P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis

Genome Biology

Volumn 16, Issue 1, 2015, Pages

  Cui, Chenghua ^a,b   Gan, Ying ^a   Gu, Liankun ^a   Wilson, James ^c   Liu, Zhaojun ^a   Zhang, Baozhen ^a   Deng, Dajun ^a  

^a PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

^b INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Cancer; Engineered methyltransferase; Metastasis; Methylation; P16

Indexed keywords

DNA; DNA METHYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE; PROTEIN P16; ZINC FINGER PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA (CYTOSINE 5) METHYLTRANSFERASE;

ARTICLE; CATALYSIS; CELL MIGRATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENZYME ACTIVITY; GENE INACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METASTASIS; PHENOTYPE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR INVASION; ANIMAL; CELL MOTION; CHEMISTRY; EXPERIMENTAL NEOPLASM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; LUNG TUMOR; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; PATHOLOGY; SCID MOUSE; SECONDARY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASMS, EXPERIMENTAL; ZINC FINGERS;

EID: 84947930919     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0819-6     Document Type: Article

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