메뉴 건너뛰기




Volumn 15, Issue 11, 2015, Pages 1305-1314

Emerging therapeutic approaches in renal cell carcinoma

Author keywords

anti programmed death 1 therapies; immunotherapy; ipilimumab; nivolumab; renal cell carcinoma; targeted therapy

Indexed keywords

ALPHA INTERFERON; AXITINIB; BEVACIZUMAB; CABOZANTINIB; CXCL9 CHEMOKINE; EVEROLIMUS; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN G4; INTERLEUKIN 2; LENVATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MPDL 3280A; NIVOLUMAB; PAZOPANIB; PLACEBO; PROGRAMMED DEATH 1 LIGAND 1; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TIVOZANIB; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

EID: 84948107042     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.2015.1090315     Document Type: Review
Times cited : (13)

References (64)
  • 2
    • 28844484134 scopus 로고    scopus 로고
    • Renal-cell carcinoma
    • Cohen HT, McGovern FJ. Renal-cell carcinoma. N Engl J Med 2005; 353 (23): 2477-90
    • (2005) N Engl J Med , vol.353 , Issue.23 , pp. 2477-2490
    • Cohen, H.T.1    McGovern, F.J.2
  • 3
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe G, Fisher RI, Rosenberg SA, et al. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 1995; 13 (3): 688-96
    • (1995) J Clin Oncol , vol.13 , Issue.3 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3
  • 4
    • 48249117436 scopus 로고    scopus 로고
    • High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: A retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006
    • Klapper JA, Downey SG, Smith FO, et al. High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006. Cancer 2008; 113 (2): 293-301
    • (2008) Cancer , vol.113 , Issue.2 , pp. 293-301
    • Klapper, J.A.1    Downey, S.G.2    Smith, F.O.3
  • 5
    • 84879689379 scopus 로고    scopus 로고
    • Prognostic factors for survival in 1059 patients treated with sunitinib for metastatic renal cell carcinoma
    • Motzer RJ, Escudier B, Bukowski R, et al. Prognostic factors for survival in 1059 patients treated with sunitinib for metastatic renal cell carcinoma. Br J Cancer 2013; 108 (12): 2470-7
    • (2013) Br J Cancer , vol.108 , Issue.12 , pp. 2470-2477
    • Motzer, R.J.1    Escudier, B.2    Bukowski, R.3
  • 6
    • 77953757715 scopus 로고    scopus 로고
    • Plethora of agents, plethora of targets, plethora of side effects in metastatic renal cell carcinoma
    • Schmidinger M, Bellmunt J. Plethora of agents, plethora of targets, plethora of side effects in metastatic renal cell carcinoma. Cancer Treat Rev 2010; 36 (5): 416-24
    • (2010) Cancer Treat Rev , vol.36 , Issue.5 , pp. 416-424
    • Schmidinger, M.1    Bellmunt, J.2
  • 7
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27 (22): 3584-90
    • (2009) J Clin Oncol , vol.27 , Issue.22 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 8
    • 84875690904 scopus 로고    scopus 로고
    • A randomised, double-blind Phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: Final overall survival results and safety update
    • Sternberg CN, Hawkins RE, Wagstaff J, et al. A randomised, double-blind Phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: final overall survival results and safety update. Eur J Cancer 2013; 49 (6): 1287-96
    • (2013) Eur J Cancer , vol.49 , Issue.6 , pp. 1287-1296
    • Sternberg, C.N.1    Hawkins, R.E.2    Wagstaff, J.3
  • 9
    • 84882781441 scopus 로고    scopus 로고
    • Pazopanib versus sunitinib in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Cella D, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 2013; 369 (8): 722-31
    • (2013) N Engl J Med , vol.369 , Issue.8 , pp. 722-731
    • Motzer, R.J.1    Hutson, T.E.2    Cella, D.3
  • 10
    • 84876974877 scopus 로고    scopus 로고
    • Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised Phase III trial
    • Motzer RJ, Escudier B, Tomczak P, et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised Phase III trial. Lancet Oncol 2013; 14 (6): 552-62
    • (2013) Lancet Oncol , vol.14 , Issue.6 , pp. 552-562
    • Motzer, R.J.1    Escudier, B.2    Tomczak, P.3
  • 11
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial
    • Rini BI, Escudier B, Tomczak P, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 2011; 378 (9807): 1931-9
    • (2011) Lancet , vol.378 , Issue.9807 , pp. 1931-1939
    • Rini, B.I.1    Escudier, B.2    Tomczak, P.3
  • 12
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009; 27 (20): 3312-18
    • (2009) J Clin Oncol , vol.27 , Issue.20 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 13
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356 (2): 125-34
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 14
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356 (22): 2271-81
    • (2007) N Engl J Med , vol.356 , Issue.22 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 15
    • 77956227464 scopus 로고    scopus 로고
    • Phase 3 trial of everolimus for metastatic renal cell carcinoma: Final results and analysis of prognostic factors
    • Motzer RJ, Escudier B, Oudard S, et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 2010; 116 (18): 4256-65
    • (2010) Cancer , vol.116 , Issue.18 , pp. 4256-4265
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 16
    • 84860355062 scopus 로고    scopus 로고
    • Randomized phase II trial of sunitinib on an intermittent versus continuous dosing schedule as first-line therapy for advanced renal cell carcinoma
    • Motzer RJ, Hutson TE, Olsen MR, et al. Randomized phase II trial of sunitinib on an intermittent versus continuous dosing schedule as first-line therapy for advanced renal cell carcinoma. J Clin Oncol 2012; 30 (12): 1371-7
    • (2012) J Clin Oncol , vol.30 , Issue.12 , pp. 1371-1377
    • Motzer, R.J.1    Hutson, T.E.2    Olsen, M.R.3
  • 17
    • 84893831040 scopus 로고    scopus 로고
    • Clinical outcomes for patients with metastatic renal cell carcinoma treated with alternative sunitinib schedules
    • Atkinson BJ, Kalra S, Wang X, et al. Clinical outcomes for patients with metastatic renal cell carcinoma treated with alternative sunitinib schedules. J Urol 2014; 191 (3): 611-18
    • (2014) J Urol , vol.191 , Issue.3 , pp. 611-618
    • Atkinson, B.J.1    Kalra, S.2    Wang, X.3
  • 18
    • 84897097674 scopus 로고    scopus 로고
    • A 2 weeks on and 1 week off schedule of sunitinib is associated with decreased toxicity in metastatic renal cell carcinoma
    • Najjar YG, Mittal K, Elson P, et al. A 2 weeks on and 1 week off schedule of sunitinib is associated with decreased toxicity in metastatic renal cell carcinoma. Eur J Cancer 2014; 50 (6): 1084-9
    • (2014) Eur J Cancer , vol.50 , Issue.6 , pp. 1084-1089
    • Najjar, Y.G.1    Mittal, K.2    Elson, P.3
  • 19
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • Faivre S, Delbaldo C, Vera K, et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 2006; 24 (1): 25-35
    • (2006) J Clin Oncol , vol.24 , Issue.1 , pp. 25-35
    • Faivre, S.1    Delbaldo, C.2    Vera, K.3
  • 21
    • 84937682724 scopus 로고    scopus 로고
    • Axitinib dose titration: Analyses of exposure, blood pressure and clinical response from a randomized phase II study in metastatic renal cell carcinoma
    • Rini BI, Melichar B, Fishman MN, et al. Axitinib dose titration: analyses of exposure, blood pressure and clinical response from a randomized phase II study in metastatic renal cell carcinoma. Ann Oncol 2015; 26 (7): 1372-7
    • (2015) Ann Oncol , vol.26 , Issue.7 , pp. 1372-1377
    • Rini, B.I.1    Melichar, B.2    Fishman, M.N.3
  • 22
    • 84939180292 scopus 로고    scopus 로고
    • Overall survival analysis from a randomized phase II study of axitinib with or without dose titration for first-line metastatic renal cell carcinoma
    • Rini BI, Melichar BTY. Overall survival analysis from a randomized phase II study of axitinib with or without dose titration for first-line metastatic renal cell carcinoma. J Clin Oncol 2015; 33: suppl; abstr 4545
    • (2015) J Clin Oncol , vol.33
    • Rini, B.I.1    Bty, M.2
  • 23
    • 63049093371 scopus 로고    scopus 로고
    • Phase i trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma
    • Feldman DR, Baum MS, Ginsberg MS, et al. Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27 (9): 1432-9
    • (2009) J Clin Oncol , vol.27 , Issue.9 , pp. 1432-1439
    • Feldman, D.R.1    Baum, M.S.2    Ginsberg, M.S.3
  • 24
    • 70349673595 scopus 로고    scopus 로고
    • A phase i study of sunitinib plus bevacizumab in advanced solid tumors
    • Rini BI, Garcia JA, Cooney MM, et al. A phase I study of sunitinib plus bevacizumab in advanced solid tumors. Clin Cancer Res 2009; 15 (19): 6277-83
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6277-6283
    • Rini, B.I.1    Garcia, J.A.2    Cooney, M.M.3
  • 25
    • 55349098735 scopus 로고    scopus 로고
    • Updated results of phase i trial of sorafenib and bevacizumab in patient with metastatic renal cell cancer
    • Sosman J, Atkins MFK, McDermott D, et al. Updated results of phase I trial of sorafenib and bevacizumab in patient with metastatic renal cell cancer. J Clin Oncol 2008; 26 (Suppl): abstract 5011
    • (2008) J Clin Oncol , vol.26
    • Sosman, J.1    Atkins, M.F.K.2    McDermott, D.3
  • 26
    • 84895782404 scopus 로고    scopus 로고
    • The BeST Trial (ECOG 2804): A randomized phase II study of VEGF, RAF kinase, and MTOR combination targeted therapy with bevacizumab, sorafenib, and temsirolimus in advanced renal cell carcinoma
    • McDermott D, Pins MMJ, Flaherty K, et al. The BeST Trial (ECOG 2804): a randomized phase II study of VEGF, RAF kinase, and MTOR combination targeted therapy with bevacizumab, sorafenib, and temsirolimus in advanced renal cell carcinoma. J Clin Oncol 2013; 31 (Suppl 6; abstract 345
    • (2013) J Clin Oncol , vol.31
    • McDermott, D.1    Pins, M.M.J.2    Flaherty, K.3
  • 27
    • 84899630091 scopus 로고    scopus 로고
    • Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial
    • Rini BI, Bellmunt J, Clancy J, et al. Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial. J Clin Oncol 2014; 32 (8): 752-9
    • (2014) J Clin Oncol , vol.32 , Issue.8 , pp. 752-759
    • Rini, B.I.1    Bellmunt, J.2    Clancy, J.3
  • 28
    • 84874550573 scopus 로고    scopus 로고
    • Randomized phase II study of first-line everolimus (EVE) + bevacizumab (BEV) versus interferonalfa-2a(IFN) + BEV inpatients (pts) with metastatic renal cell carcinoma (mRCC): RECORD-2
    • Meeting abstracts
    • Ravaud A, Anak OBC. Randomized phase II study of first-line everolimus (EVE) + bevacizumab (BEV) versus interferonalfa-2a(IFN) + BEV inpatients (pts) with metastatic renal cell carcinoma (mRCC): RECORD-2. Ann Oncol 2012; 23: 7830; Meeting abstracts
    • (2012) Ann Oncol , vol.23 , pp. 7830
    • Ravaud, A.1    Obc, A.2
  • 29
    • 84939478663 scopus 로고    scopus 로고
    • Randomized phase II, three-arm trial of lenvatinib (LEN), everolimus (EVE), and LEN + EVE in patients (pts) with metastatic renal cell carcinoma (mRCC)
    • Motzer R, Glen HHT, Michaelson D, et al. Randomized phase II, three-arm trial of lenvatinib (LEN), everolimus (EVE), and LEN + EVE in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2015; 33: suppl; abstr 4506
    • (2015) J Clin Oncol , vol.33
    • Motzer, R.1    Glen, H.H.T.2    Michaelson, D.3
  • 30
    • 81255128983 scopus 로고    scopus 로고
    • Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1,-2, and-3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors
    • Eskens FA, de Jonge MJ, Bhargava P, et al. Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1,-2, and-3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors. Clin Cancer Res 2011; 17 (22): 7156-63
    • (2011) Clin Cancer Res , vol.17 , Issue.22 , pp. 7156-7163
    • Eskens, F.A.1    De Jonge, M.J.2    Bhargava, P.3
  • 31
    • 84891713447 scopus 로고    scopus 로고
    • Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: Results from a phase III trial
    • Motzer RJ, Nosov D, Eisen T, et al. Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: results from a phase III trial. J Clin Oncol 2013; 31 (30): 3791-9
    • (2013) J Clin Oncol , vol.31 , Issue.30 , pp. 3791-3799
    • Motzer, R.J.1    Nosov, D.2    Eisen, T.3
  • 32
    • 84879601057 scopus 로고    scopus 로고
    • Cabozantinib as a novel therapy for renal cell carcinoma
    • Vaishampayan U. Cabozantinib as a novel therapy for renal cell carcinoma. Curr Oncol Rep 2013; 15 (2): 76-82
    • (2013) Curr Oncol Rep , vol.15 , Issue.2 , pp. 76-82
    • Vaishampayan, U.1
  • 33
    • 84905175125 scopus 로고    scopus 로고
    • A phase i study of cabozantinib (XL184) in patients with renal cell cancer
    • Choueiri TK, Pal SK, McDermott DF, et al. A phase I study of cabozantinib (XL184) in patients with renal cell cancer. Ann Oncol 2014; 25 (8): 1603-8
    • (2014) Ann Oncol , vol.25 , Issue.8 , pp. 1603-1608
    • Choueiri, T.K.1    Pal, S.K.2    McDermott, D.F.3
  • 36
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000; 192 (7): 1027-34
    • (2000) J Exp Med , vol.192 , Issue.7 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 37
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 2012; 24 (2): 207-12
    • (2012) Curr Opin Immunol , vol.24 , Issue.2 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 38
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12 (4): 252-64
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 39
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002; 8 (8): 793-800
    • (2002) Nat Med , vol.8 , Issue.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 40
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 2008; 8 (6): 467-77
    • (2008) Nat Rev Immunol , vol.8 , Issue.6 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 41
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M, Johnson LA, Heemskerk B, et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009; 114 (8): 1537-44
    • (2009) Blood , vol.114 , Issue.8 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3
  • 42
    • 84880706331 scopus 로고    scopus 로고
    • Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase i trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up
    • Drake CG, Sznol M, et al. Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up. Clin Oncol 2013; suppl; abstr 4514
    • (2013) Clin Oncol
    • Drake, C.G.1    Sznol, M.2
  • 43
    • 84929572937 scopus 로고    scopus 로고
    • Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial
    • Motzer RJ, Rini BI, McDermott DF, et al. Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial. J Clin Oncol 2015; 33 (13): 1430-7
    • (2015) J Clin Oncol , vol.33 , Issue.13 , pp. 1430-1437
    • Motzer, R.J.1    Rini, B.I.2    McDermott, D.F.3
  • 44
    • 84944162017 scopus 로고    scopus 로고
    • Updated survival results from a randomized, dose-ranging Phase II study of nivolumab (NIVO) in metastatic renal cell carcinoma (mRCC)
    • Plimack ER, Rini BI. Updated survival results from a randomized, dose-ranging Phase II study of nivolumab (NIVO) in metastatic renal cell carcinoma (mRCC). J Clin Oncol 2015; 33: suppl; abstr 4553
    • (2015) J Clin Oncol , vol.33
    • Plimack, E.R.1    Rini, B.I.2
  • 46
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012; 366 (26): 2455-65
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 47
    • 84880264878 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC)
    • Cho DC, Sznol M. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2013; suppl; abstr 4505
    • (2013) J Clin Oncol
    • Cho, D.C.1    Sznol, M.2
  • 48
    • 84914176528 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC)
    • Amin A, Infante JR, Ernstoff MS, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2014; 32: 5s-suppl; abstr 5010
    • (2014) J Clin Oncol , vol.32 , Issue.5
    • Amin, A.1    Infante, J.R.2    Ernstoff, M.S.3
  • 50
    • 84940487291 scopus 로고    scopus 로고
    • Immune correlates and long term follow up of a phase Ia study of MPDL3280A, an engineered PD-L1 antibody, in patients with metastatic renal cell carcinoma (mRCC)
    • Madrid 2014
    • McDermott DF, Sosman JA. Immune correlates and long term follow up of a phase Ia study of MPDL3280A, an engineered PD-L1 antibody, in patients with metastatic renal cell carcinoma (mRCC). Ann Oncol Proceedings of the European Society of Medical Oncology Meeting 2014, Madrid, 2014,. Abstract 809O
    • (2014) Ann Oncol Proceedings of the European Society of Medical Oncology Meeting
    • McDermott, D.F.1    Sosman, J.A.2
  • 53
    • 0035056017 scopus 로고    scopus 로고
    • CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
    • Chambers CA, Kuhns MS, Egen JG, et al. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 2001; 19: 565-94
    • (2001) Annu Rev Immunol , vol.19 , pp. 565-594
    • Chambers, C.A.1    Kuhns, M.S.2    Egen, J.G.3
  • 54
    • 37349072460 scopus 로고    scopus 로고
    • Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
    • Yang JC, Hughes M, Kammula U, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother 2007; 30 (8): 825-30
    • (2007) J Immunother , vol.30 , Issue.8 , pp. 825-830
    • Yang, J.C.1    Hughes, M.2    Kammula, U.3
  • 55
    • 84939150439 scopus 로고    scopus 로고
    • Expanded cohort results from CheckMate 016: A Phase 1 study of nivolumab in combination with ipilimumab in the metastatic renal cell carcinoma (mRCC)
    • Hammers HJ, Infante JR. Expanded cohort results from CheckMate 016: A Phase 1 study of nivolumab in combination with ipilimumab in the metastatic renal cell carcinoma (mRCC). J Clinc Oncol 2015; 33: suppl; abstr 4516
    • (2015) J Clinc Oncol , vol.33
    • Hammers, H.J.1    Infante, J.R.2
  • 57
    • 84921742040 scopus 로고    scopus 로고
    • Immunomodulatory activity of nivolumab in previously treated and untreated metastatic renal cell carcinoma (mRCC): Biomarker-based results from a randomized clinical trial
    • Choueiri TK, Escudier BJ. Immunomodulatory activity of nivolumab in previously treated and untreated metastatic renal cell carcinoma (mRCC): Biomarker-based results from a randomized clinical trial. J Clin Oncol 2014; 32: 5s-suppl; abstr 5012
    • (2014) J Clin Oncol , vol.32 , Issue.5
    • Choueiri, T.K.1    Escudier, B.J.2
  • 58
    • 84936821509 scopus 로고    scopus 로고
    • Immunomodulatory activity of nivolumab in metastatic renal cell carcinoma (mRCC): Association of biomarkers with clinical outcomes
    • Choueiri TK, Escudier BJ. Immunomodulatory activity of nivolumab in metastatic renal cell carcinoma (mRCC): Association of biomarkers with clinical outcomes. J Clin Oncol 2015; 33: suppl; abstr 4500
    • (2015) J Clin Oncol , vol.33
    • Choueiri, T.K.1    Escudier, B.J.2
  • 59
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • Xin H, Zhang C, Herrmann A, et al. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res 2009; 69 (6): 2506-13
    • (2009) Cancer Res , vol.69 , Issue.6 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3
  • 60
    • 84890632231 scopus 로고    scopus 로고
    • The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer
    • Sharpe K, Stewart GD, Mackay A, et al. The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer. Clin Cancer Res 2013; 19 (24): 6924-34
    • (2013) Clin Cancer Res , vol.19 , Issue.24 , pp. 6924-6934
    • Sharpe, K.1    Stewart, G.D.2    MacKay, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.