkevych, Mykola ^a   Petravic, Janka ^a   Bereczky, Sandor ^b   Rooth, Ingegerd ^b   Färnert, Anna ^b   Davenport, Miles P ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

malaria; mathematical modeling; P. falciparum; statistical analysis

Indexed keywords

ADAPTIVE IMMUNITY; ADULT; AGE; AGED; ARTICLE; CHILD; DISEASE COURSE; DISEASE DURATION; GROWTH RATE; HOST PARASITE INTERACTION; HUMAN; INFECTION RATE; INFECTION RISK; MALARIA; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULAR CLONING; PARASITE DEVELOPMENT; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; TANZANIA; VERY ELDERLY; ADOLESCENT; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; GENETICS; GENOTYPE; GROWTH, DEVELOPMENT AND AGING; MALARIA, FALCIPARUM; MALE; MIXED INFECTION; MORTALITY; PARASITEMIA; PARASITOLOGY; PATHOGENICITY; POISSON DISTRIBUTION; PRESCHOOL CHILD; RISK; SURVIVAL; THEORETICAL MODEL;

MEROZOITE SURFACE PROTEIN 2, PLASMODIUM; PARASITE ANTIGEN; PROTOZOAL PROTEIN;

ADOLESCENT; AGE FACTORS; ANTIGENS, PROTOZOAN; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COINFECTION; CROSS-SECTIONAL STUDIES; GENOTYPE; HUMANS; MALARIA, FALCIPARUM; MALE; MODELS, THEORETICAL; PARASITEMIA; PLASMODIUM FALCIPARUM; POISSON DISTRIBUTION; PROTOZOAN PROTEINS; RISK; SURVIVAL ANALYSIS; TANZANIA;

EID: 84927722386     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu561     Document Type: Article

References (27)

1. Bendixen M, Msangeni HA, Pedersen BV, Shayo D, Bodker R. Diversity of Plasmodium falciparum populations and complexity of infections in relation to transmission intensity and host age: a study from the Usambara Mountains, Tanzania. Trans R Soc Trop Med Hyg 2001; 95:143-8.
2. Bruce MC, Galinski MR, Barnwell JW, et al. Genetic diversity and dynamics of plasmodium falciparum and P. vivax populations in multiply infected children with asymptomatic malaria infections in Papua New Guinea. Parasitology 2000; 121(Pt 3):257-72.
3. Henning L, Schellenberg D, Smith T, et al. A prospective study of Plasmodium falciparum multiplicity of infection and morbidity in Tanzanian children. Trans R Soc Trop Med Hyg 2004; 98:687-94.
4. Ntoumi F, Contamin H, Rogier C, Bonnefoy S, Trape JF, Mercereau-Puijalon O. Age-dependent carriage of multiple Plasmodium falciparum merozoite surface antigen-2 alleles in asymptomatic malaria infections. Am J Trop Med Hyg 1995; 52:81-8.
5. Smith T, Beck HP, Kitua A, et al. Age dependence of the multiplicity of Plasmodium falciparum infections and of other malariological indices in an area of high endemicity. Trans R Soc Trop Med Hyg 1999; 93 (suppl 1):15-20.
6. Soulama I, Nébié I, Ouédraogo A, et al. Plasmodium falciparum genotypes diversity in symptomatic malaria of children living in an urban and a rural setting in Burkina Faso. Malar J 2009; 8:135.
7. Farnert A, Rooth I, Svensson , Snounou G, Bjorkman A. Complexity of Plasmodium falciparum infections is consistent over time and protects against clinical disease in Tanzanian children. J Infect Dis 1999; 179:989-95.
8. Bereczky S, Liljander A, Rooth I, et al. Multiclonal asymptomatic Plasmodium falciparum infections predict a reduced risk of malaria disease in a Tanzanian population. Microbes Infect 2007; 9:103-10.
9. al-Yaman F, Genton B, Reeder JC, Anders RF, Smith T, Alpers MP. Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: a prospective community study. Trans R Soc Trop Med Hyg 1997; 91:602-5.
10. Muller DA, Charlwood JD, Felger I, Ferreira C, do Rosario V, Smith T. Prospective risk of morbidity in relation to multiplicity of infection with Plasmodium falciparum in Sao Tome. Acta Trop 2001; 78:155-62.
11. Kitua AY, Smith T, Alonso PL, et al. Plasmodium falciparum malaria in the first year of life in an area of intense and perennial transmission. Trop Med Int Health 1996; 1:475-84.
12. Walton GA. On the control of malaria in Freetown, Sierra Leone; plasmodium falciparum and Anopheles gambiae in relation to malaria occurring in infants. Ann Trop Med Parasitol 1947; 41:380-407.
13. Smith T, Felger I, Kitua A, Tanner M, Beck HP. Dynamics of multiple Plasmodium falciparum infections in infants in a highly endemic area of Tanzania. Trans R Soc Trop Med Hyg 1999; 93(suppl 1):35-9.
14. Smith T, Vounatsou P. Estimation of infection and recovery rates for highly polymorphic parasites when detectability is imperfect, using hidden Markov models. Stat Med 2003; 22:1709-24.
15. Felger I, Maire M, Bretscher MT, et al. The dynamics of natural Plasmodium falciparum infections. PLoS ONE 2012; 7:e45542.
16. Zwetyenga J, Rogier C, Tall A, et al. No influence of age on infection complexity and allelic distribution in Plasmodium falciparum infections in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. Am J Trop Med Hyg 1998; 59:726-35.
17. Liljander A, Chandramohan D, Kweku M, et al. Influences of intermittent preventive treatment and persistent multiclonal Plasmodium falciparum infections on clinical malaria risk. PLoS ONE 2010; 5: e13649.
18. Mueller I, Schoepflin S, Smith TA, et al. Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. Proc Natl Acad Sci USA 2012; 109:10030-5.
19. Farnert A. Plasmodium falciparum population dynamics: only snapshots in time? Trends Parasitol 2008; 24:340-4.
20. Farnert A, Snounou G, Rooth I, Bjorkman A. Daily dynamics of Plasmodium falciparum subpopulations in asymptomatic children in a holoendemic area. Am J Trop Med Hyg 1997; 56:538-47.
21. Pinkevych M, Petravic J, Chelimo K, Kazura JW, Moormann AM, Davenport MP. The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection. PLoS Comput Biol 2012; 8: e1002729.
22. Pinkevych M, Petravic J, Chelimo K, et al. Decreased Growth Rate of P. falciparum Blood Stage Parasitemia With Age in a Holoendemic Population. J Infect Dis 2014; 209:1136-43.
23. Snounou G, Viriyakosol S, Zhu XP, et al. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 1993; 61:315-20.
24. Bejon P, Andrews L, Andersen RF, et al. Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites. J Infect Dis 2005; 191:619-26.
25. Smith DL, Dushoff J, Snow RW, Hay SI. The entomological inoculation rate and Plasmodium falciparum infection in African children. Nature 2005; 438:492-5.
26. Woolhouse MEJ, Dye C, Etard JF, et al. Heterogeneities in the transmission of infectious agents: Implications for the design of control programs. Proc Natl Acad Sci USA 1997; 94:338-42.
27. Rono J, Osier FH, Olsson D, et al. Breadth of anti-merozoite antibody responses is associated with the genetic diversity of asymptomatic Plasmodium falciparum infections and protection against clinical malaria. Clin Infect Dis 2013; 57:1409-16.