Antioxidant and anti-inflammatory activities of a natural compound, shizukahenriol, through Nrf2 activation

Molecules

Volumn 20, Issue 9, 2015, Pages 15989-16003

  Park, Jong Hyun ^a   Choi, Ji Won ^a,b   Ju, Eun Ji ^a,b   Pae, Ae Nim ^a,c   Park, Ki Duk ^a,c  

^a Korea Institute of Science and Technology   (South Korea)

^b Yonsei University   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

Author keywords

BV 2 mouse microglial cells; Natural products; Neuroprotection; Nuclear factor E2 related factor 2; Shizukahenriol

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BIOLOGICAL PRODUCT; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOUSE; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BIOLOGICAL PRODUCTS; CELL LINE; HYDROGEN PEROXIDE; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84947982725     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules200915989     Document Type: Article

References (33)

1. Barnham, K.J., Masters, C.L., Bush, A.I. Neurodegenerative diseases and oxidative stress. Nat. Rev. Drug Discov. 2004, 3, 205-214.
2. Andersen, J.K. Oxidative stress in neurodegeneration: Cause or consequence? Neuroscience 2004, 5, S18-S25.
3. Hwang, O. Role of oxidative stress in Parkinson?s disease. Exp. Neurobiol. 2013, 22, 11-17.
4. Choi, H.J., Lee, S.Y., Cho, Y., No, H., Kim, S.W., Hwang, O. Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: Implications for Parkinson?s disease. Neurochem. Int. 2006, 48, 255-262.
5. Satoh, T., McKercher, S.R., Lipton, S.A. Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic. Biol. Med. 2014, 66, 45-57.
6. Liu, H., Talalay, P. Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention. Proc. Natl. Acad. Sci. USA 2013, 110, 19065-19070.
7. Han, J.M., Lee, Y.J., Lee, S.Y., Kim, E.M., Moon, Y., Kim, H.W., Hwang, O. Protective effect of sulforaphane against dopaminergic cell death. J. Pharmacol. Exp. Ther. 2007, 321, 249-256.
8. Wakabayashi, N., Dinkova-Kostova, A.T., Holtzclaw, W.D., Kang, M., Kobayashi, A., Yamamoto, M., Kensler, T.W., Talalay, P. Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteins of the Keap1 sensor modified by inducers. Proc. Natl. Acad. Sci. USA 2004, 101, 2040-2045.
9. De Vries, H.E., Witte, M., Hondius, D., Rozemuller, A.J.M., Drukarch, B., Hoozemans, J., Horssen, J.V. Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic. Biol. Med. 2008, 45, 1375-1383.
10. Sporn, M.B., Liby, K.T. NRF2 and cancer: The good, the bad and the importance of context. Nat. Rev. Cancers 2012, 12, 564-571.
11. Thimmulappa, R.K., Lee, H., Rangasamy, T., Reddy, S.P., Yamamoto, M., Kensler, T.W., Biswal, S. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J. Clin. Investig. 2006, 116, 984-995.
12. Koh, K., Kim, J., Jang, Y.J., Yoon, K., Cha, Y., Lee, H.J., Kim, J. Transcription factor Nrf2 suppresses LPS-induced hyperactivation of BV-2 microglial cells. J. Neuroimmunol. 2011, 233, 160-167.
13. Lee, I.S., Lim, J., Gal, J., Kang, J.C., Kim, H.J., Kang B.Y., Choi, H.J. Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV-2 cells. Neurochem. Int. 2011, 58, 153-160.
14. Lin, W., Wu, R.T., Wu, T., Khor, T.O., Wang H., Kong A.N. Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem. Pharmacol. 2008, 76, 967-973.
15. Jeong, W.S., Kim, I.W., Hu, R., Kong, A.N. Modulatory properties of various natural chemopreventive agents on the activation of NF-?B signaling pathway. Pharm. Res. 2004, 21, 661-670.
16. Innamorato, N.G., Rojo, A.I., Garcia-Yague, A.J., Yamamoto, M., de Ceballos, M.L., Cuadrado, A. The transcription factor Nrf2 is a therapeutic target against brain inflammation. J. Immunol. 2008, 181, 680-689.
17. Woo, S.Y., Kim, J.H., Moon, M.K., Han, S.H., Yeon, S.K., Choi, J.W., Jang, B.K., Song, H.J., Kang, Y.G., Kim, J.W., et al. Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson?s disease therapy. J. Med. Chem. 2014, 57, 1473-1487.
18. Kim, J.H., Woo, S.Y., Lee, J.A., Son, H.J., Han, S.H., Jang, B.K., Choi, J.W., Kim, D.J., Park, K.D., Hwang, O. A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia. Br. J. Pharmacol. 2015, 172, 1087-1100.
19. Wilms, H., Sievers, J., Richert, U., Rostami-Yazdi, M.R., Mrowietz, U., Lucius, R. Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1, TNF-α and IL-6 in an in-vitro model of brain inflammation. J. Neuroinflammation 2010, 7, doi:10.1186/1742-2094-7-30.
20. Linker, R.A., Lee, D.H., Ryan, S., van Dam, A.M., Conrad, R., Bista, P., Zeng, W., Hronowsky, X., Buko, A., Chollate, S., et al. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 2011, 134, 678-692.
21. Newman, D.J., Cragg, G.M., Snader, K.M. Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod. 2003, 66, 1022-1037.
22. Newman, D.J., Cragg, G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012, 75, 311-335.
23. Surh, Y.J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 2003, 3, 768-780.
24. Kong, H.Z. Taxonomic notes on Chloranthus henryi Heml. and its allies. Acta Phytotaxon. Sin. 2000, 38, 355-365.
25. Yang, T.Y.A., Chiang, T.Y., Peng, C.I., Hsu, T.W. Chloranthus henryi Heml. (Chloranthaceae), a new record to the flora of Taiwan. Taiwania 2006, 51, 283-286.
26. Wu, B., He, S., Pan, Y. Sesquiterpenoid with new skeleton from Chloranthus henryi. Tetrahedron Lett. 2007, 48, 453-456.
27. Wu, B., He, S., Wu, X.D., Wu, D.K., Pan, Y.J. Cadinane and eudesmane sesquiterpenoids from Chloranthus henryi. Helv. Chim. Acta 2007, 90, 1586-1592.
28. Wu, B., He, S., Wu, X.D., Pan, Y.J. Bioactive terpenes from the roots of Chloranthus henryi. Planta Med. 2006, 72, 1334-1338.
29. Lee, Y.M., Moon, J.S., Yun, B.S., Park, K.D., Choi, G.J., Kim, J.C., Lee, S.H., Kim S.U. Antifungal activity of CHE-23C, a dimeric sesquiterpene from Choranthus henryi. J. Agric. Food Chem. 2009, 57, 5750-5755.
30. Zhang, M., An, C., Gao, Y., Leak, R.K., Chen, J., Zhang, F. Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog. Neurobiol. 2013, 100, 30-47.
31. Brennan, M.S., Matos, M.F., Li, B., Hronowski, X., Gao, B., Juhasz, P., Rhodes, K.J., Scannevin, R.H. Dimethyl fumarate and monoethyl fumarate exhibit differential effects on Keap1, Nrf2 activation, and glutathione depletion in vitro. PLoS ONE 2015, 10, e0120254.
32. Taguchi, K., Motohashi, H., Yamamoto, M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011, 16, 123-140.
33. Seaver, L.C., Imlay, J.A. Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli. J. Bacteriol. 2001, 183, 7173-7181.