-
1
-
-
84883076264
-
Severe sepsis and septic shock
-
Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369:840-51.
-
(2013)
N Engl J Med.
, vol.369
, pp. 840-851
-
-
Angus, D.C.1
Poll, T.2
-
3
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303-10.
-
(2001)
Crit Care Med.
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
4
-
-
0031036347
-
A new class of membrane-bound chemokine with a CX3C motif
-
Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, et al. A new class of membrane-bound chemokine with a CX3C motif. Nature. 1997;385:640-4.
-
(1997)
Nature.
, vol.385
, pp. 640-644
-
-
Bazan, J.F.1
Bacon, K.B.2
Hardiman, G.3
Wang, W.4
Soo, K.5
Rossi, D.6
-
5
-
-
59649092443
-
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival
-
Landsman L, Bar-On L, Zernecke A, Kim KW, Krauthgamer R, Shagdarsuren E, et al. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood. 2009;113:963-72.
-
(2009)
Blood.
, vol.113
, pp. 963-972
-
-
Landsman, L.1
Bar-On, L.2
Zernecke, A.3
Kim, K.W.4
Krauthgamer, R.5
Shagdarsuren, E.6
-
6
-
-
84863428261
-
CX3CL1/fractalkine is a novel regulator of normal and malignant human B cell function
-
Corcione A, Ferretti E, Pistoia V. CX3CL1/fractalkine is a novel regulator of normal and malignant human B cell function. J Leukoc Biol. 2012;92:51-8.
-
(2012)
J Leukoc Biol.
, vol.92
, pp. 51-58
-
-
Corcione, A.1
Ferretti, E.2
Pistoia, V.3
-
7
-
-
0035851124
-
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)
-
Garton KJ, Gough PJ, Blobel CP, Murphy G, Greaves DR, Dempsey PJ, et al. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem. 2001;276:37993-8001.
-
(2001)
J Biol Chem.
, vol.276
, pp. 37993-38001
-
-
Garton, K.J.1
Gough, P.J.2
Blobel, C.P.3
Murphy, G.4
Greaves, D.R.5
Dempsey, P.J.6
-
8
-
-
36849080928
-
Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages
-
Miksa M, Amin D, Wu R, Ravikumar TS, Wang P. Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages. Mol Med. 2007;13:553-60.
-
(2007)
Mol Med.
, vol.13
, pp. 553-560
-
-
Miksa, M.1
Amin, D.2
Wu, R.3
Ravikumar, T.S.4
Wang, P.5
-
9
-
-
34547877615
-
Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets
-
Schulz C, Schafer A, Stolla M, Kerstan S, Lorenz M, von Bruhl ML, et al. Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets. Circulation. 2007;116:764-73.
-
(2007)
Circulation.
, vol.116
, pp. 764-773
-
-
Schulz, C.1
Schafer, A.2
Stolla, M.3
Kerstan, S.4
Lorenz, M.5
Bruhl, M.L.6
-
10
-
-
84899429632
-
Role of fractalkine/CX3CL1 and its receptor in the pathogenesis of inflammatory and malignant diseases with emphasis on B cell malignancies
-
Ferretti E, Pistoia V, Corcione A. Role of fractalkine/CX3CL1 and its receptor in the pathogenesis of inflammatory and malignant diseases with emphasis on B cell malignancies. Mediators Inflamm. 2014;2014:480941.
-
(2014)
Mediators Inflamm.
, vol.2014
, pp. 480941
-
-
Ferretti, E.1
Pistoia, V.2
Corcione, A.3
-
11
-
-
78149492552
-
Fractalkine/CX3CL1: a potential new target for inflammatory diseases
-
Jones BA, Beamer M, Ahmed S. Fractalkine/CX3CL1: a potential new target for inflammatory diseases. Mol Interv. 2010;10:263-70.
-
(2010)
Mol Interv.
, vol.10
, pp. 263-270
-
-
Jones, B.A.1
Beamer, M.2
Ahmed, S.3
-
12
-
-
84861308990
-
Therapeutic potential of the chemokine-receptor duo fractalkine/CX3CR1: an update
-
D'Haese JG, Friess H, Ceyhan GO. Therapeutic potential of the chemokine-receptor duo fractalkine/CX3CR1: an update. Expert Opin Ther Targets. 2012;16:613-8.
-
(2012)
Expert Opin Ther Targets.
, vol.16
, pp. 613-618
-
-
D'Haese, J.G.1
Friess, H.2
Ceyhan, G.O.3
-
13
-
-
56149116902
-
Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis
-
Ishida Y, Hayashi T, Goto T, Kimura A, Akimoto S, Mukaida N, et al. Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis. J Immunol. 2008;181:4208-18.
-
(2008)
J Immunol.
, vol.181
, pp. 4208-4218
-
-
Ishida, Y.1
Hayashi, T.2
Goto, T.3
Kimura, A.4
Akimoto, S.5
Mukaida, N.6
-
14
-
-
58849107626
-
Administration of exogenous fractalkine, a CX3C chemokine, is capable of modulating inflammatory response in cecal ligation and puncture-induced sepsis
-
He M, Moochhala SM, Adhikari S, Bhatia M. Administration of exogenous fractalkine, a CX3C chemokine, is capable of modulating inflammatory response in cecal ligation and puncture-induced sepsis. Shock. 2009;31:33-9.
-
(2009)
Shock.
, vol.31
, pp. 33-39
-
-
He, M.1
Moochhala, S.M.2
Adhikari, S.3
Bhatia, M.4
-
15
-
-
84869881030
-
NF-κB-mediated inverse regulation of fractalkine and CX3CR1 during CLP-induced sepsis
-
Raspé C, Höcherl K, Rath S, Sauvant C, Bucher M. NF-κB-mediated inverse regulation of fractalkine and CX3CR1 during CLP-induced sepsis. Cytokine. 2013;61:97-103.
-
(2013)
Cytokine.
, vol.61
, pp. 97-103
-
-
Raspé, C.1
Höcherl, K.2
Rath, S.3
Sauvant, C.4
Bucher, M.5
-
16
-
-
44449152668
-
Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression
-
Pachot A, Cazalis MA, Venet F, Turrel F, Faudot C, Voirin N, et al. Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression. J Immunol. 2008;180:6421-9.
-
(2008)
J Immunol.
, vol.180
, pp. 6421-6429
-
-
Pachot, A.1
Cazalis, M.A.2
Venet, F.3
Turrel, F.4
Faudot, C.5
Voirin, N.6
-
17
-
-
84884905541
-
Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients
-
Klein Klouwenberg PM, Ong DS, Bos LD, de Beer FM, van Hooijdonk RT, Huson MA, et al. Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients. Crit Care Med. 2013;41:2373-8.
-
(2013)
Crit Care Med.
, vol.41
, pp. 2373-2378
-
-
Klein Klouwenberg, P.M.1
Ong, D.S.2
Bos, L.D.3
Beer, F.M.4
Hooijdonk, R.T.5
Huson, M.A.6
-
18
-
-
84898986179
-
Electronic implementation of a novel surveillance paradigm for ventilator-associated events. Feasibility and validation
-
Klein Klouwenberg PM, van Mourik MS, Ong DS, Horn J, Schultz MJ, Cremer OL, et al. Electronic implementation of a novel surveillance paradigm for ventilator-associated events. Feasibility and validation. Am J Respir Crit Care Med. 2014;189:947-55.
-
(2014)
Am J Respir Crit Care Med
, vol.189
, pp. 947-955
-
-
Klein Klouwenberg, P.M.1
Mourik, M.S.2
Ong, D.S.3
Horn, J.4
Schultz, M.J.5
Cremer, O.L.6
-
19
-
-
84943279884
-
A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission
-
Scicluna BP, Klein Klouwenberg PM, van Vught LA, Wiewel MA, Ong DS, Zwinderman AH, et al. A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission. Am J Respir Crit Care Med. 2015;192:826-35.
-
(2015)
Am J Respir Crit Care Med.
, vol.192
, pp. 826-835
-
-
Scicluna, B.P.1
Klein Klouwenberg, P.M.2
Vught, L.A.3
Wiewel, M.A.4
Ong, D.S.5
Zwinderman, A.H.6
-
20
-
-
84942506347
-
External validation confirms the legitimacy of a new clinical classification of ARDS for predicting outcome
-
Bos LD, Cremer OL, Ong DS, Caser EB, Barbas CS, Villar J, et al. External validation confirms the legitimacy of a new clinical classification of ARDS for predicting outcome. Intensive Care Med. 2015;41(11):2004-5.
-
(2015)
Intensive Care Med
, vol.41
, Issue.11
, pp. 2004-2005
-
-
Bos, L.D.1
Cremer, O.L.2
Ong, D.S.3
Caser, E.B.4
Barbas, C.S.5
Villar, J.6
-
21
-
-
84946726626
-
Epidemiology, management, and risk-adjusted mortality of ICU-acquired enterococcal bacteremia
-
Ong DS, Bonten MJ, Safdari K, Spitoni C, Frencken JF, Witteveen E, et al. Epidemiology, management, and risk-adjusted mortality of ICU-acquired enterococcal bacteremia. Clin Infect Dis. 2015;61:1413-20.
-
(2015)
Clin Infect Dis.
, vol.61
, pp. 1413-1420
-
-
Ong, D.S.1
Bonten, M.J.2
Safdari, K.3
Spitoni, C.4
Frencken, J.F.5
Witteveen, E.6
-
22
-
-
84925347630
-
Cytomegalovirus seroprevalence as a risk factor for poor outcome in acute respiratory distress syndrome
-
Ong DS, Klein Klouwenberg PM, Verduyn Lunel FM, Spitoni C, Frencken JF, Dekker HA, et al. Cytomegalovirus seroprevalence as a risk factor for poor outcome in acute respiratory distress syndrome. Crit Care Med. 2015;43:394-400.
-
(2015)
Crit Care Med.
, vol.43
, pp. 394-400
-
-
Ong, D.S.1
Klein Klouwenberg, P.M.2
Verduyn Lunel, F.M.3
Spitoni, C.4
Frencken, J.F.5
Dekker, H.A.6
-
23
-
-
84933278553
-
Plasma suPAR as a prognostic biological marker for ICU mortality in ARDS patients
-
Geboers DG, de Beer FM, Tuip-de Boer AM, van der Poll T, Horn J, Cremer OL, et al. Plasma suPAR as a prognostic biological marker for ICU mortality in ARDS patients. Intensive Care Med. 2015;41:1281-90.
-
(2015)
Intensive Care Med.
, vol.41
, pp. 1281-1290
-
-
Geboers, D.G.1
Beer, F.M.2
Tuip-de Boer, A.M.3
Poll, T.4
Horn, J.5
Cremer, O.L.6
-
24
-
-
84897556197
-
Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012
-
Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA. 2014;311:1308-16.
-
(2014)
JAMA.
, vol.311
, pp. 1308-1316
-
-
Kaukonen, K.M.1
Bailey, M.2
Suzuki, S.3
Pilcher, D.4
Bellomo, R.5
-
25
-
-
0023821657
-
CDC definitions for nosocomial infections, 1988
-
Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control. 1988;16:128-40.
-
(1988)
Am J Infect Control.
, vol.16
, pp. 128-140
-
-
Garner, J.S.1
Jarvis, W.R.2
Emori, T.G.3
Horan, T.C.4
Hughes, J.M.5
-
26
-
-
22144444944
-
The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit
-
Calandra T, Cohen J. The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit. Crit Care Med. 2005;33:1538-48.
-
(2005)
Crit Care Med.
, vol.33
, pp. 1538-1548
-
-
Calandra, T.1
Cohen, J.2
-
27
-
-
0037389094
-
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
-
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250-6.
-
(2003)
Crit Care Med.
, vol.31
, pp. 1250-1256
-
-
Levy, M.M.1
Fink, M.P.2
Marshall, J.C.3
Abraham, E.4
Angus, D.5
Cook, D.6
-
28
-
-
38849091997
-
Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond
-
Pencina MJ, D'Agostino Sr RB, D'Agostino Jr RB, Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med. 2008;27:157-72.
-
(2008)
Stat Med.
, vol.27
, pp. 157-172
-
-
Pencina, M.J.1
D'Agostino, R.B.2
D'Agostino, R.B.3
Vasan, R.S.4
-
30
-
-
0033624690
-
NF-kappaB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1beta, TNF-alpha, and LPS
-
Garcia GE, Xia Y, Chen S, Wang Y, Ye RD, Harrison JK, et al. NF-kappaB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1beta, TNF-alpha, and LPS. J Leukoc Biol. 2000;67:577-84.
-
(2000)
J Leukoc Biol.
, vol.67
, pp. 577-584
-
-
Garcia, G.E.1
Xia, Y.2
Chen, S.3
Wang, Y.4
Ye, R.D.5
Harrison, J.K.6
-
31
-
-
27644484364
-
Protective effect of alpha-lipoic acid in lipopolysaccharide-induced endothelial fractalkine expression
-
Sung MJ, Kim W, Ahn SY, Cho CH, Koh GY, Moon SO, et al. Protective effect of alpha-lipoic acid in lipopolysaccharide-induced endothelial fractalkine expression. Circ Res. 2005;97:880-90.
-
(2005)
Circ Res.
, vol.97
, pp. 880-890
-
-
Sung, M.J.1
Kim, W.2
Ahn, S.Y.3
Cho, C.H.4
Koh, G.Y.5
Moon, S.O.6
-
32
-
-
84882637960
-
Biomarkers of endothelial activation/dysfunction in infectious diseases
-
Page AV, Liles WC. Biomarkers of endothelial activation/dysfunction in infectious diseases. Virulence. 2013;4:507-16.
-
(2013)
Virulence.
, vol.4
, pp. 507-516
-
-
Page, A.V.1
Liles, W.C.2
-
33
-
-
84923014522
-
Endothelial barrier dysfunction in septic shock
-
Opal SM, van der Poll T. Endothelial barrier dysfunction in septic shock. J Intern Med. 2015;277:277-93.
-
(2015)
J Intern Med.
, vol.277
, pp. 277-293
-
-
Opal, S.M.1
Poll, T.2
-
34
-
-
0027294656
-
Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock
-
Newman W, Beall LD, Carson CW, Hunder GG, Graben N, Randhawa ZI, et al. Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J Immunol. 1993;150:644-54.
-
(1993)
J Immunol.
, vol.150
, pp. 644-654
-
-
Newman, W.1
Beall, L.D.2
Carson, C.W.3
Hunder, G.G.4
Graben, N.5
Randhawa, Z.I.6
-
35
-
-
0030854053
-
Soluble E-selectin levels in sepsis and critical illness. Correlation with infection and hemodynamic dysfunction
-
Cummings CJ, Sessler CN, Beall LD, Fisher BJ, Best AM, Fowler 3rd AA. Soluble E-selectin levels in sepsis and critical illness. Correlation with infection and hemodynamic dysfunction. Am J Respir Crit Care Med. 1997;156:431-7.
-
(1997)
Am J Respir Crit Care Med
, vol.156
, pp. 431-437
-
-
Cummings, C.J.1
Sessler, C.N.2
Beall, L.D.3
Fisher, B.J.4
Best, A.M.5
Fowler, A.A.6
-
36
-
-
84896725390
-
Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors
-
Telen MJ. Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. Hematol Oncol Clin North Am. 2014;28:341-54.
-
(2014)
Hematol Oncol Clin North Am.
, vol.28
, pp. 341-354
-
-
Telen, M.J.1
-
37
-
-
0029101772
-
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers
-
Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J. 1995;9:899-909.
-
(1995)
FASEB J.
, vol.9
, pp. 899-909
-
-
Collins, T.1
Read, M.A.2
Neish, A.S.3
Whitley, M.Z.4
Thanos, D.5
Maniatis, T.6
-
38
-
-
33746928340
-
Emerging roles for ectodomain shedding in the regulation of inflammatory responses
-
Garton KJ, Gough PJ, Raines EW. Emerging roles for ectodomain shedding in the regulation of inflammatory responses. J Leukoc Biol. 2006;79:1105-16.
-
(2006)
J Leukoc Biol.
, vol.79
, pp. 1105-1116
-
-
Garton, K.J.1
Gough, P.J.2
Raines, E.W.3
-
40
-
-
84876708502
-
Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis
-
Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13:426-35.
-
(2013)
Lancet Infect Dis.
, vol.13
, pp. 426-435
-
-
Wacker, C.1
Prkno, A.2
Brunkhorst, F.M.3
Schlattmann, P.4
-
41
-
-
84865816812
-
Fractalkine - a local inflammatory marker aggravating platelet activation at the vulnerable plaque
-
Flierl U, Schafer A. Fractalkine - a local inflammatory marker aggravating platelet activation at the vulnerable plaque. Thromb Haemost. 2012;108:457-63.
-
(2012)
Thromb Haemost.
, vol.108
, pp. 457-463
-
-
Flierl, U.1
Schafer, A.2
-
42
-
-
84865181707
-
Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1
-
Stolla M, Pelisek J, von Bruhl ML, Schafer A, Barocke V, Heider P, et al. Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1. PLoS One. 2012;7, e43572.
-
(2012)
PLoS One.
, vol.7
-
-
Stolla, M.1
Pelisek, J.2
Bruhl, M.L.3
Schafer, A.4
Barocke, V.5
Heider, P.6
-
43
-
-
84901757490
-
CX(3)CL1 (fractalkine) and its receptor CX(3)CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin
-
Staumont-Salle D, Fleury S, Lazzari A, Molendi-Coste O, Hornez N, Lavogiez C, et al. CX(3)CL1 (fractalkine) and its receptor CX(3)CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin. J Exp Med. 2014;211:1185-96.
-
(2014)
J Exp Med.
, vol.211
, pp. 1185-1196
-
-
Staumont-Salle, D.1
Fleury, S.2
Lazzari, A.3
Molendi-Coste, O.4
Hornez, N.5
Lavogiez, C.6
-
44
-
-
84898041245
-
Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis
-
Ridderstad Wollberg A, Ericsson-Dahlstrand A, Jureus A, Ekerot P, Simon S, Nilsson M, et al. Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis. Proc Natl Acad Sci USA. 2014;111:5409-14.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 5409-5414
-
-
Ridderstad Wollberg, A.1
Ericsson-Dahlstrand, A.2
Jureus, A.3
Ekerot, P.4
Simon, S.5
Nilsson, M.6
-
45
-
-
84926202106
-
Fractalkine (CX3CL1): A biomarker reflecting symptomatic severity in patients with knee osteoarthritis
-
Huo LW, Ye YL, Wang GW, Ye YG. Fractalkine (CX3CL1): A biomarker reflecting symptomatic severity in patients with knee osteoarthritis. J Investig Med. 2015;63:1-6.
-
(2015)
J Investig Med.
, vol.63
, pp. 1-6
-
-
Huo, L.W.1
Ye, Y.L.2
Wang, G.W.3
Ye, Y.G.4
|