MIF, MIF alleles, and prospects for therapeutic intervention in autoimmunity

Journal of Clinical Immunology

Volumn 33, Issue SUPPL.1, 2013, Pages

  Bucala, Richard ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

autoimmunity; Macrophage migration inhibitory factor; MIF; systemic lupus erythematosus

Indexed keywords

CYTOKINE ANTIBODY; MACROPHAGE MIGRATION INHIBITION FACTOR; MACROPHAGE MIGRATION INHIBITION FACTOR ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; IMMUNOPATHOGENESIS; INNATE IMMUNITY; MACROPHAGE MIGRATION INHIBITORY FACTOR GENE; NONHUMAN; PHARMACOGENOMICS; POLYMORPHIC LOCUS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ALLELES; ANIMALS; ANTIBODIES, MONOCLONAL; AUTOIMMUNITY; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MACROPHAGE MIGRATION-INHIBITORY FACTORS; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 84872599310     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-012-9781-1     Document Type: Article

References (34)

1. Rich AR, Lewis MR. The nature of allergy in tuberculosis as revealed by tissue culture studies. Bull Johns Hopkins Hosp. 1932;50:115-31.
2. George M, Vaughn JH. In vitro cell migration as a model for delayed hypersensitivity. Proc Soc Exptl Biol Med. 1962;111:514-21.
3. Bucala R. MIF Rediscovered. In: Bucala R, editor. MIF, A Most Interesting Factor. London: World Scientific Press; 2007. p. 19-34.
4. Weiser WY, Temple PA, Witek-Giannotti JS, Remold HG, Clark SC, David JR. Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor. Proc Natl Acad Sci USA. 1989;86(19):7522-6. (Pubitemid 19254488)
5. Bernhagen J, Calandra T, Mitchell RA, Martin SB, Tracey KJ, Voelter W, Manogue KR, Cerami A, Bucala R. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature. 1993;365:756-9. (Pubitemid 23339882)
6. Bernhagen J, Mitchell RA, Calandra T, Voelter W, Cerami A, Bucala R. Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF). Biochemistry. 1994;33(47):14144- 55. (Pubitemid 24382359)
7. Flaster H, Bernhagen J, Calandra T, Bucala R. The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol. 2007;21(6):1267-80. (Pubitemid 46984737)
8. Baugh JA, Chitnis S, Donnelly SC, Monteiro J, Lin X, Plant BJ, Wolfe F, Gregersen PK, Bucala R. A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis. Genes Immun. 2002;3(3):170-6. (Pubitemid 38961128)
9. Zhong X, Reynolds R, Kidd J, Kidd K, Jenison R, Marler R, Ward D. Single-nucleotide polymorphism genotyping on optical thin-film biosensor chips. Proc Natl Acad Sci USA. 2003;100:11559-64. (Pubitemid 37205975)
10. Radstake TRDJ, Sweep FCGJ, Welsing P, Franke B, Vermeulen SHHM, Geurts-Moespot A, Calandra T, Donn R, van Riel PLCM. Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor. Arthritis Rheum. 2005;52(10):3020-9. (Pubitemid 41447081)
11. Mizue Y, Ghani S, Leng L, McDonald C, Kong P, Baugh J, Lane SJ, Craft J, Nishihira J, Donnelly SC, Zhu Z, Bucala R. Role for macrophage migration inhibitory factor (MIF) in asthma. Proc Natl Acad Sci USA. 2005;102:14410-5. (Pubitemid 41429711)
12. Wu S-P, Leng L, Feng Z, Liu N, Zhao H, McDonald C, Lee A, Arnett FC, Gregersen PK, Mayes MD, Bucala R. MIF promoter polymorphisms influence the clinical expression of scleroderma. Arthritis Rheum. 2006;54:3661-9. (Pubitemid 44737179)
13. Awandare GA, Martinson JJ, Were T, Ouma C, Davenport GC, Ong'echa JM, Wang WK, Leng L, Ferrell RE, Bucala R, Perkins DJ. MIF promoter polymorphisms and susceptibility to severe malarial anemia. J Infect Dis. 2009;15:629-37.
14. McDevitt MA, Xie J, Shanmugasundaram G, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz CN, Mitchell R, Keefer J, David J, Leng L, Bucala R. A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med. 2006;203:1185-96. (Pubitemid 43736589)
15. Yende S, Angus DC, Kong L, Kellum JA, Weissfeld L, Ferrell R, Finegold D, Carter M, Leng L, Peng Z-Y, Bucala R. The influence of macrophage migration inhibitory factor (MIF) polymorphisms on outcome from community-acquired pneumonia. FASEB J. 2009;23:2403-11.
16. Renner P, Roger T, Bochud P-Y, Sprong T, Sweep FCGJ, Bochud M, Faust SN, Haralambous E, Betts H, Chanson AL, Reymond MK, Mermel E, Erard V, van Deuren M, Read RC, Levin M, Calandra T. A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease. FASEB J. 2011;26:1-10.
17. Meyer-Siegler KL, Vera PL, Iczkowski KA, Bifulco C, Lee A, Gregersen PK, Leng L, Bucala R. Macrophage migration inhibitory factor (MIF) gene polymorphisms are associated with increased prostate cancer incidence. Genes Immun. 2007;8(8):646-52. (Pubitemid 350238434)
18. Grigorenko EL, Han SS, Yrigollen CM, Leng L, Mizue Y, Anderson GM, Mulder EJ, de Bildt A, Minderaa RB, Volkmar FR, Chang JT, Bucala R. Macrophage migration inhibitory factor and autism spectrum disorders. Pediatrics. 2008;122(2):E438-45.
19. Peterson KS, Winchester R. Systemic lupus erythematosus: pathogenesis. In: Koopman WJ, Moreland LW, editors. Arthritis and allied conditions. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 1523-74.
20. Foote A, Briganti EM, Kipen Y, Santos L, Leech M, Morand EF. Macrophage migration inhibitory factor in systemic lupus erythematosus. J Rheumatol. 2004;31:268-73. (Pubitemid 38160747)
21. Leng L, Chen L, Fan J, Greven D, Arjona A, Du X, Austin D, Kashgarian M, Yin Z, Huang X, Lan H, Lolis E, Nikolic-Paterson D, Bucala R. A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice. J Immunol. 2011;186:527-38.
22. Hoi AY, Hickey MJ, Hall P, Yamana J, O'Sullivan KM, Santos LL, James WG, Kitching AR, Morand EF. Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice. J Immunol. 2006;177(8):5687-96. (Pubitemid 44527645)
23. Sreih AG, Ezzeddine R, Leng L, LaChance A, Yu G, Mizue Y, Subrahmanyan L, Pons-Estel B, Abelson A-K, Svenungsson E, Gunnarsson I, Cavett J, Glenn S, Zhang L, Montogomery R, Perl A, Salmon J, Alacon-Riquelme M, Harley J, Bucala R. Dual effect of macrophage migration inhibitory factor gene on the development and the severity of human systemic lupus erythematosus. Arthritis Rheum. 2011;63:3942-51.
24. Fingerle-Rowson G, Petrenko O, Netz CN, Forsthuber TG, Mitchell R, Huss R, Moll U, Müller W, Bucala R. The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci USA. 2003;100:9354-9. (Pubitemid 37033932)
25. Bucala R. MIF and the genetic basis of macrophage responsiveness. Current Immunology Reviews. 2006;2:217-23.
26. Daun JM, Cannon JG. Macrophage migration inhibitory factor antagonizes hydrocortisone-induced increases in cytosolic IkBa. Am J Physiol. 2000;279:R1043-9.
27. Wang FF, Zhu LA, Zou YQ, Zheng H, Wilson A, Yang CD, Shen N, Wallace DJ, Weisman MH, Chen SL, Lu LJ. New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus. Arthritis Res Ther. 2012;14(3):R103.
28. Leng L, Metz C, Fang Y, Xu J, Donnelly S, Baugh J, Delonery T, Chen Y, Mitchell RA, Bucala R. MIF signal transduction initiated by binding to CD74. J Exp Med. 2003;197:1467-76. (Pubitemid 36686708)
29. Shi X, Leng L, Wang T, Wang W, Du X, McDonald C, Chen Z, Murphy JW, Lolis E, Noble P, Knudson W, Bucala R. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity. 2006;25:595-606. (Pubitemid 44529040)
30. Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR, Dewor M, Georgiev I, Schober A, Leng L, Kooistra T, Fingerle-Rowson G, Ghezzi P, Kleemann R, Mccoll SR, Bucala R, Hickey MJ, Weber C. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med. 2007;13(5):587-96. (Pubitemid 46828480)
31. Lue H, Thiele M, Franz J, Dahl E, Speckgens S, Leng L, Fingerle-Rowson G, Bucala R, Luscher B, Bernhagen J. Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity. Oncogene. 2007;26(35):5046-59. (Pubitemid 47206949)
32. Mitchell RA, Metz CN, Peng T, Bucala R. Sustained mitogen-activated protein kinase (MAPK) and cytoplasmic phospholipase A2 activation by macrophage migration inhibitory factor (MIF). Regulatory role in cell proliferation and glucocorticoid action. J Biol Chem. 1999;274(25):18100-6. (Pubitemid 29283341)
33. Roger T, Chanson AL, Knaup-Reymond M, Calandra T. Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1. Eur J Immunol. 2005;35:3405-13. (Pubitemid 43025521)
34. Aeberli D, Yang Y, Mansell A, Santos L, Leech M, Morand EF. Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase. FEBS Lett. 2006;580(3):974-81. (Pubitemid 43152322)