Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda

Parasite Immunology

Volumn 35, Issue 5-6, 2013, Pages 164-173

  Proietti, C ^a,b   Verra, F ^a   Bretscher, M T ^a   Stone, W ^a,c   Kanoi, B N ^d   Balikagala, B ^d   Egwang, T G ^d   Corran, P ^a   Ronca, R ^e   Arca B ^e,f   Riley, E M ^a   Crisanti, A ^g   Drakeley, C ^a   Bousema, T ^a,c  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b 62Microtest Matrices ^*  (United Kingdom)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d Med Biotech Laboratories Uganda   (Uganda)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Antibody, epidemiology; Humoral immunity; Malaria, PCR, submicroscopic

Indexed keywords

ANTIBODY; APICAL MEMBRANE ANTIGEN 1; ARTEMETHER PLUS BENFLUMETOL; CIRCUMSPOROZOITE PROTEIN; MEROZOITE SURFACE PROTEIN 1; MICROORGANISM PROTEIN; SALIVARY GLAND PROTEIN 6; UNCLASSIFIED DRUG;

ADULT; ANOPHELES; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE TRANSMISSION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMORAL IMMUNITY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MICROSCOPY; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME; UGANDA;

ADULT; AGE FACTORS; ANIMALS; ANOPHELES GAMBIAE; ANTIBODIES; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INSECT PROTEINS; MALARIA, FALCIPARUM; MALE; PARASITEMIA; PLASMODIUM FALCIPARUM; PREVALENCE; UGANDA; YOUNG ADULT;

EID: 84877136334     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/pim.12031     Document Type: Article

References (35)

1. Gupta S, Snow RW, Donnelly CA, Marsh K & Newbold C. Immunity to non-cerebral severe malaria is acquired after one or two infections. Nat Med 1999; 5: 340-343.
2. Baird JK. Host Age as a determinant of naturally acquired immunity to Plasmodium falciparum. Parasitol Today 1995; 11: 105-111.
3. Cham GK, Turner L, Kurtis JD, et al. Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children. Infect Immun 2010; 78: 4653-4659.
4. Osier FH, Fegan G, Polley SD, et al. Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria. Infect Immun 2008; 76: 2240-2248.
5. Drakeley CJ, Corran PH, Coleman PG, et al. Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure. Proc Natl Acad Sci USA 2005; 102: 5108-5113.
6. Bejon P, Warimwe G, Mackintosh CL, et al. Analysis of immunity to febrile malaria in children that distinguishes immunity from lack of exposure. Infect Immun 2009; 77: 1917-1923.
7. Bousema T, Kreuels B & Gosling R. Adjusting for heterogeneity of malaria transmission in longitudinal studies. J Infect Dis 2011; 204: 1-3.
8. Kinyanjui SM, Bejon P, Osier FH, Bull PC & Marsh K. What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity. Malar J 2009; 8: 242.
9. Bejon P, Abdulla S, Lusingu J, et al. Response to 'Poor control vaccines in two randomised trials of malaria vaccine?'. Vaccine 2009; 27: 4745-4746.
10. Bejon P, Cook J, Bergmann-Leitner E, et al. Effect of the pre-erythrocytic candidate malaria vaccine RTS, S/AS01E on blood-stage immunity in young children. J Infect Dis 2011; 204: 9-18.
11. Greenhouse B, Ho B, Hubbard A, et al. Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. J Infect Dis 2011; 204: 19-26.
12. Muller HM, Fruh K, von Brunn A, et al. Development of the human immune response against the major surface protein (gp190) of Plasmodium falciparum. Infect Immun 1989; 57: 3765-3769.
13. Shekalaghe S, Alifrangis M, Mwanziva C, et al. Low density parasitaemia, red blood cell polymorphisms and Plasmodium falciparum-specific immune responses in a low endemic area in northern Tanzania. BMC Infect Dis 2009; 9: 69.
14. Proietti C, Pettinato DD, Kanoi BN, et al. Continuing intense malaria transmission in northern Uganda. Am J Trop Med Hyg 2011; 84: 830-837.
15. Egwang TG, Apio B, Riley E & Okello D. Plasmodium falciparum malariometric indices in Apac district, northern Uganda. East Afr Med J 2000; 77: 413-416.
16. Snounou G, Viriyakosol S, Zhu XP, et al. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 1993; 61: 315-320.
17. Corran PH, Cook J, Lynch C, et al. Dried blood spots as a source of anti-malarial antibodies for epidemiological studies. Malar J 2008; 7: 195.
18. Bousema T, Youssef RM, Cook J, et al. Serologic markers for detecting malaria in areas of low endemicity, Somalia, 2008. Emerg Infect Dis 2010; 16: 392-399.
19. Bousema T, Drakeley C, Gesase S, et al. Identification of hot spots of malaria transmission for targeted malaria control. J Infect Dis 2010; 201: 1764-1774.
20. Bull PC, Lowe BS, Kaleli N, et al. Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan children. J Infect Dis 2002; 185: 1688-1691.
21. Kinyanjui SM, Mwangi T, Bull PC, Newbold CI & Marsh K. Protection against clinical malaria by heterologous immunoglobulin G antibodies against malaria-infected erythrocyte variant surface antigens requires interaction with asymptomatic infections. J Infect Dis 2004; 190: 1527-1533.
22. Akpogheneta OJ, Dunyo S, Pinder M & Conway DJ. Boosting antibody responses to Plasmodium falciparum merozoite antigens in children with highly seasonal exposure to infection. Parasite Immunol 2010; 32: 296-304.
23. Bousema JT, Roeffen W, Van Der KM, et al. Rapid onset of transmission-reducing antibodies in Javanese migrants exposed to malaria in Papua, Indonesia. Am J Trop Med Hyg 2006; 74: 425-431.
24. Pombo DJ, Lawrence G, Hirunpetcharat C, et al. Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum. Lancet 2002; 360: 610-617.
25. Roestenberg M, McCall M, Hopman J, et al. Protection against a malaria challenge by sporozoite inoculation. N Engl J Med 2009; 361: 468-477.
26. Rizzo C, Ronca R, Fiorentino G, et al. Humoral response to the Anopheles gambiae salivary protein gSG6: a serological indicator of exposure to Afrotropical malaria vectors. PLoS One 2011; 6: e17980.
27. Stone W, Bousema T, Jones S, et al. IgG Responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk. PLoS One 2012; 7: e40170.
28. Akpogheneta OJ, Duah NO, Tetteh KK, et al. Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific. Infect Immun 2008; 76: 1748-1755.
29. Fonjungo PN, Elhassan IM, Cavanagh DR, et al. A longitudinal study of human antibody responses to Plasmodium falciparum rhoptry-associated protein 1 in a region of seasonal and unstable malaria transmission. Infect Immun 1999; 67: 2975-2985.
30. Taylor RR, Egan A, McGuinness D, et al. Selective recognition of malaria antigens by human serum antibodies is not genetically determined but demonstrates some features of clonal imprinting. Int Immunol 1996; 8: 905-915.
31. Okell LC, Bousema T, Griffin JT, Ouedraogo AL, Ghani AC & Drakeley CJ. Factors determining the occurrence of submicroscopic malaria infections and their relevance for control. Nat Commun 2012; 3: 1237.
32. Kinyanjui SM, Conway DJ, Lanar DE & Marsh K. IgG antibody responses to Plasmodium falciparum merozoite antigens in Kenyan children have a short half-life. Malar J 2007; 6: 82.
33. Weiss GE, Traore B, Kayentao K, et al. The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections. PLoS Pathog 2010; 6: e1000912.
34. Wipasa J, Suphavilai C, Okell LC, et al. Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax. PLoS Pathog 2010; 6: e1000770.
35. Good-Jacobson KL & Tarlinton DM. Multiple routes to B-cell memory. Int Immunol 2012; 24: 403-408.