Discovery of 2-Acylaminothiophene-3-Carboxamides as Multitarget Inhibitors for BCR-ABL Kinase and Microtubules

Journal of Chemical Information and Modeling

Volumn 55, Issue 11, 2015, Pages 2435-2442

  Cao, Ran ^a,b   Wang, Yanli ^a   Huang, Niu ^a  

^a NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DIAGNOSIS; DIGITAL LIBRARIES; DISEASES; ENZYMES; PATIENT TREATMENT; SCAFFOLDS (BIOLOGY);

CHRONIC MYELOID LEUKEMIAS; COMPUTATIONAL PROTOCOLS; EXPERIMENTAL TESTING; PROTEIN-BINDING SITES; STRUCTURAL MODIFICATIONS; STRUCTURAL SIMILARITY; STRUCTURE ACTIVITY RELATIONSHIPS; VIRTUAL SCREENING STRATEGIES;

BINDING SITES;

ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; PROTEIN KINASE INHIBITOR; THIOPHENE DERIVATIVE;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; DRUG RESISTANCE; GENETICS; HUMAN; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; METABOLISM; MICROTUBULE; MOLECULAR DOCKING; POINT MUTATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MICROTUBULES; MOLECULAR DOCKING SIMULATION; POINT MUTATION; PROTEIN KINASE INHIBITORS; THIOPHENES;

EID: 84947921308     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/acs.jcim.5b00540     Document Type: Article

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