Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation

Journal of Infectious Diseases

Volumn 212, Issue 10, 2015, Pages 1677-1682

  Weiser, Jeffrey N ^a   Roche, Aoife M ^a   Hergott, Christopher B ^a,b   LaRose, Meredith I ^b   Connolly, Tarah ^c   Jorgensen, William L ^d   Leng, Lin ^c   Bucala, Richard ^c   Das, Rituparna ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

Macrophage migration inhibitory factor; Pneumococcus; Pneumonia

Indexed keywords

3 (3 HYDROXYBENZYL) 5 METHYLBENZOOXAZOL 2 ONE; IMMUNOMODULATING AGENT; MACROPHAGE MIGRATION INHIBITION FACTOR; UNCLASSIFIED DRUG; ISOMERASE; MIF PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; CELL INFILTRATION; CONTROLLED STUDY; IMMUNOMODULATION; INFECTION CONTROL; INFLAMMATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIA; SURVIVAL; ANIMAL; C57BL MOUSE; DISEASE MODEL; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY; SURVIVAL ANALYSIS;

ANIMALS; DISEASE MODELS, ANIMAL; INTRAMOLECULAR OXIDOREDUCTASES; LUNG; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MICE, INBRED C57BL; PNEUMONIA, PNEUMOCOCCAL; SURVIVAL ANALYSIS;

EID: 84947974330     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv262     Document Type: Article

References (15)

1. Austrian R, Gold J. Pneumococcal bacteremia with especial reference to bacteremic pneumococcal pneumonia. Ann Intern Med 1964; 60:759-76.
2. Centers for Disease Control and Prevention. Active Bacterial Core Surveillance report, Emerging Infections Program Network, Streptococcus pneumoniae. http://www.cdc.gov/abcs/reports-findings/survreports/ spneu10.html. Accessed November 2013.
3. Marks M, Burns T, Abadi M, et al. Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice. Infect Immun 2007; 75:1586-97.
4. Marriott HM, Gascoyne KA, Gowda R, et al. Interleukin-1beta regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages. Infect Immun 2012; 80:1140-9.
5. Rijneveld AW, de Vos AF, Florquin S, Verbeek JS, van der Poll T. CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia. J Infect Dis 2005; 191:1755-60.
6. Das R, LaRose MI, Hergott CB, Leng L, Bucala R, Weiser JN. Macrophage migration inhibitory factor promotes clearance of pneumococcal colonization. J Immunol 2014; 193:764-72.
7. Yende S, Angus DC, Kong L, et al. The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community- acquired pneumonia. Faseb J 2009; 23:2403-11.
8. Sun H, Choo-Wing R, Fan J, et al. Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia. Respir Res 2013; 14:27.
9. Matthias KA, Roche AM, Standish AJ, Shchepetov M, Weiser JN. Neutrophil-toxin interactions promote antigen delivery and mucosal clearance of Streptococcus pneumoniae. J Immunol 2008; 180:6246-54.
10. Flores M, Saavedra R, Bautista R, et al. Macrophage migration inhibitory factor (MIF) is critical for the host resistance against Toxoplasma gondii. FASEB J 2008; 22:3661-71.
11. Vernatter J, Pirofski LA. Current concepts in host-microbe interaction leading to pneumococcal pneumonia. Curr Opin Infect Dis 2013; 26:277-83.
12. Davis KM, Nakamura S, Weiser JN. Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice. J Clin Invest 2011; 121:3666-76.
13. Gregory JL, Morand EF, McKeown SJ, et al. Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2. J Immunol 2006; 177:8072-9.
14. Sauler M, Leng L, Trentalange M, et al. Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 2014; 306:L487-96.
15. Bucala R. MIF, MIF alleles, and prospects for therapeutic intervention in autoimmunity. J Clin Immunol 2013; 33(suppl 1):S72-8.