Stathmin expression and its relationship to microtubule-associated protein tau and outcome in breast cancer

Cancer

Volumn 118, Issue 19, 2012, Pages 4660-4669

  Baquero, Maria T ^a   Hanna, Jason A ^a   Neumeister, Veronique ^a   Cheng, Huan ^a   Molinaro, Annette M ^b   Harris, Lyndsay N ^a   Rimm, David L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

immunohistochemistry; microtubule associated protein; predictive; prognostic; quantitative analysis; stathmin; tau; taxanes

Indexed keywords

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; STATHMIN; TAU PROTEIN;

AGE; ARTICLE; BREAST CANCER; CANCER GRADING; CLINICAL FEATURE; COHORT ANALYSIS; CONFIDENCE INTERVAL; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; HAZARD RATIO; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MENOPAUSE; MICROTUBULE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; SURVIVAL RATE; SURVIVAL TIME; TISSUE MICROARRAY; TUMOR VOLUME; UNIVARIATE ANALYSIS;

ADULT; AGED; ANALYSIS OF VARIANCE; BLOTTING, WESTERN; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; COHORT STUDIES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM STAGING; ODDS RATIO; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; RNA, SMALL INTERFERING; STATHMIN; TAU PROTEINS; TISSUE ARRAY ANALYSIS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84866483805     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27453     Document Type: Article

References (43)

1. Cheng SL, Lecanda F, Davidson MK, et al. Human osteoblasts express a repertoire of cadherins, which are critical for Bmp-2-induced osteogenic differentiation. J Bone Miner Res. 1998; 13: 633-644.
2. Alli E, Bash-Babula J, Yang JM, Hait WN,. Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer. Cancer Res. 2002; 62: 6864-6869.
3. Martello LA, Verdier-Pinard P, Shen HJ, et al. Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-Tubulin mutation. Cancer Res. 2003; 63: 1207-1213.
4. Rouzier R, Rajan R, Wagner P, et al. Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer. Proc Natl Acad Sci U S A. 2005; 102: 8315-8320.
5. Bhat KM, Setaluri V,. Microtubule-associated proteins as targets in cancer chemotherapy. Clin Cancer Res. 2007; 13: 2849-2854.
6. Alli E, Yang JM, Ford JM, Hait WN,. Reversal of stathmin-mediated resistance to paclitaxel and vinblastine in human breast carcinoma cells. Mol Pharmacol. 2007; 71: 1233-1240.
7. Alli E, Yang JM, Hait WN,. Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53. Oncogene. 2007; 26: 1003-1012.
8. Felgner H, Frank R, Biernat J, et al. Domains of neuronal microtubule-associated proteins and flexural rigidity of microtubules. J Cell Biol. 1997; 138: 1067-1075.
9. Al-Bassam J, Ozer RS, Safer D, Halpain S, Milligan RA,. MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. J Cell Biol. 2002; 157: 1187-1196.
10. Rosenberg KJ, Ross JL, Feinstein HE, Feinstein SC, Israelachvili J,. Complementary dimerization of microtubule-associated tau protein: Implications for microtubule bundling and tau-mediated pathogenesis. Proc Natl Acad Sci U S A. 2008; 105: 7445-7450.
11. Choi MC, Raviv U, Miller HP, et al. Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study. Biophys J. 2009; 97: 519-527.
12. Larsson N, Melander H, Marklund U, Osterman O, Gullberg M,. G2/M transition requires multisite phosphorylation of oncoprotein 18 by two distinct protein kinase systems. J Biol Chem. 1995; 270: 14175-14183.
13. Marklund U, Larsson N, Gradin HM, Brattsand G, Gullberg M,. Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics. EMBO J. 1996; 15: 5290-5298.
14. Larsson N, Marklund U, Gradin HM, Brattsand G, Gullberg M,. Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis. Mol Cell Biol. 1997; 17: 5530-5539.
15. Belmont LD, Mitchison TJ,. Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell. 1996; 84: 623-631.
16. Curmi PA, Andersen SS, Lachkar S, et al. The stathmin/tubulin interaction in vitro. J Biol Chem. 1997; 272: 25029-25036.
17. Howell B, Larsson N, Gullberg M, Cassimeris L,. Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin. Mol Biol Cell. 1999; 10: 105-118.
18. Manna T, Thrower D, Miller HP, Curmi P, Wilson L,. Stathmin strongly increases the minus end catastrophe frequency and induces rapid treadmilling of bovine brain microtubules at steady state in vitro. J Biol Chem. 2006; 281: 2071-2078.
19. Rodriguez OC, Schaefer AW, Mandato CA, Forscher P, Bement WM, Waterman-Storer CM,. Conserved microtubule-actin interactions in cell movement and morphogenesis. Nat Cell Biol. 2003; 5: 599-609.
20. Ringhoff DN, Cassimeris L,. Gene expression profiles in mouse embryo fibroblasts lacking stathmin, a microtubule regulatory protein, reveal changes in the expression of genes contributing to cell motility. BMC Genomics. 2009; 10: 343.
21. Takahashi K, Suzuki K,. Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex. Cell Signal. 2009; 21: 695-703.
22. Golouh R, Cufer T, Sadikov A, et al. The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study. Breast Cancer Res Treat. 2008; 110: 317-326.
23. Singer S, Malz M, Herpel E, et al. Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer. Cancer Res. 2009; 69: 2234-2243.
24. Fang D, Nguyen TK, Leishear K, et al. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res. 2005; 65: 9328-9337.
25. Jeon TY, Han ME, Lee YW, et al. Overexpression of stathmin1 in the diffuse type of gastric cancer and its roles in proliferation and migration of gastric cancer cells. Br J Cancer. 2010; 102: 710-718.
26. Wei SH, Lin F, Wang X, Gao P, Zhang HZ,. Prognostic significance of stathmin expression in correlation with metastasis and clinicopathological characteristics in human ovarian carcinoma. Acta Histochem. 2008; 110: 59-65.
27. Aoki D, Oda Y, Hattori S, et al. Overexpression of class III beta-Tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma. Clin Cancer Res. 2009; 15: 1473-1480.
28. Xi W, Rui W, Fang L, Ke D, Ping G, Hui-Zhong Z,. Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients. J Cancer Res Clin Oncol. 2009; 135: 837-846.
29. Balasubramani M, Nakao C, Uechi GT, et al. Characterization and detection of cellular and proteomic alterations in stable stathmin-overexpressing, taxol-resistant BT549 breast cancer cells using offgel IEF/PAGE difference gel electrophoresis. Mutat Res. 2011; 722: 154-164.
30. Barden CB, Shister KW, Zhu B, et al. Classification of follicular thyroid tumors by molecular signature: results of gene profiling. Clin Cancer Res. 2003; 9: 1792-1800.
31. Curmi PA, Noguès C, Lachkar S, et al. Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours. Br J Cancer. 2000; 82: 142-150.
32. Saal LH, Johansson P, Holm K, et al. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A. 2007; 104: 7564-7569.
33. Dolled-Filhart M, McCabe A, Giltnane J, Cregger M, Camp RL, Rimm DL,. Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Res. 2006; 66: 5487-5494.
34. Dolled-Filhart M, McCabe A, Giltnane J, Cregger M, Camp RL, Rimm DL,. Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Res. 2006; 66: 5487-5494.
35. McCabe A, Dolled-Filhart M, Camp RL, Rimm DL,. Automated quantitative analysis (AQUA) of in situ protein expression, antibody concentration, and prognosis. J Natl Cancer Inst. 2005; 97: 1808-1815.
36. Giltnane JM, Moeder CB, Camp RL, Rimm DL,. Quantitative multiplexed analysis of ErbB family coexpression for primary breast cancer prognosis in a large retrospective cohort. Cancer. 2009; 115: 2400-2409.
37. Moeder CB, Giltnane JM, Harigopal M, et al. American Society of Clinical Oncology, College of American Pathologists. Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. J Clin Oncol. 2007; 25: 5418-5425.
38. Baquero MT, Lostritto K, Gustavson MD, et al. Evaluation of prognostic and predictive value of microtubule associated protein tau in two independent cohorts. Breast Cancer Res. 2011; 13: R85.
39. Reiman T, Lai R, Veillard AS, et al. for the LACE-Bio Group. Cross-validation study of class III beta-Tubulin as a predictive marker for benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of four randomized trials. Ann Oncol. 2012; 23: 86-93.
40. Pentheroudakis G, Batistatou A, Kalogeras KT, Kronenwett R, Wirtz RM, Bournakis E, et al. Prognostic utility of beta-Tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: a translational Hellenic Cooperative Oncology Group (HeCOG) study. Breast Cancer Res Treat. 2011; 127: 179-193.
41. Bernard-Marty C, Treilleux I, Dumontet C, et al. Microtubule-associated parameters as predictive markers of docetaxel activity in advanced breast cancer patients: results of a pilot study. Clin Breast Cancer. 2002; 3: 341-345.
42. Fauci J, O'Brien P,. TLE3 predicts sensitivity to taxane therapy in ovarian carcinoma. In: Society for Gynecologic Oncologists 41st Annual Meeting; March 14-17, 2010; San Francisco, CA. Poster presentation.
43. Ross DT, Seitz RS, Ring BZ, Wang Y, Beck RA, Soltermann A,. TLE3 expression is predictive of response to chemotherapy in NSCLC. In: American Association for Cancer Research Annual Meeting; April 17-21, 2010; Washington, DC. Poster Presentation.