AXIN2 polymorphisms, the β-catenin destruction complex expression profile and breast cancer susceptibility

Asian Pacific Journal of Cancer Prevention

Volumn 16, Issue 16, 2015, Pages 7277-7284

  Aristizabal Pachon, Andres Felipe ^a   Carvalho, Thais Inacio ^b   Carrara, Helio Humberto ^a   Andrade, Jurandyr ^a   Takahashi, Catarina Satie ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Hospital Santa Casa of Ribeirao Preto   (Brazil)

Author keywords

AXIN2; Beta; Breast cancer; Catenin destruction complex; Gene expression; RFLP PCR; RT qPCR; SNP

Indexed keywords

AXIN; AXIN2 PROTEIN, HUMAN; BETA CATENIN; TUMOR MARKER; WNT PROTEIN;

BREAST NEOPLASMS; CANCER STAGING; CARCINOMA, DUCTAL, BREAST; CASE CONTROL STUDY; COMPARATIVE STUDY; ENZYME IMMUNOASSAY; FEMALE; FOLLOW UP; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN; METABOLISM; MIDDLE AGED; PATHOLOGY; POLYMERASE CHAIN REACTION; PROGNOSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TUMOR INVASION;

AXIN PROTEIN; BETA CATENIN; BIOMARKERS, TUMOR; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CASE-CONTROL STUDIES; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOENZYME TECHNIQUES; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROGNOSIS; WNT PROTEINS;

EID: 84948170956     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2015.16.16.7277     Document Type: Article

References (48)

1. Alanazi MS, Parine NR, Shaik JP, et al (2013). Association of single nucleotide polymorphisms in Wnt signaling pathway genes with breast cancer in Saudi patients. PLoS One, 8, 59555.
2. Brito C, Portela MC, Vasconcellos MT (2009). Survival of breast cancer women in the state of Rio de Janeiro, Southeastern Brazil. Rev Saude Publica, 43, 481-9.
3. Castiglia D, Bernardini S, Alvino E, et al (2008). Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. Genes Chromosomes Cancer, 47, 614-24.
4. Clevers H, Nusse R (2012). Wnt/beta-catenin signaling and disease. Cell, 149, 1192-205.
5. Chapman A, Durand J, Ouadi L, et al (2011). Identification of genetic alterations of AXIN2 gene in adrenocortical tumors. J Clin Endocrinol Metab, 96, 1477-81.
6. Dong X, Seelan RS, Qian C, et al (2001). Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene. Cytogenet Cell Genet, 93, 26-8.
7. Gabrovska PN, Smith RA, Tiang T, et al (2012). Development of an eight gene expression profile implicating human breast tumours of all grade. Mol Biol Rep, 39, 3879-92.
8. Gunes EG, Pinarbasi E, Pinarbasi H, et al (2009). Strong association between lung cancer and the AXIN2 polymorphism. Mol Med Report, 2, 1029-35.
9. Han Y, Zhou L, Ma L, et al (2014). The axis inhibition protein 2 polymorphisms and non-syndromic orofacial clefts susceptibility in a Chinese Han population. J Oral Pathol Med, 43, 554-60.
10. Herbst A, Jurinovic V, Krebs S, et al (2014). Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling. BMC Genomics, 15, 74.
11. Howe LR, Brown AM (2004). Wnt signaling and breast cancer. Cancer Biol Ther, 3, 36-41.
12. Jho EH, Zhang T, Domon C, et al (2002). Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol, 22, 1172-83.
13. Jonsson M, Borg A, Nilbert M, et al (2000). Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer. Eur J Cancer, 36, 242-8.
14. Kanzaki H, Ouchida M, Hanafusa H, et al (2006). Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population. Int J Mol Med, 18, 279-84.
15. Kao SH, Wang WL, Chen CY, et al (2014). GSK3beta controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene, 33, 3172-82.
16. Khalil S, Tan GA, Giri DD, et al (2012). Activation status of Wnt/ss-catenin signaling in normal and neoplastic breast tissues: relationship to HER2/neu expression in human and mouse. PLoS One, 7, 33421.
17. Klarmann GJ, Decker A, Farrar WL (2008). Epigenetic gene silencing in the Wnt pathway in breast cancer. Epigenetics, 3, 59-63.
18. Lamb R, Ablett MP, Spence K, et al (2013). Wnt pathway activity in breast cancer sub-types and stem-like cells. PLoS One, 8, 67811.
19. Lammi L, Arte S, Somer M, et al (2004). Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet, 74, 1043-50.
20. Lehmann BD, Bauer JA, Chen X, et al (2011). Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest, 121, 2750-67.
21. Letra A, Menezes R, Granjeiro JM, et al (2009). AXIN2 and CDH1 polymorphisms, tooth agenesis, and oral clefts. Birth Defects Res A Clin Mol Teratol, 85, 169-73.
22. Li J, Sheng C, Li W, et al (2014). Protein phosphatase-2A is downregulated in patients within clear cell renal cell carcinoma. Int J Clin Exp Pathol, 7, 1147-53.
23. Lustig B, Jerchow B, Sachs M, et al (2002). Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol, 22, 1184-93.
24. MacDonald BT, Tamai K, He X (2009). Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell, 17, 9-26.
25. Moon RT, Kohn AD, De Ferrari GV, et al (2004). WNT and betacatenin signalling: diseases and therapies. Nat Rev Genet, 5, 691-701.
26. Mosimann C, Hausmann G, Basler K (2009). Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol, 10, 276-86.
27. Mostowska A, Biedziak B, Jagodzinski PP (2006). Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis. J Hum Genet, 51, 262-6.
28. Mostowska A, Pawlik P, Sajdak S, et al (2014). An analysis of polymorphisms within the Wnt signaling pathway in relation to ovarian cancer risk in a Polish population. Mol Diagn Ther, 18, 85-91.
29. Nelson S, Nathke IS (2013). Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance. J Cell Sci, 126, 873-7.
30. Pedace L, Castiglia D, De Simone P, et al (2011). AXIN2 germline mutations are rare in familial melanoma. Genes Chromosomes Cancer, 50, 370-3.
31. Pinarbasi E, Gunes EG, Pinarbasi H, et al (2011). AXIN2 polymorphism and its association with prostate cancer in a Turkish population. Med Oncol, 28, 1373-8.
32. Polakis P (2007). The many ways of Wnt in cancer. Curr Opin Genet Dev, 17, 45-51.
33. Rennoll SA, Konsavage WM, Jr., Yochum GS (2014). Nuclear AXIN2 represses MYC gene expression. Biochem Biophys Res Commun, 443, 217-22.
34. Rubinfeld B, Robbins P, El-Gamil M, et al (1997). Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science, 275, 1790-2.
35. Sablina AA, Chen W, Arroyo JD, et al (2007). The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell, 129, 969-82.
36. Salahshor S, Woodgett JR (2005). The links between axin and carcinogenesis. J Clin Pathol, 58, 225-36.
37. Santos RA, Teixeira AC, Mayorano MB, et al (2010). Basal levels of DNA damage detected by micronuclei and comet assays in untreated breast cancer patients and healthy women. Clin Exp Med, 10, 87-92.
38. Schmittgen TD, Livak KJ (2008). Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc, 3, 1101-8.
39. Srivastava M, Khurana P, Sugadev R (2012). Lung cancer signature biomarkers: tissue specific semantic similarity based clustering of digital differential display (DDD) data. BMC Res Notes, 5, 617.
40. Stamos JL, Weis WI (2013). The beta-catenin destruction complex. Cold Spring Harb Perspect Biol, 5, 7898.
41. Suraweera N, Robinson J, Volikos E, et al (2006). Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. Int J Cancer, 119, 1837-42.
42. Teixeira AC, Dos Santos RA, Poersch A, et al (2009). DNA repair in Etoposide-induced DNA damage in lymphocytes of breast cancer patients and healthy women. Int J Clin Exp Med, 2, 280-8.
43. Tudoran O, Virtic O, Balacescu L, et al (2014). Differential peripheral blood gene expression profile based on her2 expression on primary tumors of breast cancer patients. PLoS One, 9, 102764.
44. Wang X, Goode EL, Fredericksen ZS, et al (2008). Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. Cancer Epidemiol Biomarkers Prev, 17, 2101-8.
45. Westermarck J, Hahn WC (2008). Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol Med, 14, 152-60.
46. Willert K, Shibamoto S, Nusse R (1999). Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev, 13, 1768-73.
47. Xie HL, Chen ZC, He CM, et al (2003). [Cloning and expression analysis of lung carcinoma related gene HLCDG1]. Ai Zheng, 22, 1014-7.
48. Yook JI, Li XY, Ota I, et al (2006). A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol, 8, 1398-406.