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Volumn 25, Issue 6, 2015, Pages 317-322

Targeting Cancer Cells Using LNA-Modified Aptamer-siRNA Chimeras

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; EPITHELIAL CELL ADHESION MOLECULE; LOCKED NUCLEIC ACID; SMALL INTERFERING RNA; STATHMIN; SURVIVIN; CELL ADHESION MOLECULE; EPCAM PROTEIN, HUMAN; OLIGONUCLEOTIDE; TUMOR ANTIGEN;

EID: 84947920586     PISSN: 21593337     EISSN: 21593345     Source Type: Journal    
DOI: 10.1089/nat.2015.0550     Document Type: Article
Times cited : (22)

References (42)
  • 1
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • Urban-Klein B, S Werth, S Abuharbeid, F Czubayko, and A Aigner. (2005). RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther 12:461-466.
    • (2005) Gene Ther , vol.12 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 2
    • 34247255870 scopus 로고    scopus 로고
    • Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1
    • Peer D, P Zhu, CV Carman, J Lieberman, and M Shimaoka. (2007). Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U S A 104:4095-4100.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4095-4100
    • Peer, D.1    Zhu, P.2    Carman, C.V.3    Lieberman, J.4    Shimaoka, M.5
  • 3
    • 77951132901 scopus 로고    scopus 로고
    • Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
    • Davis ME, JE Zuckerman, CH Choi, D Seligson, A Tolcher, et al. (2010). Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464:1067-1070.
    • (2010) Nature , vol.464 , pp. 1067-1070
    • Davis, M.E.1    Zuckerman, J.E.2    Choi, C.H.3    Seligson, D.4    Tolcher, A.5
  • 4
    • 84880701787 scopus 로고    scopus 로고
    • A novel therapeutic drug for colon cancer: EpCAM scFv-truncated protamine (tp)-siRNA
    • Hao H, Y Zhen, Z Wang, F Chen, and X Xie. (2013). A novel therapeutic drug for colon cancer: EpCAM scFv-truncated protamine (tp)-siRNA. Cell Biol Int 37:860-864.
    • (2013) Cell Biol Int , vol.37 , pp. 860-864
    • Hao, H.1    Zhen, Y.2    Wang, Z.3    Chen, F.4    Xie, X.5
  • 5
    • 84878226716 scopus 로고    scopus 로고
    • An aptamer-siRNA chimera silences the eukaryotic elongation factor 2 gene and induces apoptosis in cancers expressing alphavbeta3 integrin
    • Hussain AF, MK Tur, and S Barth. (2013). An aptamer-siRNA chimera silences the eukaryotic elongation factor 2 gene and induces apoptosis in cancers expressing alphavbeta3 integrin. Nucleic Acid Ther 23:203-212.
    • (2013) Nucleic Acid Ther , vol.23 , pp. 203-212
    • Hussain, A.F.1    Tur, M.K.2    Barth, S.3
  • 6
    • 84879204063 scopus 로고    scopus 로고
    • Targeting cancer cell-specific RNA interference by siRNA delivery using a complex carrier of affibody-displaying bio-nanocapsules and liposomes
    • Nishimura Y, H Mieda, J Ishii, C Ogino, T Fujiwara, et al. (2013). Targeting cancer cell-specific RNA interference by siRNA delivery using a complex carrier of affibody-displaying bio-nanocapsules and liposomes. J Nanobiotechnology 11:19.
    • (2013) J Nanobiotechnology , vol.11 , pp. 19
    • Nishimura, Y.1    Mieda, H.2    Ishii, J.3    Ogino, C.4    Fujiwara, T.5
  • 7
    • 84885364568 scopus 로고    scopus 로고
    • Aptamers as theranostic agents: Modifications, serum stability and functionalisation
    • Basel
    • Shigdar S, J Macdonald, O'Connor M, T Wang, D Xiang, et al. (2013). Aptamers as theranostic agents: modifications, serum stability and functionalisation. Sensors (Basel) 13:13624-13637.
    • (2013) Sensors , vol.13 , pp. 13624-13637
    • Shigdar, S.1    Macdonald, J.2    O'Connor, M.3    Wang, T.4    Xiang, D.5
  • 8
    • 84907816763 scopus 로고    scopus 로고
    • Aptamer-based therapeutics of the past, present and future: From the perspective of eye-related diseases
    • Kanwar JR, JS Shankaranarayanan, S Gurudevan, and RK Kanwar. (2014). Aptamer-based therapeutics of the past, present and future: from the perspective of eye-related diseases. Drug Discov Today 19:1309-1321.
    • (2014) Drug Discov Today , vol.19 , pp. 1309-1321
    • Kanwar, J.R.1    Shankaranarayanan, J.S.2    Gurudevan, S.3    Kanwar, R.K.4
  • 9
    • 77958152852 scopus 로고    scopus 로고
    • Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals
    • Orava EW, N Cicmil, and J Gariepy. (2010). Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals. Biochim Biophys Acta 1798:2190-2200.
    • (2010) Biochim Biophys Acta , vol.1798 , pp. 2190-2200
    • Orava, E.W.1    Cicmil, N.2    Gariepy, J.3
  • 10
    • 33846252731 scopus 로고    scopus 로고
    • Discovery and development of anticancer aptamers
    • Ireson CR, and LR Kelland. (2006). Discovery and development of anticancer aptamers. Mol Cancer Ther 5:2957-2962.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2957-2962
    • Ireson, C.R.1    Kelland, L.R.2
  • 11
    • 58849093242 scopus 로고    scopus 로고
    • On the abundance of EpCAM on cancer stem cells
    • author reply 143
    • Gires O, CA Klein, and PA Baeuerle. (2009). On the abundance of EpCAM on cancer stem cells. Nat Rev Cancer 9: 143; author reply 143.
    • (2009) Nat Rev Cancer , vol.9 , pp. 143
    • Gires, O.1    Klein, C.A.2    Baeuerle, P.A.3
  • 12
    • 69249092641 scopus 로고    scopus 로고
    • EpCAM is involved in maintenance of the murine embryonic stem cell phenotype
    • Gonzalez B, S Denzel, B Mack, M Conrad, and O Gires. (2009). EpCAM is involved in maintenance of the murine embryonic stem cell phenotype. Stem Cells 27:1782-1791.
    • (2009) Stem Cells , vol.27 , pp. 1782-1791
    • Gonzalez, B.1    Denzel, S.2    Mack, B.3    Conrad, M.4    Gires, O.5
  • 14
    • 4143074922 scopus 로고    scopus 로고
    • EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy
    • Osta WA, Y Chen, K Mikhitarian, M Mitas, M Salem, et al. (2004). EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 64:5818-5824.
    • (2004) Cancer Res , vol.64 , pp. 5818-5824
    • Osta, W.A.1    Chen, Y.2    Mikhitarian, K.3    Mitas, M.4    Salem, M.5
  • 15
    • 36348991571 scopus 로고    scopus 로고
    • Activation of hepatic stem cell marker EpCAM by Wntbeta-catenin signaling in hepatocellular carcinoma
    • Yamashita T, A Budhu, M Forgues, and XW Wang. (2007). Activation of hepatic stem cell marker EpCAM by Wntbeta-catenin signaling in hepatocellular carcinoma. Cancer Res 67:10831-10839.
    • (2007) Cancer Res , vol.67 , pp. 10831-10839
    • Yamashita, T.1    Budhu, A.2    Forgues, M.3    Wang, X.W.4
  • 16
    • 79954858874 scopus 로고    scopus 로고
    • RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule
    • Shigdar S, J Lin, Y Yu, M Pastuovic, M Wei, et al. (2011). RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci 102:991-998.
    • (2011) Cancer Sci , vol.102 , pp. 991-998
    • Shigdar, S.1    Lin, J.2    Yu, Y.3    Pastuovic, M.4    Wei, M.5
  • 17
    • 84876264381 scopus 로고    scopus 로고
    • Selection of DNA aptamers against epithelial cell adhesion molecule for cancer cell imaging and circulating tumor cell capture
    • Song Y, Z Zhu, Y An, W Zhang, H Zhang, et al. (2013). Selection of DNA aptamers against epithelial cell adhesion molecule for cancer cell imaging and circulating tumor cell capture. Anal Chem 85:4141-4149.
    • (2013) Anal Chem , vol.85 , pp. 4141-4149
    • Song, Y.1    Zhu, Z.2    An, Y.3    Zhang, W.4    Zhang, H.5
  • 18
    • 84870448531 scopus 로고    scopus 로고
    • Target-specific delivery of doxorubicin to retinoblastoma using epithelial cell adhesion molecule aptamer
    • Subramanian N, V Raghunathan, JR Kanwar, RK Kanwar, SV Elchuri, et al. (2012). Target-specific delivery of doxorubicin to retinoblastoma using epithelial cell adhesion molecule aptamer. Mol Vis 18:2783-2795.
    • (2012) Mol Vis , vol.18 , pp. 2783-2795
    • Subramanian, N.1    Raghunathan, V.2    Kanwar, J.R.3    Kanwar, R.K.4    Elchuri, S.V.5
  • 19
    • 81855218276 scopus 로고    scopus 로고
    • Chimeric aptamers in cancer cell-targeted drug delivery
    • Kanwar JR, K Roy, and RK Kanwar. (2011). Chimeric aptamers in cancer cell-targeted drug delivery. Crit Rev Biochem Mol Biol 46:459-477.
    • (2011) Crit Rev Biochem Mol Biol , vol.46 , pp. 459-477
    • Kanwar, J.R.1    Roy, K.2    Kanwar, R.K.3
  • 20
    • 84896879273 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells
    • Li L, D Xiang, S Shigdar, W Yang, Q Li, et al. (2014). Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. Int J Nanomedicine 9:1083-1096.
    • (2014) Int J Nanomedicine , vol.9 , pp. 1083-1096
    • Li, L.1    Xiang, D.2    Shigdar, S.3    Yang, W.4    Li, Q.5
  • 21
    • 84927713763 scopus 로고    scopus 로고
    • EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex
    • Subramanian N, JR Kanwar, P Athalya, N Janakiraman, V Khetan, et al. (2015). EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex. J Biomed Sci 22:4.
    • (2015) J Biomed Sci , vol.22 , pp. 4
    • Subramanian, N.1    Kanwar, J.R.2    Athalya, P.3    Janakiraman, N.4    Khetan, V.5
  • 23
    • 84940166180 scopus 로고    scopus 로고
    • Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression
    • El Deeb NM, and E Abdelzaher. (2014). Stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma and their relation to survivin expression. Pathol Res Pract 210:751-758.
    • (2014) Pathol Res Pract , vol.210 , pp. 751-758
    • El Deeb, N.M.1    Abdelzaher, E.2
  • 24
    • 84873348586 scopus 로고    scopus 로고
    • Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex
    • Guvenc H, MS Pavlyukov, K Joshi, H Kurt, YK Banasavadi-Siddegowda, et al. (2013). Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin Cancer Res 19:631-642.
    • (2013) Clin Cancer Res , vol.19 , pp. 631-642
    • Guvenc, H.1    Pavlyukov, M.S.2    Joshi, K.3    Kurt, H.4    Banasavadi-Siddegowda, Y.K.5
  • 25
    • 84921459726 scopus 로고    scopus 로고
    • Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc
    • Lond
    • Kanwar JR, G Mahidhara, K Roy, S Sasidharan, S Krishnakumar, et al. (2015). Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc. Nanomedicine (Lond) 10:35-55.
    • (2015) Nanomedicine , vol.10 , pp. 35-55
    • Kanwar, J.R.1    Mahidhara, G.2    Roy, K.3    Sasidharan, S.4    Krishnakumar, S.5
  • 26
    • 84878011763 scopus 로고    scopus 로고
    • Cell cycle inhibition therapy that targets stathmin in in vitro and in vivo models of breast cancer
    • Miceli C, A Tejada, A Castaneda, and SJ Mistry. (2013). Cell cycle inhibition therapy that targets stathmin in in vitro and in vivo models of breast cancer. Cancer Gene Ther 20:298-307.
    • (2013) Cancer Gene Ther , vol.20 , pp. 298-307
    • Miceli, C.1    Tejada, A.2    Castaneda, A.3    Mistry, S.J.4
  • 27
    • 80052811789 scopus 로고    scopus 로고
    • Reversal of stathmin-mediated microtubule destabilization sensitizes retinoblastoma cells to a low dose of antimicrotubule agents: A novel synergistic therapeutic intervention
    • Mitra M, M Kandalam, CS Sundaram, RS Verma, UK Maheswari, et al. (2011). Reversal of stathmin-mediated microtubule destabilization sensitizes retinoblastoma cells to a low dose of antimicrotubule agents: a novel synergistic therapeutic intervention. Invest Ophthalmol Vis Sci 52:5441-5448.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 5441-5448
    • Mitra, M.1    Kandalam, M.2    Sundaram, C.S.3    Verma, R.S.4    Maheswari, U.K.5
  • 28
    • 84862545032 scopus 로고    scopus 로고
    • Stathmin 1: A protein with many tasks. New biomarker and potential target in cancer
    • Nemunaitis J. (2012). Stathmin 1: a protein with many tasks. New biomarker and potential target in cancer. Expert Opin Ther Targets 16:631-634.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 631-634
    • Nemunaitis, J.1
  • 29
    • 84866483805 scopus 로고    scopus 로고
    • Stathmin expression and its relationship to microtubule-associated protein tau and outcome in breast cancer
    • Baquero MT, JA Hanna, V Neumeister, H Cheng, AM Molinaro, et al. (2012). Stathmin expression and its relationship to microtubule-associated protein tau and outcome in breast cancer. Cancer 118:4660-4669.
    • (2012) Cancer , vol.118 , pp. 4660-4669
    • Baquero, M.T.1    Hanna, J.A.2    Neumeister, V.3    Cheng, H.4    Molinaro, A.M.5
  • 30
    • 84926294413 scopus 로고    scopus 로고
    • Locked nucleic acid modified bispecific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy
    • Roy K, RK Kanwar, CHA Cheung, CL Fleming, RN Veedu, et al. (2015). Locked nucleic acid modified bispecific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy. RSC Adv 5:29008-29016.
    • (2015) RSC Adv , vol.5 , pp. 29008-29016
    • Roy, K.1    Kanwar, R.K.2    Cheung, C.H.A.3    Fleming, C.L.4    Veedu, R.N.5
  • 31
    • 70249110439 scopus 로고    scopus 로고
    • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
    • Dassie JP, XY Liu, GS Thomas, RM Whitaker, KW Thiel, et al. (2009). Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol 27:839-849.
    • (2009) Nat Biotechnol , vol.27 , pp. 839-849
    • Dassie, J.P.1    Liu, X.Y.2    Thomas, G.S.3    Whitaker, R.M.4    Thiel, K.W.5
  • 33
    • 84883563787 scopus 로고    scopus 로고
    • RNAstructure: Web servers for RNA secondary structure prediction and analysis
    • Bellaousov S, JS Reuter, MG Seetin, and DH Mathews. (2013). RNAstructure: Web servers for RNA secondary structure prediction and analysis. Nucleic Acids Res 41:W471-W474.
    • (2013) Nucleic Acids Res , vol.41 , pp. W471-W474
    • Bellaousov, S.1    Reuter, J.S.2    Seetin, M.G.3    Mathews, D.H.4
  • 34
    • 0042121256 scopus 로고    scopus 로고
    • Mfold web server for nucleic acid folding and hybridization prediction
    • Zuker M (2003). Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 31:3406-3415.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3406-3415
    • Zuker, M.1
  • 36
    • 0028114548 scopus 로고
    • Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding
    • Brown DA, SH Kang, SM Gryaznov, L DeDionisio, O Heidenreich, et al. (1994). Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding. J Biol Chem 269:26801-26805.
    • (1994) J Biol Chem , vol.269 , pp. 26801-26805
    • Brown, D.A.1    Kang, S.H.2    Gryaznov, S.M.3    DeDionisio, L.4    Heidenreich, O.5
  • 37
    • 81455144711 scopus 로고    scopus 로고
    • Locked vs. unlocked nucleic acids (LNA vs. UNA): Contrasting structures work towards common therapeutic goals
    • Campbell MA, and J Wengel. (2011). Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals. Chem Soc Rev 40:5680-5689.
    • (2011) Chem Soc Rev , vol.40 , pp. 5680-5689
    • Campbell, M.A.1    Wengel, J.2
  • 38
    • 77949613471 scopus 로고    scopus 로고
    • The EpCAM high/CD44 high colorectal carcinoma stem cell phenotype is not preferentially expressed in tumour buds
    • Prall F, C Maletzki, and M Linnebacher. (2010). The EpCAM high/CD44 high colorectal carcinoma stem cell phenotype is not preferentially expressed in tumour buds. Histopathology 56:553-555.
    • (2010) Histopathology , vol.56 , pp. 553-555
    • Prall, F.1    Maletzki, C.2    Linnebacher, M.3
  • 39
    • 84856804158 scopus 로고    scopus 로고
    • EpCAM is a putative stem marker in retinoblastoma and an effective target for T-cell-mediated immunotherapy
    • Mitra M, M Kandalam, A Harilal, RS Verma, UM Krishnan, et al. (2012) EpCAM is a putative stem marker in retinoblastoma and an effective target for T-cell-mediated immunotherapy. Mol Vis 18:290-308.
    • (2012) Mol Vis , vol.18 , pp. 290-308
    • Mitra, M.1    Kandalam, M.2    Harilal, A.3    Verma, R.S.4    Krishnan, U.M.5
  • 40
    • 68649096106 scopus 로고    scopus 로고
    • EpCAM is overexpressed in gastric cancer and its downregulation suppresses proliferation of gastric cancer
    • Wenqi D, W Li, C Shanshan, C Bei, Z Yafei, et al. (2009). EpCAM is overexpressed in gastric cancer and its downregulation suppresses proliferation of gastric cancer. J Cancer Res Clin Oncol 135:1277-1285.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 1277-1285
    • Wenqi, D.1    Li, W.2    Shanshan, C.3    Bei, C.4    Yafei, Z.5
  • 41
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, J Ji, A Budhu, M Forgues, W Yang, et al. (2009). EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 136:1012-1024.
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3    Forgues, M.4    Yang, W.5
  • 42
    • 84926609639 scopus 로고    scopus 로고
    • Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery
    • Camb
    • Subramanian N, JR Kanwar, B Akilandeswari, RK Kanwar, V Khetan, et al. (2015). Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery. Chem Commun (Camb) 51:6940-6943.
    • (2015) Chem Commun , vol.51 , pp. 6940-6943
    • Subramanian, N.1    Kanwar, J.R.2    Akilandeswari, B.3    Kanwar, R.K.4    Khetan, V.5


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