-
2
-
-
28844484134
-
Renal-cell carcinoma
-
Cohen HT, McGovern FJ. Renal-cell carcinoma. N Engl J Med 2005; 353 (23): 2477-90
-
(2005)
N Engl J Med
, vol.353
, Issue.23
, pp. 2477-2490
-
-
Cohen, H.T.1
McGovern, F.J.2
-
3
-
-
0028929682
-
Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
-
Fyfe G, Fisher RI, Rosenberg SA, et al. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 1995; 13 (3): 688-96
-
(1995)
J Clin Oncol
, vol.13
, Issue.3
, pp. 688-696
-
-
Fyfe, G.1
Fisher, R.I.2
Rosenberg, S.A.3
-
4
-
-
48249117436
-
High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: A retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006
-
Klapper JA, Downey SG, Smith FO, et al. High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006. Cancer 2008; 113 (2): 293-301
-
(2008)
Cancer
, vol.113
, Issue.2
, pp. 293-301
-
-
Klapper, J.A.1
Downey, S.G.2
Smith, F.O.3
-
5
-
-
84879689379
-
Prognostic factors for survival in 1059 patients treated with sunitinib for metastatic renal cell carcinoma
-
Motzer RJ, Escudier B, Bukowski R, et al. Prognostic factors for survival in 1059 patients treated with sunitinib for metastatic renal cell carcinoma. Br J Cancer 2013; 108 (12): 2470-7
-
(2013)
Br J Cancer
, vol.108
, Issue.12
, pp. 2470-2477
-
-
Motzer, R.J.1
Escudier, B.2
Bukowski, R.3
-
6
-
-
77953757715
-
Plethora of agents, plethora of targets, plethora of side effects in metastatic renal cell carcinoma
-
Schmidinger M, Bellmunt J. Plethora of agents, plethora of targets, plethora of side effects in metastatic renal cell carcinoma. Cancer Treat Rev 2010; 36 (5): 416-24
-
(2010)
Cancer Treat Rev
, vol.36
, Issue.5
, pp. 416-424
-
-
Schmidinger, M.1
Bellmunt, J.2
-
7
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27 (22): 3584-90
-
(2009)
J Clin Oncol
, vol.27
, Issue.22
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
8
-
-
84875690904
-
A randomised, double-blind Phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: Final overall survival results and safety update
-
Sternberg CN, Hawkins RE, Wagstaff J, et al. A randomised, double-blind Phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: final overall survival results and safety update. Eur J Cancer 2013; 49 (6): 1287-96
-
(2013)
Eur J Cancer
, vol.49
, Issue.6
, pp. 1287-1296
-
-
Sternberg, C.N.1
Hawkins, R.E.2
Wagstaff, J.3
-
9
-
-
84882781441
-
Pazopanib versus sunitinib in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Cella D, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 2013; 369 (8): 722-31
-
(2013)
N Engl J Med
, vol.369
, Issue.8
, pp. 722-731
-
-
Motzer, R.J.1
Hutson, T.E.2
Cella, D.3
-
10
-
-
84876974877
-
Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised Phase III trial
-
Motzer RJ, Escudier B, Tomczak P, et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised Phase III trial. Lancet Oncol 2013; 14 (6): 552-62
-
(2013)
Lancet Oncol
, vol.14
, Issue.6
, pp. 552-562
-
-
Motzer, R.J.1
Escudier, B.2
Tomczak, P.3
-
11
-
-
82755183572
-
Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial
-
Rini BI, Escudier B, Tomczak P, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 2011; 378 (9807): 1931-9
-
(2011)
Lancet
, vol.378
, Issue.9807
, pp. 1931-1939
-
-
Rini, B.I.1
Escudier, B.2
Tomczak, P.3
-
12
-
-
70249097380
-
Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009; 27 (20): 3312-18
-
(2009)
J Clin Oncol
, vol.27
, Issue.20
, pp. 3312-3318
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
13
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356 (2): 125-34
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
14
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356 (22): 2271-81
-
(2007)
N Engl J Med
, vol.356
, Issue.22
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
15
-
-
77956227464
-
Phase 3 trial of everolimus for metastatic renal cell carcinoma: Final results and analysis of prognostic factors
-
Motzer RJ, Escudier B, Oudard S, et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 2010; 116 (18): 4256-65
-
(2010)
Cancer
, vol.116
, Issue.18
, pp. 4256-4265
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
16
-
-
84860355062
-
Randomized phase II trial of sunitinib on an intermittent versus continuous dosing schedule as first-line therapy for advanced renal cell carcinoma
-
Motzer RJ, Hutson TE, Olsen MR, et al. Randomized phase II trial of sunitinib on an intermittent versus continuous dosing schedule as first-line therapy for advanced renal cell carcinoma. J Clin Oncol 2012; 30 (12): 1371-7
-
(2012)
J Clin Oncol
, vol.30
, Issue.12
, pp. 1371-1377
-
-
Motzer, R.J.1
Hutson, T.E.2
Olsen, M.R.3
-
17
-
-
84893831040
-
Clinical outcomes for patients with metastatic renal cell carcinoma treated with alternative sunitinib schedules
-
Atkinson BJ, Kalra S, Wang X, et al. Clinical outcomes for patients with metastatic renal cell carcinoma treated with alternative sunitinib schedules. J Urol 2014; 191 (3): 611-18
-
(2014)
J Urol
, vol.191
, Issue.3
, pp. 611-618
-
-
Atkinson, B.J.1
Kalra, S.2
Wang, X.3
-
18
-
-
84897097674
-
A 2 weeks on and 1 week off schedule of sunitinib is associated with decreased toxicity in metastatic renal cell carcinoma
-
Najjar YG, Mittal K, Elson P, et al. A 2 weeks on and 1 week off schedule of sunitinib is associated with decreased toxicity in metastatic renal cell carcinoma. Eur J Cancer 2014; 50 (6): 1084-9
-
(2014)
Eur J Cancer
, vol.50
, Issue.6
, pp. 1084-1089
-
-
Najjar, Y.G.1
Mittal, K.2
Elson, P.3
-
19
-
-
33644847440
-
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
Faivre S, Delbaldo C, Vera K, et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 2006; 24 (1): 25-35
-
(2006)
J Clin Oncol
, vol.24
, Issue.1
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
-
21
-
-
84937682724
-
Axitinib dose titration: Analyses of exposure, blood pressure and clinical response from a randomized phase II study in metastatic renal cell carcinoma
-
Rini BI, Melichar B, Fishman MN, et al. Axitinib dose titration: analyses of exposure, blood pressure and clinical response from a randomized phase II study in metastatic renal cell carcinoma. Ann Oncol 2015; 26 (7): 1372-7
-
(2015)
Ann Oncol
, vol.26
, Issue.7
, pp. 1372-1377
-
-
Rini, B.I.1
Melichar, B.2
Fishman, M.N.3
-
22
-
-
84939180292
-
Overall survival analysis from a randomized phase II study of axitinib with or without dose titration for first-line metastatic renal cell carcinoma
-
Rini BI, Melichar BTY. Overall survival analysis from a randomized phase II study of axitinib with or without dose titration for first-line metastatic renal cell carcinoma. J Clin Oncol 2015; 33: suppl; abstr 4545
-
(2015)
J Clin Oncol
, vol.33
-
-
Rini, B.I.1
Bty, M.2
-
23
-
-
63049093371
-
Phase i trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma
-
Feldman DR, Baum MS, Ginsberg MS, et al. Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27 (9): 1432-9
-
(2009)
J Clin Oncol
, vol.27
, Issue.9
, pp. 1432-1439
-
-
Feldman, D.R.1
Baum, M.S.2
Ginsberg, M.S.3
-
24
-
-
70349673595
-
A phase i study of sunitinib plus bevacizumab in advanced solid tumors
-
Rini BI, Garcia JA, Cooney MM, et al. A phase I study of sunitinib plus bevacizumab in advanced solid tumors. Clin Cancer Res 2009; 15 (19): 6277-83
-
(2009)
Clin Cancer Res
, vol.15
, Issue.19
, pp. 6277-6283
-
-
Rini, B.I.1
Garcia, J.A.2
Cooney, M.M.3
-
25
-
-
55349098735
-
Updated results of phase i trial of sorafenib and bevacizumab in patient with metastatic renal cell cancer
-
Sosman J, Atkins MFK, McDermott D, et al. Updated results of phase I trial of sorafenib and bevacizumab in patient with metastatic renal cell cancer. J Clin Oncol 2008; 26 (Suppl): abstract 5011
-
(2008)
J Clin Oncol
, vol.26
-
-
Sosman, J.1
Atkins, M.F.K.2
McDermott, D.3
-
26
-
-
84895782404
-
The BeST Trial (ECOG 2804): A randomized phase II study of VEGF, RAF kinase, and MTOR combination targeted therapy with bevacizumab, sorafenib, and temsirolimus in advanced renal cell carcinoma
-
McDermott D, Pins MMJ, Flaherty K, et al. The BeST Trial (ECOG 2804): a randomized phase II study of VEGF, RAF kinase, and MTOR combination targeted therapy with bevacizumab, sorafenib, and temsirolimus in advanced renal cell carcinoma. J Clin Oncol 2013; 31 (Suppl 6; abstract 345
-
(2013)
J Clin Oncol
, vol.31
-
-
McDermott, D.1
Pins, M.M.J.2
Flaherty, K.3
-
27
-
-
84899630091
-
Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial
-
Rini BI, Bellmunt J, Clancy J, et al. Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial. J Clin Oncol 2014; 32 (8): 752-9
-
(2014)
J Clin Oncol
, vol.32
, Issue.8
, pp. 752-759
-
-
Rini, B.I.1
Bellmunt, J.2
Clancy, J.3
-
28
-
-
84874550573
-
Randomized phase II study of first-line everolimus (EVE) + bevacizumab (BEV) versus interferonalfa-2a(IFN) + BEV inpatients (pts) with metastatic renal cell carcinoma (mRCC): RECORD-2
-
Meeting abstracts
-
Ravaud A, Anak OBC. Randomized phase II study of first-line everolimus (EVE) + bevacizumab (BEV) versus interferonalfa-2a(IFN) + BEV inpatients (pts) with metastatic renal cell carcinoma (mRCC): RECORD-2. Ann Oncol 2012; 23: 7830; Meeting abstracts
-
(2012)
Ann Oncol
, vol.23
, pp. 7830
-
-
Ravaud, A.1
Obc, A.2
-
29
-
-
84939478663
-
Randomized phase II, three-arm trial of lenvatinib (LEN), everolimus (EVE), and LEN + EVE in patients (pts) with metastatic renal cell carcinoma (mRCC)
-
Motzer R, Glen HHT, Michaelson D, et al. Randomized phase II, three-arm trial of lenvatinib (LEN), everolimus (EVE), and LEN + EVE in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2015; 33: suppl; abstr 4506
-
(2015)
J Clin Oncol
, vol.33
-
-
Motzer, R.1
Glen, H.H.T.2
Michaelson, D.3
-
30
-
-
81255128983
-
Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1,-2, and-3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors
-
Eskens FA, de Jonge MJ, Bhargava P, et al. Biologic and clinical activity of tivozanib (AV-951, KRN-951), a selective inhibitor of VEGF receptor-1,-2, and-3 tyrosine kinases, in a 4-week-on, 2-week-off schedule in patients with advanced solid tumors. Clin Cancer Res 2011; 17 (22): 7156-63
-
(2011)
Clin Cancer Res
, vol.17
, Issue.22
, pp. 7156-7163
-
-
Eskens, F.A.1
De Jonge, M.J.2
Bhargava, P.3
-
31
-
-
84891713447
-
Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: Results from a phase III trial
-
Motzer RJ, Nosov D, Eisen T, et al. Tivozanib versus sorafenib as initial targeted therapy for patients with metastatic renal cell carcinoma: results from a phase III trial. J Clin Oncol 2013; 31 (30): 3791-9
-
(2013)
J Clin Oncol
, vol.31
, Issue.30
, pp. 3791-3799
-
-
Motzer, R.J.1
Nosov, D.2
Eisen, T.3
-
32
-
-
84879601057
-
Cabozantinib as a novel therapy for renal cell carcinoma
-
Vaishampayan U. Cabozantinib as a novel therapy for renal cell carcinoma. Curr Oncol Rep 2013; 15 (2): 76-82
-
(2013)
Curr Oncol Rep
, vol.15
, Issue.2
, pp. 76-82
-
-
Vaishampayan, U.1
-
33
-
-
84905175125
-
A phase i study of cabozantinib (XL184) in patients with renal cell cancer
-
Choueiri TK, Pal SK, McDermott DF, et al. A phase I study of cabozantinib (XL184) in patients with renal cell cancer. Ann Oncol 2014; 25 (8): 1603-8
-
(2014)
Ann Oncol
, vol.25
, Issue.8
, pp. 1603-1608
-
-
Choueiri, T.K.1
Pal, S.K.2
McDermott, D.F.3
-
36
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000; 192 (7): 1027-34
-
(2000)
J Exp Med
, vol.192
, Issue.7
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
-
37
-
-
84859158384
-
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
-
Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 2012; 24 (2): 207-12
-
(2012)
Curr Opin Immunol
, vol.24
, Issue.2
, pp. 207-212
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
38
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12 (4): 252-64
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.4
, pp. 252-264
-
-
Pardoll, D.M.1
-
39
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002; 8 (8): 793-800
-
(2002)
Nat Med
, vol.8
, Issue.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
-
40
-
-
44349150012
-
Inhibitory B7-family molecules in the tumour microenvironment
-
Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 2008; 8 (6): 467-77
-
(2008)
Nat Rev Immunol
, vol.8
, Issue.6
, pp. 467-477
-
-
Zou, W.1
Chen, L.2
-
41
-
-
70349569569
-
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
-
Ahmadzadeh M, Johnson LA, Heemskerk B, et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009; 114 (8): 1537-44
-
(2009)
Blood
, vol.114
, Issue.8
, pp. 1537-1544
-
-
Ahmadzadeh, M.1
Johnson, L.A.2
Heemskerk, B.3
-
42
-
-
84880706331
-
Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase i trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up
-
Drake CG, Sznol M, et al. Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up. Clin Oncol 2013; suppl; abstr 4514
-
(2013)
Clin Oncol
-
-
Drake, C.G.1
Sznol, M.2
-
43
-
-
84929572937
-
Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial
-
Motzer RJ, Rini BI, McDermott DF, et al. Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial. J Clin Oncol 2015; 33 (13): 1430-7
-
(2015)
J Clin Oncol
, vol.33
, Issue.13
, pp. 1430-1437
-
-
Motzer, R.J.1
Rini, B.I.2
McDermott, D.F.3
-
44
-
-
84944162017
-
Updated survival results from a randomized, dose-ranging Phase II study of nivolumab (NIVO) in metastatic renal cell carcinoma (mRCC)
-
Plimack ER, Rini BI. Updated survival results from a randomized, dose-ranging Phase II study of nivolumab (NIVO) in metastatic renal cell carcinoma (mRCC). J Clin Oncol 2015; 33: suppl; abstr 4553
-
(2015)
J Clin Oncol
, vol.33
-
-
Plimack, E.R.1
Rini, B.I.2
-
46
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012; 366 (26): 2455-65
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
47
-
-
84880264878
-
Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC)
-
Cho DC, Sznol M. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2013; suppl; abstr 4505
-
(2013)
J Clin Oncol
-
-
Cho, D.C.1
Sznol, M.2
-
48
-
-
84914176528
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC)
-
Amin A, Infante JR, Ernstoff MS, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2014; 32: 5s-suppl; abstr 5010
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
-
-
Amin, A.1
Infante, J.R.2
Ernstoff, M.S.3
-
50
-
-
84940487291
-
Immune correlates and long term follow up of a phase Ia study of MPDL3280A, an engineered PD-L1 antibody, in patients with metastatic renal cell carcinoma (mRCC)
-
Madrid 2014
-
McDermott DF, Sosman JA. Immune correlates and long term follow up of a phase Ia study of MPDL3280A, an engineered PD-L1 antibody, in patients with metastatic renal cell carcinoma (mRCC). Ann Oncol Proceedings of the European Society of Medical Oncology Meeting 2014, Madrid, 2014,. Abstract 809O
-
(2014)
Ann Oncol Proceedings of the European Society of Medical Oncology Meeting
-
-
McDermott, D.F.1
Sosman, J.A.2
-
53
-
-
0035056017
-
CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
-
Chambers CA, Kuhns MS, Egen JG, et al. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 2001; 19: 565-94
-
(2001)
Annu Rev Immunol
, vol.19
, pp. 565-594
-
-
Chambers, C.A.1
Kuhns, M.S.2
Egen, J.G.3
-
54
-
-
37349072460
-
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
-
Yang JC, Hughes M, Kammula U, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother 2007; 30 (8): 825-30
-
(2007)
J Immunother
, vol.30
, Issue.8
, pp. 825-830
-
-
Yang, J.C.1
Hughes, M.2
Kammula, U.3
-
55
-
-
84939150439
-
Expanded cohort results from CheckMate 016: A Phase 1 study of nivolumab in combination with ipilimumab in the metastatic renal cell carcinoma (mRCC)
-
Hammers HJ, Infante JR. Expanded cohort results from CheckMate 016: A Phase 1 study of nivolumab in combination with ipilimumab in the metastatic renal cell carcinoma (mRCC). J Clinc Oncol 2015; 33: suppl; abstr 4516
-
(2015)
J Clinc Oncol
, vol.33
-
-
Hammers, H.J.1
Infante, J.R.2
-
57
-
-
84921742040
-
Immunomodulatory activity of nivolumab in previously treated and untreated metastatic renal cell carcinoma (mRCC): Biomarker-based results from a randomized clinical trial
-
Choueiri TK, Escudier BJ. Immunomodulatory activity of nivolumab in previously treated and untreated metastatic renal cell carcinoma (mRCC): Biomarker-based results from a randomized clinical trial. J Clin Oncol 2014; 32: 5s-suppl; abstr 5012
-
(2014)
J Clin Oncol
, vol.32
, Issue.5
-
-
Choueiri, T.K.1
Escudier, B.J.2
-
58
-
-
84936821509
-
Immunomodulatory activity of nivolumab in metastatic renal cell carcinoma (mRCC): Association of biomarkers with clinical outcomes
-
Choueiri TK, Escudier BJ. Immunomodulatory activity of nivolumab in metastatic renal cell carcinoma (mRCC): Association of biomarkers with clinical outcomes. J Clin Oncol 2015; 33: suppl; abstr 4500
-
(2015)
J Clin Oncol
, vol.33
-
-
Choueiri, T.K.1
Escudier, B.J.2
-
59
-
-
65549129226
-
Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
-
Xin H, Zhang C, Herrmann A, et al. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res 2009; 69 (6): 2506-13
-
(2009)
Cancer Res
, vol.69
, Issue.6
, pp. 2506-2513
-
-
Xin, H.1
Zhang, C.2
Herrmann, A.3
-
60
-
-
84890632231
-
The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer
-
Sharpe K, Stewart GD, Mackay A, et al. The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer. Clin Cancer Res 2013; 19 (24): 6924-34
-
(2013)
Clin Cancer Res
, vol.19
, Issue.24
, pp. 6924-6934
-
-
Sharpe, K.1
Stewart, G.D.2
MacKay, A.3
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