Proportionate dwarfism in mice lacking heterochromatin protein 1 binding protein 3 (HP1BP3) is associated with alterations in the endocrine IGF-1 pathway

Endocrinology (United States)

Volumn 156, Issue 12, 2015, Pages 4558-4570

  Garfinkel, Benjamin P ^a   Arad, Shiri ^a   Le, Phuong T ^b   Bustin, Michael ^c   Rosen, Clifford J ^b   Gabet, Yankel ^d   Orly, Joseph ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b Maine Medical Center Research Institute   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; HETEROCHROMATIN PROTEIN 1 BINDING PROTEIN 3; HISTONE H1; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; STAT5 PROTEIN; TUBULIN; UNCLASSIFIED DRUG; HP1BP3 PROTEIN, MOUSE; MESSENGER RNA; NUCLEAR PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY GROWTH; BODY HEIGHT; BONE DEFECT; BONE DEVELOPMENT; BONE MARROW; BONE MARROW CELL; BONE MASS; BONE STRUCTURE; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; CORTICAL BONE; DWARFISM; FEMALE; HORMONAL REGULATION; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; ORGAN WEIGHT; OSTEOBLAST; OSTEOCLAST; POSTNATAL GROWTH; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLEEN CELL; TRABECULAR BONE; TRANSCRIPTION REGULATION; WEIGHT REDUCTION; ANIMAL; BODY SIZE; BODY WEIGHT; BONE; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; LIVER; METABOLISM; RADIOGRAPHY; UPREGULATION;

ANIMALS; BODY SIZE; BODY WEIGHT; BONE AND BONES; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELLS, CULTURED; DWARFISM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR I; LIVER; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; OSTEOBLASTS; OSTEOCLASTS; RECEPTOR, IGF TYPE 1; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION; X-RAY MICROTOMOGRAPHY;

EID: 84948174493     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2015-1668     Document Type: Article

References (57)

1. Garfinkel BP, Melamed-Book N, Anuka E, Bustin M, Orly J. HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth. Nucleic Acids Res. 2015;43(4):2074-2090.
2. Clarke B. Normal bone anatomy and physiology. Clin J Am Soc Nephrol. 2008;3(suppl 3):S131-S139.
3. Heaney RP, Abrams S, Dawson-Hughes B, et al. Peak bone mass. Osteoporos Int. 2000;11(12):985-1009.
4. Libanati C, Baylink DJ, Lois-Wenzel E, Srinvasan N, Mohan S. Studies on the potential mediators of skeletal changes occurring during puberty in girls. J Clin Endocrinol Metab. 1999;84(8):2807-2814.
5. Niu T, Rosen CJ. The insulin-like growth factor-I gene and osteoporosis: a critical appraisal. Gene. 2005;361:38-56.
6. Rosen CJ, Bouxsein ML. Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol. 2006;2(1):35-43.
7. Ralston SH, de Crombrugghe B. Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev. 2006;20(18):2492-2506.
8. Richards JB, Zheng HF, Spector TD. Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet. 2012;13(8):576-588.
9. Hernandez-de Sosa N, Athanasiadis G, Malouf J, et al. Heritability of bone mineral density in a multivariate family-based study. Calcif Tissue Int. 2014;94(6):590-596.
10. Rosen CJ, Donahue LR. Insulin-like growth factors and bone: the osteoporosis connection revisited. Proc Soc Exp Biol Med. 1998; 219(1):1-7.
11. Kawai M, Rosen CJ. Insulin-like growth factor-I and bone: lessons from mice and men. Pediatr Nephrol. 2009;24(7):1277-1285.
12. Ahmed SF, Farquharson C. The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins. J Endocrinol. 2010;206:249-259.
13. Giustina A, Mazziotti G, Canalis E. Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev. 2008;29(5):535-559.
14. Venken K, Schuit F, Van Lommel L, et al. Growth without growth hormone receptor: estradiol is a major growth hormone-independent regulator of hepatic IGF-I synthesis. J Bone Miner Res. 2005; 20(12):2138-2149.
15. Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 1993;75(1): 59-72.
16. Mohan S, Baylink DJ. Impaired skeletal growth in mice with haploinsufficiency of IGF-I: genetic evidence that differences in IGF-I expression could contribute to peak bone mineral density differences. J Endocrinol. 2005;185(3):415-420.
17. Xian L, Wu X, Pang L, et al. Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Nat Med. 2012; 18(7):1095-1101.
18. Yakar S, Rosen CJ, Beamer WG, et al. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest. 2002; 110(6):771-781.
19. Reed BY, Zerwekh JE, Sakhaee K, Breslau NA, Gottschalk F, Pak CY. Serum IGF 1 is low and correlated with osteoblastic surface in idiopathic osteoporosis. J Bone Miner Res. 1995;10(8):1218-1224.
20. Saggese G, Baroncelli GI, Bertelloni S, Cinquanta L, Di Nero G. Effects of long-term treatment with growth hormone on bone and mineral metabolism in children with growth hormone deficiency. J Pediatr. 1993;122(1):37-45.
21. Woods KA, Camacho-Hübner C, Savage MO, Clark AJ. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med. 1996;335(18):1363-1367.
22. Daza DO, Sundström G, Bergqvist CA, Duan C, Larhammar D. Evolution of the insulin-like growth factor binding protein (IGFBP) family. Endocrinology. 2011;152(6):2278-2289.
23. Russo VC, Azar WJ, Yau SW, Sabin MA, Werther GA. IGFBP-2: the dark horse in metabolism and cancer. Cytokine Growth Factor Rev. 2015;26(3):329-346.
24. Holly J, Perks C. The role of insulin-like growth factor binding proteins. Neuroendocrinology. 2006;83(3-4):154-160.
25. Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev. 2002;23(6):824-854.
26. Yau SW, Azar WJ, Sabin MA, Werther GA, Russo VC. IGFBP-2- taking the lead in growth, metabolism and cancer. J Cell Commun Signal. 2015;1-18.
27. Govoni KE, Baylink DJ, Mohan S. The multi-functional role of insulin-like growth factor binding proteins in bone. Pediatr Nephrol. 2005;20(3):261-268.
28. Bagi CM, Hanson N, Andresen C, et al. The use of micro-CT to evaluate cortical bone geometry and strength in nude rats: correlation with mechanical testing, pQCT and DXA. Bone. 2006;38(1): 136-144.
29. Hui SL, Slemenda CW, Johnston CC Jr. The contribution of bone loss to postmenopausal osteoporosis. Osteoporos Int. 1990;1(1): 30-34.
30. Davey HW, Xie T, McLachlan MJ, Wilkins RJ, Waxman DJ, Grattan DR. STAT5b is required for GH-induced liver IGF-I gene expression. Endocrinology. 2001;142(9):3836-3841.
31. Ohlsson C, Mohan S, Sjögren K, et al. The role of liver-derived insulin-like growth factor-I. Endocr Rev. 2009;30(5):494-535.
32. Landau D, Chin E, Bondy C, et al. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Endocrinology. 1995;136(5):1835-1842.
33. Baxter-Jones AD, Faulkner RA, Forwood MR, Mirwald RL, Bailey DA. Bone mineral accrual from 8 to 30 years of age: an estimation of peak bone mass. J Bone Miner Res. 2011;26(8):1729-1739.
34. Recker RR, Davies KM, Hinders SM, Heaney RP, Stegman MR, Kimmel DB. Bone gain in young adult women. JAMA. 1992; 268(17):2403-2408.
35. Yakar S, Liu JL, Stannard B, et al. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA. 1999;96(13):7324-7329.
36. Yakar S, Canalis E, Sun H, et al. Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions. J Bone Miner Res. 2009;24(8):1481-1492.
37. Ben Lagha N, Seurin D, Le Bouc Y, et al. Insulin-like growth factor binding protein (IGFBP-1) involvement in intrauterine growth retardation: study on IGFBP-1 overexpressing transgenic mice. Endocrinology. 2006;147(10):4730-4737.
38. Crossey PA, Pillai CC, Miell JP. Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice. J Clin Invest. 2002;110(3):411-418.
39. Gay E, Seurin D, Babajko S, Doublier S, Cazillis M, Binoux M. Liver-specific expression of human insulin-like growth factor binding protein-1 in transgenic mice: repercussions on reproduction, ante- and perinatal mortality and postnatal growth 1. Endocrinology. 1997;138(7):2937-2947.
40. Rajkumar K, Barron D, Lewitt MS, Murphy LJ. Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice. Endocrinology. 1995;136(9):4029-4034.
41. Hoeflich A, Wu M, Mohan S, et al. Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain. Endocrinology. 1999;140(12):5488-5496.
42. Wood TL, Rogler LE, Czick ME, Schuller AG, Pintar JE. Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene. Mol Endocrinol. 2000;14(9):1472-1482.
43. Boyne MS, Thame M, Bennett FI, Osmond C, Miell JP, Forrester TE. The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study. J Clin Endocrinol Metab. 2003;88(4):1687-1691.
44. Verhaeghe J, Van Herck E, Billen J, Moerman P, Van Assche FA, Giudice LC. Regulation of insulin-like growth factor-I and insulinlike growth factor binding protein-1 concentrations in preterm fetuses. Am J Obstet Gynecol. 2003;188(2):485-491.
45. Amin S, Riggs BL, Atkinson EJ, Oberg AL, Melton LJ 3rd, Khosla S. A potentially deleterious role of IGFBP-2 on bone density in aging men and women. J Bone Miner Res. 2004;19(7):1075-1083.
46. Amin S, Riggs BL, Melton LJ 3rd, Achenbach SJ, Atkinson EJ, Khosla S. High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. J Bone Miner Res. 2007;22(6):799-807.
47. Sims NA, Clément-Lacroix P, Da Ponte F, et al. Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J Clin Invest. 2000;106(9):1095-1103.
48. Wajnrajch MP, Gertner JM, Harbison MD, Chua SC Jr, Leibel RL. Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Nat Genet. 1996;12(1):88-90.
49. Zhou Y, Xu BC, Maheshwari HG, et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci USA. 1997;94:13215-13220.
50. Lupu F, Terwilliger JD, Lee K, Segre GV, Efstratiadis A. Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol. 2001;229:141-162.
51. Xing W, Govoni KE, Donahue LR, et al. Genetic evidence that thyroid hormone is indispensable for prepubertal insulin-like growth factor-I expression and bone acquisition in mice. J Bone Miner Res. 2012;27(5):1067-1079.
52. Elis S, Courtland HW, Wu Y, et al. Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1. J Bone Miner Res. 2010;25(6): 1257-1266.
53. DeMambro VE, Clemmons DR, Horton LG, et al. Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice. Endocrinology. 2008;149(5):2051-2061.
54. Callewaert F, Sinnesael M, Gielen E, Boonen S, Vanderschueren D. Skeletal sexual dimorphism: relative contribution of sex steroids, GH-IGF1, and mechanical loading. J Endocrinol. 2010;207:127-134.
55. Vidal O, Lindberg MK, Hollberg K, et al. Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci USA. 2000;97(10):5474-5479.
56. Windahl SH, Vidal O, Andersson G, Gustafsson JA, Ohlsson C. Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERα(-/-) mice. J Clin Invest. 1999; 104(7):895-901.
57. Venken K, Movérare-Skrtic S, Kopchick JJ, et al. Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty. J Bone Miner Res. 2007;22(1):72-82.