메뉴 건너뛰기




Volumn 8, Issue 1, 2015, Pages

Awakening the endogenous Leloir pathway for efficient galactose utilization by Yarrowia lipolytica

Author keywords

Citric acid; GAL genes; Galactose; Lipid accumulation; Metabolic pathways; Single cell oil; Yeasts

Indexed keywords

CITRIC ACID; GENES; LIPIDS; OILS AND FATS; YEAST;

EID: 84947967112     PISSN: 17546834     EISSN: None     Source Type: Journal    
DOI: 10.1186/s13068-015-0370-4     Document Type: Article
Times cited : (53)

References (37)
  • 1
    • 84857917010 scopus 로고    scopus 로고
    • Identification and characterization of DGA2, an acyltransferase of the DGAT1 acyl-CoA:diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts
    • 1:CAS:528:DC%2BC38XitVGgu7k%3D
    • Beopoulos A, Haddouche R, Kabran P, Dulermo T, Chardot T, Nicaud JM. Identification and characterization of DGA2, an acyltransferase of the DGAT1 acyl-CoA:diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts. Appl Microbiol Biotechnol. 2012;93(4):1523-37.
    • (2012) Appl Microbiol Biotechnol , vol.93 , Issue.4 , pp. 1523-1537
    • Beopoulos, A.1    Haddouche, R.2    Kabran, P.3    Dulermo, T.4    Chardot, T.5    Nicaud, J.M.6
  • 2
    • 84908274916 scopus 로고    scopus 로고
    • Hexokinase - A limiting factor in lipid production from fructose in Yarrowia lipolytica
    • 1:CAS:528:DC%2BC2cXhslGgu7fF
    • Lazar Z, Dulermo T, Neuvéglise C, Crutz-Le Coq AM, Nicaud JM. Hexokinase - A limiting factor in lipid production from fructose in Yarrowia lipolytica. Met Eng. 2014;26:89-99.
    • (2014) Met Eng , vol.26 , pp. 89-99
    • Lazar, Z.1    Dulermo, T.2    Neuvéglise, C.3    Crutz-Le Coq, A.M.4    Nicaud, J.M.5
  • 3
    • 84891862050 scopus 로고    scopus 로고
    • Enhanced production of erythritol by Yarrowia lipolytica on glycerol in repeated batch cultures
    • Mirończuk AM, Furgała J, Rakicka M, Rymowicz W. Enhanced production of erythritol by Yarrowia lipolytica on glycerol in repeated batch cultures. J Ind Microbiol Biotechnol. 2014;41(1):57-64.
    • (2014) J Ind Microbiol Biotechnol , vol.41 , Issue.1 , pp. 57-64
    • Mirończuk, A.M.1    Furgała, J.2    Rakicka, M.3    Rymowicz, W.4
  • 4
    • 84892840633 scopus 로고    scopus 로고
    • Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production
    • Blazeck J, Hill A, Liu L, Knight R, Miller J, Pan A, Otoupal P, Alper HS. Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production. Nat Comm. 2014;5:3131.
    • (2014) Nat Comm , vol.5 , pp. 3131
    • Blazeck, J.1    Hill, A.2    Liu, L.3    Knight, R.4    Miller, J.5    Pan, A.6    Otoupal, P.7    Alper, H.S.8
  • 6
    • 0028353132 scopus 로고
    • The DeLey-Doudoroff pathway of galactose metabolism in Azotobacter vinelandii
    • 1:CAS:528:DyaK2cXksFelsbk%3D
    • Wong TY, Yao XT. The DeLey-Doudoroff pathway of galactose metabolism in Azotobacter vinelandii. Appl Environ Microbiol. 1994;60(6):2065-8.
    • (1994) Appl Environ Microbiol , vol.60 , Issue.6 , pp. 2065-2068
    • Wong, T.Y.1    Yao, X.T.2
  • 7
    • 84864383662 scopus 로고    scopus 로고
    • L-Xylo-3-hexulose reductase is the missing link in the oxidoreductive pathway for d-galactose catabolism in filamentous fungi
    • 1:CAS:528:DC%2BC38XhtV2ns7fM
    • Mojzita D, Herold S, Metz B, Seiboth B, Richard P. l-Xylo-3-hexulose reductase is the missing link in the oxidoreductive pathway for d-galactose catabolism in filamentous fungi. J Biol Chem. 2012;287(31):26010-8.
    • (2012) J Biol Chem , vol.287 , Issue.31 , pp. 26010-26018
    • Mojzita, D.1    Herold, S.2    Metz, B.3    Seiboth, B.4    Richard, P.5
  • 8
    • 0025997532 scopus 로고
    • Galactokinase encoded by GAL1 is a bifunctional protein required for the induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype of Saccharomyces cerevisiae
    • 1:CAS:528:DyaK3sXhslajsw%3D%3D
    • Meyer J, Walker-Jonah A, Hollenberg CP. Galactokinase encoded by GAL1 is a bifunctional protein required for the induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype of Saccharomyces cerevisiae. Mol Cell Biol. 1991;11:5454-61.
    • (1991) Mol Cell Biol , vol.11 , pp. 5454-5461
    • Meyer, J.1    Walker-Jonah, A.2    Hollenberg, C.P.3
  • 9
    • 54449085117 scopus 로고    scopus 로고
    • Galactose metabolism in yeast-structure and regulation of the Leloir pathway enzymes and the genes encoding them
    • 1:CAS:528:DC%2BD1cXhsVOqsL3F
    • Sellick CA, Campbell RN, Reece RJ. Galactose metabolism in yeast-structure and regulation of the Leloir pathway enzymes and the genes encoding them. Int Rev Cell Mol Biol. 2008;269:111-50.
    • (2008) Int Rev Cell Mol Biol , vol.269 , pp. 111-150
    • Sellick, C.A.1    Campbell, R.N.2    Reece, R.J.3
  • 10
    • 77953399342 scopus 로고    scopus 로고
    • Multiple GAL pathway gene clusters evolved independently and by different mechanisms in fungi
    • 1:CAS:528:DC%2BC3cXnslKns7o%3D
    • Slot JC, Rokas A. Multiple GAL pathway gene clusters evolved independently and by different mechanisms in fungi. PNAS. 2010;107(22):10136-41.
    • (2010) PNAS , vol.107 , Issue.22 , pp. 10136-10141
    • Slot, J.C.1    Rokas, A.2
  • 11
    • 84961723993 scopus 로고
    • Dependence of lactose metabolism upon mutarotase encoded in the gal operon in Escherichia coli
    • Bouffard GG, Rudd KE, Adhya SL. Dependence of lactose metabolism upon mutarotase encoded in the gal operon in Escherichia coli. J Mol Biol. 1994;162:156-9.
    • (1994) J Mol Biol , vol.162 , pp. 156-159
    • Bouffard, G.G.1    Rudd, K.E.2    Adhya, S.L.3
  • 12
  • 13
    • 0031810672 scopus 로고    scopus 로고
    • Yeast carbon catabolite repression
    • 1:CAS:528:DyaK1cXkt1OitLY%3D
    • Gancedo JM. Yeast carbon catabolite repression. Microbiol Mol Biol Rev. 1998;62(2):334-61.
    • (1998) Microbiol Mol Biol Rev , vol.62 , Issue.2 , pp. 334-361
    • Gancedo, J.M.1
  • 14
    • 0031047133 scopus 로고    scopus 로고
    • Catabolite inactivation of the galactose transporter in the yeast Saccharomyces cerevisiae: Ubiquitination, endocytosis, and degradation in the vacuole
    • 1:CAS:528:DyaK2sXhsFGgs7c%3D
    • Horak J, Wolf DH. Catabolite inactivation of the galactose transporter in the yeast Saccharomyces cerevisiae: Ubiquitination, endocytosis, and degradation in the vacuole. J Bacteriol. 1997;179:1541-9.
    • (1997) J Bacteriol , vol.179 , pp. 1541-1549
    • Horak, J.1    Wolf, D.H.2
  • 15
    • 0031037914 scopus 로고    scopus 로고
    • Constitutive expression in gal7 mutants of Kluyveromyces lactis is due to the internal production of galactose as an inducer of the Gal/Lac regulon
    • 1:CAS:528:DyaK2sXhtl2jsLo%3D
    • Cardinali G, Vollenbroich V, Jeon MS, de Graaf AA, Hollenberg CP. Constitutive expression in gal7 mutants of Kluyveromyces lactis is due to the internal production of galactose as an inducer of the Gal/Lac regulon. Mol Cell Biol. 1997;17(3):1722-30.
    • (1997) Mol Cell Biol , vol.17 , Issue.3 , pp. 1722-1730
    • Cardinali, G.1    Vollenbroich, V.2    Jeon, M.S.3    De Graaf, A.A.4    Hollenberg, C.P.5
  • 16
    • 34547101006 scopus 로고    scopus 로고
    • Induction of the gal pathway and cellulase genes involves no transcriptional inducer function of the galactokinase in Hypocrea jecorina
    • 1:CAS:528:DC%2BD2sXmsVOksbo%3D
    • Hartl L, Kubicek CP, Seiboth B. Induction of the gal pathway and cellulase genes involves no transcriptional inducer function of the galactokinase in Hypocrea jecorina. J Biol Chem. 2007;282(25):18654-9.
    • (2007) J Biol Chem , vol.282 , Issue.25 , pp. 18654-18659
    • Hartl, L.1    Kubicek, C.P.2    Seiboth, B.3
  • 17
    • 0036203256 scopus 로고    scopus 로고
    • Lactose metabolism and cellulase production in Hypocrea jecorina: The gal7 gene, encoding galactose-1-phosphate uridylyl-transferase, is essential for growth on galactose but not for cellulase induction
    • 1:CAS:528:DC%2BD38XjslShtbw%3D
    • Seiboth B, Hofmann G, Kubicek CP. Lactose metabolism and cellulase production in Hypocrea jecorina: The gal7 gene, encoding galactose-1-phosphate uridylyl-transferase, is essential for growth on galactose but not for cellulase induction. Mol Genet Genomics. 2002;267:124-32.
    • (2002) Mol Genet Genomics , vol.267 , pp. 124-132
    • Seiboth, B.1    Hofmann, G.2    Kubicek, C.P.3
  • 18
    • 0037167184 scopus 로고    scopus 로고
    • The Hypocrea jecorina gal10 (uridine 5′-diphosphate-glucose 4-epimerase) encoding gene differs from yeast homologues in structure, genomic organization and expression
    • 1:CAS:528:DC%2BD38XmvF2qur8%3D
    • Seiboth B, Karaffa L, Sandor E, Kubicek C. The Hypocrea jecorina gal10 (uridine 5′-diphosphate-glucose 4-epimerase) encoding gene differs from yeast homologues in structure, genomic organization and expression. Gene. 2002;295:143-9.
    • (2002) Gene , vol.295 , pp. 143-149
    • Seiboth, B.1    Karaffa, L.2    Sandor, E.3    Kubicek, C.4
  • 19
    • 1442300801 scopus 로고    scopus 로고
    • The galactokinase of Hypocrea jecorina is essential for cellulase induction by lactose but dispensable for growth on d-galactose
    • 1:CAS:528:DC%2BD2cXhslOitbg%3D
    • Seiboth B, Harti L, Pali M, Fekete E, Karaffa L, Kubicek C. The galactokinase of Hypocrea jecorina is essential for cellulase induction by lactose but dispensable for growth on d-galactose. Mol Microbiol. 2004;51(4):1015-25.
    • (2004) Mol Microbiol , vol.51 , Issue.4 , pp. 1015-1025
    • Seiboth, B.1    Harti, L.2    Pali, M.3    Fekete, E.4    Karaffa, L.5    Kubicek, C.6
  • 22
    • 84877128343 scopus 로고    scopus 로고
    • Comparative physiology of oleaginous species from the Yarrowia clade
    • 1:CAS:528:DC%2BC3sXnvVequ7o%3D
    • Michely S, Gaillardin C, Nicaud JM, Neuvéglise C. Comparative physiology of oleaginous species from the Yarrowia clade. PLoS one. 2013;8(5):e63356 (1-10).
    • (2013) PLoS One. , vol.8 , Issue.5 , pp. e63356
    • Michely, S.1    Gaillardin, C.2    Nicaud, J.M.3    Neuvéglise, C.4
  • 23
    • 77749292807 scopus 로고    scopus 로고
    • Characterization of two different types of UDP-glucose/-galactose 4-epimerase involved in galactosylation in fission yeast
    • 1:CAS:528:DC%2BC3cXktFOksL0%3D
    • Suzuki S, Matsuzawa T, Nukigi Y, Takegawa K, Tanaka N. Characterization of two different types of UDP-glucose/-galactose 4-epimerase involved in galactosylation in fission yeast. Microbiology. 2010;156:708-18.
    • (2010) Microbiology , vol.156 , pp. 708-718
    • Suzuki, S.1    Matsuzawa, T.2    Nukigi, Y.3    Takegawa, K.4    Tanaka, N.5
  • 24
    • 84873450128 scopus 로고    scopus 로고
    • Disruption of the MIG1 gene enhances lipid biosynthesis in the oleaginous yeast Yarrowia lipolytica ACA-DC 50109
    • 1:CAS:528:DC%2BC3sXjtFWjtrw%3D
    • Wang ZP, Xu HM, Wang GY, Chi Z, Chi ZM. Disruption of the MIG1 gene enhances lipid biosynthesis in the oleaginous yeast Yarrowia lipolytica ACA-DC 50109. Biochim Biophys Acta. 2013;1831(4):675-82.
    • (2013) Biochim Biophys Acta , vol.1831 , Issue.4 , pp. 675-682
    • Wang, Z.P.1    Xu, H.M.2    Wang, G.Y.3    Chi, Z.4    Chi, Z.M.5
  • 26
    • 79958211835 scopus 로고    scopus 로고
    • Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host
    • 1:CAS:528:DC%2BC3MXns1Slt7s%3D
    • Young E, Poucher A, Comer A, Bailey A, Alper H. Functional survey for heterologous sugar transport proteins, using Saccharomyces cerevisiae as a host. Appl Environ Microbiol. 2011;77(10):3311-9.
    • (2011) Appl Environ Microbiol , vol.77 , Issue.10 , pp. 3311-3319
    • Young, E.1    Poucher, A.2    Comer, A.3    Bailey, A.4    Alper, H.5
  • 28
    • 0000837748 scopus 로고    scopus 로고
    • Yarrowia lipolytica
    • Springer-Verlag KD Breunig G Barth Berlin K Wolf 1 Barth G, Gaillardin C. Yarrowia lipolytica. In: Wolf K, Breunig KD, Barth G, editors. vol. 1. Berlin: Springer-Verlag; 1996. p. 313-88
    • Barth G, Gaillardin C. Yarrowia lipolytica. In: Wolf K, Breunig KD, Barth G, editors. Nonconventional yeasts in biotechnology, vol. 1. Berlin: Springer-Verlag; 1996. p. 313-88.
    • (1996) Nonconventional Yeasts in Biotechnology , pp. 313-388
    • Barth, G.1    Gaillardin, C.2
  • 29
    • 0023107298 scopus 로고
    • LEU2 directed expression of β-galactosidase activity and phleomycin resistance in Yarrowia lipolytica
    • 1:CAS:528:DyaL2sXktFyrsbo%3D
    • Gaillardin C, Ribet AM. LEU2 directed expression of β-galactosidase activity and phleomycin resistance in Yarrowia lipolytica. Curr Genet. 1987;11:369-75.
    • (1987) Curr Genet , vol.11 , pp. 369-375
    • Gaillardin, C.1    Ribet, A.M.2
  • 30
    • 0028953840 scopus 로고
    • Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds
    • 1:CAS:528:DyaK2MXkvVamsb4%3D
    • Mumberg D, Müller R, Funk M. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene. 1995;156:119-22.
    • (1995) Gene , vol.156 , pp. 119-122
    • Mumberg, D.1    Müller, R.2    Funk, M.3
  • 31
    • 0025073498 scopus 로고
    • Overlapping reading frames at the LYS5 locus in the yeast Yarrowia lipolytica
    • 1:CAS:528:DyaK3MXhvVCquw%3D%3D
    • Xuan JW, Fournier P, Declerck N, Chasles M, Gaillardin C. Overlapping reading frames at the LYS5 locus in the yeast Yarrowia lipolytica. Mol Cell Biol. 1990;10:4795-806.
    • (1990) Mol Cell Biol , vol.10 , pp. 4795-4806
    • Xuan, J.W.1    Fournier, P.2    Declerck, N.3    Chasles, M.4    Gaillardin, C.5
  • 32
    • 0034891767 scopus 로고    scopus 로고
    • Insertional mutagenesis in the n-alkane-assimilating yeast Yarrowia lipolytica: Generation of tagged mutations in genes involved in hydrophobic substrate utilization
    • 1:CAS:528:DC%2BD3MXmtFKrs70%3D
    • Mauersberger S, Wang HJ, Gaillardin C, Barth G, Nicaud JM. Insertional mutagenesis in the n-alkane-assimilating yeast Yarrowia lipolytica: Generation of tagged mutations in genes involved in hydrophobic substrate utilization. J Bacteriol. 2001;183:5102-9.
    • (2001) J Bacteriol , vol.183 , pp. 5102-5109
    • Mauersberger, S.1    Wang, H.J.2    Gaillardin, C.3    Barth, G.4    Nicaud, J.M.5
  • 33
    • 0003903343 scopus 로고    scopus 로고
    • Cold Spring Harbor Laboratory Press New York 3 Sambrook J, Russell DW. Molecular cloning: A laboratory manual. 3rd ed. New York: Cold Spring Harbor Laboratory Press; 2001
    • Sambrook J, Russell DW. Molecular cloning: A laboratory manual. 3rd ed. New York: Cold Spring Harbor Laboratory Press; 2001.
    • (2001) Molecular Cloning: A Laboratory Manual
    • Sambrook, J.1    Russell, D.W.2
  • 34
    • 0025776579 scopus 로고
    • A sequence assembly and editing program for efficient management of large projects
    • 1:CAS:528:DyaK3MXlt12isr4%3D
    • Dear S, Staden R. A sequence assembly and editing program for efficient management of large projects. Nucleic Acids Res. 1991;19(14):3907-11.
    • (1991) Nucleic Acids Res , vol.19 , Issue.14 , pp. 3907-3911
    • Dear, S.1    Staden, R.2
  • 35
    • 84884828047 scopus 로고    scopus 로고
    • Kabran Gnankon AP, Haddouche R, Nicaud JM. Characterization of the two intracellular lipases of Y. Lipolytica encoded by TGL3 and TGL4 genes: New insights into the role of intracellular lipases and lipid body organisation
    • 1:CAS:528:DC%2BC3sXht1emsrrJ
    • Dulermo T, Tréton B, Beopoulos A. Kabran Gnankon AP, Haddouche R, Nicaud JM. Characterization of the two intracellular lipases of Y. lipolytica encoded by TGL3 and TGL4 genes: New insights into the role of intracellular lipases and lipid body organisation. Biochim Biophys Acta. 2013;1831(9):1486-95.
    • (2013) Biochim Biophys Acta , vol.1831 , Issue.9 , pp. 1486-1495
    • Dulermo, T.1    Tréton, B.2    Beopoulos, A.3
  • 36
    • 0242384024 scopus 로고    scopus 로고
    • New disruption cassettes for rapid gene disruption and marker rescue in the yeast Yarrowia lipolytica
    • 1:CAS:528:DC%2BD3sXos1Kmsb0%3D
    • Fickers P, Le Dall MT, Gaillardin C, Thonart P, Nicaud JM. New disruption cassettes for rapid gene disruption and marker rescue in the yeast Yarrowia lipolytica. J Microbiol Meth. 2003;55:727-37.
    • (2003) J Microbiol Meth. , vol.55 , pp. 727-737
    • Fickers, P.1    Le Dall, M.T.2    Gaillardin, C.3    Thonart, P.4    Nicaud, J.M.5
  • 37
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative CT method
    • 1:CAS:528:DC%2BD1cXmvVemt7c%3D
    • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nat Protoc. 2008;3(6):1101-8.
    • (2008) Nat Protoc , vol.3 , Issue.6 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.